DE69618780D1 - Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens - Google Patents

Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens

Info

Publication number
DE69618780D1
DE69618780D1 DE69618780T DE69618780T DE69618780D1 DE 69618780 D1 DE69618780 D1 DE 69618780D1 DE 69618780 T DE69618780 T DE 69618780T DE 69618780 T DE69618780 T DE 69618780T DE 69618780 D1 DE69618780 D1 DE 69618780D1
Authority
DE
Germany
Prior art keywords
alkyl
carboxylate
benzodioxan
serratia marcescens
benzodioxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69618780T
Other languages
English (en)
Inventor
F Rossi
M Zepp
L Heefner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of DE69618780D1 publication Critical patent/DE69618780D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/88—Serratia
    • Y10S435/881—Serratia marcescens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69618780T 1995-06-07 1996-06-07 Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens Expired - Lifetime DE69618780D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,381 US5529929A (en) 1995-06-07 1995-06-07 Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
PCT/US1996/010127 WO1996040976A1 (en) 1995-06-07 1996-06-07 Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Publications (1)

Publication Number Publication Date
DE69618780D1 true DE69618780D1 (de) 2002-03-14

Family

ID=23895695

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69618780T Expired - Lifetime DE69618780D1 (de) 1995-06-07 1996-06-07 Optische trennung von alkyl 1,4-benzodioxan-2- carboxylaten mit einer esterase aus serratia marcescens

Country Status (7)

Country Link
US (1) US5529929A (de)
EP (1) EP0833937B1 (de)
JP (1) JP2001503241A (de)
AT (1) ATE212381T1 (de)
CA (1) CA2231456A1 (de)
DE (1) DE69618780D1 (de)
WO (1) WO1996040976A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR010860A1 (es) * 1996-12-27 2000-07-12 Smithkline Beecham Plc Procedimiento para preparar compuestos mediante resolucion enzimatica y compuestos relacionados
PT1054996E (pt) 1998-02-17 2004-05-31 Searle & Co Processo para resolucao enzimatica de lactamas
US6060461A (en) * 1999-02-08 2000-05-09 Drake; James Franklin Topically applied clotting material
AU2003212866A1 (en) * 2002-01-31 2003-12-31 Southwest Research Institute Controlled release compositions and methods for using same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IL91453A0 (en) * 1988-09-02 1990-04-29 Tanabe Seiyaku Co Preparation of optically active 3-phenyl-glycidic acid esters
US5274300A (en) * 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
JP2880204B2 (ja) * 1989-11-22 1999-04-05 岩城製薬株式会社 （＋）‐ホモピロピン酸の製造法
CA2037634C (en) * 1990-03-13 1995-11-21 Takeji Shibatani Esterase and process for preparing the same
JP2687789B2 (ja) * 1991-08-13 1997-12-08 田辺製薬株式会社 光学活性３−フェニルグリシッド酸エステル類化合物の製法
JP3087419B2 (ja) * 1991-11-14 2000-09-11 味の素株式会社 （ｓ）−１−フェニル−１，３−プロパンジオールまたはその誘導体の製造方法
JP2658716B2 (ja) * 1992-01-24 1997-09-30 田辺製薬株式会社 新規微生物及びそれを用いるｄ−ビオチンの製法

Also Published As

Publication number Publication date
EP0833937A1 (de) 1998-04-08
EP0833937B1 (de) 2002-01-23
US5529929A (en) 1996-06-25
CA2231456A1 (en) 1996-12-19
AU705275B2 (en) 1999-05-20
AU6112196A (en) 1996-12-30
ATE212381T1 (de) 2002-02-15
WO1996040976A1 (en) 1996-12-19
JP2001503241A (ja) 2001-03-13

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