NL300159I2 - Werkwijze voor het verwijderen van galzuren uit een patiënt. - Google Patents

Werkwijze voor het verwijderen van galzuren uit een patiënt.

Info

Publication number
NL300159I2
NL300159I2 NL300159C NL300159C NL300159I2 NL 300159 I2 NL300159 I2 NL 300159I2 NL 300159 C NL300159 C NL 300159C NL 300159 C NL300159 C NL 300159C NL 300159 I2 NL300159 I2 NL 300159I2
Authority
NL
Netherlands
Prior art keywords
patient
reaction product
alkylating agent
ch2ch2
nitrogen atoms
Prior art date
Application number
NL300159C
Other languages
English (en)
Other versions
NL300159I1 (nl
Inventor
Mandeville W Harry Iii
Holmes-Farley Stephen Randall
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300159(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of NL300159I1 publication Critical patent/NL300159I1/nl
Publication of NL300159I2 publication Critical patent/NL300159I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NL300159C 1994-06-10 2004-09-06 Werkwijze voor het verwijderen van galzuren uit een patiënt. NL300159I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10
PCT/US1995/007181 WO1995034585A1 (en) 1994-06-10 1995-06-05 Process for removing bile salts from a patient and alkylated compositions therefor

Publications (2)

Publication Number Publication Date
NL300159I1 NL300159I1 (nl) 2004-11-01
NL300159I2 true NL300159I2 (nl) 2004-12-01

Family

ID=22980525

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300159C NL300159I2 (nl) 1994-06-10 2004-09-06 Werkwijze voor het verwijderen van galzuren uit een patiënt.

Country Status (21)

Country Link
US (12) US5679717A (nl)
EP (2) EP0909768A3 (nl)
JP (1) JP3931217B2 (nl)
KR (1) KR100271693B1 (nl)
CN (1) CN1150217C (nl)
AT (1) ATE184027T1 (nl)
AU (1) AU698752C (nl)
CA (1) CA2191478C (nl)
DE (3) DE69511861T2 (nl)
DK (1) DK0764174T3 (nl)
ES (1) ES2135743T3 (nl)
FR (1) FR04C0021I2 (nl)
GR (1) GR3031702T3 (nl)
IL (2) IL114073A (nl)
LU (1) LU91100I2 (nl)
MX (1) MX9606171A (nl)
NL (1) NL300159I2 (nl)
NZ (1) NZ288076A (nl)
RU (1) RU2160742C2 (nl)
TW (1) TW474813B (nl)
WO (1) WO1995034585A1 (nl)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
JP4749649B2 (ja) * 1998-10-12 2011-08-17 中外製薬株式会社 リン酸結合性ポリマー
TW568788B (en) 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
DE19850817A1 (de) * 1998-11-04 2000-05-11 Basf Ag Modifizierte kationische Polymere, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Papierherstellung
US6271264B1 (en) 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
EP1881013A1 (en) 1999-04-16 2008-01-23 Abbott Laboratories Process for producing cross-linked polyallylamine hydrochloride
US6190649B1 (en) * 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
AU774636B2 (en) * 1999-07-14 2004-07-01 Genzyme Corporation Fat-binding polymers, optionally combined with lipase inhibitors
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
JP4265911B2 (ja) * 2000-07-28 2009-05-20 エフ．ホフマン−ラ ロシュ アーゲー 新規医薬組成物
US8263112B2 (en) * 2000-11-20 2012-09-11 Sorbent Therapeutics, Inc. In vivo use of water absorbent polymers
DE60132256T2 (de) 2000-11-20 2008-12-24 Sorbent Therapeutics, Inc., Vernon Hills Wasserabsorbierende polymere und deren verwendung
DE60142527D1 (de) 2000-11-28 2010-08-19 Mitsubishi Tanabe Pharma Corp Exkretionsbeschleuniger für eine akkumulative chlorverbindung
AT409630B (de) * 2000-12-13 2002-09-25 Dsm Fine Chem Austria Gmbh Alkylierung von n-bzw. amino- oder ammoniumgruppen haltigen, vernetzten polymeren
WO2002066543A1 (en) * 2001-02-16 2002-08-29 Genzyme Corporation Method of drying a material having a cohesive phase
DK1923064T3 (en) * 2001-04-18 2017-10-02 Genzyme Corp Use of amine polymer for lowering serum glucose
EP1379258B1 (en) * 2001-04-18 2006-06-28 Genzyme Corporation Low salt forms of polyallylamine
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
AU2002257147B9 (en) * 2001-04-18 2005-08-18 Genzyme Corporation Methods of treating syndrome X with aliphatic polyamines
EP1923064B1 (en) 2001-04-18 2017-06-28 Genzyme Corporation Use of amine polymer for lowering serum glucose
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
AT414237B (de) * 2002-09-03 2006-10-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von quaternären halogen-alkyl-ammoniumsalzen
AT411463B (de) * 2002-09-03 2004-01-26 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von alkylierten n- bzw. amino-, ammonium- oder spirobicyclischen ammoniumgruppen haltigen, vernetzten polymeren
AU2003282867A1 (en) * 2002-10-22 2004-05-13 Genzyme Corporation Amine polymers for promoting bone formation
JP4901474B2 (ja) 2003-05-30 2012-03-21 ランバクシー ラボラトリーズ リミテッド 置換ピロール誘導体
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
JPWO2005092349A1 (ja) 2004-03-26 2008-02-07 田辺三菱製薬株式会社 インスリン抵抗性改善剤
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
KR101228233B1 (ko) * 2004-03-30 2013-01-31 리립사, 인크. 이온 결합 중합체 및 이의 용도
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US7854924B2 (en) 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
EP1778740A1 (en) * 2004-08-12 2007-05-02 VersaMatrix A/S Beaded and cross-linked poly(aminoalkylene) matrix and uses thereof
WO2006021218A1 (en) * 2004-08-27 2006-03-02 Versamatrix A/S Polyether polymer matrix
DE602005026819D1 (de) * 2004-08-27 2011-04-21 Novo Nordisk As Funktionelles harz mit hoher beladung
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
JP4547620B2 (ja) * 2004-12-02 2010-09-22 日東紡績株式会社 架橋アリルアミン類重合体の製造方法
MY144940A (en) * 2005-01-25 2011-11-30 Avantor Performance Mat Inc Chromatographic media
JP2008533272A (ja) * 2005-03-16 2008-08-21 ユーエスヴィー リミテッド 架橋ポリアリルアミンポリマーの調製のための改良された方法
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
AR056499A1 (es) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd Compuestos
HUE026628T2 (en) 2005-09-15 2016-06-28 Genzyme Corp Pouches for amine polymers
WO2007041569A1 (en) * 2005-09-30 2007-04-12 Ilypsa, Inc. Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
KR20080057319A (ko) * 2005-09-30 2008-06-24 일립사, 인코포레이티드 가교 쉘을 갖는 코어-쉘 복합체의 제조 방법, 및 이로부터수득되는 코어-쉘 복합체
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US20080085259A1 (en) * 2006-05-05 2008-04-10 Huval Chad C Amine condensation polymers as phosphate sequestrants
ES2398477T3 (es) 2006-06-16 2013-03-19 Mitsubishi Tanabe Pharma Corporation Agente para la prevención y/o el tratamiento de glomerulopatía
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
US8158412B2 (en) * 2006-07-13 2012-04-17 Associates for Public Health Inoculation loop assembly
CA2658338A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
JP2010504975A (ja) 2006-09-29 2010-02-18 ゲンズイメ コーポレーション アミドデンドリマー組成物
BRPI0720234A2 (pt) 2006-12-14 2013-12-24 Genzyme Corp Composição farmacêutica
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008079302A2 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
EP2114376A1 (en) * 2007-02-23 2009-11-11 Genzyme Corporation Amine polymer compositions
US20100196305A1 (en) * 2007-03-08 2010-08-05 Dhal Pradeep K Sulfone polymer compositions
EP2152277A1 (en) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amine dendrimer compositions
EP2016947A1 (en) 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Novel one step process for preparing cross-linked poly(allylamine) polymers
US20100316589A1 (en) * 2007-12-14 2010-12-16 Hitesh Bhagat Coated Pharmaceutical Compositions
PA8807201A1 (es) * 2007-12-14 2009-07-23 Genzyme Corp Composiciones farmaceuticas
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
WO2010022380A2 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
KR102150184B1 (ko) * 2008-08-22 2020-08-31 리립사, 인크. 가교결합된 양이온교환 폴리머, 조성물 및 고칼륨혈증 치료 용도
WO2010041268A2 (en) 2008-09-02 2010-04-15 Usv Limited Crosslinked polymers
WO2010062734A1 (en) * 2008-11-03 2010-06-03 University Of Maryland, Baltimore Blood coagulation inducing polymer hydrogel
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
US20100190963A1 (en) 2008-12-16 2010-07-29 Millipore Corporation Stirred Tank Reactor And Method
US8673272B2 (en) * 2009-07-27 2014-03-18 Isp Investments Inc. Ultraviolet-absorbing compounds
GB0915449D0 (en) * 2009-09-04 2009-10-07 Univ Robert Gordon Composition
RU2612795C2 (ru) * 2010-02-24 2017-03-13 Релипса, Инк. Аминосодержащие полимеры для применения в качестве секвестрантов желчных кислот
BR112012021444A2 (pt) 2010-02-24 2016-05-31 Relypsa Inc polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas.
WO2011146394A1 (en) * 2010-05-17 2011-11-24 Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
TR201005327A2 (tr) 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Sinerjik farmasötik formülasyonlar.
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
DK3400944T3 (da) 2010-11-08 2020-10-12 Albireo Ab Ibat-inhibitorer til behandling af leversygdomme
PL2637646T3 (pl) 2010-11-08 2017-01-31 Albireo Ab Kombinacja farmaceutyczna zawierająca inhibitor ibat i środek wiążący kwasy żółciowe
PL2771003T3 (pl) 2011-10-28 2017-10-31 Lumena Pharmaceuticals Llc Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom
US10813946B2 (en) 2012-10-08 2020-10-27 Vifor (International) Ltd. Potassium binding polymers for treating hypertension and hyperkalemia
ES2471340B1 (es) 2012-12-21 2015-08-17 Laboratorios Rubió, S.A. Composición farmacéutica oral para fármacos de elevada posología
AU2014237340C1 (en) * 2013-03-15 2018-11-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN103446179B (zh) * 2013-05-14 2017-03-15 厦门绿洲安源投资管理有限公司 作为磷酸盐、脂肪酸和胆汁酸绑定螯合剂的双亲聚富勒烯树状交联聚阳离子凝胶的应用
DK3287133T3 (da) 2013-06-05 2019-07-01 Tricida Inc Proton-bindende polymerer til oral indgivelse
US9475891B2 (en) 2013-09-19 2016-10-25 Navinta, Llc Process for the preparation of colesevelam hydrochloride
EP2875807B1 (en) 2013-11-20 2021-03-24 Sanovel Ilac Sanayi ve Ticaret A.S. Tablet formulation of colesevelam
ITMI20132132A1 (it) 2013-12-19 2015-06-20 Chemi Spa Processo per la preparazione di colesevelam
CA2952223C (en) 2014-06-13 2023-08-01 United Therapeutics Corporation Treprostinil formulations
CN113855703A (zh) 2014-12-10 2021-12-31 特里赛达公司 用于口服施用的质子结合聚合物
WO2016135065A1 (en) 2015-02-23 2016-09-01 Amneal Pharmaceuticals Company Gmbh Process for granulating sevelamer carbonate
EP3705507B1 (en) * 2015-10-21 2023-03-22 Saudi Arabian Oil Company Porous materials
MA44875A (fr) 2016-05-06 2019-03-13 Tricida Inc Compositions pour le traitement de troubles acido-basiques
CN106008813B (zh) * 2016-06-15 2017-11-14 新发药业有限公司 溶液聚合制备盐酸考来维仑的方法
US10563042B2 (en) 2016-12-14 2020-02-18 Ecolab Usa Inc. Quaternary cationic polymers
CN107232191B (zh) * 2017-06-22 2021-05-18 华中师范大学 一种全氟丁基改性聚乙烯亚胺大分子含氟表面活性剂及其制备与在农药缓释中的应用
CA3080651A1 (en) 2017-11-03 2019-05-09 Tricida, Inc. Compositions for and method of treating acid-base disorders
WO2019241056A1 (en) 2018-06-12 2019-12-19 Ecolab Usa Inc. Quaternary cationic surfactants and polymers for use as release and coating modifying agents in creping and tissue papers
CN112047854B (zh) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580490A (fr) * 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3288770A (en) * 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
BE756035A (fr) * 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (nl) * 1969-12-27 1971-06-29
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
AR206390A1 (es) * 1973-02-05 1976-07-23 Rohm & Haas Una matriz de resina polimerica reticulada y procedimiento para su preparacion
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4217429A (en) * 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) * 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (nl) * 1974-02-13 1977-02-28
US4016209A (en) * 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4101478A (en) * 1976-04-12 1978-07-18 Kostjuchenko Vladimir Mitrofan Synthetic rubber mix
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (fi) * 1977-02-17 1985-04-10 Merck & Co Inc Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
US4298715A (en) * 1978-03-01 1981-11-03 Monsanto Company Polyamine/epihalohydrin reaction products
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
IT1106718B (it) * 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
WO1983002392A1 (en) * 1982-01-18 1983-07-21 Kihara, Kunio Cholesterol lowering drug
JPS6090243A (ja) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
EP0142962A3 (en) * 1983-11-14 1986-01-15 Nitto Boseki Co., Ltd. Process for producing poly (allylamine) derivatives
JPS60106803A (ja) * 1983-11-14 1985-06-12 Nitto Boseki Co Ltd アリル尿素重合体の製造方法
CA1220897A (en) * 1984-01-11 1987-04-21 Kiyoshi Shimizu Process for producing polymers of monoallylamine
OA08092A (fr) * 1984-05-11 1987-03-31 Bristol Myers Co Novel bile sequestrant resin and uses.
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
DE3901527A1 (de) 1989-01-20 1990-07-26 Hoechst Ag Alkylierte polyethyleniminderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) * 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) * 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
US5142019A (en) * 1991-10-03 1992-08-25 Ppg Industries, Inc. Oligomers formed from reaction of acrylamidoglycolate alkyl ethers with β-hydroxyalkylamines
DK0580079T3 (da) * 1992-07-22 1997-06-30 Hoechst Ag Tværbundne, nitrogenholdige vinylcopolymerer, fremgangsmåde til deres fremstilling samt anvendelse af disse forbindelser
ES2110543T3 (es) * 1992-07-22 1998-02-16 Hoechst Ag Derivados de poli(vinil-aminas) que tienen centros hidrofilos, procedimiento para su preparacion asi como la utilizacion de los compuestos como medicamentos, vehiculos de sustancias activas e ingredientes auxiliares para alimentos.
JP3412842B2 (ja) * 1992-07-28 2003-06-03 ミヨシ油脂株式会社 金属捕集剤及びその製造方法
CZ43995A3 (en) * 1992-08-20 1995-12-13 Du Pont Cross-linked polymeric ammonium salt, its use in the preparation of a medicament and a pharmaceutical composition containing such salt
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5703188A (en) 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5624963A (en) 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
EP0706399A4 (en) * 1993-06-02 1998-08-12 Geltex Pharma Inc PREPARATIONS AND METHOD FOR REMOVING BILE SALTS
US5607669A (en) 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient

Also Published As

Publication number Publication date
TW474813B (en) 2002-02-01
FR04C0021I2 (fr) 2008-05-16
EP0764174B1 (en) 1999-09-01
ES2135743T3 (es) 1999-11-01
IL114073A0 (en) 1995-10-31
ATE184027T1 (de) 1999-09-15
LU91100I9 (nl) 2019-01-29
US6433026B2 (en) 2002-08-13
RU2160742C2 (ru) 2000-12-20
GR3031702T3 (en) 2000-02-29
DE122004000034I2 (de) 2006-04-27
AU698752B2 (en) 1998-11-05
FR04C0021I1 (nl) 2007-10-26
US6066678A (en) 2000-05-23
DE122004000034I1 (de) 2005-02-24
EP0764174A1 (en) 1997-03-26
CA2191478C (en) 2007-10-16
JP3931217B2 (ja) 2007-06-13
DK0764174T3 (da) 2000-03-27
EP0909768A2 (en) 1999-04-21
IL114073A (en) 2003-06-24
IL142419A0 (en) 2002-03-10
US20050131161A1 (en) 2005-06-16
US20040014899A1 (en) 2004-01-22
US5693675A (en) 1997-12-02
LU91100I2 (fr) 2004-11-08
NL300159I1 (nl) 2004-11-01
AU698752C (en) 2002-08-08
WO1995034585A1 (en) 1995-12-21
US20010044519A1 (en) 2001-11-22
US5981693A (en) 1999-11-09
US7101960B2 (en) 2006-09-05
AU2699095A (en) 1996-01-05
NZ288076A (en) 1998-08-26
EP0909768A3 (en) 2001-01-17
US20070155950A1 (en) 2007-07-05
US20020095002A1 (en) 2002-07-18
CN1150435A (zh) 1997-05-21
US7399821B2 (en) 2008-07-15
KR100271693B1 (ko) 2000-11-15
US5679717A (en) 1997-10-21
CN1150217C (zh) 2004-05-19
US20090155201A1 (en) 2009-06-18
CA2191478A1 (en) 1995-12-21
DE69511861T2 (de) 2000-02-10
JPH10501842A (ja) 1998-02-17
US5917007A (en) 1999-06-29
DE69511861D1 (de) 1999-10-07
US6784254B2 (en) 2004-08-31
MX9606171A (es) 1998-07-31
US6225355B1 (en) 2001-05-01

Similar Documents

Publication Publication Date Title
NL300159I2 (nl) Werkwijze voor het verwijderen van galzuren uit een patiënt.
MX9606172A (es) Polimeros reticulados para retirar sales biliares de un paciente.
IL133434A (en) Use of polyamine polymers in the preparation of medicaments for removing bile salts and for treating hypercholesterolemia
DE59102512D1 (de) 2'-o-alkylnukleotide sowie polymere, die solche nukleotide enthalten.
RU96124807A (ru) Способ удаления из организма человека солей желчных кислот и алкилированные композиции для этого способа
CA2150287A1 (en) Agent for treating hepato-biliary diseases
DE69326231T2 (de) Cholesterinspiegelsenkendes mittel
FR2705673B1 (fr) Compositions comportant des dérivés d'acides aminés, leurs procédés de préparation et leurs utilisations.
IL119207A0 (en) Treatment of tinnitus using neuroprotective agents
MX9804226A (es) Derivados novedosos de 2,3,5-trimetil-4-hidroxianilida, su preparacion y su aplicacion de terapeutica.
CA2079205A1 (en) Use of Hyaluronic Acid and Forms to Prevent Arterial Restenosis
WO1990003172A3 (en) Bile acids for treatment of viral infections
HUT49846A (en) Process for producing n-(3',4'-dimethoxycinnamoyl)-anthranilic acid (tranilast)
FR2714385B1 (fr) Copolymère d'acide phosphonique-carboxylique et procédé de préparation de ce copolymère.
CA2106695A1 (en) Hyaluronic Acid and Forms to Prevent Arterial Restenosis
DE68902887D1 (de) Propargylguanidin-derivate und verfahren zu deren herstellung.
FR2699919B1 (fr) Dérivés d'imidazole, leur procédé de préparation et leur application en thérapeutique.
CA2120045A1 (en) Use of Hyaluronic Acid and Forms to Prevent Arterial Restenosis
IT9022447A0 (it) Circuito di recupero dell'offset intrinseco particolarmente per amplificatori