EP0837875A4 - Inhibiteurs de la farnesyle transferase - Google Patents

Inhibiteurs de la farnesyle transferase

Info

Publication number
EP0837875A4
EP0837875A4 EP96929648A EP96929648A EP0837875A4 EP 0837875 A4 EP0837875 A4 EP 0837875A4 EP 96929648 A EP96929648 A EP 96929648A EP 96929648 A EP96929648 A EP 96929648A EP 0837875 A4 EP0837875 A4 EP 0837875A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96929648A
Other languages
German (de)
English (en)
Other versions
EP0837875A2 (fr
Inventor
S Jane Desolms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/600,794 external-priority patent/US5627202A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority claimed from PCT/US1996/003975 external-priority patent/WO1996034010A2/fr
Publication of EP0837875A2 publication Critical patent/EP0837875A2/fr
Publication of EP0837875A4 publication Critical patent/EP0837875A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP96929648A 1995-03-29 1996-03-25 Inhibiteurs de la farnesyle transferase Withdrawn EP0837875A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41262695A 1995-03-29 1995-03-29
US41282895A 1995-03-29 1995-03-29
US412626 1995-03-29
US412828 1995-03-29
US441995P 1995-09-27 1995-09-27
US4419P 1995-09-27
US08/600,794 US5627202A (en) 1995-03-29 1996-02-13 Inhibitors of farnesyl-protein transferase
PCT/US1996/003975 WO1996034010A2 (fr) 1995-03-29 1996-03-25 Inhibiteurs de la farnesyle transferase
2000-02-22

Publications (2)

Publication Number Publication Date
EP0837875A2 EP0837875A2 (fr) 1998-04-29
EP0837875A4 true EP0837875A4 (fr) 1998-10-07

Family

ID=27485364

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96929648A Withdrawn EP0837875A4 (fr) 1995-03-29 1996-03-25 Inhibiteurs de la farnesyle transferase

Country Status (3)

Country Link
EP (1) EP0837875A4 (fr)
AU (1) AU708620B2 (fr)
CA (1) CA2216532A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720484A (en) * 1985-01-07 1988-01-19 Adir S.A.R.L. Peptide compounds having a nitrogenous polycyclic structure
EP0282374A1 (fr) * 1987-02-13 1988-09-14 Adir Et Compagnie Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0564924A2 (fr) * 1992-04-08 1993-10-13 Bayer Corporation Dérivés de 2-oxoéthyle comme agents immunosuppresseurs
WO1994015959A1 (fr) * 1993-01-05 1994-07-21 Astra Aktiebolag Nouveaux peptides
EP0610743A1 (fr) * 1993-02-09 1994-08-17 Bayer Corporation Nouveaux aminométhylène-peptides immunosuppressifs
EP0618221A2 (fr) * 1993-04-02 1994-10-05 Bristol-Myers Squibb Company Inhibiteurs hétérocycliques de la farnesyl-protein-transferase
EP0675112A1 (fr) * 1994-03-31 1995-10-04 Bristol-Myers Squibb Company Inhibiteurs de farnésyl-protéine-transférase contenant l'imidazole
EP0696593A2 (fr) * 1994-08-11 1996-02-14 Bristol-Myers Squibb Company Inhibiteurs de la farnesyl protéine transférase

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720484A (en) * 1985-01-07 1988-01-19 Adir S.A.R.L. Peptide compounds having a nitrogenous polycyclic structure
EP0282374A1 (fr) * 1987-02-13 1988-09-14 Adir Et Compagnie Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0564924A2 (fr) * 1992-04-08 1993-10-13 Bayer Corporation Dérivés de 2-oxoéthyle comme agents immunosuppresseurs
WO1994015959A1 (fr) * 1993-01-05 1994-07-21 Astra Aktiebolag Nouveaux peptides
EP0610743A1 (fr) * 1993-02-09 1994-08-17 Bayer Corporation Nouveaux aminométhylène-peptides immunosuppressifs
EP0618221A2 (fr) * 1993-04-02 1994-10-05 Bristol-Myers Squibb Company Inhibiteurs hétérocycliques de la farnesyl-protein-transferase
EP0675112A1 (fr) * 1994-03-31 1995-10-04 Bristol-Myers Squibb Company Inhibiteurs de farnésyl-protéine-transférase contenant l'imidazole
EP0696593A2 (fr) * 1994-08-11 1996-02-14 Bristol-Myers Squibb Company Inhibiteurs de la farnesyl protéine transférase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9634010A3 *

Also Published As

Publication number Publication date
CA2216532A1 (fr) 1996-10-31
AU708620B2 (en) 1999-08-05
AU6895096A (en) 1996-11-18
EP0837875A2 (fr) 1998-04-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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