ATE258604T1 - Verfahren zur enzymatischen auflösung von laktamen - Google Patents

Verfahren zur enzymatischen auflösung von laktamen

Info

Publication number
ATE258604T1
ATE258604T1 AT99908070T AT99908070T ATE258604T1 AT E258604 T1 ATE258604 T1 AT E258604T1 AT 99908070 T AT99908070 T AT 99908070T AT 99908070 T AT99908070 T AT 99908070T AT E258604 T1 ATE258604 T1 AT E258604T1
Authority
AT
Austria
Prior art keywords
lactams
enzyme
lactam esters
enzymatic resolution
enzymatic dissolution
Prior art date
Application number
AT99908070T
Other languages
English (en)
Inventor
Donald W Hansen Jr
Mahima Trivedi
Rolando E Gapud
John S Ng
Alok K Asthi
Ping T Wang
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE258604T1 publication Critical patent/ATE258604T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99908070T 1998-02-17 1999-02-16 Verfahren zur enzymatischen auflösung von laktamen ATE258604T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7483098P 1998-02-17 1998-02-17
PCT/US1999/001485 WO1999041405A1 (en) 1998-02-17 1999-02-16 Process for the enzymatic resolution of lactams

Publications (1)

Publication Number Publication Date
ATE258604T1 true ATE258604T1 (de) 2004-02-15

Family

ID=22121926

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99908070T ATE258604T1 (de) 1998-02-17 1999-02-16 Verfahren zur enzymatischen auflösung von laktamen

Country Status (10)

Country Link
US (2) US6277626B1 (de)
EP (1) EP1054996B1 (de)
JP (1) JP2003517266A (de)
AT (1) ATE258604T1 (de)
AU (1) AU2758899A (de)
DE (1) DE69914458T2 (de)
DK (1) DK1054996T3 (de)
ES (1) ES2216495T3 (de)
PT (1) PT1054996E (de)
WO (1) WO1999041405A1 (de)

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GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
US6548293B1 (en) 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
RU2007106863A (ru) * 2004-08-26 2008-08-27 Пфайзер Инк. (US) Энантиоселективное биопреобразование для получения промежуточных соединений ингибитора белка тирозинкиназы
KR101331768B1 (ko) 2005-11-08 2013-11-22 버텍스 파마슈티칼스 인코포레이티드 Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
EP2123769B1 (de) * 2007-02-19 2016-05-18 Kaneka Corporation Verfahren zur herstellung von optisch aktivem 3-aminopiperidin oder salz davon
CA2686838C (en) 2007-05-09 2017-03-14 Vertex Pharmaceuticals Incorporated Modulators of cftr
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
HRP20170241T2 (hr) 2007-12-07 2023-03-17 Vertex Pharmaceuticals Incorporated Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline
DK2639223T3 (en) 2007-12-07 2017-06-19 Vertex Pharma Process for Preparation of Cycloalkylcarboxiamido-pyridine Benzoic Acids
NZ736561A (en) 2008-02-28 2018-02-23 Vertex Pharma Heteroaryl derivatives as cftr modulators
DK3150198T3 (da) 2010-04-07 2021-11-01 Vertex Pharma Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
RU2718044C2 (ru) 2013-11-12 2020-03-30 Вертекс Фармасьютикалз Инкорпорейтед Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний
HRP20211194T1 (hr) 2014-11-18 2021-10-29 Vertex Pharmaceuticals Inc. Postupak za provođenje testova velike propusnosti putem tekućinske kromatografije visoke djelotvornosti
CN111621541B (zh) * 2019-02-27 2025-10-31 广安摩珈生物科技有限公司 使用电渗析技术拆分光学异构体的方法

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JPS57198098A (en) 1981-05-29 1982-12-04 Sagami Chem Res Center Preparation of optically active monoester monocarboxylic acid
EP0115860B1 (de) 1983-02-03 1988-10-12 Sumitomo Chemical Company, Limited Optisch aktive 4-Hydroxy-2-Cyclopentenonen und ihre Darstellung
US5106750A (en) 1988-08-30 1992-04-21 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
US5585252A (en) 1988-08-30 1996-12-17 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
DE3921593A1 (de) 1989-06-28 1991-01-10 Schering Ag Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester
US5420037A (en) 1989-09-26 1995-05-30 E. R. Squibb & Sons, Inc. Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
CA2068038A1 (en) 1991-05-08 1992-11-09 Christopher Yee Enzymatic resolution of .alpha.-tertiary carboxylic acid esters
US5620876A (en) 1992-04-29 1997-04-15 E. R. Squibb & Sons, Inc. Enzymatic hydrolysis and esterification processes for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5447865A (en) 1992-06-10 1995-09-05 Amprost Pharmaceutical, Inc. Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation
IT1259583B (it) 1992-06-19 1996-03-20 Gianfranco Palumbo Imballaggio per confezioni, ad esempio confezioni di prodotti igenico sanitari.
US5258517A (en) 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
NL9202208A (nl) 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
JPH06192221A (ja) * 1992-12-25 1994-07-12 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸の製造方法
JPH06199221A (ja) * 1992-12-28 1994-07-19 Daihatsu Motor Co Ltd アンチスキッド装置の故障検出方法
US5516676A (en) 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5523233A (en) * 1995-05-03 1996-06-04 Merck & Co., Inc. Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
US5529929A (en) 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
IL130580A0 (en) * 1996-12-27 2000-06-01 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase
JPH11113594A (ja) * 1997-10-20 1999-04-27 Taiho Yakuhin Kogyo Kk 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸および／またはその鏡像対掌体エステルの製造方法

Also Published As

Publication number Publication date
US20010055798A1 (en) 2001-12-27
ES2216495T3 (es) 2004-10-16
DK1054996T3 (da) 2004-05-24
AU2758899A (en) 1999-08-30
PT1054996E (pt) 2004-05-31
DE69914458D1 (de) 2004-03-04
US6638758B2 (en) 2003-10-28
WO1999041405A1 (en) 1999-08-19
US6277626B1 (en) 2001-08-21
EP1054996B1 (de) 2004-01-28
EP1054996A1 (de) 2000-11-29
JP2003517266A (ja) 2003-05-27
DE69914458T2 (de) 2004-10-28

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