IL108029A - Enzymatic preparation of transglycidic acid esters with optical activity and their use in the preparation of benzene (azapines) - Google Patents
Enzymatic preparation of transglycidic acid esters with optical activity and their use in the preparation of benzene (azapines)Info
- Publication number
- IL108029A IL108029A IL10802993A IL10802993A IL108029A IL 108029 A IL108029 A IL 108029A IL 10802993 A IL10802993 A IL 10802993A IL 10802993 A IL10802993 A IL 10802993A IL 108029 A IL108029 A IL 108029A
- Authority
- IL
- Israel
- Prior art keywords
- ester
- preparation
- process according
- trans
- optically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9202208A NL9202208A (nl) | 1992-12-18 | 1992-12-18 | Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL108029A0 IL108029A0 (en) | 1994-04-12 |
IL108029A true IL108029A (en) | 1998-09-24 |
Family
ID=19861657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10802993A IL108029A (en) | 1992-12-18 | 1993-12-15 | Enzymatic preparation of transglycidic acid esters with optical activity and their use in the preparation of benzene (azapines) |
Country Status (11)
Country | Link |
---|---|
US (1) | US5407828A (de) |
EP (1) | EP0602740B1 (de) |
JP (1) | JP3781788B2 (de) |
AT (1) | ATE176931T1 (de) |
CA (1) | CA2111595C (de) |
DE (1) | DE69323600T2 (de) |
DK (1) | DK0602740T3 (de) |
ES (1) | ES2129491T3 (de) |
FI (1) | FI102974B (de) |
IL (1) | IL108029A (de) |
NL (1) | NL9202208A (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1249777B (it) * | 1990-05-17 | 1995-03-18 | Zambon Spa | Processo per la preparazione di intermedi per la sintesi del diltiazem |
JP3610600B2 (ja) * | 1994-08-22 | 2005-01-12 | チッソ株式会社 | 光学活性エンド−2−ノルボルネオール類の製造方法 |
WO1999041405A1 (en) | 1998-02-17 | 1999-08-19 | G.D. Searle & Co. | Process for the enzymatic resolution of lactams |
IT1302261B1 (it) | 1998-09-24 | 2000-09-05 | Zambon Spa | Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli |
CA2574625A1 (en) * | 2004-07-23 | 2006-01-26 | Thijs Kuilman | Process for the preparation of (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionamide and (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionic acid alkyl ester |
CN107446960A (zh) * | 2017-09-30 | 2017-12-08 | 湖南理工学院 | 一种采用生物酶催化立体选择性拆分2,3‑二苯基丙酸对映体的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2628667B2 (ja) * | 1986-10-17 | 1997-07-09 | ノボ ノルディスク アクティーゼルスカブ | 位置非特異性リパーゼ |
US5273898A (en) * | 1986-10-17 | 1993-12-28 | Noro Nordisk A/S | Thermally stable and positionally non-specific lipase isolated from Candida |
DE3886412T2 (de) * | 1987-09-28 | 1994-05-11 | Novonordisk As | Verfahren zur immobilisierung von lipasen. |
NL8801311A (nl) * | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
FI95931C (fi) * | 1988-09-02 | 1996-04-10 | Tanabe Seiyaku Co | Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi |
US6521445B1 (en) * | 1988-10-26 | 2003-02-18 | Sepracor, Inc. | Process for preparing optically active glycidate esters |
JPH088879B2 (ja) * | 1989-09-13 | 1996-01-31 | 田辺製薬株式会社 | 光学活性3―フェニルグリシッド酸エステル類化合物の製法 |
FR2672600B1 (fr) * | 1991-02-08 | 1994-10-14 | Synthelabo | Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle. |
-
1992
- 1992-12-18 NL NL9202208A patent/NL9202208A/nl not_active Application Discontinuation
-
1993
- 1993-12-13 ES ES93203495T patent/ES2129491T3/es not_active Expired - Lifetime
- 1993-12-13 AT AT93203495T patent/ATE176931T1/de active
- 1993-12-13 DK DK93203495T patent/DK0602740T3/da active
- 1993-12-13 EP EP93203495A patent/EP0602740B1/de not_active Expired - Lifetime
- 1993-12-13 US US08/165,344 patent/US5407828A/en not_active Expired - Lifetime
- 1993-12-13 DE DE69323600T patent/DE69323600T2/de not_active Expired - Lifetime
- 1993-12-15 IL IL10802993A patent/IL108029A/en not_active IP Right Cessation
- 1993-12-16 JP JP31669193A patent/JP3781788B2/ja not_active Expired - Fee Related
- 1993-12-16 CA CA002111595A patent/CA2111595C/en not_active Expired - Fee Related
- 1993-12-17 FI FI935712A patent/FI102974B/fi active
Also Published As
Publication number | Publication date |
---|---|
CA2111595A1 (en) | 1994-06-19 |
JPH06335399A (ja) | 1994-12-06 |
ATE176931T1 (de) | 1999-03-15 |
DK0602740T3 (da) | 1999-09-27 |
EP0602740B1 (de) | 1999-02-24 |
FI102974B1 (fi) | 1999-03-31 |
NL9202208A (nl) | 1994-07-18 |
DE69323600T2 (de) | 1999-09-23 |
CA2111595C (en) | 2004-12-14 |
FI935712A0 (fi) | 1993-12-17 |
US5407828A (en) | 1995-04-18 |
IL108029A0 (en) | 1994-04-12 |
EP0602740A1 (de) | 1994-06-22 |
FI935712A (fi) | 1994-06-19 |
DE69323600D1 (de) | 1999-04-01 |
ES2129491T3 (es) | 1999-06-16 |
FI102974B (fi) | 1999-03-31 |
JP3781788B2 (ja) | 2006-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4732853A (en) | Method of making chiral epoxy alcohols | |
EP0343714B1 (de) | Phenylglycidat-Stereoisomere, Umsetzungsprodukte mit 2-Nitrothiophenol und Herstellung von Diltiazen | |
EP0602740B1 (de) | Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure | |
KR20050053618A (ko) | 에스시탈로프람의 제조에 사용할 수 있는 중간체들의 분리방법 | |
KR100250513B1 (ko) | 2-아미노-3-히드록시-3-페닐프로피오산의 입체이성질체 농축물의 제조방법 | |
JP3223317B2 (ja) | (2r,3s)−3−(4−メトキシ−フェニル)−グリシド酸エステルのエナンシオメトリ−純度を増大せしめる方法 | |
WO2014030106A2 (en) | Process for preparation of optically active (2r,3s)-3-(4- methoxyphenyl)glycidic acid methyl ester and cis lactam and uses thereof | |
US5169779A (en) | Process for the preparation of methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxy-phenyl)propionate | |
EP0440723B1 (de) | Verfahren zur herstellung optisch aktiver glycidat-ester | |
EP0237983A2 (de) | Verfahren zur biotechnologischen Herstellung von L(-)-Carnitinchlorid | |
WO2004003001A1 (en) | Process for the enzymatic resolution of 1,3-dioxolane-4-carboxylates | |
US5274300A (en) | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion | |
US6153414A (en) | Method for racemic biochemical resolution of CIS-and trans-pyprolopiperidine | |
US5883264A (en) | Process for preparing optically active trans-3-phenylglycidamide compounds | |
JP4225694B2 (ja) | アミノアルコール類とのエステル交換による3−フェニルグリシド酸エステル類の酵素的速度論的分割方法 | |
JP4843812B2 (ja) | 酵素を使用するラセミα−置換ヘテロ環式カルボン酸の光学分割方法 | |
US5248601A (en) | Process for preparing L(-)-carnitine chloride | |
EP1487990A2 (de) | Verfahren zur herstellung optisch aktiver beta-aminocarbonsäuren aus racemischen n-acylierten beta-aminocarbonsäuren | |
JP2622251B2 (ja) | 光学活性3−(4−メトキシフェニル)グリシッド酸エステル類化合物の製法 | |
JP2000072761A (ja) | 光学活性グリシッド酸エステル化合物の製法 | |
JP3095539B2 (ja) | 光学活性α,β−エポキシカルボン酸およびそのエステルの製造法 | |
JPH09299099A (ja) | 光学活性トランス−3−フェニルグリシッドアミド類化合物の製法 | |
JPH0614798A (ja) | 光学活性なピペリジン誘導体の製造法 | |
MXPA97001992A (en) | Procedure for preparing compounds of trans-3-phenylglicidamide optically acti | |
JPH11243990A (ja) | 光学活性環状ビアリール化合物の製法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |