IL121860A0 - Interleukin-18 binding proteins their preparation and use - Google Patents
Interleukin-18 binding proteins their preparation and useInfo
- Publication number
- IL121860A0 IL121860A0 IL12186097A IL12186097A IL121860A0 IL 121860 A0 IL121860 A0 IL 121860A0 IL 12186097 A IL12186097 A IL 12186097A IL 12186097 A IL12186097 A IL 12186097A IL 121860 A0 IL121860 A0 IL 121860A0
- Authority
- IL
- Israel
- Prior art keywords
- interleukin
- preparation
- binding proteins
- proteins
- binding
- Prior art date
Links
- 102000044166 interleukin-18 binding protein Human genes 0.000 title 1
- 108010070145 interleukin-18 binding protein Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
Priority Applications (42)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12186097A IL121860A0 (en) | 1997-08-14 | 1997-09-29 | Interleukin-18 binding proteins their preparation and use |
IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
AT98938877T ATE443719T1 (de) | 1997-08-14 | 1998-08-13 | Interleukin-18 bindende proteine, deren herstellung und verwendung |
KR1020007001504A KR100687388B1 (ko) | 1997-08-14 | 1998-08-13 | 인터루킨-18 결합 단백질, 이들의 제조방법 및 용도 |
DK98938877.2T DK1003781T3 (da) | 1997-08-14 | 1998-08-13 | Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse |
IL13452398A IL134523A0 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
HK00108180.3A HK1028773B (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
SI9830922T SI1003781T1 (sl) | 1997-08-14 | 1998-08-13 | Interlevkin-18 vezavni proteini, njihova priprava in uporaba |
DE69841175T DE69841175D1 (de) | 1997-08-14 | 1998-08-13 | Interleukin-18 bindende proteine, deren herstellung und verwendung |
NZ502392A NZ502392A (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals |
HU0003533A HU226698B1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
SK176-2000A SK287194B6 (sk) | 1997-08-14 | 1998-08-13 | Interleukínový-18 väzbový proteín - IL-18BP, DNA, replikovateľný vektor, transformovaná hostiteľská bunka, protilátka k IL-18BP, spôsob výroby IL-18BP, prostriedok s jeho obsahom a jeho použitie |
JP2000509740A JP4272348B2 (ja) | 1997-08-14 | 1998-08-13 | インターロイキン−18結合タンパク質、それらの調製および用途 |
CNB988081342A CN1243021C (zh) | 1997-08-14 | 1998-08-13 | 白细胞介素-18结合蛋白质及其制备和用途 |
DE1003781T DE1003781T1 (de) | 1997-08-14 | 1998-08-13 | Interleukin-18 bindende proteine, deren herstellung und verwendung |
EP98938877A EP1003781B1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
EEP200000073A EE05538B1 (et) | 1997-08-14 | 1998-08-13 | Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine |
PL338647A PL206070B1 (pl) | 1997-08-14 | 1998-08-13 | Izolowane białko wiążące IL-18, sposób jego wytwarzania i izolowania, izolowana cząsteczka DNA, zdolny do replikacji wektor, transformowana komórka gospodarza, przeciwciało, kompozycja farmaceutyczna oraz zastosowanie |
PT98938877T PT1003781E (pt) | 1997-08-14 | 1998-08-13 | Proteínas de ligação a interleucina-18, sua preparação e utilização |
CA2298855A CA2298855C (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
ES98938877T ES2149149T3 (es) | 1997-08-14 | 1998-08-13 | Proteinas de union a interleuquina-18, su preparacion y uso. |
US09/485,632 US6605280B1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18 |
BRPI9811940-0 BRPI9811940B8 (pt) | 1997-08-14 | 1998-08-13 | vetor de expressão para um polipeptídeo de ligação da interleucina-18 (il-18-bp), célula hospedeira procariótica transformada com o referido vetor, processo para produção de il-18-bp, proteína de fusão compreendendo o referido polipeptídeo, bem como il-18bp modificada. |
AU87460/98A AU755794B2 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
CZ20000490A CZ300818B6 (cs) | 1997-08-14 | 1998-08-13 | Interleukin-18-vazebné proteiny, príprava a použití |
EA200000216A EA003675B1 (ru) | 1997-08-14 | 1998-08-13 | Белки, связывающие интерлейкин-18, их получение и применение |
UA2000031437A UA75862C2 (uk) | 1997-08-14 | 1998-08-13 | Виділений поліпептид, що зв'язується з il-18 (il-18bp) (варіанти), виділена молекула нуклеїнової кислоти, що його кодує (варіанти), антитіло, що зв'язується з даним поліпептидом, спосіб очищення il-18bp та композиція, що його містить |
PCT/IL1998/000379 WO1999009063A1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
ARP980104054A AR013422A1 (es) | 1997-08-14 | 1998-08-14 | UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA |
BG104149A BG65519B1 (bg) | 1997-08-14 | 2000-02-10 | Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение |
NO20000700A NO327240B1 (no) | 1997-08-14 | 2000-02-11 | Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter. |
IL134523A IL134523A (en) | 1997-08-14 | 2000-02-13 | Proteins that bind interleukin-18, their preparation and use |
US09/790,338 US7220717B2 (en) | 1997-08-14 | 2001-02-21 | Interleukin-18 binding proteins, their preparation and use |
US10/434,583 US7101689B2 (en) | 1997-08-14 | 2003-05-08 | Interleukin-18 binding proteins, their preparation and use |
US11/376,794 US7799541B2 (en) | 1997-08-14 | 2006-03-15 | Interleukin-18 binding proteins, their preparation and use |
US11/505,554 US7704944B2 (en) | 1997-08-14 | 2006-08-16 | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
US11/724,737 US7696154B2 (en) | 1997-08-14 | 2007-03-15 | Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins |
ARP070104104A AR062867A2 (es) | 1997-08-14 | 2007-09-17 | Proteinas de enlace a interleuquina -18, (il- 18bp), secuencias de adn que codifican para la il -18 bp, secuencias de adnc, un vehiculo de expresion replicable, celula huesped, un proceso para su produccion y aislacion, anticuerpos, composiciones farmaceuticas, el uso de dichas composiciones para la |
US12/511,756 US8436148B2 (en) | 1997-08-14 | 2009-07-29 | Antibodies against interleukin-18 binding protein, their preparation and use |
CY20091101232T CY1109664T1 (el) | 1997-08-14 | 2009-11-25 | Πρωτεϊνες δεσμευσεως ιντερλευκινης-18, η παρασκευη και η χρηση τους |
US12/715,089 US20100254941A1 (en) | 1997-08-14 | 2010-03-01 | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12155497A IL121554A0 (en) | 1997-08-14 | 1997-08-14 | Interleukin-18 binding proteins their preparation and use |
IL12163997A IL121639A0 (en) | 1997-08-14 | 1997-08-27 | Interleukin-18 binding proteins their preparation and use |
IL12186097A IL121860A0 (en) | 1997-08-14 | 1997-09-29 | Interleukin-18 binding proteins their preparation and use |
IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
PCT/IL1998/000379 WO1999009063A1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
IL121860A0 true IL121860A0 (en) | 1998-02-22 |
Family
ID=27517687
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12186097A IL121860A0 (en) | 1997-08-14 | 1997-09-29 | Interleukin-18 binding proteins their preparation and use |
IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
IL13452398A IL134523A0 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
IL134523A IL134523A (en) | 1997-08-14 | 2000-02-13 | Proteins that bind interleukin-18, their preparation and use |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
IL13452398A IL134523A0 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
IL134523A IL134523A (en) | 1997-08-14 | 2000-02-13 | Proteins that bind interleukin-18, their preparation and use |
Country Status (28)
Country | Link |
---|---|
US (4) | US6605280B1 (cs) |
EP (1) | EP1003781B1 (cs) |
JP (1) | JP4272348B2 (cs) |
KR (1) | KR100687388B1 (cs) |
CN (1) | CN1243021C (cs) |
AR (2) | AR013422A1 (cs) |
AT (1) | ATE443719T1 (cs) |
AU (1) | AU755794B2 (cs) |
BG (1) | BG65519B1 (cs) |
BR (1) | BRPI9811940B8 (cs) |
CA (1) | CA2298855C (cs) |
CY (1) | CY1109664T1 (cs) |
CZ (1) | CZ300818B6 (cs) |
DE (2) | DE1003781T1 (cs) |
DK (1) | DK1003781T3 (cs) |
EA (1) | EA003675B1 (cs) |
EE (1) | EE05538B1 (cs) |
ES (1) | ES2149149T3 (cs) |
HU (1) | HU226698B1 (cs) |
IL (5) | IL121860A0 (cs) |
NO (1) | NO327240B1 (cs) |
NZ (1) | NZ502392A (cs) |
PL (1) | PL206070B1 (cs) |
PT (1) | PT1003781E (cs) |
SI (1) | SI1003781T1 (cs) |
SK (1) | SK287194B6 (cs) |
UA (1) | UA75862C2 (cs) |
WO (1) | WO1999009063A1 (cs) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393663B2 (en) * | 1997-08-01 | 2008-07-01 | Serono Genetics Institute S.A. | Expressed sequence tags and encoded human proteins |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
EP1110969A4 (en) * | 1998-09-01 | 2002-01-09 | Hayashibara Biochem Lab | INTERLEUKIN 18-BINDING PROTEINS |
AR022952A1 (es) * | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
IL131047A0 (en) * | 1999-07-22 | 2001-01-28 | Yeda Res & Dev | Use of il-18 inhibitors |
DE60041432D1 (de) * | 1999-11-16 | 2009-03-12 | Hayashibara Biochem Lab | Antikörper spezifisch für den Interleukin-18 Vorläufer |
EP2332579A3 (en) | 2000-02-10 | 2011-09-21 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
SK288032B6 (sk) * | 2000-02-21 | 2012-12-03 | Merck Serono Sa | Use of IL-18 inhibitors for manufacture of medicament for treatment and/or prevention of alcoholic hepatitis |
AU2005211606B2 (en) * | 2000-05-05 | 2007-02-22 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis |
MXPA02010895A (es) * | 2000-05-05 | 2003-03-27 | Applied Research Systems | Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis. |
AU2002211744B8 (en) | 2000-10-11 | 2008-03-20 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
JP4860897B2 (ja) * | 2001-01-29 | 2012-01-25 | メルク セロノ ソシエテ アノニム | 心疾患の治療および/または予防のためのil−18阻害剤の使用 |
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1997
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