CA2216167C - Derives d'antibiotiques a base de glycopeptides - Google Patents

Derives d'antibiotiques a base de glycopeptides Download PDF

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Publication number
CA2216167C
CA2216167C CA002216167A CA2216167A CA2216167C CA 2216167 C CA2216167 C CA 2216167C CA 002216167 A CA002216167 A CA 002216167A CA 2216167 A CA2216167 A CA 2216167A CA 2216167 C CA2216167 C CA 2216167C
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CA
Canada
Prior art keywords
alkyl
alkoxy
halo
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002216167A
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English (en)
Other versions
CA2216167A1 (fr
Inventor
Robin David Grey Cooper
Bret Eugene Huff
Thalia Ioanna Nicas
John Thomas Quatroche
Michael John Rodriguez
Nancy J. Snyder
Michael A. Staszak
Richard C. Thompson
Stephen C. Wilkie
Mark J. Zweifel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/410,155 external-priority patent/US5840684A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2216167A1 publication Critical patent/CA2216167A1/fr
Application granted granted Critical
Publication of CA2216167C publication Critical patent/CA2216167C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention se rapporte à des composés dérivés d'antibiotiques à base de glycopeptides. Ces composés dérivés possèdent une activité antibactérienne contre une large variété de bactéries, y compris une activité contre des isolats résistant à la vancomycine. Les méthodes de fabrication et d'utilisation de ces composés dérivés d'antibiotiques à base de glycopeptides sont également décrites.
CA002216167A 1995-03-24 1996-03-14 Derives d'antibiotiques a base de glycopeptides Expired - Lifetime CA2216167C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/410,155 US5840684A (en) 1994-01-28 1995-03-24 Glycopeptide antibiotic derivatives
US08/410,155 1995-03-24
PCT/US1996/003550 WO1996030401A1 (fr) 1995-03-24 1996-03-14 Derives d'antibiotiques a base de glycopeptides

Publications (2)

Publication Number Publication Date
CA2216167A1 CA2216167A1 (fr) 1996-10-03
CA2216167C true CA2216167C (fr) 2007-07-17

Family

ID=38288150

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002216167A Expired - Lifetime CA2216167C (fr) 1995-03-24 1996-03-14 Derives d'antibiotiques a base de glycopeptides

Country Status (1)

Country Link
CA (1) CA2216167C (fr)

Also Published As

Publication number Publication date
CA2216167A1 (fr) 1996-10-03

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Effective date: 20160314