IL109775A - Ascomycin derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Ascomycin derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109775A
IL109775A IL10977594A IL10977594A IL109775A IL 109775 A IL109775 A IL 109775A IL 10977594 A IL10977594 A IL 10977594A IL 10977594 A IL10977594 A IL 10977594A IL 109775 A IL109775 A IL 109775A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
hydroxy groups
ascomycin derivatives
Prior art date
Application number
IL10977594A
Other languages
English (en)
Other versions
IL109775A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939310975A external-priority patent/GB9310975D0/en
Priority claimed from GB939310969A external-priority patent/GB9310969D0/en
Priority claimed from GB939312590A external-priority patent/GB9312590D0/en
Priority claimed from GB939313553A external-priority patent/GB9313553D0/en
Priority claimed from GB939319617A external-priority patent/GB9319617D0/en
Priority claimed from GB939319618A external-priority patent/GB9319618D0/en
Priority claimed from GB939326045A external-priority patent/GB9326045D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL109775A0 publication Critical patent/IL109775A0/xx
Publication of IL109775A publication Critical patent/IL109775A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Color Printing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
IL10977594A 1993-05-27 1994-05-25 Ascomycin derivatives their preparation and pharmaceutical compositions containing them IL109775A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB939310975A GB9310975D0 (en) 1993-05-27 1993-05-27 Organic compounds
GB939310969A GB9310969D0 (en) 1993-05-27 1993-05-27 Organic compounds
GB939312590A GB9312590D0 (en) 1993-06-18 1993-06-18 Organic compounds
GB939313553A GB9313553D0 (en) 1993-07-01 1993-07-01 Organic compounds
GB939319617A GB9319617D0 (en) 1993-09-23 1993-09-23 Organic compounds
GB939319618A GB9319618D0 (en) 1993-09-23 1993-09-23 Organic compounds
GB939326045A GB9326045D0 (en) 1993-12-21 1993-12-21 Organic compounds

Publications (2)

Publication Number Publication Date
IL109775A0 IL109775A0 (en) 1994-08-26
IL109775A true IL109775A (en) 1999-07-14

Family

ID=27562893

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10977594A IL109775A (en) 1993-05-27 1994-05-25 Ascomycin derivatives their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US5493019A (xx)
EP (1) EP0626385B1 (xx)
JP (1) JP3076724B2 (xx)
CN (1) CN1048495C (xx)
AT (1) ATE252105T1 (xx)
AU (1) AU682499B2 (xx)
CA (1) CA2124260C (xx)
CY (1) CY2523B1 (xx)
CZ (1) CZ286157B6 (xx)
DE (1) DE69433234T2 (xx)
DK (1) DK0626385T3 (xx)
ES (1) ES2208651T3 (xx)
FI (1) FI107159B (xx)
HK (1) HK1011684A1 (xx)
HU (1) HU218919B (xx)
IL (1) IL109775A (xx)
MY (1) MY110603A (xx)
NO (1) NO308302B1 (xx)
NZ (1) NZ260596A (xx)
PH (1) PH30420A (xx)
PT (1) PT626385E (xx)
RU (1) RU2130460C1 (xx)
SI (1) SI0626385T1 (xx)
SK (1) SK281541B6 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100434682B1 (ko) 1994-10-26 2004-08-18 노바티스 아게 약학조성물
US6201165B1 (en) 1997-10-16 2001-03-13 Board Of Regents, University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof
RU2214244C9 (ru) 1998-03-26 2020-07-29 Астеллас Фарма Инк. Препараты с замедленным высвобождением
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
CA2492989C (en) 2002-07-23 2012-11-20 Novartis Ag Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
WO2005063242A1 (en) * 2003-12-30 2005-07-14 Astellas Pharma Inc. Use of macrolides for treating or preventing airflow obstruction
GT200500282A (es) 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
EP1688161A1 (en) * 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
CA2768210C (en) * 2009-07-15 2017-08-15 S*Bio Pte Ltd 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
EP3834826A4 (en) 2018-08-10 2022-07-27 Koushi Yamaguchi THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN THE MATERNO-FETAL RELATIONSHIP
US20220062245A1 (en) 2018-12-18 2022-03-03 Koushi Yamaguchi Agent for improving infertility, recurrent miscarriage, and state of pregnancy
CA3127613A1 (en) * 2019-01-23 2020-07-30 The Johns Hopkins University Non-immunosuppressive fk506 analogs and use thereof
WO2022139524A1 (ko) * 2020-12-24 2022-06-30 서울대학교산학협력단 신규 fk506 유도체 및 이를 포함하는 발모 촉진용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078235A3 (de) * 1981-10-23 1983-06-29 Ciba-Geigy Ag Dihalogenierte Steroide
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
EP0385936A1 (de) * 1989-02-27 1990-09-05 Ciba-Geigy Ag Peptidlacton und derivate davon, Verfahren zu ihrer Herstellung und Mittel zur Ausführung des Verfahrens
JPH05505798A (ja) * 1990-03-13 1993-08-26 フアイソンズ・ピーエルシー 免疫抑制マクロ環状化合物
CA2051872A1 (en) * 1990-09-24 1992-03-25 Kevin M. Byrne Directed biosynthesis process for prolyl-immunomycin
GB2249787A (en) * 1990-11-19 1992-05-20 Fujisawa Pharmaceutical Co Lactone compounds
WO1992013862A1 (en) * 1991-02-05 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Lactone compounds
JP3036923B2 (ja) * 1991-10-28 2000-04-24 理化学研究所 デプシペプチドａ、ｂその製造方法、並びに抗ウイルス剤及び抗菌剤
HUT66531A (en) * 1992-05-07 1994-12-28 Sandoz Ag Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them

Also Published As

Publication number Publication date
EP0626385B1 (en) 2003-10-15
FI942444A (fi) 1994-11-28
PT626385E (pt) 2004-03-31
HK1011684A1 (en) 1999-07-16
NO941936D0 (no) 1994-05-25
CN1099756A (zh) 1995-03-08
SK61194A3 (en) 1995-02-08
CZ129594A3 (en) 1995-01-18
SI0626385T1 (en) 2004-02-29
JP3076724B2 (ja) 2000-08-14
CY2523B1 (en) 2006-02-08
NO941936L (no) 1994-11-28
ATE252105T1 (de) 2003-11-15
FI107159B (fi) 2001-06-15
AU6331794A (en) 1994-12-01
NZ260596A (en) 1995-10-26
CA2124260A1 (en) 1994-11-28
DE69433234D1 (de) 2003-11-20
HU218919B (hu) 2000-12-28
AU682499B2 (en) 1997-10-09
HUT71396A (en) 1995-11-28
US5493019A (en) 1996-02-20
JPH06340672A (ja) 1994-12-13
DE69433234T2 (de) 2004-08-05
FI942444A0 (fi) 1994-05-25
MY110603A (en) 1998-08-29
NO308302B1 (no) 2000-08-28
EP0626385A1 (en) 1994-11-30
CA2124260C (en) 2007-04-17
DK0626385T3 (da) 2004-02-16
RU2130460C1 (ru) 1999-05-20
ES2208651T3 (es) 2004-06-16
HU9401582D0 (en) 1994-08-29
CZ286157B6 (cs) 2000-01-12
PH30420A (en) 1997-05-09
SK281541B6 (sk) 2001-04-09
CN1048495C (zh) 2000-01-19
IL109775A0 (en) 1994-08-26

Similar Documents

Publication Publication Date Title
CY2523B1 (en) Tetrahydropyran derivatives
NO302568B1 (no) Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem
DE60228761D1 (de) Pharmazeutische zusammensetzung (kit) enthaltend dihydropyridinonverbindungen und eine verbindung mit immunmodulatorischer (oder antiinflammatorischer) wirkung und ihre verwendung
PL300068A1 (en) 9-(substituted glycil) amido-6-demethyl-6-deoxytetracyclines, methods of obtaining such compounds as well as their organic and inorganic salts or metal complexes, pharmaceutical agent and veterinari agent
ES2111769T3 (es) Nuevos usos de il-10.
RU94018524A (ru) Производные тетрагидропирана, способ их получения и фармацевтическая композиция на их основе
IL105607A0 (en) Heteroatoms-containing tricyclic compounds,their preparation and pharmaceutical compositions containing them
CZ126595A3 (en) Derivatives of acylated aminoalkaneimidazoles and -triazoles, process of their preparation and pharmaceutical composition containing thereof
IL113780A (en) Glucopyranoside benzothiophenes process for their preparation and pharmaceutical compositions containing them
IL103417A (en) Alkyl 5- 2-(2, 5-dialkoxyphenyl) ethyl9-2-hydroxybenzoates their preparation and pharmaceutical compositions containing them
DK0610076T3 (da) Cytotoksiske forbindelser

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees