TR199901487T2 - Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase. - Google Patents

Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase.

Info

Publication number
TR199901487T2
TR199901487T2 TR1999/01487T TR9901487T TR199901487T2 TR 199901487 T2 TR199901487 T2 TR 199901487T2 TR 1999/01487 T TR1999/01487 T TR 1999/01487T TR 9901487 T TR9901487 T TR 9901487T TR 199901487 T2 TR199901487 T2 TR 199901487T2
Authority
TR
Turkey
Prior art keywords
acetic acid
acid esters
benzodiazepine
lipase
esters containing
Prior art date
Application number
TR1999/01487T
Other languages
Turkish (tr)
Inventor
Stephen Wells Andrew
Original Assignee
Smithkline Beecham Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc. filed Critical Smithkline Beecham Plc.
Publication of TR199901487T2 publication Critical patent/TR199901487T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Bu bulus, enantiomerik olarak saf benzodiazepin asetik asit esterleri ve bir lipazin kullanilmasi ile bir rasemik karisimin çözülmesi suretiyle bunlarin hazirlanmasi ile ilgilidir.This invention relates to the use of enantiomerically pure benzodiazepine acetic acid esters and a lipazine to prepare them by dissolving a racemic mixture.

TR1999/01487T 1996-12-27 1997-12-23 Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase. TR199901487T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3385396P 1996-12-27 1996-12-27

Publications (1)

Publication Number Publication Date
TR199901487T2 true TR199901487T2 (en) 1999-11-22

Family

ID=21872833

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01487T TR199901487T2 (en) 1996-12-27 1997-12-23 Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase.

Country Status (17)

Country Link
EP (1) EP0964928A1 (en)
JP (1) JP2001507231A (en)
KR (1) KR20000069705A (en)
CN (1) CN1246157A (en)
AR (1) AR010860A1 (en)
AU (1) AU730064B2 (en)
BR (1) BR9714099A (en)
CA (1) CA2276134A1 (en)
CO (1) CO4930272A1 (en)
HU (1) HUP0002825A3 (en)
IL (1) IL130580A0 (en)
NO (1) NO993174D0 (en)
NZ (1) NZ336376A (en)
PL (1) PL334293A1 (en)
TR (1) TR199901487T2 (en)
WO (1) WO1998029561A1 (en)
ZA (1) ZA9711566B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2216495T3 (en) * 1998-02-17 2004-10-16 G.D. SEARLE & CO. PROCEDURE FOR THE ENZYMATIC RESOLUTION OF LACTAMAS.
DE60143262D1 (en) * 2000-06-01 2010-11-25 Sk Holdings Co Ltd METHOD FOR THE OPTICAL RESOLUTION OF A RAZEMIC ALPHA-SUBSTITUTED, HETEROCYCLIC CARBOXYLIC ACID UNDER ENZYME USE
KR100378741B1 (en) * 2000-06-01 2003-04-07 에스케이 주식회사 Method for preparing R- or S-form α-substituted heterocyclic carboxyl acid and counter enantiomeric form of α-substituted heterocyclic carboxyl acid ester thereto using enzyme
KR100379756B1 (en) * 2000-10-02 2003-04-11 한국과학기술연구원 Resolution of chiral compounds
US6828119B2 (en) * 2001-01-04 2004-12-07 Bristol Myers Squibb Company Enzymatic deprotection of amines and hydroxides
FR2853327B1 (en) * 2003-04-04 2012-07-27 Solvay PROCESS FOR THE PRODUCTION OF ENANTIOPOR BETA-AMINOACID DERIVATIVES AND ENANTIOPA BETA-AMINOACIDIC DERIVATIVES
KR100650798B1 (en) * 2004-07-19 2006-11-27 (주)제이코통상 Method for preparing optically active carboxylic acid
FR2876102A1 (en) * 2004-10-04 2006-04-07 Solvay ENANTIOPUR HETEROCYCLIC COMPOUND
KR100650797B1 (en) * 2005-12-12 2006-11-27 (주)케미코월드 Method for preparing optically active cyclopropane carboxamide
FR2986804A1 (en) * 2012-02-09 2013-08-16 Servier Lab PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID OR ITS ESTERS, AND APPLICATION TO THE SYNTHESIS OF IVABRADIN AND IES SALTS
CN117363683A (en) * 2023-10-09 2024-01-09 江苏惠利生物科技有限公司 Enzymatic resolution method of lipase benzodiazepine-acetate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA924760B (en) * 1991-06-28 1993-03-31 Smithkline Beecham Corp Bicyclic fibrinogen antagonists
DE69332860T2 (en) * 1992-12-21 2004-03-11 Smithkline Beecham Corp. BICYCLIC FIBRINOGEN ANTAGONISTE
MA23420A1 (en) * 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Also Published As

Publication number Publication date
AU730064B2 (en) 2001-02-22
CA2276134A1 (en) 1998-07-09
AU5331498A (en) 1998-07-31
EP0964928A1 (en) 1999-12-22
NO993174L (en) 1999-06-25
NZ336376A (en) 2000-11-24
HUP0002825A3 (en) 2002-09-30
BR9714099A (en) 2000-03-21
KR20000069705A (en) 2000-11-25
CO4930272A1 (en) 2000-06-27
PL334293A1 (en) 2000-02-14
HUP0002825A2 (en) 2000-12-28
WO1998029561A1 (en) 1998-07-09
IL130580A0 (en) 2000-06-01
NO993174D0 (en) 1999-06-25
CN1246157A (en) 2000-03-01
ZA9711566B (en) 1998-06-29
AR010860A1 (en) 2000-07-12
JP2001507231A (en) 2001-06-05

Similar Documents

Publication Publication Date Title
ATE337775T1 (en) STRUCTURES AND COMPOSITIONS FOR INCREASING THE STABILITY OF ACTIVE PEROXIDES
TR199901487T2 (en) Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase.
ZA979771B (en) Fatty acid esters of glycolic acid and its salts as permeation enhancers.
FI972496A (en) Fusarium isolate and lipases, cutinases and enzyme compositions derived therefrom
YU19499A (en) Benzonaphthyridines as bronchial therapeutics
DE60042209D1 (en) ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES
TR199903037T2 (en) Bleaching enzymes.
AU2904300A (en) Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
DK1032378T3 (en) Use of a mixture of a diol and an alpha-hydroxy acid for the treatment of hyperkeratotic skin diseases
BR9803694A (en) 6- and 7-aminotetrahydroisoquinolinecarboxylic acids substituted.
PL336633A1 (en) Novel class of compounds constituting derivatives of bencoporphyrin
GB2324091B (en) Metalloproteinase inhibitors
GB2324528B (en) Cytostatic hydroxamic acid derivatives
BR0114884A (en) Calcally Compounds
AU2979495A (en) Dioxo-thiopyrano-pyridine carboxylic acid derivatives and their use as medicaments
NO960826L (en) Use of enzymes from krill in substances
TR199901862T2 (en) New Wristbands.
ES2181897T3 (en) ENZYMATIC COMPOSITION.
TR199901631T2 (en) The process for the preparation of esters and salts of clavulanic acid.
ATE231510T1 (en) PENAMSULFONES AS BETA-LACTAMASE INHIBITORS
AU3027697A (en) Pharmaceutical compositions containing cyclosporine and a carrier comprising at least an ester of alpha-glycerophosphoric acid
AU7028798A (en) Use of 2-methylthiazolidine-2,4-dicarboxylic acid as mucolytic agent
ATE417934T1 (en) ENZYMATIC PROCESS FOR DISSOLVING ENANTIOMERIC MIXTURES OF BETA-LACTAMS
TR200103126T2 (en) Anticonvulsant derivatives for use in the improvement of structural tremor
TR199801514A2 (en) N-Piruvil-L-Prolin �retimi i�in yintem.