IL112900A - Intermediates for the preparation of hiv protease inhibitors - Google Patents
Intermediates for the preparation of hiv protease inhibitorsInfo
- Publication number
- IL112900A IL112900A IL112900A IL11290092A IL112900A IL 112900 A IL112900 A IL 112900A IL 112900 A IL112900 A IL 112900A IL 11290092 A IL11290092 A IL 11290092A IL 112900 A IL112900 A IL 112900A
- Authority
- IL
- Israel
- Prior art keywords
- intermediates
- preparation
- protease inhibitors
- hiv protease
- vinyl
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Confectionery (AREA)
- Cleaning Or Clearing Of The Surface Of Open Water (AREA)
- Measurement Of Force In General (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919110170A GB9110170D0 (en) | 1991-05-10 | 1991-05-10 | Amino acid derivatives |
| GB929203014A GB9203014D0 (en) | 1991-05-10 | 1992-02-13 | Amino acid derivatives |
| IL10177092A IL101770A (en) | 1991-05-10 | 1992-05-04 | Amino acid derivatives their manufacture and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL112900A true IL112900A (en) | 1997-06-10 |
Family
ID=26298885
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL112900A IL112900A (en) | 1991-05-10 | 1992-05-04 | Intermediates for the preparation of hiv protease inhibitors |
| IL10177092A IL101770A (en) | 1991-05-10 | 1992-05-04 | Amino acid derivatives their manufacture and pharmaceutical compositions containing them |
| IL11290095A IL112900A0 (en) | 1991-05-10 | 1995-03-07 | Amino acid derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10177092A IL101770A (en) | 1991-05-10 | 1992-05-04 | Amino acid derivatives their manufacture and pharmaceutical compositions containing them |
| IL11290095A IL112900A0 (en) | 1991-05-10 | 1995-03-07 | Amino acid derivatives |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5430041A (ro) |
| EP (1) | EP0512343B1 (ro) |
| JP (1) | JPH06102639B2 (ro) |
| AT (1) | ATE125792T1 (ro) |
| AU (1) | AU660308B2 (ro) |
| CA (1) | CA2067690C (ro) |
| CZ (1) | CZ281839B6 (ro) |
| DE (1) | DE69203780T2 (ro) |
| DK (1) | DK0512343T3 (ro) |
| DZ (1) | DZ1578A1 (ro) |
| ES (1) | ES2075976T3 (ro) |
| FI (2) | FI110938B (ro) |
| GR (1) | GR3017902T3 (ro) |
| HR (1) | HRP931025B1 (ro) |
| HU (1) | HU210283B (ro) |
| IE (1) | IE69169B1 (ro) |
| IL (3) | IL112900A (ro) |
| IS (1) | IS1747B (ro) |
| MX (1) | MX9202146A (ro) |
| MY (1) | MY108770A (ro) |
| NO (1) | NO300496B1 (ro) |
| NZ (1) | NZ242593A (ro) |
| RO (1) | RO109540B1 (ro) |
| SK (1) | SK281183B6 (ro) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| MXPA93002392A (es) | 1992-03-11 | 2005-02-04 | Narhex Ltd | Derivados amino de hidrocarburos-oxo e hidroxi-substituidos. |
| JPH07504654A (ja) * | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5733906A (en) * | 1993-10-12 | 1998-03-31 | Eli Lilly And Company | Inhibitors of HIV Protease useful for the treatment of Aids |
| US5491166A (en) * | 1992-12-22 | 1996-02-13 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
| US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
| US5591885A (en) * | 1994-09-23 | 1997-01-07 | Hoffman-La Roche Inc. | Process for the preparation of halogenated α-aminoketone compounds |
| GB0123467D0 (en) | 2001-09-28 | 2001-11-21 | Hoffmann La Roche | Carbocyclic HIV Protease inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE447633B (sv) * | 1978-09-19 | 1986-12-01 | Albany Int Corp | Forfarande for separering och modul for genomforande av forfarandet |
| JPS63166826A (ja) * | 1986-12-27 | 1988-07-11 | Shin Etsu Chem Co Ltd | 抗ヒトレトロウイルス剤 |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| CA2010531A1 (en) * | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
| CA2012901A1 (en) * | 1989-04-05 | 1990-10-05 | Quirico Branca | Amino acid derivatives |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
-
1992
- 1992-04-21 US US07/871,880 patent/US5430041A/en not_active Expired - Fee Related
- 1992-04-25 DE DE69203780T patent/DE69203780T2/de not_active Expired - Fee Related
- 1992-04-25 EP EP92107090A patent/EP0512343B1/en not_active Expired - Lifetime
- 1992-04-25 AT AT92107090T patent/ATE125792T1/de not_active IP Right Cessation
- 1992-04-25 DK DK92107090.0T patent/DK0512343T3/da active
- 1992-04-25 ES ES92107090T patent/ES2075976T3/es not_active Expired - Lifetime
- 1992-04-30 CA CA002067690A patent/CA2067690C/en not_active Expired - Fee Related
- 1992-05-04 IL IL112900A patent/IL112900A/xx not_active IP Right Cessation
- 1992-05-04 NZ NZ242593A patent/NZ242593A/en unknown
- 1992-05-04 IL IL10177092A patent/IL101770A/en not_active IP Right Cessation
- 1992-05-04 AU AU16007/92A patent/AU660308B2/en not_active Ceased
- 1992-05-06 HU HU9201514A patent/HU210283B/hu not_active IP Right Cessation
- 1992-05-06 DZ DZ920045A patent/DZ1578A1/fr active
- 1992-05-07 MY MYPI92000791A patent/MY108770A/en unknown
- 1992-05-07 SK SK1384-92A patent/SK281183B6/sk unknown
- 1992-05-07 CZ CS921384A patent/CZ281839B6/cs not_active IP Right Cessation
- 1992-05-07 JP JP4141077A patent/JPH06102639B2/ja not_active Expired - Fee Related
- 1992-05-08 IS IS3858A patent/IS1747B/is unknown
- 1992-05-08 NO NO921828A patent/NO300496B1/no not_active IP Right Cessation
- 1992-05-08 RO RO92-200623A patent/RO109540B1/ro unknown
- 1992-05-08 FI FI922094A patent/FI110938B/fi not_active IP Right Cessation
- 1992-05-08 MX MX9202146A patent/MX9202146A/es unknown
- 1992-07-01 IE IE921490A patent/IE69169B1/en not_active IP Right Cessation
-
1993
- 1993-07-06 HR HR931025A patent/HRP931025B1/xx not_active IP Right Cessation
-
1995
- 1995-03-07 IL IL11290095A patent/IL112900A0/xx unknown
- 1995-04-05 US US08/417,315 patent/US5583248A/en not_active Expired - Fee Related
- 1995-10-27 GR GR950403001T patent/GR3017902T3/el unknown
-
1999
- 1999-02-24 FI FI990399A patent/FI990399A7/fi unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |