NO20000700L - Interleukin-18-proteiner samt fremstilling og anvendelse derav - Google Patents
Interleukin-18-proteiner samt fremstilling og anvendelse deravInfo
- Publication number
- NO20000700L NO20000700L NO20000700A NO20000700A NO20000700L NO 20000700 L NO20000700 L NO 20000700L NO 20000700 A NO20000700 A NO 20000700A NO 20000700 A NO20000700 A NO 20000700A NO 20000700 L NO20000700 L NO 20000700L
- Authority
- NO
- Norway
- Prior art keywords
- interleukin
- proteins
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12155497A IL121554A0 (en) | 1997-08-14 | 1997-08-14 | Interleukin-18 binding proteins their preparation and use |
IL12163997A IL121639A0 (en) | 1997-08-14 | 1997-08-27 | Interleukin-18 binding proteins their preparation and use |
IL12186097A IL121860A0 (en) | 1997-08-14 | 1997-09-29 | Interleukin-18 binding proteins their preparation and use |
IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
PCT/IL1998/000379 WO1999009063A1 (en) | 1997-08-14 | 1998-08-13 | Interleukin-18 binding proteins, their preparation and use |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20000700D0 NO20000700D0 (no) | 2000-02-11 |
NO20000700L true NO20000700L (no) | 2000-04-14 |
NO327240B1 NO327240B1 (no) | 2009-05-18 |
Family
ID=27517687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20000700A NO327240B1 (no) | 1997-08-14 | 2000-02-11 | Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter. |
Country Status (29)
Country | Link |
---|---|
US (4) | US6605280B1 (no) |
EP (1) | EP1003781B1 (no) |
JP (1) | JP4272348B2 (no) |
KR (1) | KR100687388B1 (no) |
CN (1) | CN1243021C (no) |
AR (2) | AR013422A1 (no) |
AT (1) | ATE443719T1 (no) |
AU (1) | AU755794B2 (no) |
BG (1) | BG65519B1 (no) |
BR (1) | BRPI9811940B8 (no) |
CA (1) | CA2298855C (no) |
CY (1) | CY1109664T1 (no) |
CZ (1) | CZ300818B6 (no) |
DE (2) | DE1003781T1 (no) |
DK (1) | DK1003781T3 (no) |
EA (1) | EA003675B1 (no) |
EE (1) | EE05538B1 (no) |
ES (1) | ES2149149T3 (no) |
HK (1) | HK1028773A1 (no) |
HU (1) | HU226698B1 (no) |
IL (5) | IL121860A0 (no) |
NO (1) | NO327240B1 (no) |
NZ (1) | NZ502392A (no) |
PL (1) | PL206070B1 (no) |
PT (1) | PT1003781E (no) |
SI (1) | SI1003781T1 (no) |
SK (1) | SK287194B6 (no) |
UA (1) | UA75862C2 (no) |
WO (1) | WO1999009063A1 (no) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393663B2 (en) * | 1997-08-01 | 2008-07-01 | Serono Genetics Institute S.A. | Expressed sequence tags and encoded human proteins |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
CA2340579A1 (en) * | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin 18-binding protein |
AR022952A1 (es) | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
IL131047A0 (en) * | 1999-07-22 | 2001-01-28 | Yeda Res & Dev | Use of il-18 inhibitors |
CA2324168A1 (en) * | 1999-11-16 | 2001-05-16 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Antibody specific to interleukin 18 precursor |
HUP0300423A3 (en) | 2000-02-10 | 2008-07-28 | Abbott Lab | Antibodies that bind human interleukin-18 and methods of making and using |
ME00546B (me) * | 2000-02-21 | 2011-10-10 | Serono Lab | Korišćenje inhibitora il-18 |
AU2005211606B2 (en) * | 2000-05-05 | 2007-02-22 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis |
KR100798545B1 (ko) * | 2000-05-05 | 2008-01-28 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 죽상경화증의 치료 또는 예방을 위한 il-18 저해물질의용도 |
WO2002031115A2 (en) * | 2000-10-11 | 2002-04-18 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
WO2002060479A1 (en) * | 2001-01-29 | 2002-08-08 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of heart disease |
SI1425028T1 (sl) * | 2001-05-16 | 2010-02-26 | Yeda Res & Dev | Uporaba inhibitorjev za il-18 za zdravljenje ali prepreäśevanje sepse |
SK288413B6 (sk) * | 2001-05-25 | 2016-10-03 | Ares Trading S. A. | Použitie proteínu viažuceho IL-18 |
SG173211A1 (en) | 2001-06-26 | 2011-08-29 | Amgen Inc | Antibodies to opgl |
UA78516C2 (en) * | 2001-08-10 | 2007-04-10 | Applied Research Systems | Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity |
SI1487541T1 (sl) | 2002-03-22 | 2009-02-28 | Serono Lab | Uporaba inhibitorjev il-18 za zdravljenje in /alipreventivo bolezni perifernega oĺ˝ilja |
PL376536A1 (pl) | 2002-08-28 | 2006-01-09 | Immunex Corporation | Kompozycje i sposoby leczenia chorób układu sercowo-naczyniowego |
EP1572291B1 (en) * | 2002-10-08 | 2013-04-03 | Ares Trading S.A. | The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine |
IL152232A0 (en) * | 2002-10-10 | 2003-05-29 | Yeda Res & Dev | Promoter to il-18bp, its preparation and use |
AU2004235595C1 (en) * | 2003-04-30 | 2009-09-24 | Japan Science And Technology Agency | Human antihuman interleukin-18 antibody, fragment thereof and method of using the same |
PL1622939T3 (pl) | 2003-05-13 | 2012-08-31 | Merck Serono Sa | Aktywne warianty białka wiążącego IL-18 i ich medyczne zastosowania |
CA2544146C (en) * | 2003-11-05 | 2012-10-02 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
MXPA06005219A (es) * | 2003-11-12 | 2007-01-19 | Univ Colorado Regents | Composiciones y metodos para la regulacion del factor-alfa de necrosis tumoral. |
US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
IL159670A0 (en) * | 2003-12-31 | 2004-06-01 | Yeda Res & Dev | Use of il-18 binding protein in inflammations |
JP4713567B2 (ja) * | 2004-03-01 | 2011-06-29 | アレス トレーディング ソシエテ アノニム | 哺乳類細胞のil−18bpの産生のための無血清細胞培地の使用 |
US7557084B2 (en) * | 2004-03-31 | 2009-07-07 | Regeneron Pharmaceuticals, Inc. | IL-18 specific polypeptides and therapeutic uses thereof |
ES2313367T3 (es) * | 2004-06-29 | 2009-03-01 | Ares Trading S.A. | Procedimiento para la purificacion de proteina de union al il-18. |
SI1885753T1 (sl) * | 2005-06-03 | 2011-12-30 | Ares Trading Sa | Proizvodnja rekombinantnega il-18 vezavnega proteina |
SI1888100T1 (sl) | 2005-06-03 | 2012-01-31 | Merck Serono Sa | Uporaba izooblik il-18pb za zdravljenje in/ali prepreäśevanje nevroloĺ kih vnetnih bolezni |
JP5091127B2 (ja) * | 2005-06-10 | 2012-12-05 | アレス トレーディング ソシエテ アノニム | Il−18結合タンパク質の精製のための方法 |
CN101003812B (zh) * | 2006-01-17 | 2011-01-05 | 温州医学院 | 一种用于制备重组人egf-il18融合蛋白的方法 |
AU2007267213B2 (en) | 2006-05-25 | 2012-03-29 | Glaxo Group Limited | Modified humanised anti-interleukin-18 antibodies |
WO2010040736A2 (en) * | 2008-10-07 | 2010-04-15 | Ablynx Nv | Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling |
US20150352561A1 (en) * | 2013-01-02 | 2015-12-10 | Wilsa Holdings ,LLC | Method and Apparatus for Conditioning Fluids |
PT3041864T (pt) * | 2013-09-05 | 2021-10-26 | Ab2 Bio Sa | Proteína de ligação a il-18 (il-18bp) em doenças inflamatórias |
JP7274259B2 (ja) | 2015-03-05 | 2023-05-16 | エイビー2 バイオ ソシエテアノニム | 炎症性疾患におけるil-18結合タンパク質(il-18bp)および抗体 |
EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
WO2023143535A1 (zh) * | 2022-01-28 | 2023-08-03 | 和径医药科技(上海)有限公司 | 一种靶向il-18bp的抗体及其应用 |
WO2023178192A1 (en) * | 2022-03-15 | 2023-09-21 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
CN114605521A (zh) * | 2022-04-06 | 2022-06-10 | 内蒙古农业大学 | 一种细胞免疫调节蛋白及其应用 |
CN114891125B (zh) * | 2022-06-16 | 2023-04-11 | 广东医科大学 | 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用 |
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US5985863A (en) | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
US5744451A (en) | 1995-09-12 | 1998-04-28 | Warner-Lambert Company | N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity |
US5776731A (en) | 1996-02-21 | 1998-07-07 | Immunex Corporation | DNA encoding type-I interleukin-I receptor-like protein designated 2F1 |
EP0936923B1 (en) | 1996-11-15 | 2003-12-17 | Kennedy Institute Of Rheumatology | SUPPRESSION OF TNFalpha AND IL-12 IN THERAPY |
ATE346085T1 (de) | 1996-12-06 | 2006-12-15 | Vertex Pharma | Inhibitoren des interleukin-1-beta konvertierenden enzyms |
US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
US6087116A (en) | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
JP2002504091A (ja) | 1997-03-18 | 2002-02-05 | ベーアーエスエフ アクツィエンゲゼルシャフト | コルチコステロイドに対する応答性を調整するための方法及び組成物 |
ES2266693T3 (es) | 1997-08-01 | 2007-03-01 | Serono Genetics Institute S.A. | Ests 5' para proteinas secretadas expresadas en varios tejidos. |
EP1378571B1 (en) | 1997-08-01 | 2011-01-12 | Merck Serono Biodevelopment | 5' ESTs for secreted proteins expressed in various tissues |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
SI1421956T1 (sl) | 1998-04-28 | 2007-10-31 | Serono Lab | Postopek za stopenjsko vezavo polietilenglikola (peg) na polipeptid |
CA2276216A1 (en) | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
CA2340579A1 (en) | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin 18-binding protein |
AR022952A1 (es) | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
AU6078500A (en) | 1999-07-09 | 2001-01-30 | Amgen, Inc. | Combination therapy for conditions leading to bone loss |
WO2001019373A2 (en) | 1999-09-17 | 2001-03-22 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
-
1997
- 1997-09-29 IL IL12186097A patent/IL121860A0/xx unknown
- 1997-11-06 IL IL12213497A patent/IL122134A0/xx unknown
-
1998
- 1998-07-22 IL IL12546398A patent/IL125463A0/xx unknown
- 1998-08-13 SK SK176-2000A patent/SK287194B6/sk not_active IP Right Cessation
- 1998-08-13 AT AT98938877T patent/ATE443719T1/de active
- 1998-08-13 DK DK98938877.2T patent/DK1003781T3/da active
- 1998-08-13 EA EA200000216A patent/EA003675B1/ru not_active IP Right Cessation
- 1998-08-13 HU HU0003533A patent/HU226698B1/hu unknown
- 1998-08-13 CN CNB988081342A patent/CN1243021C/zh not_active Expired - Lifetime
- 1998-08-13 AU AU87460/98A patent/AU755794B2/en not_active Expired
- 1998-08-13 DE DE1003781T patent/DE1003781T1/de active Pending
- 1998-08-13 WO PCT/IL1998/000379 patent/WO1999009063A1/en not_active Application Discontinuation
- 1998-08-13 DE DE69841175T patent/DE69841175D1/de not_active Expired - Lifetime
- 1998-08-13 PL PL338647A patent/PL206070B1/pl unknown
- 1998-08-13 UA UA2000031437A patent/UA75862C2/uk unknown
- 1998-08-13 ES ES98938877T patent/ES2149149T3/es not_active Expired - Lifetime
- 1998-08-13 SI SI9830922T patent/SI1003781T1/sl unknown
- 1998-08-13 BR BRPI9811940 patent/BRPI9811940B8/pt not_active IP Right Cessation
- 1998-08-13 US US09/485,632 patent/US6605280B1/en not_active Expired - Lifetime
- 1998-08-13 NZ NZ502392A patent/NZ502392A/xx not_active IP Right Cessation
- 1998-08-13 CA CA2298855A patent/CA2298855C/en not_active Expired - Lifetime
- 1998-08-13 EE EEP200000073A patent/EE05538B1/xx unknown
- 1998-08-13 JP JP2000509740A patent/JP4272348B2/ja not_active Expired - Lifetime
- 1998-08-13 PT PT98938877T patent/PT1003781E/pt unknown
- 1998-08-13 CZ CZ20000490A patent/CZ300818B6/cs not_active IP Right Cessation
- 1998-08-13 EP EP98938877A patent/EP1003781B1/en not_active Expired - Lifetime
- 1998-08-13 KR KR1020007001504A patent/KR100687388B1/ko not_active IP Right Cessation
- 1998-08-13 IL IL13452398A patent/IL134523A0/xx active IP Right Grant
- 1998-08-14 AR ARP980104054A patent/AR013422A1/es active IP Right Grant
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2000
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- 2000-02-11 NO NO20000700A patent/NO327240B1/no not_active IP Right Cessation
- 2000-02-13 IL IL134523A patent/IL134523A/en not_active IP Right Cessation
- 2000-12-19 HK HK00108180A patent/HK1028773A1/xx not_active IP Right Cessation
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2003
- 2003-05-08 US US10/434,583 patent/US7101689B2/en not_active Expired - Lifetime
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2006
- 2006-03-15 US US11/376,794 patent/US7799541B2/en not_active Expired - Fee Related
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2007
- 2007-09-17 AR ARP070104104A patent/AR062867A2/es not_active Application Discontinuation
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2009
- 2009-07-29 US US12/511,756 patent/US8436148B2/en not_active Expired - Fee Related
- 2009-11-25 CY CY20091101232T patent/CY1109664T1/el unknown
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