DE69323600T2 - Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure - Google Patents

Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure

Info

Publication number
DE69323600T2
DE69323600T2 DE69323600T DE69323600T DE69323600T2 DE 69323600 T2 DE69323600 T2 DE 69323600T2 DE 69323600 T DE69323600 T DE 69323600T DE 69323600 T DE69323600 T DE 69323600T DE 69323600 T2 DE69323600 T2 DE 69323600T2
Authority
DE
Germany
Prior art keywords
optically active
acid
ester
transglycidic
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69323600T
Other languages
English (en)
Other versions
DE69323600D1 (de
Inventor
Joannes Gerardus Theo Kierkels
Wijnand Peter Helena Peeters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Publication of DE69323600D1 publication Critical patent/DE69323600D1/de
Application granted granted Critical
Publication of DE69323600T2 publication Critical patent/DE69323600T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DE69323600T 1992-12-18 1993-12-13 Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure Expired - Lifetime DE69323600T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL9202208A NL9202208A (nl) 1992-12-18 1992-12-18 Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.

Publications (2)

Publication Number Publication Date
DE69323600D1 DE69323600D1 (de) 1999-04-01
DE69323600T2 true DE69323600T2 (de) 1999-09-23

Family

ID=19861657

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323600T Expired - Lifetime DE69323600T2 (de) 1992-12-18 1993-12-13 Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure

Country Status (11)

Country Link
US (1) US5407828A (de)
EP (1) EP0602740B1 (de)
JP (1) JP3781788B2 (de)
AT (1) ATE176931T1 (de)
CA (1) CA2111595C (de)
DE (1) DE69323600T2 (de)
DK (1) DK0602740T3 (de)
ES (1) ES2129491T3 (de)
FI (1) FI102974B1 (de)
IL (1) IL108029A (de)
NL (1) NL9202208A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249777B (it) * 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
JP3610600B2 (ja) * 1994-08-22 2005-01-12 チッソ株式会社 光学活性エンド−２−ノルボルネオール類の製造方法
DE69914458T2 (de) 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago Verfahren zur enzymatischen auflösung von laktamen
IT1302261B1 (it) * 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
WO2006008170A1 (en) * 2004-07-23 2006-01-26 Dsm Ip Assets B.V. Process for the preparation of (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionamide and (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionic acid alkyl ester
CN107446960A (zh) * 2017-09-30 2017-12-08 湖南理工学院 一种采用生物酶催化立体选择性拆分2,3‑二苯基丙酸对映体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002775A1 (en) * 1986-10-17 1988-04-21 Novo Industri A/S Positionally non-specific lipase from candida sp, a method for producing it, its use and a recombinant dna process for producing it
US5273898A (en) * 1986-10-17 1993-12-28 Noro Nordisk A/S Thermally stable and positionally non-specific lipase isolated from Candida
DE3886412T2 (de) * 1987-09-28 1994-05-11 Novonordisk As Verfahren zur immobilisierung von lipasen.
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IL91453A0 (en) * 1988-09-02 1990-04-29 Tanabe Seiyaku Co Preparation of optically active 3-phenyl-glycidic acid esters
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
JPH088879B2 (ja) * 1989-09-13 1996-01-31 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Also Published As

Publication number Publication date
CA2111595C (en) 2004-12-14
CA2111595A1 (en) 1994-06-19
DE69323600D1 (de) 1999-04-01
EP0602740A1 (de) 1994-06-22
JP3781788B2 (ja) 2006-05-31
FI102974B (fi) 1999-03-31
DK0602740T3 (da) 1999-09-27
ATE176931T1 (de) 1999-03-15
FI935712A0 (fi) 1993-12-17
NL9202208A (nl) 1994-07-18
JPH06335399A (ja) 1994-12-06
FI935712A (fi) 1994-06-19
FI102974B1 (fi) 1999-03-31
US5407828A (en) 1995-04-18
ES2129491T3 (es) 1999-06-16
IL108029A (en) 1998-09-24
IL108029A0 (en) 1994-04-12
EP0602740B1 (de) 1999-02-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL