IL108689A - Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid - Google Patents

Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid

Info

Publication number
IL108689A
IL108689A IL108689A IL10868994A IL108689A IL 108689 A IL108689 A IL 108689A IL 108689 A IL108689 A IL 108689A IL 10868994 A IL10868994 A IL 10868994A IL 108689 A IL108689 A IL 108689A
Authority
IL
Israel
Prior art keywords
acid
heparin
aqueous solution
general formula
nucleophilic
Prior art date
Application number
IL108689A
Other languages
English (en)
Hebrew (he)
Other versions
IL108689A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL108689A0 publication Critical patent/IL108689A0/xx
Publication of IL108689A publication Critical patent/IL108689A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL108689A 1993-03-29 1994-02-17 Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid IL108689A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (2)

Publication Number Publication Date
IL108689A0 IL108689A0 (en) 1994-05-30
IL108689A true IL108689A (en) 1998-03-10

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
IL108689A IL108689A (en) 1993-03-29 1994-02-17 Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid

Country Status (18)

Country Link
US (1) US5405949A (fr)
EP (1) EP0618234B1 (fr)
JP (1) JP2731721B2 (fr)
KR (1) KR100194122B1 (fr)
AT (1) ATE154039T1 (fr)
AU (1) AU664939B2 (fr)
CA (1) CA2114862C (fr)
DE (1) DE69403537T2 (fr)
DK (1) DK0618234T3 (fr)
ES (1) ES2102087T3 (fr)
FI (1) FI105101B (fr)
GR (1) GR3024416T3 (fr)
IL (1) IL108689A (fr)
IT (1) IT1264101B1 (fr)
NO (1) NO305994B1 (fr)
NZ (1) NZ250815A (fr)
TW (1) TW266215B (fr)
ZA (1) ZA94970B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2435637A1 (fr) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Synthese de l'heparine et d'autres glycosaminoglycanes en phase solide et en phase solution
CN1547477B (zh) 2001-09-12 2010-12-22 希格马托研究瑞士公司 具有抗血管生成活性且没有抗凝作用的作为类肝素酶抑制剂的部分脱硫酸化糖胺聚糖衍生物
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
CA3015193A1 (fr) * 2016-03-09 2017-09-14 Glytech, Inc. Methode de production de saccharide renfermant un groupe sulfate et/ou un groupe phosphate
WO2021128253A1 (fr) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 Dérivé de glycosaminoglycane et son application

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
ES2102087T3 (es) 1997-07-16
ZA94970B (en) 1994-08-24
EP0618234B1 (fr) 1997-06-04
CA2114862C (fr) 1999-05-25
CA2114862A1 (fr) 1994-09-30
NZ250815A (en) 1996-02-27
DE69403537D1 (de) 1997-07-10
ATE154039T1 (de) 1997-06-15
JPH06298805A (ja) 1994-10-25
ITBO930125A1 (it) 1994-09-29
KR100194122B1 (ko) 1999-06-15
DE69403537T2 (de) 1997-09-18
FI105101B (fi) 2000-06-15
TW266215B (fr) 1995-12-21
NO941128L (no) 1994-09-30
JP2731721B2 (ja) 1998-03-25
DK0618234T3 (da) 1997-08-25
IL108689A0 (en) 1994-05-30
AU664939B2 (en) 1995-12-07
NO305994B1 (no) 1999-08-30
US5405949A (en) 1995-04-11
EP0618234A1 (fr) 1994-10-05
GR3024416T3 (en) 1997-11-28
AU5508594A (en) 1994-10-06
KR940021582A (ko) 1994-10-19
FI941431A0 (fi) 1994-03-28
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
FI941431A (fi) 1994-09-30
NO941128D0 (no) 1994-03-28

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