IL114615A0 - Modulators of the function of fas receptors and other proteins - Google Patents

Modulators of the function of fas receptors and other proteins

Info

Publication number
IL114615A0
IL114615A0 IL11461595A IL11461595A IL114615A0 IL 114615 A0 IL114615 A0 IL 114615A0 IL 11461595 A IL11461595 A IL 11461595A IL 11461595 A IL11461595 A IL 11461595A IL 114615 A0 IL114615 A0 IL 114615A0
Authority
IL
Israel
Prior art keywords
receptor
proteins
modulators
function
fas
Prior art date
Application number
IL11461595A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL11461595A priority Critical patent/IL114615A0/xx
Priority claimed from IL11498695A external-priority patent/IL114986A0/xx
Priority claimed from IL11531995A external-priority patent/IL115319A0/xx
Publication of IL114615A0 publication Critical patent/IL114615A0/xx
Priority to EP95944148A priority patent/EP0871645B1/en
Priority to DK95944148T priority patent/DK0871645T3/da
Priority to JP51932496A priority patent/JP3787355B2/ja
Priority to KR1019970703992A priority patent/KR100536394B1/ko
Priority to MX9704501A priority patent/MX9704501A/es
Priority to CN95196789A priority patent/CN1105725C/zh
Priority to DE69535634T priority patent/DE69535634T2/de
Priority to AU46022/96A priority patent/AU706401B2/en
Priority to UA97063391A priority patent/UA58489C2/uk
Priority to CA2207815A priority patent/CA2207815C/en
Priority to ES95944148T priority patent/ES2292172T3/es
Priority to PT95944148T priority patent/PT871645E/pt
Priority to AT95944148T priority patent/ATE377073T1/de
Priority to US08/860,082 priority patent/US7108999B1/en
Priority to PCT/US1995/016542 priority patent/WO1996018641A1/en
Priority claimed from IL11658895A external-priority patent/IL116588A0/xx
Priority claimed from IL11793296A external-priority patent/IL117932A0/xx
Priority to PT96919472T priority patent/PT914325E/pt
Priority to RU98102761/13A priority patent/RU2235779C2/ru
Priority to ES08018971T priority patent/ES2405657T3/es
Priority to AT96919472T priority patent/ATE431357T1/de
Priority to ES96919472T priority patent/ES2326704T3/es
Priority to EP08018971A priority patent/EP2042509B1/en
Priority to DK08018971.5T priority patent/DK2042509T3/da
Priority to SI9630769T priority patent/SI0914325T1/sl
Priority to EP96919472A priority patent/EP0914325B1/en
Priority to MX9800537A priority patent/MX9800537A/es
Priority to PCT/US1996/010521 priority patent/WO1997003998A1/en
Priority to DE69637931T priority patent/DE69637931D1/de
Priority to US08/983,502 priority patent/US6399327B1/en
Priority to IL122950A priority patent/IL122950A/en
Priority to AU61805/96A priority patent/AU708799B2/en
Priority to DK96919472T priority patent/DK0914325T3/da
Priority to CA2226973A priority patent/CA2226973C/en
Priority to CNB961966580A priority patent/CN100390195C/zh
Priority to KR10-1998-0700354A priority patent/KR100491095B1/ko
Priority to PT80189715T priority patent/PT2042509E/pt
Priority to JP50667597A priority patent/JP3980641B2/ja
Priority to SI9630778T priority patent/SI2042509T1/sl
Priority to FI972457A priority patent/FI121273B/fi
Priority to NO19972716A priority patent/NO324725B1/no
Priority to NO19980198A priority patent/NO321092B1/no
Priority to HK98106458A priority patent/HK1007248A1/xx
Priority to HK99101995A priority patent/HK1016990A1/xx
Priority to US09/516,747 priority patent/US6586571B1/en
Priority to US09/824,134 priority patent/US20020082401A1/en
Priority to US09/933,814 priority patent/US6808891B2/en
Priority to US10/368,438 priority patent/US20030219411A1/en
Priority to US10/923,031 priority patent/US7323548B2/en
Priority to US11/522,472 priority patent/US7799901B2/en
Priority to CY0700017A priority patent/CY2586B2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Holo Graphy (AREA)
  • Peptides Or Proteins (AREA)
IL11461595A 1994-12-15 1995-07-16 Modulators of the function of fas receptors and other proteins IL114615A0 (en)

Priority Applications (50)

Application Number Priority Date Filing Date Title
IL11461595A IL114615A0 (en) 1995-07-16 1995-07-16 Modulators of the function of fas receptors and other proteins
EP95944148A EP0871645B1 (en) 1994-12-15 1995-12-14 Modulators of the function of fas/apo1 receptors
DK95944148T DK0871645T3 (da) 1994-12-15 1995-12-14 Modulationer af FAS/APO1-receptorers funktion
JP51932496A JP3787355B2 (ja) 1994-12-15 1995-12-14 Ｆａｓ／ａｐｏ１受容体機能のモジュレーター
KR1019970703992A KR100536394B1 (ko) 1994-12-15 1995-12-14 Fas/ap01수용체들의기능조절인자
MX9704501A MX9704501A (es) 1994-12-15 1995-12-14 Moduladores de la funcion de receptores de fas/ap01.
CN95196789A CN1105725C (zh) 1994-12-15 1995-12-14 Fas/ap01受体功能的调节物
DE69535634T DE69535634T2 (de) 1994-12-15 1995-12-14 Modulatoren der funktion des fas/ap01 rezeptors
AU46022/96A AU706401B2 (en) 1994-12-15 1995-12-14 Modulators of the function of FAS/APO1 receptors
UA97063391A UA58489C2 (uk) 1994-12-15 1995-12-14 Модулятори функцій рецепторів fas
CA2207815A CA2207815C (en) 1994-12-15 1995-12-14 Modulators of the function of fas/apo1 receptors
ES95944148T ES2292172T3 (es) 1994-12-15 1995-12-14 Moduladores de la funcion de los receptores fas/apo1.
PT95944148T PT871645E (pt) 1994-12-15 1995-12-14 Moduladores da função dos receptores fas/apo1
AT95944148T ATE377073T1 (de) 1994-12-15 1995-12-14 Modulatoren der funktion des fas/ap01 rezeptors
US08/860,082 US7108999B1 (en) 1994-12-15 1995-12-14 Modulators of the function of FAS/AP01 receptors
PCT/US1995/016542 WO1996018641A1 (en) 1994-12-15 1995-12-14 Modulators of the function of fas/apo1 receptors
DK08018971.5T DK2042509T3 (da) 1995-07-16 1996-06-14 Modulatorer af funktionen af fas-receptorer og andre proteiner
CNB961966580A CN100390195C (zh) 1995-07-16 1996-06-14 Fas受体和其它蛋白质功能的调节物
ES08018971T ES2405657T3 (es) 1995-07-16 1996-06-14 Moduladores de la función de los receptores de FAS y otras proteínas
AT96919472T ATE431357T1 (de) 1995-07-16 1996-06-14 Modulatoren der funktion des fas rezeptors und anderer proteine
ES96919472T ES2326704T3 (es) 1995-07-16 1996-06-14 Moduladores de la funcion de receptores fas y otras proteinas.
EP08018971A EP2042509B1 (en) 1995-07-16 1996-06-14 Modulators of the function of FAS receptors and other proteins
PT96919472T PT914325E (pt) 1995-07-16 1996-06-14 Moduladores da função de receptores de fas e outras proteínas
SI9630769T SI0914325T1 (sl) 1995-07-16 1996-06-14 Modulatorji funkcije receptorja fas in drugih proteinov
EP96919472A EP0914325B1 (en) 1995-07-16 1996-06-14 Modulators of the function of fas receptors and other proteins
MX9800537A MX9800537A (es) 1995-07-16 1996-06-14 Moduladores de la funcion de receptores fas y otras proteinas.
PCT/US1996/010521 WO1997003998A1 (en) 1995-07-16 1996-06-14 Modulators of the function of fas receptors and other proteins
DE69637931T DE69637931D1 (de) 1995-07-16 1996-06-14 Modulatoren der funktion des fas rezeptors und anderer proteine
US08/983,502 US6399327B1 (en) 1995-07-16 1996-06-14 Modulators of the function of FAS receptors and other proteins
IL122950A IL122950A (en) 1995-07-16 1996-06-14 Mach proteins, their preparation and their pharmaceutical preparations
AU61805/96A AU708799B2 (en) 1995-07-16 1996-06-14 Modulators of the function of fas receptors and other proteins
DK96919472T DK0914325T3 (da) 1995-07-16 1996-06-14 Modulatorer af funktionen af FAS receptorer og andre proteiner
CA2226973A CA2226973C (en) 1995-07-16 1996-06-14 Modulators of the function of fas receptors and other proteins
RU98102761/13A RU2235779C2 (ru) 1995-07-16 1996-06-14 Последовательность днк, кодирующая полипептид, который связывается с mort-1 (варианты), полипептид (варианты) и способ его получения, вектор, способ модулирования действия лиганда fas-r или tnf на клетки (варианты), способ обработки клеток, способ выделения и идентификации белков, способ модулирования индуцируемого mort-1 действия или индуцируемого mort-1 связывающим белком действия на клетки
KR10-1998-0700354A KR100491095B1 (ko) 1995-07-16 1996-06-14 에프에이에스수용체들및다른단백질들의기능조절인자들
PT80189715T PT2042509E (pt) 1995-07-16 1996-06-14 Moduladores da função de recetores de fas e outras proteínas
JP50667597A JP3980641B2 (ja) 1995-07-16 1996-06-14 Ｆａｓ受容体およびほかのタンパク質の機能のモジュレーター
SI9630778T SI2042509T1 (sl) 1995-07-16 1996-06-14 Modulatorji funkcije receptorjev FAS in drugih proteinov
FI972457A FI121273B (fi) 1994-12-15 1997-06-10 FAS/APO1-reseptorien toiminnan modulaattorit
NO19972716A NO324725B1 (no) 1994-12-15 1997-06-12 MORT-1-protein, DNA-sekvens som koder for MORT-1 og antistoffer spesifikke for MORT-1, samt fremgangsmate for fremstilling, farmasoytiske sammensetninger og anvendelser.
NO19980198A NO321092B1 (no) 1995-07-16 1998-01-15 Modulatorer av funksjonen til FAS-reseptorer, mer spesifikt isolert DNA sekvens, vektor, transformert eukaryot eller prokaryot vertscelle, isolert ploypeptid, sammensetning og anvendelse derav.
HK98106458A HK1007248A1 (en) 1994-12-15 1998-06-24 Modulator of the function of fas/apo1 receptors
HK99101995A HK1016990A1 (en) 1995-07-16 1999-05-04 Modulators of the function of fas receptors and other proteins
US09/516,747 US6586571B1 (en) 1995-07-16 2000-03-01 Modulators of the function of FAS receptors and other proteins
US09/824,134 US20020082401A1 (en) 1994-12-15 2001-04-03 Modulators of the function of FAS/APO1 receptors
US09/933,814 US6808891B2 (en) 1994-12-15 2001-08-22 Modulators of the function of FAS/APO1 receptors
US10/368,438 US20030219411A1 (en) 1995-07-16 2003-02-20 Modulators of the function of FAS receptors and other proteins
US10/923,031 US7323548B2 (en) 1994-12-15 2004-08-23 Modulators of the function of FAS/APO1 receptors
US11/522,472 US7799901B2 (en) 1995-07-16 2006-09-18 Modulators of the function of FAS receptors and other proteins
CY0700017A CY2586B2 (en) 1994-12-15 2007-11-20 Modulators of the function of FAS/APO1 receptors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL11461595A IL114615A0 (en) 1995-07-16 1995-07-16 Modulators of the function of fas receptors and other proteins
IL11498695A IL114986A0 (en) 1995-08-17 1995-08-17 Modulators of the function of fas receptors and other proteins
IL11531995A IL115319A0 (en) 1995-09-14 1995-09-14 Modulators of the function of fas receptors and other proteins
IL11658895A IL116588A0 (en) 1995-12-27 1995-12-27 Modulators of the function of fas receptors and other proteins
IL11793296A IL117932A0 (en) 1996-04-16 1996-04-16 Modulators of the function of FAS receptors and other proteins

Publications (1)

Publication Number Publication Date
IL114615A0 true IL114615A0 (en) 1995-11-27

Family

ID=27517674

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11461595A IL114615A0 (en) 1994-12-15 1995-07-16 Modulators of the function of fas receptors and other proteins

Country Status (18)

Country Link
US (3) US6586571B1 (xx)
EP (2) EP0914325B1 (xx)
JP (1) JP3980641B2 (xx)
KR (1) KR100491095B1 (xx)
CN (1) CN100390195C (xx)
AT (1) ATE431357T1 (xx)
AU (1) AU708799B2 (xx)
CA (1) CA2226973C (xx)
DE (1) DE69637931D1 (xx)
DK (2) DK2042509T3 (xx)
ES (2) ES2326704T3 (xx)
HK (1) HK1016990A1 (xx)
IL (1) IL114615A0 (xx)
MX (1) MX9800537A (xx)
NO (1) NO321092B1 (xx)
PT (2) PT2042509E (xx)
SI (2) SI0914325T1 (xx)
WO (1) WO1997003998A1 (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US5976822A (en) * 1995-05-18 1999-11-02 Coulter International Corp. Method and reagent for monitoring apoptosis and distinguishing apoptosis from necrosis
US5786173A (en) * 1996-03-19 1998-07-28 Idun Pharmaceuticals, Inc. MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use
US5712115A (en) * 1996-03-19 1998-01-27 Incyte Pharmaceuticals, Inc. Human cell death-associated protein
US6008042A (en) * 1996-05-16 1999-12-28 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-7
US5932694A (en) * 1996-06-24 1999-08-03 Ludwig Institute For Cancer Research Nucleic acid molecule encoding a bifunctional protein, the protein so encoded and uses thereof
EP0842665A3 (en) * 1996-11-14 2002-12-18 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists
US5932425A (en) * 1997-02-18 1999-08-03 Signal Pharmaceuticals, Inc. Compositions and methods for modulating cellular NF-κB activation
US20040230039A1 (en) 1997-03-01 2004-11-18 Yeda Research And Development Co., Ltd. Cash (caspase homologue) with death effector domain, modulators of the function of FAS receptors
IL120759A0 (en) 1997-03-03 1997-09-30 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
AU8038698A (en) 1997-06-27 1999-01-19 Ono Pharmaceutical Co. Ltd. Novel plasmid dna containing reporter gene dna and use of the same
JPH1175859A (ja) * 1997-09-08 1999-03-23 R P R Jienseru Kk アポト−シス関連遺伝子発現性のウイルスベクター系
AU753027B2 (en) * 1998-02-11 2002-10-03 Genvec, Inc. Vectors, cells and methods for the production of deleterious viral eukaryotic gene transfer vectors
US6207458B1 (en) * 1998-05-07 2001-03-27 University Of Washigton/Stowers Insitute For Medical Research Proteins capable of regulating NF-κB JNK and apoptosis pathways and methods of using the same
US6759041B1 (en) 1998-05-29 2004-07-06 Mochida Pharmaceutical Co., Ltd. Preventives/remedies for autoimmune demyelinating diseases
AU5205499A (en) 1998-07-27 2000-02-21 Pharmacia & Upjohn Company Method for autoactivation of procaspase 8
US7052834B1 (en) 1998-12-31 2006-05-30 St. Jude Children's Research Hospital Tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
AU2222000A (en) * 1998-12-31 2000-07-31 St. Jude Children's Research Hospital A tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
WO2010006177A2 (en) * 2008-07-10 2010-01-14 Dana-Farber Cancer Institute, Inc. Muc1, caspase-8,and ded-containing proteins

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4699880A (en) 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
IL73883A (en) 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4766067A (en) 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5017691A (en) 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4879111A (en) 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4795699A (en) 1987-01-14 1989-01-03 President And Fellows Of Harvard College T7 DNA polymerase
US4921794A (en) 1987-01-14 1990-05-01 President And Fellows Of Harvard College T7 DNA polymerase
IL83878A (en) 1987-09-13 1995-07-31 Yeda Res & Dev Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5149782A (en) 1988-08-19 1992-09-22 Tanox Biosystems, Inc. Molecular conjugates containing cell membrane-blending agents
US5000000A (en) * 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
IL94039A (en) 1989-08-06 2006-09-05 Yeda Res & Dev Antibodies to tbp - 1 and their use
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5142033A (en) 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US4994370A (en) 1989-01-03 1991-02-19 The United States Of America As Represented By The Department Of Health And Human Services DNA amplification technique
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
CA2017025C (en) 1989-05-18 2008-07-22 David Wallach Tumor necrosis factor binding protein ii, its purification and antibodies thereto
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
IL101769A (en) 1992-05-03 2007-02-11 Yeda Res & Dev Modulation of TNF receptor action
IL104355A (en) 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
IL109633A (en) 1994-05-11 2005-05-17 Yeda Res & Dev Tnf receptor promoter
IL111125A0 (en) 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
US6538121B1 (en) * 1994-11-01 2003-03-25 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
JP3787355B2 (ja) * 1994-12-15 2006-06-21 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Ｆａｓ／ａｐｏ１受容体機能のモジュレーター
EP0813419B8 (en) * 1995-02-22 2005-08-24 Yeda Research & Development Company, Ltd. Modulators of regulatory proteins
AU5133296A (en) * 1995-02-22 1996-09-11 Yeda Research And Development Co. Ltd. Modulators of regulatory proteins
US7807783B1 (en) * 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US5786173A (en) 1996-03-19 1998-07-28 Idun Pharmaceuticals, Inc. MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use
US5712115A (en) 1996-03-19 1998-01-27 Incyte Pharmaceuticals, Inc. Human cell death-associated protein
US6008042A (en) * 1996-05-16 1999-12-28 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-7
WO1997046662A1 (en) 1996-06-05 1997-12-11 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-7
US5837837A (en) 1997-02-27 1998-11-17 Millennium Pharmaceuticals, Inc. Nucleic acids molecules encoding Caspase-8h and Caspase-8i
DE19713393C2 (de) 1997-04-01 2002-12-05 Apotech Res & Dev Ltd Flip-Gen und Flip-Protein

Also Published As

Publication number Publication date
WO1997003998A1 (en) 1997-02-06
AU6180596A (en) 1997-02-18
NO980198D0 (no) 1998-01-15
HK1016990A1 (en) 1999-11-12
DK2042509T3 (da) 2013-03-11
JPH11509422A (ja) 1999-08-24
US20030219411A1 (en) 2003-11-27
AU708799B2 (en) 1999-08-12
DE69637931D1 (de) 2009-06-25
CA2226973A1 (en) 1997-02-06
US6586571B1 (en) 2003-07-01
CN100390195C (zh) 2008-05-28
CN1198165A (zh) 1998-11-04
ATE431357T1 (de) 2009-05-15
JP3980641B2 (ja) 2007-09-26
PT914325E (pt) 2009-07-20
EP2042509A1 (en) 2009-04-01
ES2405657T3 (es) 2013-05-31
WO1997003998A9 (en) 2002-03-14
KR100491095B1 (ko) 2005-12-19
SI0914325T1 (sl) 2009-10-31
PT2042509E (pt) 2013-03-11
NO321092B1 (no) 2006-03-13
DK0914325T3 (da) 2009-08-17
EP0914325A1 (en) 1999-05-12
CA2226973C (en) 2012-01-03
NO980198L (no) 1998-03-09
EP2042509B1 (en) 2013-02-20
KR19990029051A (ko) 1999-04-15
ES2326704T3 (es) 2009-10-16
US7799901B2 (en) 2010-09-21
MX9800537A (es) 1998-05-31
SI2042509T1 (sl) 2013-04-30
EP0914325B1 (en) 2009-05-13
US20070154905A1 (en) 2007-07-05
EP0914325A4 (en) 2001-07-25

Similar Documents

Publication Publication Date Title
IL114615A0 (en) Modulators of the function of fas receptors and other proteins
CA2172376A1 (en) Antibodies to cd40
WO2000031124A3 (en) Peptides that modulate the interaction of b class ephrins and pdz domains
AU2071397A (en) Receptor derived peptides involved in modulation of response to ligand binding
AU6354198A (en) Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
MX9600666A (es) Proteinas de protocadherina y su uso.
ID23183A (id) Perangsangan modulator reseptor asam amino
DE19882126T1 (de) Hydrierung von Kohlenwasserstoffen
DE69824333D1 (de) Schwarz-Farbe Zerfliessverminderung unter Verwendung von nichtspezifischen ionischen, pH und kolloidalen Effekten
AU1866499A (en) Compounds and methods for modulating synaptic stability
PT813419E (pt) Moduladores de proteinas reguladoras
AU6692598A (en) Growth factor receptor binding protein
BR9808915A (pt) Moduladores da função dos receptores da famìlia de receptores fnt/fgn
AU4375493A (en) Isolated protein receptors, antibodies which bind thereto, nucleic acid sequence coding therefor, and uses thereof
HK1034995A1 (en) Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
WO1995022609A3 (en) Human glutamate receptor proteins
EA199900794A1 (ru) Cash (гомолог каспазы) с "гибель-эффекторным" доменом, модуляторы функций fas-рецепторов
WO2000061747A3 (en) Clasp-2 transmembrane proteins
GB2299771B (en) Improved shale shaker
WO1996023883A3 (en) Modified ligands for receptor tyrosine kinases
WO1999028465A3 (en) Pias molecules that recognize and bind stat proteins and uses thereof
AU5535798A (en) Emulsifying compositions and acidic bituminous emulsions containing them
AU7478098A (en) Methods of treatment using nbs-1, antibodies and proteins thereto, and uses of the antibodies
DE69804782D1 (de) Isomerisierung von fluorkohlenwasserstoffen
WO2001042295A3 (en) Clasp-7 transmembrane protein