SK14598A3 - 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors - Google Patents
4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors Download PDFInfo
- Publication number
- SK14598A3 SK14598A3 SK145-98A SK14598A SK14598A3 SK 14598 A3 SK14598 A3 SK 14598A3 SK 14598 A SK14598 A SK 14598A SK 14598 A3 SK14598 A3 SK 14598A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- alkyl
- phenyl
- compound
- carbon atoms
- Prior art date
Links
- 0 CC(C)(C)OC(S[C@](C1)C[C@@](C*)*1C(OCC=C)=O)=O Chemical compound CC(C)(C)OC(S[C@](C1)C[C@@](C*)*1C(OCC=C)=O)=O 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9515975.2A GB9515975D0 (en) | 1995-08-04 | 1995-08-04 | Chemical compounds |
| PCT/GB1996/001810 WO1997006138A1 (fr) | 1995-08-04 | 1996-07-30 | Derives de 4-mercaptopyrrolidine en tant qu'inhibiteurs de farnesyle transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK14598A3 true SK14598A3 (en) | 1998-09-09 |
Family
ID=10778742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK145-98A SK14598A3 (en) | 1995-08-04 | 1996-07-30 | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6232338B1 (fr) |
| EP (1) | EP0842151A1 (fr) |
| JP (1) | JPH11510178A (fr) |
| KR (1) | KR100502770B1 (fr) |
| CN (2) | CN1101380C (fr) |
| AU (1) | AU720353B2 (fr) |
| BR (1) | BR9609701A (fr) |
| CA (1) | CA2226671C (fr) |
| CZ (1) | CZ293694B6 (fr) |
| GB (1) | GB9515975D0 (fr) |
| HU (1) | HUP9802857A3 (fr) |
| IL (1) | IL123155A0 (fr) |
| MX (1) | MX9800946A (fr) |
| MY (1) | MY141457A (fr) |
| NO (2) | NO316624B1 (fr) |
| NZ (1) | NZ313696A (fr) |
| PL (1) | PL190873B1 (fr) |
| RU (1) | RU2191773C2 (fr) |
| SK (1) | SK14598A3 (fr) |
| TR (2) | TR199800147T1 (fr) |
| TW (1) | TW345575B (fr) |
| WO (1) | WO1997006138A1 (fr) |
| ZA (1) | ZA966610B (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204293B1 (en) | 1995-11-06 | 2001-03-20 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6221865B1 (en) | 1995-11-06 | 2001-04-24 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6310095B1 (en) | 1995-11-06 | 2001-10-30 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6693123B2 (en) | 1995-11-06 | 2004-02-17 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| EP0923545A1 (fr) * | 1996-08-17 | 1999-06-23 | Zeneca Limited | 3-mercaptopyrrolidines comme inhibiteurs de la farnesyle-proteine transferase |
| EP0986384B1 (fr) | 1997-05-07 | 2012-02-22 | University Of Pittsburgh | Inhibiteurs de proteines isoprenyle transferases |
| US6342765B1 (en) | 1997-10-22 | 2002-01-29 | Astrazeneca Uk Limited | Imidazole derivatives and their use as farnesyl protein transferase inhibitors |
| EP1025089A1 (fr) | 1997-10-22 | 2000-08-09 | Zeneca Limited | Derives imidazoles et leur utilisation comme inhibiteurs de la farnesyle-transferase |
| EP1054865A1 (fr) * | 1998-02-10 | 2000-11-29 | AstraZeneca UK Limited | Inhibiteurs de la farnesyle transferase |
| GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) * | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| US6924276B2 (en) * | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| CA2497628A1 (fr) * | 2002-09-05 | 2004-03-18 | Medimmune, Inc. | Methodes de prevention ou de traitement de malignites cellulaires par administration d'antagonistes de cd2 |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| EP2316487B1 (fr) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Anticorps IL-9 recombinants et leurs utilisations |
| US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| WO2005042743A2 (fr) | 2003-08-18 | 2005-05-12 | Medimmune, Inc. | Humanisation d'anticorps |
| DK1667991T3 (da) | 2003-09-16 | 2008-08-18 | Astrazeneca Ab | Quinazolinderivater som tyrosinkinaseinhibitorer |
| EP1744751A4 (fr) * | 2004-03-18 | 2010-03-10 | Brigham & Womens Hospital | Traitement des synucleinopathies |
| US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
| US20050288298A1 (en) * | 2004-03-18 | 2005-12-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20060121042A1 (en) | 2004-10-27 | 2006-06-08 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| AU2006227377B2 (en) | 2005-03-18 | 2013-01-31 | Medimmune, Llc | Framework-shuffling of antibodies |
| WO2007002543A2 (fr) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Formulations d'anticorps possedant des profils d'agregation et de fragmentation optimises |
| WO2007092285A2 (fr) * | 2006-02-02 | 2007-08-16 | Link Medicine Corporation | Traitement de synucléinopathies |
| NZ575163A (en) | 2006-08-28 | 2011-12-22 | Jolla Inst Allergy Immunolog | Antagonistic human light-specific human monoclonal antibodies |
| MX2009010389A (es) | 2007-03-30 | 2010-01-20 | Medimmune Llc | Formulacion de anticuerpos. |
| CN101376656A (zh) * | 2007-08-30 | 2009-03-04 | 山东轩竹医药科技有限公司 | 培南衍生物 |
| EP2215246B1 (fr) | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Structures protéiques |
| US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| CA2743717A1 (fr) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Derives d'azaquinolinone et leurs applications |
| WO2010107739A2 (fr) | 2009-03-18 | 2010-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Méthodes et compositions pour traiter l'infection par un virus de la famille des flaviviridae |
| EP2668210B1 (fr) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anticorps anti-kit et leurs utilisations |
| EP2691424B1 (fr) * | 2011-03-30 | 2016-02-03 | Canon Kabushiki Kaisha | Monomère polymérisable, composé polymère, agent de contrôle de charge contenant le composé polymère, et élément de support de révélateur et toner qui contiennent l'agent de contrôle de charge |
| SG11201500489YA (en) | 2012-07-25 | 2015-02-27 | Kolltan Pharmaceuticals Inc | Anti-kit antibodies and uses thereof |
| AU2013329311A1 (en) | 2012-10-09 | 2015-04-30 | Igenica Biotherapeutics, Inc. | Anti-C16orf54 antibodies and methods of use thereof |
| ES2891755T3 (es) | 2013-06-06 | 2022-01-31 | Pf Medicament | Anticuerpos anti-C10orf54 y utilizaciones de los mismos |
| KR102553717B1 (ko) | 2013-08-26 | 2023-07-11 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| JP6626461B2 (ja) | 2014-06-04 | 2019-12-25 | バイオエヌテック リサーチ アンド デベロップメント， インコーポレイテッド | ガングリオシドｇｄ２に対するヒトモノクローナル抗体 |
| WO2016094837A2 (fr) | 2014-12-11 | 2016-06-16 | Igenica Biotherapeutics, Inc. | Anticorps anti-c10orf54 et leurs utilisations |
| BR112017015880A2 (pt) | 2015-03-03 | 2018-07-31 | Kymab Ltd | anticorpos, usos e métodos |
| US10858316B2 (en) | 2015-07-10 | 2020-12-08 | University Of Maryland, Baltimore | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof |
| KR20180100122A (ko) | 2015-12-02 | 2018-09-07 | 주식회사 에스티사이언스 | 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체 |
| WO2017096051A1 (fr) | 2015-12-02 | 2017-06-08 | Stcube & Co., Inc. | Anticorps et molécules se liant de manière immunospécifique à btn1a1 et leurs utilisations thérapeutiques |
| EP3534947A1 (fr) | 2016-11-03 | 2019-09-11 | Kymab Limited | Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés |
| AU2018277838A1 (en) | 2017-05-31 | 2019-12-19 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof |
| AU2018277545A1 (en) | 2017-05-31 | 2019-12-19 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| JP2020522562A (ja) | 2017-06-06 | 2020-07-30 | ストキューブ アンド シーオー．， インコーポレイテッド | Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法 |
| EP3694889A1 (fr) | 2017-10-13 | 2020-08-19 | Boehringer Ingelheim International GmbH | Anticorps humains dirigés contre l'antigène thomsen-nouveau (tn) |
| CA3106418A1 (fr) | 2018-07-20 | 2020-01-23 | Pierre Fabre Medicament | Recepteur pour vista |
| GB201908453D0 (en) * | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (fr) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION |
| JPS60233076A (ja) | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| EP0182213B1 (fr) | 1984-11-08 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Dérivés de carbapénème et leur préparatIon |
| KR880006244A (ko) | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| GB8921635D0 (en) | 1989-09-25 | 1989-11-08 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
| CA2036163C (fr) | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Nouveaux composes de beta-lactame et leur production |
| CA2036941A1 (fr) | 1990-02-23 | 1991-08-24 | Isao Kawamoto | Derives du carbapenem ayant une action antibiotique, mode de preparation et d'utilisation |
| GB9107363D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| US6083917A (en) * | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
| US5185248A (en) | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| JPH0578360A (ja) | 1991-01-31 | 1993-03-30 | Banyu Pharmaceut Co Ltd | ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体 |
| GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9107342D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| RU2093514C1 (ru) | 1991-06-04 | 1997-10-20 | Санкио Компани Лимитед | Производные 1-метилкарбапенема и способ их получения |
| JPH04368386A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | １−メチルカルバペネム−３−カルボン酸の製造法 |
| US5360798A (en) | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
| DE69204007T2 (de) | 1991-10-11 | 1996-03-21 | Squibb & Sons Inc | Verwendung von Farnesyl-Protein Transferaseinhibitoren zur Herstellung eines Arzneimittels zur Blockierung von durch Ras-Oncogenen hervorgerufenen neoplastischen Transformationen von Zellen. |
| JPH05239058A (ja) | 1991-12-17 | 1993-09-17 | Fujisawa Pharmaceut Co Ltd | ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物 |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| HU218676B (hu) | 1992-03-11 | 2000-10-28 | Sankyo Co. Ltd. | Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
| CA2091309A1 (fr) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Composes antibiotiques |
| GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| US5608056A (en) | 1992-04-13 | 1997-03-04 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
| EP0581501B1 (fr) | 1992-07-21 | 1998-09-09 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| EP0581502B1 (fr) | 1992-07-21 | 1998-10-21 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| CA2099818A1 (fr) | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Composes antibiotiques |
| EP0590885B1 (fr) | 1992-09-28 | 2000-03-15 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| CA2106330A1 (fr) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Composes antibiotiques |
| CA2118985A1 (fr) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
| WO1995000497A1 (fr) | 1993-06-18 | 1995-01-05 | Merck & Co., Inc. | Inhibiteurs de farnesyle-proteine transferase |
| JPH09504277A (ja) | 1993-09-30 | 1997-04-28 | メルク エンド カンパニー インコーポレーテッド | ファルネシル−タンパク質トランスフェラーゼの阻害剤 |
| US5468733A (en) * | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5840918A (en) | 1994-03-15 | 1998-11-24 | Eisai Co., Ltd. | Isoprenyl transferase inhibitors |
| CA2155448A1 (fr) * | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibiteurs de la farnesyl-proteine-transferase |
| US5571835A (en) | 1994-09-29 | 1996-11-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU707537B2 (en) | 1995-07-31 | 1999-07-15 | Anthera Pharmaceuticals, Inc. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| JP3115285B2 (ja) | 1999-04-27 | 2000-12-04 | 徳光 中ノ瀬 | 合成樹脂体を利用した水上施設 |
-
1995
- 1995-08-04 GB GBGB9515975.2A patent/GB9515975D0/en active Pending
-
1996
- 1996-07-23 TW TW085108987A patent/TW345575B/zh active
- 1996-07-30 MX MX9800946A patent/MX9800946A/es not_active IP Right Cessation
- 1996-07-30 JP JP9508201A patent/JPH11510178A/ja not_active Ceased
- 1996-07-30 KR KR1019980700778A patent/KR100502770B1/ko not_active IP Right Cessation
- 1996-07-30 IL IL12315596A patent/IL123155A0/xx not_active IP Right Cessation
- 1996-07-30 RU RU98103393/04A patent/RU2191773C2/ru not_active IP Right Cessation
- 1996-07-30 AU AU66223/96A patent/AU720353B2/en not_active Ceased
- 1996-07-30 CZ CZ1998309A patent/CZ293694B6/cs not_active IP Right Cessation
- 1996-07-30 WO PCT/GB1996/001810 patent/WO1997006138A1/fr not_active Application Discontinuation
- 1996-07-30 BR BR9609701A patent/BR9609701A/pt not_active Application Discontinuation
- 1996-07-30 CA CA002226671A patent/CA2226671C/fr not_active Expired - Fee Related
- 1996-07-30 EP EP96925855A patent/EP0842151A1/fr not_active Withdrawn
- 1996-07-30 NZ NZ313696A patent/NZ313696A/xx unknown
- 1996-07-30 CN CN96197206A patent/CN1101380C/zh not_active Expired - Fee Related
- 1996-07-30 SK SK145-98A patent/SK14598A3/sk unknown
- 1996-07-30 HU HU9802857A patent/HUP9802857A3/hu unknown
- 1996-07-30 PL PL324819A patent/PL190873B1/pl not_active IP Right Cessation
- 1996-07-30 US US09/011,135 patent/US6232338B1/en not_active Expired - Fee Related
- 1996-07-30 TR TR1998/00147T patent/TR199800147T1/xx unknown
- 1996-07-30 TR TR2001/01884T patent/TR200101884T2/xx unknown
- 1996-08-02 MY MYPI96003186A patent/MY141457A/en unknown
- 1996-08-02 ZA ZA9606610A patent/ZA966610B/xx unknown
-
1998
- 1998-02-03 NO NO19980467A patent/NO316624B1/no unknown
-
2000
- 2000-11-30 US US09/725,964 patent/US6541491B1/en not_active Expired - Fee Related
-
2002
- 2002-03-26 CN CN02108502A patent/CN1377647A/zh active Pending
- 2002-10-15 NO NO20024950A patent/NO20024950D0/no not_active Application Discontinuation
Also Published As
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| Publication | Publication Date | Title |
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| SK14598A3 (en) | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | |
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