IL114073A - Alkylated crosslinked polymers, pharmaceutical compositions containing the same and method for their preparation - Google Patents

Alkylated crosslinked polymers, pharmaceutical compositions containing the same and method for their preparation

Info

Publication number
IL114073A
IL114073A IL11407395A IL11407395A IL114073A IL 114073 A IL114073 A IL 114073A IL 11407395 A IL11407395 A IL 11407395A IL 11407395 A IL11407395 A IL 11407395A IL 114073 A IL114073 A IL 114073A
Authority
IL
Israel
Prior art keywords
reaction product
alkylating agent
preparation
same
pharmaceutical compositions
Prior art date
Application number
IL11407395A
Other languages
English (en)
Other versions
IL114073A0 (en
Original Assignee
Geltex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL114073(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geltex Pharma Inc filed Critical Geltex Pharma Inc
Publication of IL114073A0 publication Critical patent/IL114073A0/xx
Priority to IL14241901A priority Critical patent/IL142419A0/xx
Publication of IL114073A publication Critical patent/IL114073A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52Amides or imides
    • C08F220/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • A61K31/787Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/02Alkylation
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/44Preparation of metal salts or ammonium salts
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02Homopolymers or copolymers of vinylamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11407395A 1994-06-10 1995-06-08 Alkylated crosslinked polymers, pharmaceutical compositions containing the same and method for their preparation IL114073A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14241901A IL142419A0 (en) 1994-06-10 2001-04-03 Alkylated crosslinked polymers, method for their preparation and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10

Publications (2)

Publication Number Publication Date
IL114073A0 IL114073A0 (en) 1995-10-31
IL114073A true IL114073A (en) 2003-06-24

Family

ID=22980525

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11407395A IL114073A (en) 1994-06-10 1995-06-08 Alkylated crosslinked polymers, pharmaceutical compositions containing the same and method for their preparation
IL14241901A IL142419A0 (en) 1994-06-10 2001-04-03 Alkylated crosslinked polymers, method for their preparation and pharmaceutical compositions containing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL14241901A IL142419A0 (en) 1994-06-10 2001-04-03 Alkylated crosslinked polymers, method for their preparation and pharmaceutical compositions containing same

Country Status (21)

Country Link
US (12) US5693675A (fr)
EP (2) EP0764174B1 (fr)
JP (1) JP3931217B2 (fr)
KR (1) KR100271693B1 (fr)
CN (1) CN1150217C (fr)
AT (1) ATE184027T1 (fr)
AU (1) AU698752C (fr)
CA (1) CA2191478C (fr)
DE (3) DE69511861T2 (fr)
DK (1) DK0764174T3 (fr)
ES (1) ES2135743T3 (fr)
FR (1) FR04C0021I2 (fr)
GR (1) GR3031702T3 (fr)
IL (2) IL114073A (fr)
LU (1) LU91100I2 (fr)
MX (1) MX9606171A (fr)
NL (1) NL300159I2 (fr)
NZ (1) NZ288076A (fr)
RU (1) RU2160742C2 (fr)
TW (1) TW474813B (fr)
WO (1) WO1995034585A1 (fr)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487888A (en) * 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6566407B2 (en) * 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
TW568788B (en) 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
JP4749649B2 (ja) * 1998-10-12 2011-08-17 中外製薬株式会社 リン酸結合性ポリマー
DE19850817A1 (de) * 1998-11-04 2000-05-11 Basf Ag Modifizierte kationische Polymere, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Papierherstellung
US6271264B1 (en) 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
CA2362410A1 (fr) 1999-04-16 2000-10-26 Abbott Laboratories Procede de production de chlorhydrate de polyallylamine croise
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
IL147361A0 (en) * 1999-07-14 2002-08-14 Geltex Pharma Inc Fat-binding polymers, optionally combined with lipase inhibitors
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
ATE279961T1 (de) * 2000-07-28 2004-11-15 Hoffmann La Roche Neue pharmazeutische zusammensetzung
US8263112B2 (en) * 2000-11-20 2012-09-11 Sorbent Therapeutics, Inc. In vivo use of water absorbent polymers
WO2002040039A2 (fr) 2000-11-20 2002-05-23 Dow Global Technologies Inc. Utilisation in vivo de polymeres absorbeurs d'eau
US8173114B2 (en) 2000-11-28 2012-05-08 Mitsubishi Tanabe Pharma Corporation Excretion accelerator for accumulative chlorine compound
AT409630B (de) * 2000-12-13 2002-09-25 Dsm Fine Chem Austria Gmbh Alkylierung von n-bzw. amino- oder ammoniumgruppen haltigen, vernetzten polymeren
WO2002066543A1 (fr) * 2001-02-16 2002-08-29 Genzyme Corporation Procede de sechage d'un materiau a phase cohesive
WO2002085380A1 (fr) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Methode pour traiter la goutte et reduire les taux d'acide urique serique
EP1923064B1 (fr) 2001-04-18 2017-06-28 Genzyme Corporation Utilisation des aminopolymères pour réduire le glucose sérique
WO2002085379A1 (fr) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Procede permettant d'ameliorer l'acces vasculaire chez des patients ayant des shunts vasculaires
CA2444028A1 (fr) * 2001-04-18 2002-10-31 Genzyme Corporation Methodes pour traiter le syndrome x avec des polyamines aliphatiques
AU2002257145B2 (en) * 2001-04-18 2005-06-02 Genzyme Corporation Method for lowering serum glucose
DE60212819T2 (de) * 2001-04-18 2006-11-23 Genzyme Corp., Cambridge Salzformarme polyallylamine
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
AT411463B (de) 2002-09-03 2004-01-26 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von alkylierten n- bzw. amino-, ammonium- oder spirobicyclischen ammoniumgruppen haltigen, vernetzten polymeren
AT414237B (de) * 2002-09-03 2006-10-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von quaternären halogen-alkyl-ammoniumsalzen
AU2003282867A1 (en) * 2002-10-22 2004-05-13 Genzyme Corporation Amine polymers for promoting bone formation
KR20060021870A (ko) 2003-05-30 2006-03-08 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 hmg―co 억제제로서의 이의용도
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US20070212325A1 (en) 2004-03-26 2007-09-13 Mitsubishi Pharma Corporation Insulin Resistance-Improving Agent
JP4964122B2 (ja) * 2004-03-30 2012-06-27 レリプサ, インコーポレイテッド イオン結合組成物
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US20090023606A1 (en) * 2004-08-12 2009-01-22 Versamatrix A/S Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof
JP2008510860A (ja) * 2004-08-27 2008-04-10 ヴァーサマトリックス・アクティーゼルスカブ 高負荷官能性樹脂
ATE410461T1 (de) * 2004-08-27 2008-10-15 Novo Nordisk As Polyether-polymer-matrix
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
JP4547620B2 (ja) * 2004-12-02 2010-09-22 日東紡績株式会社 架橋アリルアミン類重合体の製造方法
MY144940A (en) * 2005-01-25 2011-11-30 Avantor Performance Mat Inc Chromatographic media
CA2601236A1 (fr) * 2005-03-16 2006-09-21 Usv Limited Procede ameliore de fabrication d'un polymere de polyallylamine reticule
WO2007027566A2 (fr) 2005-09-02 2007-03-08 Genzyme Corporation Recepteurs moleculaires polymeriques utilises comme sequestrants du phosphate
AR056499A1 (es) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd Compuestos
BRPI0616078B8 (pt) 2005-09-15 2021-05-25 Genzyme Corp pó de uma formulação farmacêutica de polímero de amina, uso de tal pó e formulação em sachê para polímeros de amina
JP2009510126A (ja) * 2005-09-30 2009-03-12 レリプサ, インコーポレイテッド 哺乳類の胃腸管からカリウムイオンを選択的に除去するための方法および組成物
DE112006002617T5 (de) * 2005-09-30 2008-08-28 Ilypsa Inc., Santa Clara Verfahren zur Herstellung von Core-Shell-Kompositen bzw. Kern-Hüllen-Kompositen mit vernetzten Hüllen und daraus entstehende Core-Shell-Komposite
WO2007054896A1 (fr) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Procede de preparation de sel hemicalcique d’acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
EP2016114A2 (fr) * 2006-05-05 2009-01-21 Genzyme Corporation Polymères de condensation d'amines comme agents séquestrants de phosphates
EP2039363B1 (fr) 2006-06-16 2013-01-02 Mitsubishi Tanabe Pharma Corporation Agent de prévention et/ou traitement de glomérulopathie
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
WO2008007376A2 (fr) * 2006-07-13 2008-01-17 Association For Public Health Services Ensemble à boucle d'inoculation
US20100124542A1 (en) * 2006-07-18 2010-05-20 Genzyme Corporation Amine dendrimers
WO2008042222A2 (fr) 2006-09-29 2008-04-10 Genzyme Corporation Compositions dendrimères d'amide
BRPI0720234A2 (pt) 2006-12-14 2013-12-24 Genzyme Corp Composição farmacêutica
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008079280A1 (fr) * 2006-12-21 2008-07-03 Millipore Corporation Purification de protéines
WO2008103368A1 (fr) * 2007-02-23 2008-08-28 Genzyme Corporation Compositions de polymère amine
EP2131820A1 (fr) * 2007-03-08 2009-12-16 Genzyme Corporation Compositions de polymères de sulfone
WO2008133954A1 (fr) * 2007-04-27 2008-11-06 Genzyme Corporation Compositions dendrimères amido-amine
EP2016947A1 (fr) 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Nouveau processus à une étape pour préparer des polymères poly(allylamine) réticulés
PA8807201A1 (es) * 2007-12-14 2009-07-23 Genzyme Corp Composiciones farmaceuticas
US20100316589A1 (en) * 2007-12-14 2010-12-16 Hitesh Bhagat Coated Pharmaceutical Compositions
WO2009151514A1 (fr) 2008-06-11 2009-12-17 Millipore Corporation Bioréacteur à cuve agitée
WO2009154747A1 (fr) * 2008-06-20 2009-12-23 Genzyme Corporation Compositions pharmaceutiques
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
WO2010022380A2 (fr) 2008-08-22 2010-02-25 Relypsa, Inc. Compositions de polyfluoroacrylate stabilisé par polyol linéaire
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
ES2545887T5 (es) * 2008-08-22 2020-02-17 Vifor Int Ltd Polímeros reticulados de intercambio catiónico, composiciones y uso en el tratamiento de la hiperpotasemia
US20110159087A1 (en) * 2008-09-02 2011-06-30 Dhananjay Govind Sathe Crosslinked Polymers
WO2010062734A1 (fr) * 2008-11-03 2010-06-03 University Of Maryland, Baltimore Hydrogel polymère induisant la coagulation sanguine
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
SG171446A1 (en) 2008-12-16 2011-07-28 Millipore Corp Stirred tank reactor and method
US8673272B2 (en) * 2009-07-27 2014-03-18 Isp Investments Inc. Ultraviolet-absorbing compounds
GB0915449D0 (en) * 2009-09-04 2009-10-07 Univ Robert Gordon Composition
AU2011220748B2 (en) * 2010-02-24 2015-11-05 Relypsa, Inc. Amine polymers for use as bile acid sequestrants
AU2011220742B2 (en) 2010-02-24 2016-02-25 Relypsa, Inc. Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants
KR101726707B1 (ko) * 2010-05-17 2017-04-13 이엠디 밀리포어 코포레이션 생체분자 정제용 자극 반응성 중합체
TR201005327A2 (tr) 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Sinerjik farmasötik formülasyonlar.
WO2012027331A1 (fr) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions et procédés pour traiter ou prévenir un syndrome métabolique et des maladies et troubles associés
CA2815749C (fr) 2010-11-08 2019-12-03 Albireo Ab Inhibiteurs ibat pour le traitement de maladies du foie
CN105287604B (zh) 2010-11-08 2019-07-09 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合
EA201891154A1 (ru) 2011-10-28 2019-02-28 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom
EP2916851A2 (fr) 2012-10-08 2015-09-16 Relypsa, Inc. Agents de liaison au potassium pour traiter l'hypertension et l'hyperkaliémie
ES2471340B1 (es) 2012-12-21 2015-08-17 Laboratorios Rubió, S.A. Composición farmacéutica oral para fármacos de elevada posología
MX2015011445A (es) * 2013-03-15 2016-04-20 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina.
CN103446179B (zh) * 2013-05-14 2017-03-15 厦门绿洲安源投资管理有限公司 作为磷酸盐、脂肪酸和胆汁酸绑定螯合剂的双亲聚富勒烯树状交联聚阳离子凝胶的应用
PT3003327T (pt) 2013-06-05 2017-11-09 Tricida Inc Polímeros de ligação de protões para administração oral
US9475891B2 (en) 2013-09-19 2016-10-25 Navinta, Llc Process for the preparation of colesevelam hydrochloride
EP2875807B1 (fr) 2013-11-20 2021-03-24 Sanovel Ilac Sanayi ve Ticaret A.S. Formulation de comprimé de colesevelam
ITMI20132132A1 (it) 2013-12-19 2015-06-20 Chemi Spa Processo per la preparazione di colesevelam
JP2017517550A (ja) 2014-06-13 2017-06-29 ユナイテッド セラピューティクス コーポレイション トレプロスチニル製剤
CN113855703A (zh) 2014-12-10 2021-12-31 特里赛达公司 用于口服施用的质子结合聚合物
WO2016135065A1 (fr) 2015-02-23 2016-09-01 Amneal Pharmaceuticals Company Gmbh Procédé de granulation de carbonate de sevelamer
EP3705507B1 (fr) 2015-10-21 2023-03-22 Saudi Arabian Oil Company Matériaux poreux
EP3452057A1 (fr) 2016-05-06 2019-03-13 Tricida Inc. Compositions pour le traitement de troubles acido-basiques
CN106008813B (zh) * 2016-06-15 2017-11-14 新发药业有限公司 溶液聚合制备盐酸考来维仑的方法
CN110036056B (zh) 2016-12-14 2022-09-13 埃科莱布美国股份有限公司 季阳离子聚合物
CN107232191B (zh) * 2017-06-22 2021-05-18 华中师范大学 一种全氟丁基改性聚乙烯亚胺大分子含氟表面活性剂及其制备与在农药缓释中的应用
SG11202003451UA (en) 2017-11-03 2020-05-28 Tricida Inc Compositions for and method of treating acid-base disorders
WO2019241056A1 (fr) 2018-06-12 2019-12-19 Ecolab Usa Inc. Tensioactifs cationiques quaternaires et polymères à utiliser comme agents de libération et de modification de revêtement dans des papiers de crêpage et de soie
CN112047854B (zh) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580490A (fr) * 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3288770A (en) * 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
BE756035A (fr) * 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (fr) * 1969-12-27 1971-06-29
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
AR206390A1 (es) * 1973-02-05 1976-07-23 Rohm & Haas Una matriz de resina polimerica reticulada y procedimiento para su preparacion
US4217429A (en) * 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) * 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (fr) * 1974-02-13 1977-02-28
US4016209A (en) * 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4101478A (en) * 1976-04-12 1978-07-18 Kostjuchenko Vladimir Mitrofan Synthetic rubber mix
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (fi) * 1977-02-17 1985-04-10 Merck & Co Inc Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
US4298715A (en) * 1978-03-01 1981-11-03 Monsanto Company Polyamine/epihalohydrin reaction products
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
IT1106718B (it) * 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
US4557930A (en) * 1982-01-18 1985-12-10 Mitsubishi Petrochemical Co., Ltd. Anticholesteremic anion exchange resins
JPS6090243A (ja) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
JPS60106803A (ja) * 1983-11-14 1985-06-12 Nitto Boseki Co Ltd アリル尿素重合体の製造方法
EP0142962A3 (fr) * 1983-11-14 1986-01-15 Nitto Boseki Co., Ltd. Procédé de fabrication de dérivés de polyallylamine
CA1220897A (fr) * 1984-01-11 1987-04-21 Kiyoshi Shimizu Procede de production de polymeres de monoallylamine
EP0162388B1 (fr) * 1984-05-11 1989-09-13 Bristol-Myers Company Résine séquestrante pour la bile et son application
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
DE3901527A1 (de) 1989-01-20 1990-07-26 Hoechst Ag Alkylierte polyethyleniminderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) * 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) * 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
US5142019A (en) * 1991-10-03 1992-08-25 Ppg Industries, Inc. Oligomers formed from reaction of acrylamidoglycolate alkyl ethers with β-hydroxyalkylamines
DE59307535D1 (de) * 1992-07-22 1997-11-20 Hoechst Ag Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff
ES2096150T3 (es) * 1992-07-22 1997-03-01 Hoechst Ag Copolimeros vinilicos reticulados, procedimiento para su preparacion, asi como el empleo de estos compuestos.
JP3412842B2 (ja) * 1992-07-28 2003-06-03 ミヨシ油脂株式会社 金属捕集剤及びその製造方法
NZ255758A (en) * 1992-08-20 1997-10-24 Du Pont Crosslinked polymeric ammonium salts useful as bile sequestrants
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
JPH09500368A (ja) * 1993-06-02 1997-01-14 ジェルテックス ファーマシューティカルズ,インコーポレイテッド 胆汁酸塩を除去するための組成物および方法
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient

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US20070155950A1 (en) 2007-07-05
DE69511861T2 (de) 2000-02-10
AU698752B2 (en) 1998-11-05
US6784254B2 (en) 2004-08-31
NL300159I2 (nl) 2004-12-01
US20090155201A1 (en) 2009-06-18
DE122004000034I2 (de) 2006-04-27
US20020095002A1 (en) 2002-07-18
US6433026B2 (en) 2002-08-13
ES2135743T3 (es) 1999-11-01
WO1995034585A1 (fr) 1995-12-21
AU2699095A (en) 1996-01-05
LU91100I9 (fr) 2019-01-29
US20010044519A1 (en) 2001-11-22
LU91100I2 (fr) 2004-11-08
US7101960B2 (en) 2006-09-05
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US6225355B1 (en) 2001-05-01
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US5917007A (en) 1999-06-29
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US6066678A (en) 2000-05-23
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