IL112457A - History of glycopeptide antibiotic substances, process for their preparation and pharmaceutical preparations containing them - Google Patents

History of glycopeptide antibiotic substances, process for their preparation and pharmaceutical preparations containing them

Info

Publication number
IL112457A
IL112457A IL11245795A IL11245795A IL112457A IL 112457 A IL112457 A IL 112457A IL 11245795 A IL11245795 A IL 11245795A IL 11245795 A IL11245795 A IL 11245795A IL 112457 A IL112457 A IL 112457A
Authority
IL
Israel
Prior art keywords
alkyl
alkoxy
halo
group
formula
Prior art date
Application number
IL11245795A
Other languages
English (en)
Hebrew (he)
Other versions
IL112457A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL112457A0 publication Critical patent/IL112457A0/xx
Publication of IL112457A publication Critical patent/IL112457A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
IL11245795A 1994-01-28 1995-01-26 History of glycopeptide antibiotic substances, process for their preparation and pharmaceutical preparations containing them IL112457A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15

Publications (2)

Publication Number Publication Date
IL112457A0 IL112457A0 (en) 1995-03-30
IL112457A true IL112457A (en) 2004-06-20

Family

ID=26885101

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11245795A IL112457A (en) 1994-01-28 1995-01-26 History of glycopeptide antibiotic substances, process for their preparation and pharmaceutical preparations containing them

Country Status (30)

Country Link
US (1) US5843889A (fr)
EP (3) EP0667353B1 (fr)
JP (1) JP3756539B2 (fr)
KR (1) KR100388867B1 (fr)
CN (1) CN1071334C (fr)
AT (3) ATE253077T1 (fr)
AU (1) AU703106B2 (fr)
BR (1) BR9500365A (fr)
CA (3) CA2546910C (fr)
CO (1) CO4600679A1 (fr)
CZ (2) CZ292895B6 (fr)
DE (3) DE69532013T2 (fr)
DK (3) DK1016670T3 (fr)
EG (1) EG25884A (fr)
ES (3) ES2220335T3 (fr)
FI (3) FI117095B (fr)
HU (1) HU225164B1 (fr)
IL (1) IL112457A (fr)
MY (1) MY128335A (fr)
NO (1) NO323103B1 (fr)
NZ (1) NZ270387A (fr)
PE (1) PE40996A1 (fr)
PL (1) PL180961B1 (fr)
PT (3) PT667353E (fr)
RU (1) RU2145609C1 (fr)
SG (1) SG52719A1 (fr)
SI (2) SI0667353T1 (fr)
TW (1) TW457248B (fr)
UA (1) UA43323C2 (fr)
YU (1) YU4995A (fr)

Families Citing this family (52)

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US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
EP1073447B1 (fr) 1998-05-01 2007-05-09 Eli Lilly And Company Glycopeptides n1-modifies
US6710168B1 (en) 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
WO2000004044A1 (fr) * 1998-07-14 2000-01-27 Princeton University Antibiotiques glycopeptidiques, bibliotheques combinatoires d'antibiotiques glycopeptidiques, et procedes de production correspondants
IL140093A0 (en) 1998-12-23 2002-02-10 Advanced Medicine Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
CA2726789A1 (fr) 2000-02-05 2001-11-08 Theravance, Inc. Preparations antibiotiques a base de glycopeptides contenant des cyclodextrines
WO2001081373A2 (fr) * 2000-04-25 2001-11-01 Merck & Co., Inc. Composes antibacteriens glycopeptidiques et procedes pour les utiliser
US6831150B2 (en) * 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
WO2001083520A2 (fr) 2000-05-02 2001-11-08 Theravance,Inc Derives polyacides de glycopeptides
EP1292611B1 (fr) 2000-06-22 2008-03-12 Theravance, Inc. Derives carboxy-saccharides de glycopeptides
WO2001098329A1 (fr) 2000-06-22 2001-12-27 Theravance, Inc. Derives polyhydroxy de glycopeptides
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US20050250677A1 (en) * 2002-08-30 2005-11-10 Jan Balzarini Glycopeptide antibiotic derivatives
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
US7521418B2 (en) 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
WO2005018743A1 (fr) * 2003-07-22 2005-03-03 Theravance, Inc. Utilisation d'un agent antifongique a base d'echinocandines conjointement avec un agent antibacterien glycopeptidique
BRPI0516657A (pt) * 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
CN101189380B (zh) 2005-04-01 2012-12-19 博凯技术公司 用于隔音的非织造材料和制造工艺
US8445007B2 (en) 2005-09-22 2013-05-21 Medivas, Llc Bis-(α-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
EP1933881B1 (fr) 2005-09-22 2019-03-13 Medivas, LLC Compositions polymères solides pour administration et méthodes d'utilisation de celles-ci
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
RU2481354C2 (ru) * 2007-12-26 2013-05-10 Шионоги Энд Ко., Лтд. Гликозилированные гликопептидные антибиотические производные
EP2260060A4 (fr) 2008-04-01 2013-01-16 Univ Cornell Sels de chitosane organosolubles et biomatériaux dérivés du chitosane préparés à partir desdits sels
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
AU2012250568B2 (en) 2011-05-05 2017-06-29 Matinas Biopharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
EP2969004A4 (fr) 2013-03-15 2016-09-21 Melinta Therapeutics Inc Procédés de traitement d'infections chez des patients atteints de surpoids et d'obésité utilisant d'antibiotiques
CN104418941B (zh) * 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
EP3049115A1 (fr) 2013-09-23 2016-08-03 Jawaharlal Nehru Centre For Advanced Scientific Research Conjugués de vancomycine-sucre et leurs utilisations
WO2016011245A1 (fr) * 2014-07-17 2016-01-21 The Medicines Company Oritavancine à haute pureté et son procédé de production
JP6797795B2 (ja) 2014-11-06 2020-12-09 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ グリコペプチド組成物
US20170342110A1 (en) * 2014-12-25 2017-11-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US3338786A (en) * 1966-07-29 1967-08-29 American Cyanamid Co Antibiotic av290 and production thereof
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
IT1173329B (it) * 1984-02-21 1987-06-24 Lepetit Spa Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
IL78597A0 (en) * 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
DK203089A (da) * 1988-04-28 1989-10-29 Beecham Group Plc Metaboliter
CA1339808C (fr) * 1988-10-19 1998-04-07 Manuel Debono Antibiotiques aux glycopeptides
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
ATE87502T1 (de) * 1989-12-11 1993-04-15 De Beers Ind Diamond Schleifprodukte.
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
US5187082A (en) * 1990-08-16 1993-02-16 Eli Lilly And Company Process for producing A83850 antibiotics
DK0596929T3 (da) * 1991-07-29 1995-09-11 Lepetit Spa Amidderivater af antibiotikum A 40926

Also Published As

Publication number Publication date
RU2145609C1 (ru) 2000-02-20
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
US5843889A (en) 1998-12-01
KR100388867B1 (ko) 2003-10-08
MY128335A (en) 2007-01-31
DE69532013T2 (de) 2004-07-08
NO950298L (no) 1995-07-31
ATE248856T1 (de) 2003-09-15
FI117097B (fi) 2006-06-15
CZ18495A3 (en) 1995-08-16
JP3756539B2 (ja) 2006-03-15
CA2141106A1 (fr) 1995-07-29
ATE253077T1 (de) 2003-11-15
CZ292921B6 (cs) 2004-01-14
AU1138995A (en) 1995-08-10
FI117096B (fi) 2006-06-15
EP1016670A1 (fr) 2000-07-05
RU95101039A (ru) 1996-10-27
DE69531709D1 (de) 2003-10-09
DK1031576T3 (da) 2004-08-16
FI117095B (fi) 2006-06-15
HUT68715A (en) 1995-07-28
SI1016670T1 (en) 2004-02-29
CA2546625C (fr) 2008-09-09
AU703106B2 (en) 1999-03-18
EP1031576A3 (fr) 2000-12-27
BR9500365A (pt) 1995-10-17
ES2210274T3 (es) 2004-07-01
CN1071334C (zh) 2001-09-19
CN1119649A (zh) 1996-04-03
SG52719A1 (en) 1998-09-28
ES2204444T3 (es) 2004-05-01
DE69532013D1 (de) 2003-12-04
CA2546910C (fr) 2010-09-14
NZ270387A (en) 1996-11-26
KR950032274A (ko) 1995-12-20
JPH07258289A (ja) 1995-10-09
FI20050512A (fi) 2005-05-13
FI20050513A (fi) 2005-05-13
YU4995A (sh) 1998-07-10
PL306976A1 (en) 1995-08-07
CZ292895B6 (cs) 2003-12-17
IL112457A0 (en) 1995-03-30
PT1031576E (pt) 2004-08-31
HU9500230D0 (en) 1995-03-28
PL180961B1 (pl) 2001-05-31
PT1016670E (pt) 2003-12-31
SI0667353T1 (en) 2004-04-30
NO950298D0 (no) 1995-01-26
EP1016670B1 (fr) 2003-09-03
CO4600679A1 (es) 1998-05-08
CA2546625A1 (fr) 1995-07-29
DE69533004T2 (de) 2005-04-07
EP0667353B1 (fr) 2003-10-29
PT667353E (pt) 2004-03-31
CA2546910A1 (fr) 1995-07-29
EP1031576B1 (fr) 2004-05-06
DE69531709T2 (de) 2004-07-15
DE69533004D1 (de) 2004-06-09
EP1031576A2 (fr) 2000-08-30
CA2141106C (fr) 2007-01-23
FI950374A0 (fi) 1995-01-27
EG25884A (en) 2012-09-24
DK0667353T3 (da) 2004-03-22
FI950374A (fi) 1995-07-29
HU225164B1 (en) 2006-07-28
ES2220335T3 (es) 2004-12-16
DK1016670T3 (da) 2004-01-05
ATE266042T1 (de) 2004-05-15
TW457248B (en) 2001-10-01
UA43323C2 (uk) 2001-12-17
EP0667353A1 (fr) 1995-08-16

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