DE69914458D1 - Verfahren zur enzymatischen auflösung von laktamen - Google Patents

Verfahren zur enzymatischen auflösung von laktamen

Info

Publication number
DE69914458D1
DE69914458D1 DE69914458T DE69914458T DE69914458D1 DE 69914458 D1 DE69914458 D1 DE 69914458D1 DE 69914458 T DE69914458 T DE 69914458T DE 69914458 T DE69914458 T DE 69914458T DE 69914458 D1 DE69914458 D1 DE 69914458D1
Authority
DE
Germany
Prior art keywords
lactas
enzymatically
discharging
enzyme
lactam esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69914458T
Other languages
English (en)
Other versions
DE69914458T2 (de
Inventor
W Hansen
Mahima Trivedi
E Gapud
S Ng
K Asthi
T Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69914458D1 publication Critical patent/DE69914458D1/de
Application granted granted Critical
Publication of DE69914458T2 publication Critical patent/DE69914458T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69914458T 1998-02-17 1999-02-16 Verfahren zur enzymatischen auflösung von laktamen Expired - Fee Related DE69914458T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7483098P 1998-02-17 1998-02-17
US74830P 1998-02-17
PCT/US1999/001485 WO1999041405A1 (en) 1998-02-17 1999-02-16 Process for the enzymatic resolution of lactams

Publications (2)

Publication Number Publication Date
DE69914458D1 true DE69914458D1 (de) 2004-03-04
DE69914458T2 DE69914458T2 (de) 2004-10-28

Family

ID=22121926

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69914458T Expired - Fee Related DE69914458T2 (de) 1998-02-17 1999-02-16 Verfahren zur enzymatischen auflösung von laktamen

Country Status (10)

Country Link
US (2) US6277626B1 (de)
EP (1) EP1054996B1 (de)
JP (1) JP2003517266A (de)
AT (1) ATE258604T1 (de)
AU (1) AU2758899A (de)
DE (1) DE69914458T2 (de)
DK (1) DK1054996T3 (de)
ES (1) ES2216495T3 (de)
PT (1) PT1054996E (de)
WO (1) WO1999041405A1 (de)

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Publication number Priority date Publication date Assignee Title
US5919672A (en) * 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
US6548293B1 (en) 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
AU2005276136A1 (en) * 2004-08-26 2006-03-02 Pfizer Inc. Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
EP3696174A1 (de) 2005-11-08 2020-08-19 Vertex Pharmaceuticals Incorporated Heterocyclische modulatoren von atp-bindenden kassettentransportern
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
JP5265513B2 (ja) * 2007-02-19 2013-08-14 株式会社カネカ 光学活性３−アミノピペリジン又はその塩の製造方法
CN101687842B (zh) 2007-05-09 2013-03-06 沃泰克斯药物股份有限公司 Cftr调节剂
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
LT2639223T (lt) 2007-12-07 2017-06-26 Vertex Pharmaceuticals Incorporated Cikloalkilkarboksiamido-piridino benzenkarboksirūgščių gamybos būdas
CN103626744B (zh) 2007-12-07 2016-05-11 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
ES2647531T3 (es) 2008-02-28 2017-12-22 Vertex Pharmaceuticals Incorporated Derivados de heteroarilo como moduladores de CFTR
WO2011127241A2 (en) 2010-04-07 2011-10-13 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
KR102280372B1 (ko) 2013-11-12 2021-07-22 버텍스 파마슈티칼스 인코포레이티드 Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법
CN107110831B (zh) 2014-11-18 2020-02-21 弗特克斯药品有限公司 进行高通量试验高效液相色谱的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57198098A (en) 1981-05-29 1982-12-04 Sagami Chem Res Center Preparation of optically active monoester monocarboxylic acid
DE3474546D1 (en) 1983-02-03 1988-11-17 Sumitomo Chemical Co Optically active 4-hydroxy-2-cyclopentenones, and their production
US5106750A (en) 1988-08-30 1992-04-21 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
US5585252A (en) 1988-08-30 1996-12-17 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
DE3921593A1 (de) 1989-06-28 1991-01-10 Schering Ag Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester
US5420037A (en) 1989-09-26 1995-05-30 E. R. Squibb & Sons, Inc. Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
CA2068038A1 (en) 1991-05-08 1992-11-09 Christopher Yee Enzymatic resolution of .alpha.-tertiary carboxylic acid esters
US5620876A (en) 1992-04-29 1997-04-15 E. R. Squibb & Sons, Inc. Enzymatic hydrolysis and esterification processes for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5447865A (en) 1992-06-10 1995-09-05 Amprost Pharmaceutical, Inc. Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation
IT1259583B (it) 1992-06-19 1996-03-20 Gianfranco Palumbo Imballaggio per confezioni, ad esempio confezioni di prodotti igenico sanitari.
US5258517A (en) 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
NL9202208A (nl) 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
JPH06192221A (ja) * 1992-12-25 1994-07-12 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸の製造方法
JPH06199221A (ja) * 1992-12-28 1994-07-19 Daihatsu Motor Co Ltd アンチスキッド装置の故障検出方法
US5516676A (en) 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5523233A (en) * 1995-05-03 1996-06-04 Merck & Co., Inc. Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
US5529929A (en) 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
AU730064B2 (en) * 1996-12-27 2001-02-22 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acids from esters with a lipase
JPH11113594A (ja) * 1997-10-20 1999-04-27 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸および／またはその鏡像対掌体エステルの製造方法

Also Published As

Publication number Publication date
DK1054996T3 (da) 2004-05-24
EP1054996A1 (de) 2000-11-29
AU2758899A (en) 1999-08-30
US6638758B2 (en) 2003-10-28
JP2003517266A (ja) 2003-05-27
US6277626B1 (en) 2001-08-21
US20010055798A1 (en) 2001-12-27
ES2216495T3 (es) 2004-10-16
EP1054996B1 (de) 2004-01-28
WO1999041405A1 (en) 1999-08-19
PT1054996E (pt) 2004-05-31
ATE258604T1 (de) 2004-02-15
DE69914458T2 (de) 2004-10-28

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee