NL9202208A - Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. - Google Patents

Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. Download PDF

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Publication number
NL9202208A
NL9202208A NL9202208A NL9202208A NL9202208A NL 9202208 A NL9202208 A NL 9202208A NL 9202208 A NL9202208 A NL 9202208A NL 9202208 A NL9202208 A NL 9202208A NL 9202208 A NL9202208 A NL 9202208A
Authority
NL
Netherlands
Prior art keywords
ester
trans
optically active
preparation
enzyme
Prior art date
Application number
NL9202208A
Other languages
English (en)
Dutch (nl)
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to NL9202208A priority Critical patent/NL9202208A/nl
Priority to DE69323600T priority patent/DE69323600T2/de
Priority to EP93203495A priority patent/EP0602740B1/de
Priority to AT93203495T priority patent/ATE176931T1/de
Priority to ES93203495T priority patent/ES2129491T3/es
Priority to US08/165,344 priority patent/US5407828A/en
Priority to DK93203495T priority patent/DK0602740T3/da
Priority to IL10802993A priority patent/IL108029A/en
Priority to JP31669193A priority patent/JP3781788B2/ja
Priority to CA002111595A priority patent/CA2111595C/en
Priority to FI935712A priority patent/FI102974B/fi
Publication of NL9202208A publication Critical patent/NL9202208A/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL9202208A 1992-12-18 1992-12-18 Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. NL9202208A (nl)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NL9202208A NL9202208A (nl) 1992-12-18 1992-12-18 Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
DE69323600T DE69323600T2 (de) 1992-12-18 1993-12-13 Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure
EP93203495A EP0602740B1 (de) 1992-12-18 1993-12-13 Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure
AT93203495T ATE176931T1 (de) 1992-12-18 1993-12-13 Verfahren zur enzymatischen herstellung von optisch aktiven estern einer transglycidsäure
ES93203495T ES2129491T3 (es) 1992-12-18 1993-12-13 Procedimiento para la preparacion enzimatica de esteres de acido transglicidico opticamente activos.
US08/165,344 US5407828A (en) 1992-12-18 1993-12-13 Process for stereoselection of (2R,3S)-3-phenylgycidic ester using lipase from candida antarctica
DK93203495T DK0602740T3 (da) 1992-12-18 1993-12-13 Fremgangsmåde til enzymatisk fremstilling af optisk aktive transglycidsyreestere
IL10802993A IL108029A (en) 1992-12-18 1993-12-15 Enzymatic preparation of transglycidic acid esters with optical activity and their use in the preparation of benzene (azapines)
JP31669193A JP3781788B2 (ja) 1992-12-18 1993-12-16 トランス−３−フェニルグリシド酸の光学活性エステルの製法及びベンゾ（チ）アゼピンの製法
CA002111595A CA2111595C (en) 1992-12-18 1993-12-16 Process for the enzymatic preparation of optically active transglycidic acid esters
FI935712A FI102974B (fi) 1992-12-18 1993-12-17 Menetelmä optisesti aktiivisten trans-3-fenyyliglysidihappoestereiden entsymaattiseksi valmistamiseksi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9202208A NL9202208A (nl) 1992-12-18 1992-12-18 Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
NL9202208 1992-12-18

Publications (1)

Publication Number Publication Date
NL9202208A true NL9202208A (nl) 1994-07-18

Family

ID=19861657

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9202208A NL9202208A (nl) 1992-12-18 1992-12-18 Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.

Country Status (11)

Country Link
US (1) US5407828A (de)
EP (1) EP0602740B1 (de)
JP (1) JP3781788B2 (de)
AT (1) ATE176931T1 (de)
CA (1) CA2111595C (de)
DE (1) DE69323600T2 (de)
DK (1) DK0602740T3 (de)
ES (1) ES2129491T3 (de)
FI (1) FI102974B (de)
IL (1) IL108029A (de)
NL (1) NL9202208A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249777B (it) * 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
JP3610600B2 (ja) * 1994-08-22 2005-01-12 チッソ株式会社 光学活性エンド−２−ノルボルネオール類の製造方法
WO1999041405A1 (en) 1998-02-17 1999-08-19 G.D. Searle & Co. Process for the enzymatic resolution of lactams
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
CA2574625A1 (en) * 2004-07-23 2006-01-26 Thijs Kuilman Process for the preparation of (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionamide and (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionic acid alkyl ester
CN107446960A (zh) * 2017-09-30 2017-12-08 湖南理工学院 一种采用生物酶催化立体选择性拆分2,3‑二苯基丙酸对映体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2628667B2 (ja) * 1986-10-17 1997-07-09 ノボ ノルディスク アクティーゼルスカブ 位置非特異性リパーゼ
US5273898A (en) * 1986-10-17 1993-12-28 Noro Nordisk A/S Thermally stable and positionally non-specific lipase isolated from Candida
DE3886412T2 (de) * 1987-09-28 1994-05-11 Novonordisk As Verfahren zur immobilisierung von lipasen.
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
JPH088879B2 (ja) * 1989-09-13 1996-01-31 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Also Published As

Publication number Publication date
CA2111595A1 (en) 1994-06-19
JPH06335399A (ja) 1994-12-06
ATE176931T1 (de) 1999-03-15
DK0602740T3 (da) 1999-09-27
EP0602740B1 (de) 1999-02-24
IL108029A (en) 1998-09-24
FI102974B1 (fi) 1999-03-31
DE69323600T2 (de) 1999-09-23
CA2111595C (en) 2004-12-14
FI935712A0 (fi) 1993-12-17
US5407828A (en) 1995-04-18
IL108029A0 (en) 1994-04-12
EP0602740A1 (de) 1994-06-22
FI935712A (fi) 1994-06-19
DE69323600D1 (de) 1999-04-01
ES2129491T3 (es) 1999-06-16
FI102974B (fi) 1999-03-31
JP3781788B2 (ja) 2006-05-31

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