EP0862435A4 - Inhibitoren der farnesyl-protein-transferase - Google Patents
Inhibitoren der farnesyl-protein-transferaseInfo
- Publication number
- EP0862435A4 EP0862435A4 EP96942798A EP96942798A EP0862435A4 EP 0862435 A4 EP0862435 A4 EP 0862435A4 EP 96942798 A EP96942798 A EP 96942798A EP 96942798 A EP96942798 A EP 96942798A EP 0862435 A4 EP0862435 A4 EP 0862435A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- farnesyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US749895P | 1995-11-22 | 1995-11-22 | |
US7498P | 1995-11-22 | ||
GBGB9604311.2A GB9604311D0 (en) | 1996-02-29 | 1996-02-29 | Inhibitors of farnesyl-protein transferase |
GB9604311 | 1996-02-29 | ||
PCT/US1996/018811 WO1997018813A1 (en) | 1995-11-22 | 1996-11-18 | Inhibitors of farnesyl-protein transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0862435A1 EP0862435A1 (de) | 1998-09-09 |
EP0862435A4 true EP0862435A4 (de) | 1999-02-03 |
Family
ID=26308829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96942798A Withdrawn EP0862435A4 (de) | 1995-11-22 | 1996-11-18 | Inhibitoren der farnesyl-protein-transferase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0862435A4 (de) |
JP (1) | JP2000500502A (de) |
AU (1) | AU704139B2 (de) |
CA (1) | CA2238081A1 (de) |
WO (1) | WO1997018813A1 (de) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU712504B2 (en) * | 1996-01-30 | 1999-11-11 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5891889A (en) * | 1996-04-03 | 1999-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU715202B2 (en) * | 1996-04-03 | 2000-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6117641A (en) | 1996-04-11 | 2000-09-12 | Mitotix, Inc. | Assays and reagents for identifying anti-fungal agents and uses related thereto |
ATE220110T1 (de) | 1996-04-11 | 2002-07-15 | Mitotix Inc | Assays und reaganzien zur identifizierung von fungiziden wirkstoffen und ihre verwendungen |
US6727082B1 (en) | 1996-04-11 | 2004-04-27 | Gpc Biotech Inc. | Assays and reagents for identifying anti-fungal agents, and uses related thereto |
US5965570A (en) * | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5958940A (en) * | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
WO1999027928A1 (en) * | 1997-12-04 | 1999-06-10 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
FR2780892B1 (fr) * | 1998-07-08 | 2001-08-17 | Sod Conseils Rech Applic | Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique |
US6432959B1 (en) | 1998-12-23 | 2002-08-13 | Schering Corporation | Inhibitors of farnesyl-protein transferase |
FR2788274B1 (fr) * | 1999-01-11 | 2001-02-09 | Aventis Pharma Sa | Nouveaux derives de polyhydroxypyrazines, leur preparation et les compositions pharmaceutiques qui les contiennent |
US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
WO2001068604A2 (en) | 2000-03-14 | 2001-09-20 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
AU2001216218A1 (en) | 2000-05-25 | 2001-12-11 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
MXPA02012712A (es) | 2000-06-30 | 2003-04-25 | Bristol Myers Squibb Pharma Co | N-ureidoheterocicloalquil-piperidinas como moduladores de la actividad del receptor de quimiocinas. |
KR100432577B1 (ko) * | 2002-02-08 | 2004-05-24 | 주식회사유한양행 | 이미다졸 유도체의 제조방법 |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
EA009881B1 (ru) | 2003-06-17 | 2008-04-28 | Пфайзер Инк. | Производные n-пирролидин-3-ил-амида в качестве ингибиторов обратного захвата серотонина и норадреналина |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
SI1667991T1 (sl) | 2003-09-16 | 2008-10-31 | Astrazeneca Ab | Kinazolinski derivati kot inhibitorji tirozin kinaze |
ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
CA2633624C (en) | 2005-12-30 | 2013-11-19 | Novartis Ag | 3,5-substituted piperidine compounds as renin inhibitors |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
CA2664113C (en) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
BRPI0806245B1 (pt) | 2007-01-10 | 2022-01-25 | Msd Italia S.R.L. | Compostos de fórmula i e seus usos |
WO2008093737A1 (ja) | 2007-01-31 | 2008-08-07 | Dainippon Sumitomo Pharma Co., Ltd. | アミド誘導体 |
AU2008212999A1 (en) | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
BRPI0808523A2 (pt) | 2007-03-01 | 2014-08-19 | Novartis Vaccines & Diagnostic | Inibidores de pim cinase e métodos de seu uso |
CA2685967A1 (en) | 2007-05-21 | 2008-11-21 | Novartis Ag | Csf-1r inhibitors, compositions, and methods of use |
ES2543641T3 (es) | 2007-06-25 | 2015-08-20 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidinadicarboxamida para uso como inhibidores de renina |
EP2170076B1 (de) | 2007-06-27 | 2016-05-18 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino-derivate als histondeacetylase-hemmer |
ME01461B (me) | 2008-02-07 | 2014-04-20 | Boehringer Ingelheim Int | Spirociklični heterocikli, ljekovi koji sadrže navedeno jedinjenje, njihova primjena i postupak za njihovu proizvodnju. |
NZ589883A (en) | 2008-05-13 | 2012-06-29 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy} quinazoline |
EP2313397B1 (de) | 2008-08-08 | 2016-04-20 | Boehringer Ingelheim International GmbH | Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
WO2010144909A1 (en) | 2009-06-12 | 2010-12-16 | Novartis Ag | Fused heterocyclic compounds and their uses |
CA2765527A1 (en) | 2009-06-24 | 2010-12-29 | Satoshi Suetsugu | N-substituted-cyclic amino derivative |
WO2011046771A1 (en) | 2009-10-14 | 2011-04-21 | Schering Corporation | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
CN103080093A (zh) | 2010-03-16 | 2013-05-01 | 达纳-法伯癌症研究所公司 | 吲唑化合物及其应用 |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
WO2012024170A2 (en) | 2010-08-17 | 2012-02-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
EP2615916B1 (de) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Kondensierte pyrazolderivate als neue erk-hemmer |
WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
JP2014514321A (ja) | 2011-04-21 | 2014-06-19 | メルク・シャープ・アンド・ドーム・コーポレーション | インスリン様増殖因子1受容体阻害剤 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
US10112927B2 (en) | 2012-10-18 | 2018-10-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
MX363243B (es) | 2012-11-28 | 2019-03-14 | Merck Sharp & Dohme | Composiciones para tratar cáncer y usos de dichas composiciones. |
RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の多環阻害剤 |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
WO2016105528A2 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
CA2978518C (en) | 2015-03-27 | 2023-11-21 | Nathanael S. Gray | Inhibitors of cyclin-dependent kinases |
EP3307728A4 (de) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Kombinationstherapie von transkriptionshemmern und kinasehemmern |
EP4019515A1 (de) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
AU2018252546A1 (en) | 2017-04-13 | 2019-10-10 | Sairopa B.V. | Anti-SIRPα antibodies |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
EP3833668A4 (de) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | Prmt5-inhibitoren |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0197840A1 (de) * | 1985-03-26 | 1986-10-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | (Imidazolyl-4)-piperidine, ihre Herstellung und Anwendung als Heilmittel |
WO1991009030A1 (en) * | 1989-12-12 | 1991-06-27 | Rhone-Poulenc Sante | 2-substituted 4,5-diphenyl-imidazoles |
WO1993012107A1 (en) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
WO1995000507A1 (en) * | 1993-06-22 | 1995-01-05 | Knoll Ag | Azolyl-cyclic amine derivatives with immunomodulatory activity |
EP0675112A1 (de) * | 1994-03-31 | 1995-10-04 | Bristol-Myers Squibb Company | Imidazol-enthaltende Farnesyl-Protein-Transferase-Inhibitoren |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB889225A (de) * | 1959-07-01 | |||
FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
-
1996
- 1996-11-18 WO PCT/US1996/018811 patent/WO1997018813A1/en not_active Application Discontinuation
- 1996-11-18 AU AU11626/97A patent/AU704139B2/en not_active Ceased
- 1996-11-18 CA CA002238081A patent/CA2238081A1/en not_active Abandoned
- 1996-11-18 EP EP96942798A patent/EP0862435A4/de not_active Withdrawn
- 1996-11-18 JP JP9519941A patent/JP2000500502A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0197840A1 (de) * | 1985-03-26 | 1986-10-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | (Imidazolyl-4)-piperidine, ihre Herstellung und Anwendung als Heilmittel |
WO1991009030A1 (en) * | 1989-12-12 | 1991-06-27 | Rhone-Poulenc Sante | 2-substituted 4,5-diphenyl-imidazoles |
WO1993012107A1 (en) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
WO1995000507A1 (en) * | 1993-06-22 | 1995-01-05 | Knoll Ag | Azolyl-cyclic amine derivatives with immunomodulatory activity |
EP0675112A1 (de) * | 1994-03-31 | 1995-10-04 | Bristol-Myers Squibb Company | Imidazol-enthaltende Farnesyl-Protein-Transferase-Inhibitoren |
Non-Patent Citations (1)
Title |
---|
See also references of WO9718813A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1997018813A1 (en) | 1997-05-29 |
JP2000500502A (ja) | 2000-01-18 |
AU704139B2 (en) | 1999-04-15 |
CA2238081A1 (en) | 1997-05-29 |
EP0862435A1 (de) | 1998-09-09 |
AU1162697A (en) | 1997-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0833633A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0862435A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0841919A4 (de) | Inhibitoren der farnesyl-protein transferase | |
EP0817629A4 (de) | Farnesylprotein transferase inhibitoren | |
EP0755383A4 (de) | Farnesyl-protein transferase inhibitonen | |
EP0891350A4 (de) | Inhibioten der farnesylprotein-transferase | |
EP1011669A4 (de) | Farnesyl-protein transferase inhibitoren | |
EP0784473A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0777475A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
GB9604311D0 (en) | Inhibitors of farnesyl-protein transferase | |
EP0783318A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0891360A4 (de) | Inhibitoren der farnesyl-protein transferase | |
EP0904080A4 (de) | Inhibitoren der farnesyl-protein transferase | |
EP0880320A4 (de) | Inhibitoren der farnesyl-protein transferase | |
EP0783305A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0891349A4 (de) | Inhibitoren von farnesylprotein-transferase | |
EP0817630A4 (de) | Inhibitoren der farnesyl-protein transferase | |
EP0760813A4 (de) | Inhibitoren von farnesyl-protein-transferase | |
EP0891352A4 (de) | Inhibitoren der farnesyl-protein transferase | |
GB9506174D0 (en) | Inhibitors of farnesyl-protein transferase | |
EP0891335A4 (de) | Inhibitoren von farnesylprotein-transferase | |
EP0891353A4 (de) | Farnesyl-protein transferase inhibitoren | |
EP0787123A4 (de) | Farnesyl-protein transferase inhibitoren | |
EP0959883A4 (de) | Inhibitoren der farnesyl-protein-transferase | |
EP0877610A4 (de) | Inhibitoren der farnesyl-protein transferase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980622 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched | ||
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CICCARONE, TERRENCE, M. Inventor name: DESOLMS, S., JANE Inventor name: GRAHAM, SAMUEL, L. Inventor name: SHAW, ANTHONY, W. Inventor name: KIM, BYEONG, M. |
|
17Q | First examination report despatched |
Effective date: 20001006 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010418 |