EP0842665A3 - Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists - Google Patents

Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists Download PDF

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Publication number
EP0842665A3
EP0842665A3 EP97309002A EP97309002A EP0842665A3 EP 0842665 A3 EP0842665 A3 EP 0842665A3 EP 97309002 A EP97309002 A EP 97309002A EP 97309002 A EP97309002 A EP 97309002A EP 0842665 A3 EP0842665 A3 EP 0842665A3
Authority
EP
European Patent Office
Prior art keywords
agonists
converting enzyme
interleukin
polypeptides
beta converting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97309002A
Other languages
German (de)
French (fr)
Other versions
EP0842665A2 (en
Inventor
Mark A. SmithKline Beecham Pharma. Levy
Mark E. SmithKline Beecham Pharma. Nuttall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0842665A2 publication Critical patent/EP0842665A2/en
Publication of EP0842665A3 publication Critical patent/EP0842665A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

This invention relates, in part, to newly identified polynucleotides and polypeptides: agonists and antagonists of the polypeptides; and uses of the polynucleotides, polypeptides, agonists and antagonists. In particular, the invention relates to polynucleotides and polypeptides of human interleukin-1 beta converting enzyme like apoptosis proteases hereinafter referred to as "ICE LAPs".
EP97309002A 1996-11-14 1997-11-10 Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists Withdrawn EP0842665A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3107596P 1996-11-14 1996-11-14
US31075P 1996-11-14

Publications (2)

Publication Number Publication Date
EP0842665A2 EP0842665A2 (en) 1998-05-20
EP0842665A3 true EP0842665A3 (en) 2002-12-18

Family

ID=21857513

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97309002A Withdrawn EP0842665A3 (en) 1996-11-14 1997-11-10 Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists

Country Status (2)

Country Link
EP (1) EP0842665A3 (en)
JP (1) JPH10194991A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517202A (en) 1998-06-02 2002-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Caspase-9 deficient animals and uses thereof
DE19915465A1 (en) * 1999-04-06 2000-10-19 Apotech Res & Dev Ltd Use of a caspase inhibitor to inhibit cell proliferation and use of one or more caspase inhibitors to treat diseases based on lymphocyte hyperproliferation or to suppress an immune response by lymphocytes
CN104212796A (en) * 2014-09-26 2014-12-17 北京市水产科学研究所 Method for extracting total ribonucleic acid (RNA) of fish testicle tissue

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000297A1 (en) * 1994-06-23 1996-01-04 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-1 AND 2
WO1996013603A1 (en) * 1994-11-01 1996-05-09 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-3 AND 4
AU4602296A (en) * 1994-12-15 1996-07-03 Yeda Research And Development Co. Ltd. Modulators of the function of fas/apo1 receptors
WO1997003998A1 (en) * 1995-07-16 1997-02-06 Yeda Research And Development Co. Ltd. Modulators of the function of fas receptors and other proteins
WO1997016552A1 (en) * 1995-11-03 1997-05-09 Vertex Pharmaceuticals Incorporated Dna sequences encoding cmh-1, a cysteine protease involved in apoptosis
EP0807686A2 (en) * 1996-05-16 1997-11-19 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-7
EP0808904A2 (en) * 1996-05-20 1997-11-26 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-6

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000297A1 (en) * 1994-06-23 1996-01-04 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-1 AND 2
WO1996013603A1 (en) * 1994-11-01 1996-05-09 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-3 AND 4
AU4602296A (en) * 1994-12-15 1996-07-03 Yeda Research And Development Co. Ltd. Modulators of the function of fas/apo1 receptors
WO1997003998A1 (en) * 1995-07-16 1997-02-06 Yeda Research And Development Co. Ltd. Modulators of the function of fas receptors and other proteins
WO1997016552A1 (en) * 1995-11-03 1997-05-09 Vertex Pharmaceuticals Incorporated Dna sequences encoding cmh-1, a cysteine protease involved in apoptosis
EP0807686A2 (en) * 1996-05-16 1997-11-19 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-7
EP0808904A2 (en) * 1996-05-20 1997-11-26 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic protease-6

Also Published As

Publication number Publication date
EP0842665A2 (en) 1998-05-20
JPH10194991A (en) 1998-07-28

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