ATE212381T1 - Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens - Google Patents
Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescensInfo
- Publication number
- ATE212381T1 ATE212381T1 AT96918471T AT96918471T ATE212381T1 AT E212381 T1 ATE212381 T1 AT E212381T1 AT 96918471 T AT96918471 T AT 96918471T AT 96918471 T AT96918471 T AT 96918471T AT E212381 T1 ATE212381 T1 AT E212381T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- benzodioxan
- serratia marcescens
- carboxylates
- benzodioxane
- Prior art date
Links
- 241000607715 Serratia marcescens Species 0.000 title abstract 2
- 108090000371 Esterases Proteins 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- -1 alkyl 1,4-benzodioxan-2-carboxylates Chemical class 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001389 doxazosin Drugs 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/88—Serratia
- Y10S435/881—Serratia marcescens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/477,381 US5529929A (en) | 1995-06-07 | 1995-06-07 | Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens |
| PCT/US1996/010127 WO1996040976A1 (en) | 1995-06-07 | 1996-06-07 | Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212381T1 true ATE212381T1 (de) | 2002-02-15 |
Family
ID=23895695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96918471T ATE212381T1 (de) | 1995-06-07 | 1996-06-07 | Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5529929A (de) |
| EP (1) | EP0833937B1 (de) |
| JP (1) | JP2001503241A (de) |
| AT (1) | ATE212381T1 (de) |
| CA (1) | CA2231456A1 (de) |
| DE (1) | DE69618780D1 (de) |
| WO (1) | WO1996040976A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL130580A0 (en) * | 1996-12-27 | 2000-06-01 | Smithkline Beecham Plc | Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase |
| JP2003517266A (ja) | 1998-02-17 | 2003-05-27 | ジー・ディー・サール・アンド・カンパニー | ラクタムの酵素分割方法 |
| US6060461A (en) * | 1999-02-08 | 2000-05-09 | Drake; James Franklin | Topically applied clotting material |
| AU2003212866A1 (en) * | 2002-01-31 | 2003-12-31 | Southwest Research Institute | Controlled release compositions and methods for using same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| US5037747A (en) * | 1988-01-26 | 1991-08-06 | Hoffmann-La Roche Inc. | Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis |
| US5371014A (en) * | 1988-02-12 | 1994-12-06 | Daicel Chemical Industries, Ltd. | Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor |
| NL8801311A (nl) * | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
| FI95931C (fi) * | 1988-09-02 | 1996-04-10 | Tanabe Seiyaku Co | Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi |
| US5274300A (en) * | 1988-10-26 | 1993-12-28 | Sepracor, Inc. | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion |
| JP2880204B2 (ja) * | 1989-11-22 | 1999-04-05 | 岩城製薬株式会社 | （＋）‐ホモピロピン酸の製造法 |
| IE75884B1 (en) * | 1990-03-13 | 1997-09-24 | Tanabe Seiyaku Co | Esterase from serratia and process for preparing the same |
| JP2687789B2 (ja) * | 1991-08-13 | 1997-12-08 | 田辺製薬株式会社 | 光学活性３−フェニルグリシッド酸エステル類化合物の製法 |
| JP3087419B2 (ja) * | 1991-11-14 | 2000-09-11 | 味の素株式会社 | （ｓ）−１−フェニル−１，３−プロパンジオールまたはその誘導体の製造方法 |
| JP2658716B2 (ja) * | 1992-01-24 | 1997-09-30 | 田辺製薬株式会社 | 新規微生物及びそれを用いるｄ−ビオチンの製法 |
-
1995
- 1995-06-07 US US08/477,381 patent/US5529929A/en not_active Expired - Fee Related
-
1996
- 1996-06-07 WO PCT/US1996/010127 patent/WO1996040976A1/en not_active Ceased
- 1996-06-07 CA CA002231456A patent/CA2231456A1/en not_active Abandoned
- 1996-06-07 EP EP96918471A patent/EP0833937B1/de not_active Expired - Lifetime
- 1996-06-07 AT AT96918471T patent/ATE212381T1/de active
- 1996-06-07 JP JP50221997A patent/JP2001503241A/ja active Pending
- 1996-06-07 DE DE69618780T patent/DE69618780D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6112196A (en) | 1996-12-30 |
| WO1996040976A1 (en) | 1996-12-19 |
| EP0833937A1 (de) | 1998-04-08 |
| AU705275B2 (en) | 1999-05-20 |
| CA2231456A1 (en) | 1996-12-19 |
| JP2001503241A (ja) | 2001-03-13 |
| DE69618780D1 (de) | 2002-03-14 |
| EP0833937B1 (de) | 2002-01-23 |
| US5529929A (en) | 1996-06-25 |
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