AR010860A1 - Procedimiento para preparar compuestos mediante resolucion enzimatica y compuestos relacionados - Google Patents

Procedimiento para preparar compuestos mediante resolucion enzimatica y compuestos relacionados

Info

Publication number
AR010860A1
AR010860A1 ARP970106167A ARP970106167A AR010860A1 AR 010860 A1 AR010860 A1 AR 010860A1 AR P970106167 A ARP970106167 A AR P970106167A AR P970106167 A ARP970106167 A AR P970106167A AR 010860 A1 AR010860 A1 AR 010860A1
Authority
AR
Argentina
Prior art keywords
alkyl
compounds
bipiperidin
procedure
preparing
Prior art date
Application number
ARP970106167A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR010860A1 publication Critical patent/AR010860A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Un procedimiento para preparar un compuesto de formula (I), en la que X es H, halogeno, CO2R3, OR4, COR5 o una cadena secundaria de antagonistade fibrinogeno o vitronectina; R2 es alquilo (C1-C6), opcionalmente sustituido con Ar, Het, ocicloalq uilo (C1-C6); R3 es alquilo (C1-C6) o bencilo; R4 esalquilo (C1-C6), COR3 o bencilo; R5 es 4,4-bipiperidin-1-ilo, (1- benciloxicarbonil)-4,4-bipiperidin-1-ilo o (1-t-butoxicarbonil)-4,4-bipiperidin-1-ilo; que comprende: (a)tratar un comp uesto de formula (II), en la que R1 es alquilo (C1-C20) o alquenilo (C3-C20), opcionalmente sustituidocon Ar, NR2, o NR3+, en donde R es alquilo (C1-C4); con lipasa B de Candida Antarctica; y (b) separar el ácido carbocílicoresultante, ácido 2 ,3,4,5-tetrahidro-4-metil-3-oxo-1H-1,4-benzodiazepina-2-ácetico, del correspondiente éster y compuestos relacionados.
ARP970106167A 1996-12-27 1997-12-23 Procedimiento para preparar compuestos mediante resolucion enzimatica y compuestos relacionados AR010860A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3385396P 1996-12-27 1996-12-27

Publications (1)

Publication Number Publication Date
AR010860A1 true AR010860A1 (es) 2000-07-12

Family

ID=21872833

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970106167A AR010860A1 (es) 1996-12-27 1997-12-23 Procedimiento para preparar compuestos mediante resolucion enzimatica y compuestos relacionados

Country Status (17)

Country Link
EP (1) EP0964928A1 (es)
JP (1) JP2001507231A (es)
KR (1) KR20000069705A (es)
CN (1) CN1246157A (es)
AR (1) AR010860A1 (es)
AU (1) AU730064B2 (es)
BR (1) BR9714099A (es)
CA (1) CA2276134A1 (es)
CO (1) CO4930272A1 (es)
HU (1) HUP0002825A3 (es)
IL (1) IL130580A0 (es)
NO (1) NO993174D0 (es)
NZ (1) NZ336376A (es)
PL (1) PL334293A1 (es)
TR (1) TR199901487T2 (es)
WO (1) WO1998029561A1 (es)
ZA (1) ZA9711566B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041405A1 (en) 1998-02-17 1999-08-19 G.D. Searle & Co. Process for the enzymatic resolution of lactams
KR100378741B1 (ko) * 2000-06-01 2003-04-07 에스케이 주식회사 효소를 이용하여 R-폼 또는 S-폼의 α-치환 헤테로싸이클릭 카르복실산 및 이와 상반되는 광학특성을 갖는 α-치환 헤테로싸이클릭 카르복실산 에스테르를 제조하는 방법
JP4843812B2 (ja) * 2000-06-01 2011-12-21 エスケー バイオファーマスティカルズ カンパニー リミテッド 酵素を使用するラセミα−置換ヘテロ環式カルボン酸の光学分割方法
KR100379756B1 (ko) * 2000-10-02 2003-04-11 한국과학기술연구원 이성질체 분할방법
US6828119B2 (en) * 2001-01-04 2004-12-07 Bristol Myers Squibb Company Enzymatic deprotection of amines and hydroxides
FR2853327B1 (fr) * 2003-04-04 2012-07-27 Solvay Procede pour la fabrication de derives de beta-aminoacides enantiopurs et derives de beta-aminoacides enantiopurs
KR100650798B1 (ko) * 2004-07-19 2006-11-27 (주)제이코통상 광학활성 카복실산의 제조방법
FR2876102A1 (fr) * 2004-10-04 2006-04-07 Solvay Compose heterocyclique enantiopur
KR100650797B1 (ko) * 2005-12-12 2006-11-27 (주)케미코월드 광학활성 사이클로프로판 카복사미드의 제조방법
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
CN117363683A (zh) * 2023-10-09 2024-01-09 江苏惠利生物科技有限公司 一种脂酶苯并二氮杂-乙酸酯的酶拆分方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
AU689762B2 (en) * 1992-12-21 1998-04-09 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Also Published As

Publication number Publication date
KR20000069705A (ko) 2000-11-25
WO1998029561A1 (en) 1998-07-09
CN1246157A (zh) 2000-03-01
NO993174L (no) 1999-06-25
IL130580A0 (en) 2000-06-01
TR199901487T2 (xx) 1999-11-22
CA2276134A1 (en) 1998-07-09
AU5331498A (en) 1998-07-31
PL334293A1 (en) 2000-02-14
ZA9711566B (en) 1998-06-29
BR9714099A (pt) 2000-03-21
HUP0002825A3 (en) 2002-09-30
JP2001507231A (ja) 2001-06-05
AU730064B2 (en) 2001-02-22
EP0964928A1 (en) 1999-12-22
NO993174D0 (no) 1999-06-25
NZ336376A (en) 2000-11-24
HUP0002825A2 (hu) 2000-12-28
CO4930272A1 (es) 2000-06-27

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