IL109465A - Process for preparing intermediates for the synthesis of antifungal agents - Google Patents

Process for preparing intermediates for the synthesis of antifungal agents

Info

Publication number
IL109465A
IL109465A IL109465A IL10946594A IL109465A IL 109465 A IL109465 A IL 109465A IL 109465 A IL109465 A IL 109465A IL 10946594 A IL10946594 A IL 10946594A IL 109465 A IL109465 A IL 109465A
Authority
IL
Israel
Prior art keywords
formula
chiral
defined above
compound
treating
Prior art date
Application number
IL109465A
Other languages
English (en)
Other versions
IL109465A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL109465A0 publication Critical patent/IL109465A0/xx
Publication of IL109465A publication Critical patent/IL109465A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL109465A 1993-04-30 1994-04-28 Process for preparing intermediates for the synthesis of antifungal agents IL109465A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/055,268 US5403937A (en) 1993-04-30 1993-04-30 Process for preparing intermediates for the synthesis of antifungal agents

Publications (2)

Publication Number Publication Date
IL109465A0 IL109465A0 (en) 1994-07-31
IL109465A true IL109465A (en) 1998-02-08

Family

ID=21996778

Family Applications (1)

Application Number Title Priority Date Filing Date
IL109465A IL109465A (en) 1993-04-30 1994-04-28 Process for preparing intermediates for the synthesis of antifungal agents

Country Status (24)

Country Link
US (1) US5403937A (de)
EP (1) EP0696282B1 (de)
JP (1) JP3411283B2 (de)
KR (1) KR100313650B1 (de)
CN (1) CN1057089C (de)
AT (1) ATE182146T1 (de)
AU (1) AU681659B2 (de)
CA (1) CA2161662C (de)
CZ (1) CZ284395A3 (de)
DE (1) DE69419505T2 (de)
DK (1) DK0696282T3 (de)
ES (1) ES2133559T3 (de)
FI (1) FI955119A0 (de)
GR (1) GR3030881T3 (de)
HU (1) HU219143B (de)
IL (1) IL109465A (de)
NO (1) NO308606B1 (de)
NZ (1) NZ266074A (de)
PH (1) PH31511A (de)
PL (1) PL182328B1 (de)
SG (1) SG42883A1 (de)
SK (1) SK281091B6 (de)
TW (1) TW284763B (de)
WO (1) WO1994025452A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703236A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
US5486625A (en) * 1994-07-08 1996-01-23 Schering Corporation Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents
ES2112151B1 (es) * 1995-03-17 1999-09-16 Menarini Lab Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.
US5616777A (en) * 1995-04-19 1997-04-01 Schering Corporation Chiral hydrazine derivatives
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
BR9612082A (pt) * 1995-12-20 1999-05-11 Schering Corp Processo para preparar intermediários para a síntese de agentes antifúngicos
US5756830A (en) * 1995-12-20 1998-05-26 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
KR100326276B1 (ko) * 1999-12-14 2002-03-08 정명식 테트라하이드로푸란 유도체, 이의 제조방법 및 이를포함하는 항진균제
EP2571847B1 (de) 2010-05-19 2016-09-21 Sandoz AG Verfahren zur herstellung chiraler hydrazide
AU2011254657B2 (en) * 2010-05-19 2016-02-04 Sandoz Ag Preparation of posaconazole intermediates
CN102906087B (zh) 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
JP5955837B2 (ja) * 2010-05-19 2016-07-20 サンド・アクチエンゲゼルシヤフト ポサコナゾール及びポサコナゾール中間体の精製
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
EP2758385B1 (de) * 2011-09-19 2018-03-28 MSN Laboratories Limited Verfahren zur herstellung von antimykotischen triazolverbindungen , zwischenprodukten davon und polymorphen davon
CN102643194B (zh) * 2012-03-27 2014-03-12 福州大学 一种泊沙康唑中间体的制备方法
EP2789610A1 (de) 2013-04-10 2014-10-15 Sandoz Ag Reinigung von Posaconazol-Zwischenprodukten
CN104119302B (zh) * 2013-07-03 2017-01-18 郑州裕昌有机硅化工有限公司 手性四氢呋喃类化合物及其制备方法和脱水产物
IN2013CH04757A (de) * 2013-10-22 2015-04-24 Msn Lab Private Ltd
CN105503765B (zh) * 2014-09-26 2019-03-12 浙江奥翔药业股份有限公司 泊沙康唑、组合物、中间体及其制备方法和用途
EP3227277B1 (de) * 2014-12-05 2020-02-05 Pulmocide Limited Antimykotische verbindung
KR20180115329A (ko) 2016-03-04 2018-10-22 저장 아우선 파마슈티칼 씨오., 엘티디. 포사코나졸, 조성물, 중간체, 제조방법 및 그의 용도
CN106565639B (zh) * 2016-10-14 2018-09-21 宁波大学 一种四氢呋喃类化合物及其制备方法和用途
CN114591272B (zh) * 2022-03-18 2024-04-05 浙江奥翔药业股份有限公司 作为合成泊沙康唑的中间体化合物的制备方法及其制备的中间化合物
CN116496265A (zh) * 2023-05-09 2023-07-28 浙江海翔药业股份有限公司 一种泊沙康唑卤环化中间体的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3852477T2 (de) * 1987-11-20 1995-05-04 Schering Corp Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte.
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
TW211006B (de) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
NO954314L (no) 1996-01-02
CA2161662A1 (en) 1994-11-10
HUT73760A (en) 1996-09-30
GR3030881T3 (en) 1999-11-30
EP0696282A1 (de) 1996-02-14
NZ266074A (en) 1997-08-22
PL311267A1 (en) 1996-02-05
FI955119A7 (fi) 1995-10-27
WO1994025452A1 (en) 1994-11-10
US5403937A (en) 1995-04-04
DE69419505D1 (de) 1999-08-19
IL109465A0 (en) 1994-07-31
PH31511A (en) 1998-11-03
EP0696282B1 (de) 1999-07-14
CA2161662C (en) 2001-01-02
NO308606B1 (no) 2000-10-02
SG42883A1 (en) 1997-10-17
NO954314D0 (no) 1995-10-27
DK0696282T3 (da) 2000-02-07
JPH08509730A (ja) 1996-10-15
PL182328B1 (pl) 2001-12-31
ES2133559T3 (es) 1999-09-16
JP3411283B2 (ja) 2003-05-26
TW284763B (de) 1996-09-01
SK281091B6 (sk) 2000-11-07
HK1008822A1 (en) 1999-05-21
ATE182146T1 (de) 1999-07-15
FI955119A0 (fi) 1995-10-27
CZ284395A3 (en) 1996-04-17
CN1122134A (zh) 1996-05-08
CN1057089C (zh) 2000-10-04
AU6667194A (en) 1994-11-21
HU9503084D0 (en) 1995-12-28
AU681659B2 (en) 1997-09-04
DE69419505T2 (de) 1999-11-11
HU219143B (hu) 2001-02-28
SK134295A3 (en) 1996-11-06
KR100313650B1 (ko) 2002-02-28

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Legal Events

Date Code Title Description
FF Patent granted
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees