UA41348C2 - Проліки 3-ацил-2-оксіндол-1-карбоксамідів та фармацевтична композиція - Google Patents
Проліки 3-ацил-2-оксіндол-1-карбоксамідів та фармацевтична композиціяInfo
- Publication number
- UA41348C2 UA41348C2 UA95073512A UA95073512A UA41348C2 UA 41348 C2 UA41348 C2 UA 41348C2 UA 95073512 A UA95073512 A UA 95073512A UA 95073512 A UA95073512 A UA 95073512A UA 41348 C2 UA41348 C2 UA 41348C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- represent
- independently
- group
- oxindol
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Проліки З-ацил-2-оксіндол-1-карбоксаміду формули: де R є де х приймає значення 0 або 1, А являє собою С1-С5-алкілен, необов'язково заміщений аж до двох Сз-С7-циклоалкілами, або являє собою фениленову групу, В є С2-С6-алкенілфенил, 2-, 3- або 4-піридил, 2-, 3- або 4-піперидініл, 2- або 3-піролідиніл -OCH2CO2R1 або –OCH2CONR2R3, R1 являє собою Н, С1-С7-алкіл, фенил(С1-С4) алкіл або (CH2)pCONR2RЗ, R2 и R3 незалежно один від одного являє собою Н, С1-С7-алкіл або разом з приєднаним атомом азоту являє собою морфолінову групу, R4 і R5 незалежно один від одного являють собою Н, С1-С7-алкіл, (CH2)pCONR2R3, (CH2)pNR7R8, (CH2)pOR6 або (CH2)pSR6, R6 являють собою Н, C1-С6-алкіл, Сз-С7-циклоалкіл, необов'язково заміщений аж до двох С1-С6-алкільними групами, або, взятий разом з замісником R4 і приєднаним атомом кисню, утворює тетрагідрофуранове кільце, R7 і R8 незалежно один від одного являють собою Н, C1-С6-алкіл, R9 являє собою Н або метил, R10 і R11 являють собою галоген, R12 і R13 незалежно являють собою водень, галоген, р дорівнює 1-3, за умови, що, коли заступник R є формулою II, а х приймає значення 0, А повинен бути групою, відмінною від С2-С6-алкіленової групи.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/009,188 US5270331A (en) | 1993-01-26 | 1993-01-26 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
PCT/US1993/009813 WO1994017061A1 (en) | 1993-01-26 | 1993-10-20 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
Publications (1)
Publication Number | Publication Date |
---|---|
UA41348C2 true UA41348C2 (uk) | 2001-09-17 |
Family
ID=21736103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA95073512A UA41348C2 (uk) | 1993-01-26 | 1993-10-20 | Проліки 3-ацил-2-оксіндол-1-карбоксамідів та фармацевтична композиція |
Country Status (35)
Country | Link |
---|---|
US (1) | US5270331A (uk) |
EP (1) | EP0681580B1 (uk) |
JP (1) | JP2703825B2 (uk) |
KR (1) | KR0169827B1 (uk) |
CN (1) | CN1052003C (uk) |
AP (1) | AP443A (uk) |
AT (1) | ATE155137T1 (uk) |
AU (1) | AU678187B2 (uk) |
BR (1) | BR9307768A (uk) |
CA (1) | CA2152919C (uk) |
CZ (1) | CZ181995A3 (uk) |
DE (1) | DE69312093T2 (uk) |
DK (1) | DK0681580T3 (uk) |
EG (1) | EG20302A (uk) |
ES (1) | ES2104187T3 (uk) |
FI (1) | FI940365A (uk) |
GR (1) | GR3024591T3 (uk) |
HR (1) | HRP940034B1 (uk) |
HU (1) | HUT69689A (uk) |
IL (1) | IL108384A (uk) |
MA (1) | MA23096A1 (uk) |
MX (1) | MX9400677A (uk) |
MY (1) | MY138629A (uk) |
NO (1) | NO952949D0 (uk) |
NZ (1) | NZ257278A (uk) |
OA (1) | OA10563A (uk) |
PL (1) | PL178857B1 (uk) |
RU (1) | RU2124514C1 (uk) |
SI (1) | SI9300567A (uk) |
SK (1) | SK280929B6 (uk) |
TW (1) | TW330935B (uk) |
UA (1) | UA41348C2 (uk) |
WO (1) | WO1994017061A1 (uk) |
YU (1) | YU48796B (uk) |
ZA (1) | ZA94463B (uk) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607959A (en) * | 1993-02-09 | 1997-03-04 | Pfizer Inc. | Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents |
WO1997013767A1 (de) * | 1995-10-09 | 1997-04-17 | Chemisch Pharmazeutische Forschungsgesellschaft Mbh | Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren |
ATE249828T1 (de) * | 1998-03-06 | 2003-10-15 | Astrazeneca Ab | Verwendung von isatin- und oxindolderivaten zur herstellung von arzeneimittel für die behandlung von mykobakteriellen erkrankungen |
EP0984012A3 (en) * | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
WO2003016259A2 (de) * | 2001-08-16 | 2003-02-27 | Pharmacon-Forschung Und Beratung Gmbh | Milchsäureelemente enthaltende verbindungen, deren herstellung sowie deren verwendung als pharmazeutische wirkstoffe |
CN101628842A (zh) * | 2009-08-27 | 2010-01-20 | 中国人民解放军防化指挥工程学院 | 烷氧羰基甲氧基作为羧基保护基 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
HU208421B (en) * | 1988-10-18 | 1993-10-28 | Pfizer | Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity |
DE68923673T2 (de) * | 1988-10-18 | 1996-01-18 | Pfizer | Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden. |
-
1993
- 1993-01-26 US US08/009,188 patent/US5270331A/en not_active Expired - Lifetime
- 1993-10-13 TW TW082108483A patent/TW330935B/zh active
- 1993-10-20 WO PCT/US1993/009813 patent/WO1994017061A1/en active IP Right Grant
- 1993-10-20 JP JP6511478A patent/JP2703825B2/ja not_active Expired - Fee Related
- 1993-10-20 ES ES93923879T patent/ES2104187T3/es not_active Expired - Lifetime
- 1993-10-20 DK DK93923879.6T patent/DK0681580T3/da active
- 1993-10-20 NZ NZ257278A patent/NZ257278A/en unknown
- 1993-10-20 SK SK912-95A patent/SK280929B6/sk unknown
- 1993-10-20 RU RU95117091A patent/RU2124514C1/ru not_active IP Right Cessation
- 1993-10-20 AT AT93923879T patent/ATE155137T1/de not_active IP Right Cessation
- 1993-10-20 UA UA95073512A patent/UA41348C2/uk unknown
- 1993-10-20 CZ CZ951819A patent/CZ181995A3/cs not_active IP Right Cessation
- 1993-10-20 PL PL93309989A patent/PL178857B1/pl not_active IP Right Cessation
- 1993-10-20 DE DE69312093T patent/DE69312093T2/de not_active Expired - Fee Related
- 1993-10-20 CA CA002152919A patent/CA2152919C/en not_active Expired - Fee Related
- 1993-10-20 BR BR9307768A patent/BR9307768A/pt not_active Application Discontinuation
- 1993-10-20 EP EP93923879A patent/EP0681580B1/en not_active Expired - Lifetime
- 1993-10-20 AU AU53598/94A patent/AU678187B2/en not_active Ceased
- 1993-10-21 AP APAP/P/1993/000583A patent/AP443A/en active
- 1993-10-28 SI SI9300567A patent/SI9300567A/sl not_active IP Right Cessation
-
1994
- 1994-01-16 EG EG2694A patent/EG20302A/xx active
- 1994-01-18 MY MYPI94000137A patent/MY138629A/en unknown
- 1994-01-20 IL IL10838494A patent/IL108384A/en not_active IP Right Cessation
- 1994-01-21 HR HR940034A patent/HRP940034B1/xx not_active IP Right Cessation
- 1994-01-24 ZA ZA94463A patent/ZA94463B/xx unknown
- 1994-01-25 FI FI940365A patent/FI940365A/fi not_active Application Discontinuation
- 1994-01-25 HU HU9400209A patent/HUT69689A/hu unknown
- 1994-01-25 MA MA23402A patent/MA23096A1/fr unknown
- 1994-01-25 CN CN94100697A patent/CN1052003C/zh not_active Expired - Fee Related
- 1994-01-25 MX MX9400677A patent/MX9400677A/es not_active IP Right Cessation
- 1994-01-25 YU YU2994A patent/YU48796B/sh unknown
-
1995
- 1995-07-25 OA OA60692A patent/OA10563A/en unknown
- 1995-07-25 NO NO952949A patent/NO952949D0/no unknown
- 1995-07-26 KR KR1019950703074A patent/KR0169827B1/ko not_active IP Right Cessation
-
1997
- 1997-09-02 GR GR970402235T patent/GR3024591T3/el unknown
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