EP0900081A4 - Inhibiteurs de farnesyl-proteine transferase - Google Patents
Inhibiteurs de farnesyl-proteine transferaseInfo
- Publication number
- EP0900081A4 EP0900081A4 EP97917604A EP97917604A EP0900081A4 EP 0900081 A4 EP0900081 A4 EP 0900081A4 EP 97917604 A EP97917604 A EP 97917604A EP 97917604 A EP97917604 A EP 97917604A EP 0900081 A4 EP0900081 A4 EP 0900081A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- farnesyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1479296P | 1996-04-03 | 1996-04-03 | |
US14792P | 1996-04-03 | ||
GB9610338 | 1996-05-17 | ||
GBGB9610338.7A GB9610338D0 (en) | 1996-05-17 | 1996-05-17 | Inhibitors of farnesyl-protein transferase |
PCT/US1997/004750 WO1997036591A1 (fr) | 1996-04-03 | 1997-03-27 | Inhibiteurs de farnesyl-proteine transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0900081A1 EP0900081A1 (fr) | 1999-03-10 |
EP0900081A4 true EP0900081A4 (fr) | 2002-01-09 |
Family
ID=26309349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97917604A Withdrawn EP0900081A4 (fr) | 1996-04-03 | 1997-03-27 | Inhibiteurs de farnesyl-proteine transferase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0900081A4 (fr) |
JP (1) | JP2001518067A (fr) |
AU (1) | AU707347B2 (fr) |
CA (1) | CA2250587A1 (fr) |
WO (1) | WO1997036591A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1090012A4 (fr) | 1998-07-02 | 2005-04-06 | Merck & Co Inc | Inhibiteurs de prenyl-proteine transferase |
JP2009508835A (ja) | 2005-09-16 | 2009-03-05 | アロー セラピューティクス リミテッド | ビフェニル誘導体及びc型肝炎の治療におけるその使用 |
TW201100398A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted indolo-pyridinone compounds |
WO2011153359A1 (fr) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Inhibiteurs du transporteur 1 de la glycine, procédés de fabrication associés, et utilisations associées |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA983495A (en) * | 1972-10-11 | 1976-02-10 | Gilbert Regnier | Procede de preparation de derives du benzodioxole |
US4598079A (en) * | 1981-08-20 | 1986-07-01 | Cassella Aktiengesellschaft | 2-(aryl substitued)piperazinones and nootropic compositions based thereon |
WO1993021186A1 (fr) * | 1992-04-13 | 1993-10-28 | Fujisawa Pharmaceutical Co., Ltd. | 3-pyrrolidinylthio-carbapenemes substitues, utilises comme agents antimicrobiens |
WO1995000497A1 (fr) * | 1993-06-18 | 1995-01-05 | Merck & Co., Inc. | Inhibiteurs de farnesyle-proteine transferase |
US5382584A (en) * | 1992-07-31 | 1995-01-17 | Bristol-Myers Squibb Company | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles |
EP0670314A1 (fr) * | 1993-09-22 | 1995-09-06 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteur de la farnesyl-transferase |
WO1996030343A1 (fr) * | 1995-03-29 | 1996-10-03 | Merck & Co., Inc. | Inhibiteurs de farnesyl-proteine transferase |
WO1996037204A1 (fr) * | 1995-05-24 | 1996-11-28 | Merck & Co., Inc. | Inhibiteurs de la farnesyle-proteine transferase |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915981A (en) * | 1973-03-16 | 1975-10-28 | Yoshitomi Pharmaceutical | 1-{8 2-(2-Chlorobenzoyl)-4-nitrophenyl{9 -2-(diethylaminomethyl)-imidazole |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
US4835154A (en) * | 1987-06-01 | 1989-05-30 | Smithkline Beckman Corporation | 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors |
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
WO1996016057A1 (fr) * | 1994-11-23 | 1996-05-30 | Neurogen Corporation | Certains derives d'aminoethyl imidazole et pyrrole substitues en 1; nouveaux ligands specifiques d'un sous-type de recepteur dopaminergique |
US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
-
1997
- 1997-03-27 EP EP97917604A patent/EP0900081A4/fr not_active Withdrawn
- 1997-03-27 CA CA002250587A patent/CA2250587A1/fr not_active Abandoned
- 1997-03-27 WO PCT/US1997/004750 patent/WO1997036591A1/fr not_active Application Discontinuation
- 1997-03-27 AU AU25879/97A patent/AU707347B2/en not_active Ceased
- 1997-03-27 JP JP53535797A patent/JP2001518067A/ja active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA983495A (en) * | 1972-10-11 | 1976-02-10 | Gilbert Regnier | Procede de preparation de derives du benzodioxole |
US4598079A (en) * | 1981-08-20 | 1986-07-01 | Cassella Aktiengesellschaft | 2-(aryl substitued)piperazinones and nootropic compositions based thereon |
WO1993021186A1 (fr) * | 1992-04-13 | 1993-10-28 | Fujisawa Pharmaceutical Co., Ltd. | 3-pyrrolidinylthio-carbapenemes substitues, utilises comme agents antimicrobiens |
US5382584A (en) * | 1992-07-31 | 1995-01-17 | Bristol-Myers Squibb Company | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles |
WO1995000497A1 (fr) * | 1993-06-18 | 1995-01-05 | Merck & Co., Inc. | Inhibiteurs de farnesyle-proteine transferase |
EP0670314A1 (fr) * | 1993-09-22 | 1995-09-06 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteur de la farnesyl-transferase |
WO1996030343A1 (fr) * | 1995-03-29 | 1996-10-03 | Merck & Co., Inc. | Inhibiteurs de farnesyl-proteine transferase |
WO1996037204A1 (fr) * | 1995-05-24 | 1996-11-28 | Merck & Co., Inc. | Inhibiteurs de la farnesyle-proteine transferase |
Non-Patent Citations (1)
Title |
---|
See also references of WO9736591A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0900081A1 (fr) | 1999-03-10 |
JP2001518067A (ja) | 2001-10-09 |
CA2250587A1 (fr) | 1997-10-09 |
WO1997036591A1 (fr) | 1997-10-09 |
AU707347B2 (en) | 1999-07-08 |
AU2587997A (en) | 1997-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981103 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/495 A, 7C 07D 403/06 B, 7C 07D 401/06 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20011123 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020211 |