IL115156A - Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines - Google Patents
Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosinesInfo
- Publication number
- IL115156A IL115156A IL11515695A IL11515695A IL115156A IL 115156 A IL115156 A IL 115156A IL 11515695 A IL11515695 A IL 11515695A IL 11515695 A IL11515695 A IL 11515695A IL 115156 A IL115156 A IL 115156A
- Authority
- IL
- Israel
- Prior art keywords
- cytosines
- dioxolan
- hydroxymethyl
- cancer
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/301,298 US5817667A (en) | 1991-04-17 | 1994-09-06 | Compounds and methods for the treatment of cancer |
US39063395A | 1995-02-17 | 1995-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL115156A0 IL115156A0 (en) | 1995-12-31 |
IL115156A true IL115156A (en) | 2000-07-16 |
Family
ID=26972285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11515695A IL115156A (en) | 1994-09-06 | 1995-09-04 | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
Country Status (31)
Country | Link |
---|---|
US (3) | US6063787A (xx) |
EP (2) | EP0781136B1 (xx) |
JP (1) | JP3979662B2 (xx) |
KR (1) | KR100374477B1 (xx) |
CN (3) | CN1827108A (xx) |
AP (1) | AP783A (xx) |
AT (1) | ATE267015T1 (xx) |
AU (1) | AU704977B2 (xx) |
BG (1) | BG63122B1 (xx) |
BR (1) | BR9508886A (xx) |
CA (1) | CA2199117C (xx) |
CZ (1) | CZ297873B6 (xx) |
DE (1) | DE69533066T2 (xx) |
DK (1) | DK0781136T3 (xx) |
ES (1) | ES2219666T3 (xx) |
FI (1) | FI970918A (xx) |
HU (1) | HUT77172A (xx) |
IL (1) | IL115156A (xx) |
IS (1) | IS2011B (xx) |
MY (1) | MY121548A (xx) |
NO (1) | NO313268B1 (xx) |
NZ (1) | NZ335013A (xx) |
OA (1) | OA10473A (xx) |
PL (2) | PL188359B1 (xx) |
PT (1) | PT781136E (xx) |
RO (1) | RO118748B1 (xx) |
RU (1) | RU2168995C2 (xx) |
SI (1) | SI0781136T1 (xx) |
SK (1) | SK284564B6 (xx) |
WO (1) | WO1996007413A1 (xx) |
ZA (1) | ZA957483B (xx) |
Families Citing this family (45)
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US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
US5728575A (en) * | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US6022876A (en) * | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
CN1307421C (zh) | 1997-08-08 | 2007-03-28 | 塞米得肿瘤学美国公司 | 克服生物及化学治疗抗性的方法与组合物 |
US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
WO1999037753A1 (en) | 1998-01-23 | 1999-07-29 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
CA2322008C (en) | 1998-02-25 | 2011-06-28 | Emory University | 2'-fluoronucleosides |
US6630480B1 (en) * | 1999-03-29 | 2003-10-07 | Biochem Pharma Inc. | Methods of treating leukemia |
AU2004201676B2 (en) * | 1999-03-29 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | Methods of treating leukemia |
US6653318B1 (en) | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
ES2218216T3 (es) | 1999-09-24 | 2004-11-16 | Shire Biochem Inc. | Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas. |
WO2001032153A2 (en) | 1999-11-04 | 2001-05-10 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
EP1600452A3 (en) | 1999-11-12 | 2008-09-10 | Pharmasset, Inc. | Synthesis of 2'-deoxy-L-nucleosides |
WO2002030922A2 (en) * | 2000-10-13 | 2002-04-18 | Shire Biochem Inc. | Dioxolane analogs for improved inter-cellular delivery |
WO2002056832A2 (en) | 2001-01-19 | 2002-07-25 | Newbiotics, Inc. | Methods to treat autoimmune and inflammatory conditions |
HUP0400314A3 (en) * | 2001-03-23 | 2006-02-28 | Shire Biochem Inc Laval | Pharmaceutical combinations for the treatment of cancer |
CN1744902B (zh) * | 2001-03-23 | 2010-05-26 | 希拉加拿大股份有限公司 | 治疗癌症的药物组合 |
WO2002078678A2 (en) * | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine |
JP2005512984A (ja) * | 2001-11-02 | 2005-05-12 | シャイアー バイオケム インコーポレイテッド | ジオキソランヌクレオシド類似体を含む白血病の治療のための医薬組成物 |
ATE417611T1 (de) * | 2001-11-19 | 2009-01-15 | Medigene Ag | Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen |
KR100582957B1 (ko) | 2002-06-21 | 2006-05-23 | 엘지전자 주식회사 | 비디오 데이터의 재생을 관리하기 위한 데이터 구조를 갖는기록 매체 |
EP1516329A4 (en) | 2002-06-21 | 2009-07-15 | Lg Electronics Inc | RECORDING MEDIUM COMPRISING A DATA STRUCTURE FOR MANAGING REPRODUCTION OF VIDEO DATA RECORDED ON THIS RECORDING MEDIUM |
KR20040000290A (ko) | 2002-06-24 | 2004-01-03 | 엘지전자 주식회사 | 고밀도 광디스크의 멀티 경로 데이터 스트림 관리방법 |
CN100378854C (zh) | 2002-06-24 | 2008-04-02 | Lg电子株式会社 | 具有用于管理记录在其上面的多个再现路径视频数据的再现的数据结构的记录介质及其记录和再现方法及装置 |
RU2334286C2 (ru) | 2002-06-28 | 2008-09-20 | Эл Джи Электроникс Инк. | Носитель записи со структурой данных для управления записью и воспроизведением записанных на нем данных нескольких каналов и способы и устройства записи и воспроизведения |
AU2003269518B2 (en) | 2002-10-14 | 2009-08-13 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple audio streams recorded thereon and recording and reproducing methods and apparatuses |
AU2003269521B2 (en) | 2002-10-15 | 2009-05-28 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple graphics streams recorded thereon and recording and reproducing methods and apparatuses |
US7720356B2 (en) | 2002-11-12 | 2010-05-18 | Lg Electronics Inc | Recording medium having data structure for managing reproduction of multiple reproduction path video data recorded thereon and recording and reproducing methods and apparatuses |
US7664372B2 (en) | 2002-11-20 | 2010-02-16 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple component data recorded thereon and recording and reproducing methods and apparatuses |
US7693394B2 (en) | 2003-02-26 | 2010-04-06 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of data streams recorded thereon and recording and reproducing methods and apparatuses |
US7809775B2 (en) | 2003-02-27 | 2010-10-05 | Lg Electronics, Inc. | Recording medium having data structure for managing playback control recorded thereon and recording and reproducing methods and apparatuses |
CN100397882C (zh) | 2003-02-28 | 2008-06-25 | Lg电子株式会社 | 具有用于管理记录其上的视频数据的随机/洗牌重现的数据结构的记录媒体以及记录和重现的方法和装置 |
US7620301B2 (en) | 2003-04-04 | 2009-11-17 | Lg Electronics Inc. | System and method for resuming playback |
NZ546323A (en) | 2003-10-09 | 2009-04-30 | Medigene Ag | The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin |
ES2392544T3 (es) | 2005-06-07 | 2012-12-11 | Yale University | Métodos de tratamiento del cáncer y otras enfermedades o estados patológicos usando LFMAU y LDT |
US7951788B2 (en) | 2005-12-02 | 2011-05-31 | Yale University | Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs |
NO324263B1 (no) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
AU2007293377A1 (en) * | 2006-09-01 | 2008-03-13 | University Of Georgia Research Foundation, Inc. | L- OddC prodrugs for cancer |
CN102406649A (zh) * | 2011-11-15 | 2012-04-11 | 张始状 | 人体五种正常碱基在制备治疗肿瘤药物中的应用 |
CN103720693A (zh) * | 2011-11-15 | 2014-04-16 | 张始状 | 人体五种正常碱基在制备治疗肿瘤药物中的应用 |
SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
WO2018122088A1 (en) * | 2016-12-28 | 2018-07-05 | Transgene Sa | Oncolytic viruses and therapeutic molecules |
SG10201708886RA (en) * | 2017-10-30 | 2019-05-30 | Xylonix Ip Holdings Pte Ltd | α-PGA-ZINC COMPOSITIONS AND METHODS FOR TREATING CANCER |
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US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
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IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
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-
1995
- 1995-09-04 IL IL11515695A patent/IL115156A/xx not_active IP Right Cessation
- 1995-09-05 SI SI9530703T patent/SI0781136T1/xx unknown
- 1995-09-05 CN CNA2006100549917A patent/CN1827108A/zh active Pending
- 1995-09-05 EP EP95933071A patent/EP0781136B1/en not_active Expired - Lifetime
- 1995-09-05 RU RU97105381/04A patent/RU2168995C2/ru not_active IP Right Cessation
- 1995-09-05 CZ CZ0063397A patent/CZ297873B6/cs not_active IP Right Cessation
- 1995-09-05 PL PL95318971A patent/PL188359B1/pl not_active IP Right Cessation
- 1995-09-05 CN CN95195621A patent/CN1111409C/zh not_active Expired - Lifetime
- 1995-09-05 CA CA002199117A patent/CA2199117C/en not_active Expired - Fee Related
- 1995-09-05 AT AT95933071T patent/ATE267015T1/de not_active IP Right Cessation
- 1995-09-05 HU HU9701687A patent/HUT77172A/hu unknown
- 1995-09-05 PL PL95358979A patent/PL189288B1/pl not_active IP Right Cessation
- 1995-09-05 DK DK95933071T patent/DK0781136T3/da active
- 1995-09-05 RO RO97-00419A patent/RO118748B1/ro unknown
- 1995-09-05 ES ES95933071T patent/ES2219666T3/es not_active Expired - Lifetime
- 1995-09-05 AP APAP/P/1997/000939A patent/AP783A/en active
- 1995-09-05 PT PT95933071T patent/PT781136E/pt unknown
- 1995-09-05 BR BR9508886A patent/BR9508886A/pt not_active Application Discontinuation
- 1995-09-05 EP EP04003357A patent/EP1468687A1/en not_active Withdrawn
- 1995-09-05 AU AU35862/95A patent/AU704977B2/en not_active Ceased
- 1995-09-05 KR KR1019970701464A patent/KR100374477B1/ko not_active IP Right Cessation
- 1995-09-05 JP JP50970596A patent/JP3979662B2/ja not_active Expired - Lifetime
- 1995-09-05 US US08/809,007 patent/US6063787A/en not_active Expired - Fee Related
- 1995-09-05 WO PCT/US1995/011464 patent/WO1996007413A1/en active IP Right Grant
- 1995-09-05 DE DE69533066T patent/DE69533066T2/de not_active Expired - Lifetime
- 1995-09-05 SK SK281-97A patent/SK284564B6/sk not_active IP Right Cessation
- 1995-09-06 MY MYPI95002637A patent/MY121548A/en unknown
- 1995-09-06 ZA ZA957483A patent/ZA957483B/xx unknown
-
1997
- 1997-03-03 OA OA60972A patent/OA10473A/en unknown
- 1997-03-04 FI FI970918A patent/FI970918A/fi unknown
- 1997-03-04 IS IS4434A patent/IS2011B/is unknown
- 1997-03-05 BG BG101284A patent/BG63122B1/xx unknown
- 1997-03-05 NO NO19971015A patent/NO313268B1/no not_active IP Right Cessation
-
1999
- 1999-04-01 NZ NZ335013A patent/NZ335013A/xx not_active IP Right Cessation
-
2003
- 2003-04-18 CN CNB031106706A patent/CN1251680C/zh not_active Expired - Lifetime
- 2003-08-22 US US10/646,980 patent/US7262213B2/en not_active Expired - Lifetime
-
2007
- 2007-03-05 US US11/713,975 patent/US8076347B2/en not_active Expired - Lifetime
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Legal Events
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KB | Patent renewed | ||
EXP | Patent expired |