IL113837A - [(3,4-difluorophenoxy) methyl] oxirane and its preparation - Google Patents
[(3,4-difluorophenoxy) methyl] oxirane and its preparationInfo
- Publication number
- IL113837A IL113837A IL11383792A IL11383792A IL113837A IL 113837 A IL113837 A IL 113837A IL 11383792 A IL11383792 A IL 11383792A IL 11383792 A IL11383792 A IL 11383792A IL 113837 A IL113837 A IL 113837A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- compound
- difluorophenoxy
- formula
- filtered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Paper (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65964591A | 1991-02-25 | 1991-02-25 | |
| IL10095292A IL100952A (en) | 1991-02-25 | 1992-02-14 | 4-[(2-benzothiazolyl)methylamino]-alpha-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol its preparation and pharmaceutical compositions containing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL113837A true IL113837A (en) | 1996-05-14 |
Family
ID=24646210
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11383792A IL113837A (en) | 1991-02-25 | 1992-02-14 | [(3,4-difluorophenoxy) methyl] oxirane and its preparation |
| IL10095292A IL100952A (en) | 1991-02-25 | 1992-02-14 | 4-[(2-benzothiazolyl)methylamino]-alpha-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol its preparation and pharmaceutical compositions containing it |
| IL11383795A IL113837A0 (en) | 1991-02-25 | 1995-05-24 | [(3,4-difluorophenoxy)methyl] oxirane and its preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10095292A IL100952A (en) | 1991-02-25 | 1992-02-14 | 4-[(2-benzothiazolyl)methylamino]-alpha-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol its preparation and pharmaceutical compositions containing it |
| IL11383795A IL113837A0 (en) | 1991-02-25 | 1995-05-24 | [(3,4-difluorophenoxy)methyl] oxirane and its preparation |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US5434168A (cs) |
| EP (2) | EP0501552A1 (cs) |
| JP (1) | JP2825652B2 (cs) |
| KR (1) | KR0165901B1 (cs) |
| CN (3) | CN1033454C (cs) |
| AT (1) | ATE131478T1 (cs) |
| AU (1) | AU649788B2 (cs) |
| BG (1) | BG62332B1 (cs) |
| CA (1) | CA2104000A1 (cs) |
| CY (1) | CY1924A (cs) |
| CZ (1) | CZ284705B6 (cs) |
| DE (1) | DE69206787T2 (cs) |
| DK (1) | DK0573473T3 (cs) |
| DZ (1) | DZ1560A1 (cs) |
| EE (1) | EE02983B1 (cs) |
| ES (1) | ES2083737T3 (cs) |
| FI (1) | FI933719L (cs) |
| GR (1) | GR3018692T3 (cs) |
| HK (1) | HK172296A (cs) |
| HU (2) | HUT67695A (cs) |
| IE (1) | IE69567B1 (cs) |
| IL (3) | IL113837A (cs) |
| LV (1) | LV11689B (cs) |
| MA (1) | MA22447A1 (cs) |
| MX (1) | MX9200777A (cs) |
| NO (1) | NO300591B1 (cs) |
| NZ (2) | NZ248437A (cs) |
| PL (1) | PL168791B1 (cs) |
| RO (1) | RO112959B1 (cs) |
| RU (2) | RU2106348C1 (cs) |
| SK (1) | SK278705B6 (cs) |
| TN (1) | TNSN92017A1 (cs) |
| TW (1) | TW218016B (cs) |
| WO (1) | WO1992014731A1 (cs) |
| ZA (1) | ZA921341B (cs) |
| ZW (1) | ZW1992A1 (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
| TW282469B (cs) * | 1993-06-11 | 1996-08-01 | Janssen Pharmaceutica Nv | |
| HUT77362A (hu) * | 1994-10-14 | 1998-03-30 | Janssen Pharmaceutica N.V. | Sabeluzolt tartalmazó vizes orális szuszpenziók és eljárás előállításukra |
| US5744484A (en) * | 1994-11-24 | 1998-04-28 | Janssen Pharmaceutica, N.V. | Lubeluzole intravenous solutions |
| JPH10501823A (ja) * | 1995-04-10 | 1998-02-17 | バクスター、インターナショナル、インコーポレイテッド | クモ膜下出血の治療における架橋ヘモグロビンの使用 |
| CA2228054A1 (en) * | 1995-10-25 | 1997-05-01 | Janssen Pharmaceutica N.V. | Lubeluzole n-oxide |
| US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| SI0907650T1 (en) * | 1996-06-27 | 2003-06-30 | Janssen Pharmaceutica N.V. | N- 4-(heteroarylmethyl)phenyl)-heteroarylamines |
| US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
| US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| PL340727A1 (en) * | 1997-11-10 | 2001-02-26 | Bristol Myers Squibb Co | Benzothiazolic inhibitors of proteinous thyrosinic kinase |
| GB9815785D0 (en) * | 1998-07-20 | 1998-09-16 | Cerebrus Ltd | Chemical compounds |
| EP1178977B1 (en) | 1999-05-12 | 2005-06-01 | Neurosearch A/S | Ion channel modulating agents |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3963732A (en) * | 1973-05-30 | 1976-06-15 | Tiberio Bruzzese | Process for preparing dihydroxydiphenylmethane derivatives |
| GB1458392A (en) * | 1973-11-09 | 1976-12-15 | Ici Ltd | Optically-active 1-aryloxy-2,3-epoxypropane derivatives |
| US4310658A (en) * | 1980-06-18 | 1982-01-12 | Allied Corporation | Production of polyester thermally stabilized with an oxirane |
| CA1260474A (en) * | 1984-12-03 | 1989-09-26 | Raymond A. Stokbroekx | Benzoxazol- and benzothiazolamine derivatives |
| US4861785A (en) * | 1984-12-03 | 1989-08-29 | Janssen Pharmaceutica N.V. | Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents |
| KR930005004B1 (ko) * | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법 |
| US4689330A (en) * | 1985-04-15 | 1987-08-25 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
| US4749702A (en) * | 1985-04-15 | 1988-06-07 | Janssen Pharmaceutica N. V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
| US4717760A (en) * | 1986-07-10 | 1988-01-05 | The Dow Chemical Company | Fluorinated tris-epoxides based on triphenyl methane |
| JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
-
1992
- 1992-02-10 ZW ZW19/92A patent/ZW1992A1/xx unknown
- 1992-02-11 NZ NZ24843792A patent/NZ248437A/xx unknown
- 1992-02-11 NZ NZ24159292A patent/NZ241592A/en unknown
- 1992-02-12 CN CN92101908A patent/CN1033454C/zh not_active Expired - Fee Related
- 1992-02-14 EP EP92200417A patent/EP0501552A1/en active Pending
- 1992-02-14 DE DE69206787T patent/DE69206787T2/de not_active Expired - Fee Related
- 1992-02-14 FI FI933719A patent/FI933719L/fi unknown
- 1992-02-14 AU AU12085/92A patent/AU649788B2/en not_active Ceased
- 1992-02-14 RO RO93-01147A patent/RO112959B1/ro unknown
- 1992-02-14 RU RU95112519/04A patent/RU2106348C1/ru not_active IP Right Cessation
- 1992-02-14 EP EP92905117A patent/EP0573473B1/en not_active Expired - Lifetime
- 1992-02-14 ES ES92905117T patent/ES2083737T3/es not_active Expired - Lifetime
- 1992-02-14 IL IL11383792A patent/IL113837A/en active IP Right Grant
- 1992-02-14 IL IL10095292A patent/IL100952A/en not_active IP Right Cessation
- 1992-02-14 US US08/098,297 patent/US5434168A/en not_active Expired - Fee Related
- 1992-02-14 CA CA002104000A patent/CA2104000A1/en not_active Abandoned
- 1992-02-14 WO PCT/EP1992/000356 patent/WO1992014731A1/en active IP Right Grant
- 1992-02-14 JP JP4504615A patent/JP2825652B2/ja not_active Expired - Fee Related
- 1992-02-14 AT AT92905117T patent/ATE131478T1/de not_active IP Right Cessation
- 1992-02-14 RU RU9293053624A patent/RU2094434C1/ru active
- 1992-02-14 DK DK92905117.5T patent/DK0573473T3/da active
- 1992-02-14 HU HU9302395A patent/HUT67695A/hu unknown
- 1992-02-14 PL PL92300354A patent/PL168791B1/pl unknown
- 1992-02-20 TW TW081101226A patent/TW218016B/zh active
- 1992-02-21 SK SK512-92A patent/SK278705B6/sk unknown
- 1992-02-21 MA MA22735A patent/MA22447A1/fr unknown
- 1992-02-21 CZ CS92512A patent/CZ284705B6/cs not_active IP Right Cessation
- 1992-02-24 DZ DZ920018A patent/DZ1560A1/fr active
- 1992-02-24 IE IE920575A patent/IE69567B1/en not_active IP Right Cessation
- 1992-02-24 ZA ZA921341A patent/ZA921341B/xx unknown
- 1992-02-24 MX MX9200777A patent/MX9200777A/es not_active IP Right Cessation
- 1992-02-25 TN TNTNSN92017A patent/TNSN92017A1/fr unknown
-
1993
- 1993-08-23 KR KR1019930702525A patent/KR0165901B1/ko not_active Expired - Fee Related
- 1993-08-24 BG BG98068A patent/BG62332B1/bg unknown
- 1993-08-24 NO NO933010A patent/NO300591B1/no unknown
-
1994
- 1994-11-21 EE EE9400339A patent/EE02983B1/xx unknown
-
1995
- 1995-03-24 US US08/410,549 patent/US5675027A/en not_active Expired - Fee Related
- 1995-05-24 IL IL11383795A patent/IL113837A0/xx unknown
- 1995-05-30 CN CN95105632A patent/CN1043609C/zh not_active Expired - Fee Related
- 1995-05-30 CN CN95105633A patent/CN1117048A/zh active Pending
- 1995-06-21 HU HU95P/P00319P patent/HU211560A9/hu unknown
-
1996
- 1996-01-17 GR GR960400093T patent/GR3018692T3/el unknown
- 1996-08-13 LV LVP-96-334A patent/LV11689B/en unknown
- 1996-09-12 HK HK172296A patent/HK172296A/en not_active IP Right Cessation
-
1997
- 1997-03-07 CY CY192497A patent/CY1924A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL113837A (en) | [(3,4-difluorophenoxy) methyl] oxirane and its preparation | |
| CN1038936C (zh) | 甲酰胺衍生物的制备方法 | |
| EP0184257B1 (en) | Benzoxazol- and benzothiazolamine derivatives | |
| JP2010524907A (ja) | トリアゾロピリジンカルボキサミド誘導体、その調製およびその治療的使用 | |
| AU737334B2 (en) | Halogen substituted tetracyclic tetrahydrofuran derivatives | |
| CA2657775A1 (en) | Purification process of montelukast and its amine salts | |
| EP0912533B1 (en) | Alkylaminobenzothiazole and -benzoxazole derivatives | |
| CA2295800A1 (en) | Resolution of amines | |
| WO2010000456A1 (en) | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists | |
| IE66198B1 (en) | Antipsychotic 3-piperazinylbenzazole derivatives | |
| CN1215395A (zh) | 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物 | |
| TWI380975B (zh) | 製造胺基酚類化合物的方法 | |
| CN87104641A (zh) | 4-(芳酰氨基)哌啶丁酰氨衍生物 | |
| KR20160075816A (ko) | 피리미딘일사이클로펜테인 화합물의 제조 방법 | |
| Adamo et al. | An Improved Resolution Of 2-Methyl Piperidine And Its Use in The Synthesis Of Homochiral Trans-2, 6-Dialkyl Piperidines | |
| JP7292517B2 (ja) | オキセタン－２－イルメタンアミンの調製のためのプロセスおよび中間体 | |
| HK1047275A1 (en) | Benzofurane derivatives | |
| CN101048392A (zh) | 新用途 | |
| US4749702A (en) | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines | |
| CN1557808A (zh) | 3－取代哌嗪三氮唑醇类抗真菌化合物及其盐类 | |
| US5010198A (en) | Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents | |
| US8765979B2 (en) | Synthesis of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester) | |
| CA2525849A1 (en) | 4-arylsulphonylpiperidine derivatives for antagonism of the 5-ht2a receptor | |
| KR20220099201A (ko) | 광학분할에 의한 새로운 레보세티리진의 제조방법 | |
| CN1856479A (zh) | γ－分泌酶抑制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |