IL121860A0 - Interleukin-18 binding proteins their preparation and use - Google Patents

Interleukin-18 binding proteins their preparation and use

Info

Publication number
IL121860A0
IL121860A0 IL12186097A IL12186097A IL121860A0 IL 121860 A0 IL121860 A0 IL 121860A0 IL 12186097 A IL12186097 A IL 12186097A IL 12186097 A IL12186097 A IL 12186097A IL 121860 A0 IL121860 A0 IL 121860A0
Authority
IL
Israel
Prior art keywords
interleukin
preparation
binding proteins
proteins
binding
Prior art date
Application number
IL12186097A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12155497A external-priority patent/IL121554A0/xx
Priority claimed from IL12163997A external-priority patent/IL121639A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12186097A priority Critical patent/IL121860A0/xx
Priority to IL12213497A priority patent/IL122134A0/xx
Publication of IL121860A0 publication Critical patent/IL121860A0/xx
Priority to IL12546398A priority patent/IL125463A0/xx
Priority to ES98938877T priority patent/ES2149149T3/es
Priority to CZ20000490A priority patent/CZ300818B6/cs
Priority to SI9830922T priority patent/SI1003781T1/sl
Priority to DE69841175T priority patent/DE69841175D1/de
Priority to NZ502392A priority patent/NZ502392A/xx
Priority to HU0003533A priority patent/HU226698B1/hu
Priority to SK176-2000A priority patent/SK287194B6/sk
Priority to JP2000509740A priority patent/JP4272348B2/ja
Priority to CNB988081342A priority patent/CN1243021C/zh
Priority to DE1003781T priority patent/DE1003781T1/de
Priority to EP98938877A priority patent/EP1003781B1/en
Priority to EEP200000073A priority patent/EE05538B1/xx
Priority to PL338647A priority patent/PL206070B1/pl
Priority to PT98938877T priority patent/PT1003781E/pt
Priority to CA2298855A priority patent/CA2298855C/en
Priority to IL13452398A priority patent/IL134523A0/xx
Priority to US09/485,632 priority patent/US6605280B1/en
Priority to BRPI9811940-0 priority patent/BRPI9811940B8/pt
Priority to AU87460/98A priority patent/AU755794B2/en
Priority to HK00108180.3A priority patent/HK1028773B/xx
Priority to EA200000216A priority patent/EA003675B1/ru
Priority to UA2000031437A priority patent/UA75862C2/uk
Priority to PCT/IL1998/000379 priority patent/WO1999009063A1/en
Priority to AT98938877T priority patent/ATE443719T1/de
Priority to KR1020007001504A priority patent/KR100687388B1/ko
Priority to DK98938877.2T priority patent/DK1003781T3/da
Priority to ARP980104054A priority patent/AR013422A1/es
Priority to BG104149A priority patent/BG65519B1/bg
Priority to NO20000700A priority patent/NO327240B1/no
Priority to IL134523A priority patent/IL134523A/en
Priority to US09/790,338 priority patent/US7220717B2/en
Priority to US10/434,583 priority patent/US7101689B2/en
Priority to US11/376,794 priority patent/US7799541B2/en
Priority to US11/505,554 priority patent/US7704944B2/en
Priority to US11/724,737 priority patent/US7696154B2/en
Priority to ARP070104104A priority patent/AR062867A2/es
Priority to US12/511,756 priority patent/US8436148B2/en
Priority to CY20091101232T priority patent/CY1109664T1/el
Priority to US12/715,089 priority patent/US20100254941A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/826Viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/834Urine; urinary system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
IL12186097A 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use IL121860A0 (en)

Priority Applications (42)

Application Number Priority Date Filing Date Title
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
AT98938877T ATE443719T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
KR1020007001504A KR100687388B1 (ko) 1997-08-14 1998-08-13 인터루킨-18 결합 단백질, 이들의 제조방법 및 용도
DK98938877.2T DK1003781T3 (da) 1997-08-14 1998-08-13 Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
HK00108180.3A HK1028773B (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
SI9830922T SI1003781T1 (sl) 1997-08-14 1998-08-13 Interlevkin-18 vezavni proteini, njihova priprava in uporaba
DE69841175T DE69841175D1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
NZ502392A NZ502392A (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals
HU0003533A HU226698B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
SK176-2000A SK287194B6 (sk) 1997-08-14 1998-08-13 Interleukínový-18 väzbový proteín - IL-18BP, DNA, replikovateľný vektor, transformovaná hostiteľská bunka, protilátka k IL-18BP, spôsob výroby IL-18BP, prostriedok s jeho obsahom a jeho použitie
JP2000509740A JP4272348B2 (ja) 1997-08-14 1998-08-13 インターロイキン−18結合タンパク質、それらの調製および用途
CNB988081342A CN1243021C (zh) 1997-08-14 1998-08-13 白细胞介素-18结合蛋白质及其制备和用途
DE1003781T DE1003781T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
EP98938877A EP1003781B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EEP200000073A EE05538B1 (et) 1997-08-14 1998-08-13 Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine
PL338647A PL206070B1 (pl) 1997-08-14 1998-08-13 Izolowane białko wiążące IL-18, sposób jego wytwarzania i izolowania, izolowana cząsteczka DNA, zdolny do replikacji wektor, transformowana komórka gospodarza, przeciwciało, kompozycja farmaceutyczna oraz zastosowanie
PT98938877T PT1003781E (pt) 1997-08-14 1998-08-13 Proteínas de ligação a interleucina-18, sua preparação e utilização
CA2298855A CA2298855C (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
ES98938877T ES2149149T3 (es) 1997-08-14 1998-08-13 Proteinas de union a interleuquina-18, su preparacion y uso.
US09/485,632 US6605280B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
BRPI9811940-0 BRPI9811940B8 (pt) 1997-08-14 1998-08-13 vetor de expressão para um polipeptídeo de ligação da interleucina-18 (il-18-bp), célula hospedeira procariótica transformada com o referido vetor, processo para produção de il-18-bp, proteína de fusão compreendendo o referido polipeptídeo, bem como il-18bp modificada.
AU87460/98A AU755794B2 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
CZ20000490A CZ300818B6 (cs) 1997-08-14 1998-08-13 Interleukin-18-vazebné proteiny, príprava a použití
EA200000216A EA003675B1 (ru) 1997-08-14 1998-08-13 Белки, связывающие интерлейкин-18, их получение и применение
UA2000031437A UA75862C2 (uk) 1997-08-14 1998-08-13 Виділений поліпептид, що зв'язується з il-18 (il-18bp) (варіанти), виділена молекула нуклеїнової кислоти, що його кодує (варіанти), антитіло, що зв'язується з даним поліпептидом, спосіб очищення il-18bp та композиція, що його містить
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
ARP980104054A AR013422A1 (es) 1997-08-14 1998-08-14 UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA
BG104149A BG65519B1 (bg) 1997-08-14 2000-02-10 Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение
NO20000700A NO327240B1 (no) 1997-08-14 2000-02-11 Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter.
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use
US09/790,338 US7220717B2 (en) 1997-08-14 2001-02-21 Interleukin-18 binding proteins, their preparation and use
US10/434,583 US7101689B2 (en) 1997-08-14 2003-05-08 Interleukin-18 binding proteins, their preparation and use
US11/376,794 US7799541B2 (en) 1997-08-14 2006-03-15 Interleukin-18 binding proteins, their preparation and use
US11/505,554 US7704944B2 (en) 1997-08-14 2006-08-16 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
US11/724,737 US7696154B2 (en) 1997-08-14 2007-03-15 Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
ARP070104104A AR062867A2 (es) 1997-08-14 2007-09-17 Proteinas de enlace a interleuquina -18, (il- 18bp), secuencias de adn que codifican para la il -18 bp, secuencias de adnc, un vehiculo de expresion replicable, celula huesped, un proceso para su produccion y aislacion, anticuerpos, composiciones farmaceuticas, el uso de dichas composiciones para la
US12/511,756 US8436148B2 (en) 1997-08-14 2009-07-29 Antibodies against interleukin-18 binding protein, their preparation and use
CY20091101232T CY1109664T1 (el) 1997-08-14 2009-11-25 Πρωτεϊνες δεσμευσεως ιντερλευκινης-18, η παρασκευη και η χρηση τους
US12/715,089 US20100254941A1 (en) 1997-08-14 2010-03-01 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12155497A IL121554A0 (en) 1997-08-14 1997-08-14 Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en) 1997-08-14 1997-08-27 Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use

Publications (1)

Publication Number Publication Date
IL121860A0 true IL121860A0 (en) 1998-02-22

Family

ID=27517687

Family Applications (5)

Application Number Title Priority Date Filing Date
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Country Status (28)

Country Link
US (4) US6605280B1 (cs)
EP (1) EP1003781B1 (cs)
JP (1) JP4272348B2 (cs)
KR (1) KR100687388B1 (cs)
CN (1) CN1243021C (cs)
AR (2) AR013422A1 (cs)
AT (1) ATE443719T1 (cs)
AU (1) AU755794B2 (cs)
BG (1) BG65519B1 (cs)
BR (1) BRPI9811940B8 (cs)
CA (1) CA2298855C (cs)
CY (1) CY1109664T1 (cs)
CZ (1) CZ300818B6 (cs)
DE (2) DE1003781T1 (cs)
DK (1) DK1003781T3 (cs)
EA (1) EA003675B1 (cs)
EE (1) EE05538B1 (cs)
ES (1) ES2149149T3 (cs)
HU (1) HU226698B1 (cs)
IL (5) IL121860A0 (cs)
NO (1) NO327240B1 (cs)
NZ (1) NZ502392A (cs)
PL (1) PL206070B1 (cs)
PT (1) PT1003781E (cs)
SI (1) SI1003781T1 (cs)
SK (1) SK287194B6 (cs)
UA (1) UA75862C2 (cs)
WO (1) WO1999009063A1 (cs)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) * 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18-BINDING PROTEINS
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
IL131047A0 (en) * 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
DE60041432D1 (de) * 1999-11-16 2009-03-12 Hayashibara Biochem Lab Antikörper spezifisch für den Interleukin-18 Vorläufer
EP2332579A3 (en) 2000-02-10 2011-09-21 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
SK288032B6 (sk) * 2000-02-21 2012-12-03 Merck Serono Sa Use of IL-18 inhibitors for manufacture of medicament for treatment and/or prevention of alcoholic hepatitis
AU2005211606B2 (en) * 2000-05-05 2007-02-22 Inserm - Institut National De La Sante Et De La Recherche Medicale Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
MXPA02010895A (es) * 2000-05-05 2003-03-27 Applied Research Systems Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis.
AU2002211744B8 (en) 2000-10-11 2008-03-20 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
JP4860897B2 (ja) * 2001-01-29 2012-01-25 メルク セロノ ソシエテ アノニム 心疾患の治療および/または予防のためのil−18阻害剤の使用
UA85531C2 (uk) * 2001-05-16 2009-02-10 Йеда Рисерч Энд Дивелопмент Ко. Лтд. Застосування il-18 інгібіторів для лікування або попередження пов'язаної з сепсисом дисфункції серця
EA006744B1 (ru) * 2001-05-25 2006-04-28 Арес Трейдинг С. А. Применение ингибиторов il-18 для лечения и предотвращения повреждений цнс
YU103003A (sh) 2001-06-26 2006-05-25 Abgenix Inc. Antitela za opgl
UA78516C2 (en) * 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
EP1487541B1 (en) * 2002-03-22 2008-11-19 Laboratoires Serono SA Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases
EP1545578A4 (en) 2002-08-28 2010-07-07 Immunex Corp COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASES
ES2416510T3 (es) * 2002-10-08 2013-08-01 Ares Trading S.A. Uso de una citocina capaz de unirse a IL 18BP y de inhibir la actividad de una segunda citocina
IL152232A0 (en) * 2002-10-10 2003-05-29 Yeda Res & Dev Promoter to il-18bp, its preparation and use
AU2004235595C1 (en) * 2003-04-30 2009-09-24 Japan Science And Technology Agency Human antihuman interleukin-18 antibody, fragment thereof and method of using the same
SI1622939T1 (sl) 2003-05-13 2012-06-29 Merck Serono Sa Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
PT1689777E (pt) * 2003-11-05 2007-05-31 Ares Trading Sa Processo para a purificação da proteína de ligação a il-18
BRPI0416467A (pt) 2003-11-12 2007-03-06 Univ Colorado Regents ácido nucléico purificado, célula hospedeira, proteìna purificada, anticorpo, fragmento fab, e, métodos para induzir a produção de tnf alfa, para tratar um paciente, e para triagem para inibidores da il-32
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
HRP20070474T3 (en) * 2004-03-01 2007-11-30 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
WO2005097998A2 (en) * 2004-03-31 2005-10-20 Regeneron Pharmaceuticals, Inc. Il-18 specific polypeptides and therapeutic uses thereof
WO2006003134A1 (en) * 2004-06-29 2006-01-12 Ares Trading S.A. Process for the purification of il-18 binding protein
ES2385639T3 (es) 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
ATE530227T1 (de) * 2005-06-03 2011-11-15 Merck Serono Sa Verwendung von il-18bp-isoformen zur behandlung und/oder vorbeugung neurologischer entzündungskrankheiten
ATE529433T1 (de) * 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
CN101003812B (zh) * 2006-01-17 2011-01-05 温州医学院 一种用于制备重组人egf-il18融合蛋白的方法
US8133978B2 (en) 2006-05-25 2012-03-13 Glaxo Group Limited Humanised anti-interleukin-18 antibody
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
EP2941310A4 (en) * 2013-01-02 2016-08-24 Wilsa Inc METHOD AND DEVICE FOR CONDITIONING LIQUIDS
WO2015032932A1 (en) * 2013-09-05 2015-03-12 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
EP3265807A1 (en) 2015-03-05 2018-01-10 AB2 Bio SA Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
WO2023143535A1 (zh) * 2022-01-28 2023-08-03 和径医药科技(上海)有限公司 一种靶向il-18bp的抗体及其应用
US20250297018A1 (en) * 2022-03-15 2025-09-25 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
CN114605521A (zh) * 2022-04-06 2022-06-10 内蒙古农业大学 一种细胞免疫调节蛋白及其应用
CN114891125B (zh) * 2022-06-16 2023-04-11 广东医科大学 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Il—18bp拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
ES2213209T3 (es) 1996-11-15 2004-08-16 Kennedy Institute Of Rheumatology Supresion de tnfalfa e il-12 en terapia.
WO1998024804A2 (en) 1996-12-06 1998-06-11 Vertex Pharmaceuticals Incorporated INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
DE998300T1 (de) 1997-03-18 2001-03-01 Basf Ag Zusammensetzungen zur modulation der empfänglichkeit für corticosteroiden
DE69834727T2 (de) 1997-08-01 2007-01-25 Serono Genetics Institute S.A. 5' ests für sekretierte proteine die in verschiedenen geweben expremiert werden
ATE495257T1 (de) 1997-08-01 2011-01-15 Merck Serono Biodevelopment 5' ests für sekretierte proteine, die in verschiedenen geweben exprimiert werden
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
ATE275422T1 (de) 1998-04-28 2004-09-15 Applied Research Systems Konjugate aus polyole und beta-interferon
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18-BINDING PROTEINS
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
WO2001003719A2 (en) 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
WO2001019373A2 (en) 1999-09-17 2001-03-22 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids

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US7799541B2 (en) 2010-09-21
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