ZA9711566B - Enzymatic resolution. - Google Patents

Enzymatic resolution.

Info

Publication number
ZA9711566B
ZA9711566B ZA9711566A ZA9711566A ZA9711566B ZA 9711566 B ZA9711566 B ZA 9711566B ZA 9711566 A ZA9711566 A ZA 9711566A ZA 9711566 A ZA9711566 A ZA 9711566A ZA 9711566 B ZA9711566 B ZA 9711566B
Authority
ZA
South Africa
Prior art keywords
enzymatic resolution
enzymatic
resolution
Prior art date
Application number
ZA9711566A
Inventor
Andrew S Wells
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA9711566B publication Critical patent/ZA9711566B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165Heterorings having nitrogen atoms as the only ring heteroatoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA9711566A 1996-12-27 1997-12-23 Enzymatic resolution. ZA9711566B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3385396P 1996-12-27 1996-12-27

Publications (1)

Publication Number Publication Date
ZA9711566B true ZA9711566B (en) 1998-06-29

Family

ID=21872833

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711566A ZA9711566B (en) 1996-12-27 1997-12-23 Enzymatic resolution.

Country Status (17)

Country Link
EP (1) EP0964928A1 (en)
JP (1) JP2001507231A (en)
KR (1) KR20000069705A (en)
CN (1) CN1246157A (en)
AR (1) AR010860A1 (en)
AU (1) AU730064B2 (en)
BR (1) BR9714099A (en)
CA (1) CA2276134A1 (en)
CO (1) CO4930272A1 (en)
HU (1) HUP0002825A3 (en)
IL (1) IL130580A0 (en)
NO (1) NO993174D0 (en)
NZ (1) NZ336376A (en)
PL (1) PL334293A1 (en)
TR (1) TR199901487T2 (en)
WO (1) WO1998029561A1 (en)
ZA (1) ZA9711566B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2758899A (en) * 1998-02-17 1999-08-30 G.D. Searle & Co. Process for the enzymatic resolution of lactams
KR100378741B1 (en) * 2000-06-01 2003-04-07 에스케이 주식회사 Method for preparing R- or S-form α-substituted heterocyclic carboxyl acid and counter enantiomeric form of α-substituted heterocyclic carboxyl acid ester thereto using enzyme
JP4843812B2 (en) * 2000-06-01 2011-12-21 エスケー バイオファーマスティカルズ カンパニー リミテッド Method for optical resolution of racemic α-substituted heterocyclic carboxylic acids using enzymes
KR100379756B1 (en) * 2000-10-02 2003-04-11 한국과학기술연구원 Resolution of chiral compounds
US6828119B2 (en) * 2001-01-04 2004-12-07 Bristol Myers Squibb Company Enzymatic deprotection of amines and hydroxides
FR2853327B1 (en) * 2003-04-04 2012-07-27 Solvay PROCESS FOR THE PRODUCTION OF ENANTIOPOR BETA-AMINOACID DERIVATIVES AND ENANTIOPA BETA-AMINOACIDIC DERIVATIVES
KR100650798B1 (en) * 2004-07-19 2006-11-27 (주)제이코통상 Process for preparing chiral substituted carboxylic acid
FR2876102A1 (en) * 2004-10-04 2006-04-07 Solvay ENANTIOPUR HETEROCYCLIC COMPOUND
KR100650797B1 (en) * 2005-12-12 2006-11-27 (주)케미코월드 Process for preparing chiral substituted cyclopropane carboxamide
FR2986804A1 (en) * 2012-02-09 2013-08-16 Servier Lab PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID OR ITS ESTERS, AND APPLICATION TO THE SYNTHESIS OF IVABRADIN AND IES SALTS
CN117363683A (en) * 2023-10-09 2024-01-09 江苏惠利生物科技有限公司 Enzymatic resolution method of lipase benzodiazepine-acetate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE228115T1 (en) * 1991-06-28 2002-12-15 Smithkline Beecham Corp BCYCLIC FIBRINOGEN ANTAGONISTS
ES2197160T3 (en) * 1992-12-21 2004-01-01 Smithkline Beecham Corp BICYCLING FIBRONOGEN ANTAGONISTS.
MA23420A1 (en) * 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Also Published As

Publication number Publication date
AU5331498A (en) 1998-07-31
NO993174L (en) 1999-06-25
JP2001507231A (en) 2001-06-05
CO4930272A1 (en) 2000-06-27
TR199901487T2 (en) 1999-11-22
IL130580A0 (en) 2000-06-01
HUP0002825A2 (en) 2000-12-28
CN1246157A (en) 2000-03-01
HUP0002825A3 (en) 2002-09-30
BR9714099A (en) 2000-03-21
AU730064B2 (en) 2001-02-22
AR010860A1 (en) 2000-07-12
NO993174D0 (en) 1999-06-25
PL334293A1 (en) 2000-02-14
WO1998029561A1 (en) 1998-07-09
CA2276134A1 (en) 1998-07-09
NZ336376A (en) 2000-11-24
EP0964928A1 (en) 1999-12-22
KR20000069705A (en) 2000-11-25

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