ATE212381T1 - Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens - Google Patents

Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens

Info

Publication number
ATE212381T1
ATE212381T1 AT96918471T AT96918471T ATE212381T1 AT E212381 T1 ATE212381 T1 AT E212381T1 AT 96918471 T AT96918471 T AT 96918471T AT 96918471 T AT96918471 T AT 96918471T AT E212381 T1 ATE212381 T1 AT E212381T1
Authority
AT
Austria
Prior art keywords
alkyl
benzodioxan
serratia marcescens
carboxylates
benzodioxane
Prior art date
Application number
AT96918471T
Other languages
English (en)
Inventor
Richard F Rossi Jr
Charles M Zepp
Donald L Heefner
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ATE212381T1 publication Critical patent/ATE212381T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/88—Serratia
    • Y10S435/881—Serratia marcescens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96918471T 1995-06-07 1996-06-07 Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens ATE212381T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,381 US5529929A (en) 1995-06-07 1995-06-07 Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
PCT/US1996/010127 WO1996040976A1 (en) 1995-06-07 1996-06-07 Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Publications (1)

Publication Number Publication Date
ATE212381T1 true ATE212381T1 (de) 2002-02-15

Family

ID=23895695

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918471T ATE212381T1 (de) 1995-06-07 1996-06-07 Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens

Country Status (7)

Country Link
US (1) US5529929A (de)
EP (1) EP0833937B1 (de)
JP (1) JP2001503241A (de)
AT (1) ATE212381T1 (de)
CA (1) CA2231456A1 (de)
DE (1) DE69618780D1 (de)
WO (1) WO1996040976A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998029561A1 (en) * 1996-12-27 1998-07-09 Smithkline Beecham Plc Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase
DE69914458T2 (de) 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago Verfahren zur enzymatischen auflösung von laktamen
US6060461A (en) * 1999-02-08 2000-05-09 Drake; James Franklin Topically applied clotting material
US20050220888A1 (en) * 2002-01-31 2005-10-06 Lakahmi Putcha Controlled release compositions and methods for using same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IL91453A0 (en) * 1988-09-02 1990-04-29 Tanabe Seiyaku Co Preparation of optically active 3-phenyl-glycidic acid esters
US5274300A (en) * 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
JP2880204B2 (ja) * 1989-11-22 1999-04-05 岩城製薬株式会社 （＋）‐ホモピロピン酸の製造法
SG43356A1 (en) * 1990-03-13 1997-10-17 Tanabe Seiyaku Co Novel esterase and process for preparing the same
JP2687789B2 (ja) * 1991-08-13 1997-12-08 田辺製薬株式会社 光学活性３−フェニルグリシッド酸エステル類化合物の製法
JP3087419B2 (ja) * 1991-11-14 2000-09-11 味の素株式会社 （ｓ）−１−フェニル−１，３−プロパンジオールまたはその誘導体の製造方法
JP2658716B2 (ja) * 1992-01-24 1997-09-30 田辺製薬株式会社 新規微生物及びそれを用いるｄ−ビオチンの製法

Also Published As

Publication number Publication date
EP0833937B1 (de) 2002-01-23
WO1996040976A1 (en) 1996-12-19
AU705275B2 (en) 1999-05-20
CA2231456A1 (en) 1996-12-19
US5529929A (en) 1996-06-25
DE69618780D1 (de) 2002-03-14
AU6112196A (en) 1996-12-30
EP0833937A1 (de) 1998-04-08
JP2001503241A (ja) 2001-03-13

Similar Documents

Publication Publication Date Title
HK1070050A1 (en) Processes for the preparation of aminoalcohol and (1s,4r)- or (1r,4s)-1-amino-4-(hydroxymethyl)-2-c yclopentene or salts thereof
DK1054996T3 (da) Fremgangsmåde til den enzymatiske adskillelse af lactamer
ATE40570T1 (de) Verfahren zur herstellung eines optisch aktiven 3-(3,4-dihydroxyphenyl)-serins und ein geschuetztes derivat davon.
DE68906904D1 (de) Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren.
ATE212381T1 (de) Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens
DK0417785T3 (da) Fremgangsmåde til fremstilling af optisk aktive 3-phenylglycidsyreestere
NO990155L (no) Biooppl°sning av N-acylazetidin-2-karboksylsyrer
US5155028A (en) Process for the enzymatic cleavage of vinyl 2-aryl-propionates
AU585703B2 (en) Process for the enzymatic resolution of racemic 2-amino- 1-alkanols
JP2687789B2 (ja) 光学活性３−フェニルグリシッド酸エステル類化合物の製法
DK0602740T3 (da) Fremgangsmåde til enzymatisk fremstilling af optisk aktive transglycidsyreestere
Matsumoto et al. Preparation of optically active α-hydroxy ketone derivatives by Enzyme-Mediated Hydrolysis of Enol Esters
US5861304A (en) Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic esters
JPS6012992A (ja) 光学活性カルボン酸の製造法
DE68916111T2 (de) Verfahren zur Herstellung von optisch aktiven 2-Aryloxy- oder 2-Arylthioalkansäuren.
KR20040105920A (ko) 신규한 슈도모나스 속 균주들, 그로부터 생산되는입체선택적 기질 특이성을 가진 리파아제, 및 그러한리파아제를 이용한 광학이성질체의 분할 방법
DK0873290T3 (da) Fremgangsmåde til racemisering af N-acetyl-D(L-alfa-aminocarboxylsyrer
JPH05117228A (ja) 光学活性含硫黄化合物およびその製造法
JP2005185140A (ja) 光学活性なｎ−保護−２−アミノアルコール類の製造方法