IL109775A - Ascomycin derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Ascomycin derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109775A
IL109775A IL10977594A IL10977594A IL109775A IL 109775 A IL109775 A IL 109775A IL 10977594 A IL10977594 A IL 10977594A IL 10977594 A IL10977594 A IL 10977594A IL 109775 A IL109775 A IL 109775A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
hydroxy groups
ascomycin derivatives
Prior art date
Application number
IL10977594A
Other languages
English (en)
Other versions
IL109775A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939310975A external-priority patent/GB9310975D0/en
Priority claimed from GB939310969A external-priority patent/GB9310969D0/en
Priority claimed from GB939312590A external-priority patent/GB9312590D0/en
Priority claimed from GB939313553A external-priority patent/GB9313553D0/en
Priority claimed from GB939319617A external-priority patent/GB9319617D0/en
Priority claimed from GB939319618A external-priority patent/GB9319618D0/en
Priority claimed from GB939326045A external-priority patent/GB9326045D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL109775A0 publication Critical patent/IL109775A0/xx
Publication of IL109775A publication Critical patent/IL109775A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Color Printing (AREA)
  • Seasonings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL10977594A 1993-05-27 1994-05-25 Ascomycin derivatives their preparation and pharmaceutical compositions containing them IL109775A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB939310975A GB9310975D0 (en) 1993-05-27 1993-05-27 Organic compounds
GB939310969A GB9310969D0 (en) 1993-05-27 1993-05-27 Organic compounds
GB939312590A GB9312590D0 (en) 1993-06-18 1993-06-18 Organic compounds
GB939313553A GB9313553D0 (en) 1993-07-01 1993-07-01 Organic compounds
GB939319617A GB9319617D0 (en) 1993-09-23 1993-09-23 Organic compounds
GB939319618A GB9319618D0 (en) 1993-09-23 1993-09-23 Organic compounds
GB939326045A GB9326045D0 (en) 1993-12-21 1993-12-21 Organic compounds

Publications (2)

Publication Number Publication Date
IL109775A0 IL109775A0 (en) 1994-08-26
IL109775A true IL109775A (en) 1999-07-14

Family

ID=27562893

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10977594A IL109775A (en) 1993-05-27 1994-05-25 Ascomycin derivatives their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US5493019A (hu)
EP (1) EP0626385B1 (hu)
JP (1) JP3076724B2 (hu)
CN (1) CN1048495C (hu)
AT (1) ATE252105T1 (hu)
AU (1) AU682499B2 (hu)
CA (1) CA2124260C (hu)
CY (1) CY2523B1 (hu)
CZ (1) CZ286157B6 (hu)
DE (1) DE69433234T2 (hu)
DK (1) DK0626385T3 (hu)
ES (1) ES2208651T3 (hu)
FI (1) FI107159B (hu)
HK (1) HK1011684A1 (hu)
HU (1) HU218919B (hu)
IL (1) IL109775A (hu)
MY (1) MY110603A (hu)
NO (1) NO308302B1 (hu)
NZ (1) NZ260596A (hu)
PH (1) PH30420A (hu)
PT (1) PT626385E (hu)
RU (1) RU2130460C1 (hu)
SI (1) SI0626385T1 (hu)
SK (1) SK281541B6 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4155593B2 (ja) 1994-10-26 2008-09-24 ノバルティス・アクチエンゲゼルシャフト 医薬組成物
US6657104B1 (en) 1997-10-16 2003-12-02 Texas Systems, University Of The Board Of The Regents Transgenic mouse model for cardiac hypertrophy and methods of use thereof
PT2198858E (pt) 1998-03-26 2011-09-01 Astellas Pharma Inc Composição farmacêutica de libertação constante que contém um macrólido como o tacrolimus
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
CA2492989C (en) 2002-07-23 2012-11-20 Novartis Ag Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
WO2005063242A1 (en) * 2003-12-30 2005-07-14 Astellas Pharma Inc. Use of macrolides for treating or preventing airflow obstruction
GT200500282A (es) 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
EP1688161A1 (en) * 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
CN102762577B (zh) * 2009-07-15 2015-01-07 Cti生物医药有限公司 9e-15-(2-吡咯烷-1-基-乙氧基)-7,12,25-三氧杂-19,21,24-三氮杂-四环[18.3.1.1(2,5).1(14,18)]二十六碳-1(24),2,4,9,14,16,18(26),20,22-壬烯柠檬酸盐
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
JP7465806B2 (ja) 2018-08-10 2024-04-11 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤
CA3127613A1 (en) * 2019-01-23 2020-07-30 The Johns Hopkins University Non-immunosuppressive fk506 analogs and use thereof
WO2022139524A1 (ko) * 2020-12-24 2022-06-30 서울대학교산학협력단 신규 fk506 유도체 및 이를 포함하는 발모 촉진용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078235A3 (de) * 1981-10-23 1983-06-29 Ciba-Geigy Ag Dihalogenierte Steroide
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
DK175235B1 (da) * 1987-11-09 2004-07-19 Novartis Ag Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf
EP0385936A1 (de) * 1989-02-27 1990-09-05 Ciba-Geigy Ag Peptidlacton und derivate davon, Verfahren zu ihrer Herstellung und Mittel zur Ausführung des Verfahrens
JPH05505798A (ja) * 1990-03-13 1993-08-26 フアイソンズ・ピーエルシー 免疫抑制マクロ環状化合物
CA2051872A1 (en) * 1990-09-24 1992-03-25 Kevin M. Byrne Directed biosynthesis process for prolyl-immunomycin
GB2249787A (en) * 1990-11-19 1992-05-20 Fujisawa Pharmaceutical Co Lactone compounds
WO1992013862A1 (en) * 1991-02-05 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Lactone compounds
JP3036923B2 (ja) * 1991-10-28 2000-04-24 理化学研究所 デプシペプチドａ、ｂその製造方法、並びに抗ウイルス剤及び抗菌剤
HUT66531A (en) * 1992-05-07 1994-12-28 Sandoz Ag Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them

Also Published As

Publication number Publication date
JP3076724B2 (ja) 2000-08-14
CZ129594A3 (en) 1995-01-18
HU218919B (hu) 2000-12-28
NO308302B1 (no) 2000-08-28
SK281541B6 (sk) 2001-04-09
NZ260596A (en) 1995-10-26
RU2130460C1 (ru) 1999-05-20
JPH06340672A (ja) 1994-12-13
AU6331794A (en) 1994-12-01
CN1048495C (zh) 2000-01-19
FI942444A0 (fi) 1994-05-25
NO941936L (no) 1994-11-28
CN1099756A (zh) 1995-03-08
EP0626385A1 (en) 1994-11-30
SK61194A3 (en) 1995-02-08
AU682499B2 (en) 1997-10-09
FI942444A (fi) 1994-11-28
MY110603A (en) 1998-08-29
DK0626385T3 (da) 2004-02-16
CA2124260C (en) 2007-04-17
ATE252105T1 (de) 2003-11-15
HUT71396A (en) 1995-11-28
HK1011684A1 (en) 1999-07-16
ES2208651T3 (es) 2004-06-16
DE69433234D1 (de) 2003-11-20
CZ286157B6 (cs) 2000-01-12
NO941936D0 (no) 1994-05-25
FI107159B (fi) 2001-06-15
US5493019A (en) 1996-02-20
CA2124260A1 (en) 1994-11-28
HU9401582D0 (en) 1994-08-29
EP0626385B1 (en) 2003-10-15
IL109775A0 (en) 1994-08-26
DE69433234T2 (de) 2004-08-05
CY2523B1 (en) 2006-02-08
PT626385E (pt) 2004-03-31
PH30420A (en) 1997-05-09
SI0626385T1 (en) 2004-02-29

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees