IL107596A - תולדות קארבאפנם גבישי, תכשירי רוקחות המכילים אותן ושיטות להכנתן - Google Patents

תולדות קארבאפנם גבישי, תכשירי רוקחות המכילים אותן ושיטות להכנתן

Info

Publication number
IL107596A
IL107596A IL107596A IL10759693A IL107596A IL 107596 A IL107596 A IL 107596A IL 107596 A IL107596 A IL 107596A IL 10759693 A IL10759693 A IL 10759693A IL 107596 A IL107596 A IL 107596A
Authority
IL
Israel
Prior art keywords
compound
formula
doublet
crystals
crystalline form
Prior art date
Application number
IL107596A
Other languages
English (en)
Other versions
IL107596A0 (en
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IL107596A0 publication Critical patent/IL107596A0/xx
Publication of IL107596A publication Critical patent/IL107596A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
IL107596A 1992-11-17 1993-11-12 תולדות קארבאפנם גבישי, תכשירי רוקחות המכילים אותן ושיטות להכנתן IL107596A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30688492 1992-11-17
JP17026793 1993-07-09

Publications (2)

Publication Number Publication Date
IL107596A0 IL107596A0 (en) 1994-02-27
IL107596A true IL107596A (he) 1998-02-08

Family

ID=26493307

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107596A IL107596A (he) 1992-11-17 1993-11-12 תולדות קארבאפנם גבישי, תכשירי רוקחות המכילים אותן ושיטות להכנתן

Country Status (21)

Country Link
US (1) US5424306A (he)
EP (1) EP0599512B1 (he)
JP (1) JP2848552B2 (he)
KR (1) KR100236845B1 (he)
CN (1) CN1036714C (he)
AT (1) ATE178066T1 (he)
AU (1) AU677235B2 (he)
CA (1) CA2103223C (he)
CZ (1) CZ280507B6 (he)
DE (1) DE69324106T2 (he)
DK (1) DK0599512T3 (he)
ES (1) ES2131560T3 (he)
FI (1) FI103576B (he)
GR (1) GR3029975T3 (he)
HK (1) HK1011977A1 (he)
HU (1) HU219582B (he)
IL (1) IL107596A (he)
NO (1) NO304431B1 (he)
NZ (1) NZ250201A (he)
PH (1) PH30464A (he)
TW (1) TW360657B (he)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000005535A (ko) * 1996-05-09 2000-01-25 가와무라 요시부미 1-메틸카르바페넴 유도체를 유효성분으로 함유하는 항 헬리코박터 피롤리 조성물
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
JPWO2004035539A1 (ja) * 2002-10-18 2006-02-16 明治製菓株式会社 カルバペネム類の製造方法およびその製造に用いられる中間体
CN1960992B (zh) * 2004-06-02 2011-10-19 桑多斯股份公司 晶体形式的美罗培南中间体
JP2009143808A (ja) * 2006-03-28 2009-07-02 Kaneka Corp メロペネム中間体の単離方法
SG185318A1 (en) 2007-01-12 2012-11-29 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE950607L (en) * 1988-04-01 1989-10-01 Sankyo Co 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
JPH0745499B2 (ja) * 1988-05-10 1995-05-17 三共株式会社 １―メチルカルバペネム誘導体
EP0462521A1 (en) * 1990-06-19 1991-12-27 Takeda Chemical Industries, Ltd. Crystalline penem, its production and use

Also Published As

Publication number Publication date
DE69324106T2 (de) 1999-12-09
KR940011463A (ko) 1994-06-21
GR3029975T3 (en) 1999-07-30
ATE178066T1 (de) 1999-04-15
NZ250201A (en) 1995-04-27
DK0599512T3 (da) 1999-10-11
NO934140L (no) 1994-05-18
JP2848552B2 (ja) 1999-01-20
CA2103223C (en) 2002-09-24
FI935063A (fi) 1994-05-18
HK1011977A1 (en) 1999-07-23
TW360657B (en) 1999-06-11
PH30464A (en) 1997-05-28
FI935063A0 (fi) 1993-11-16
CA2103223A1 (en) 1994-05-18
CZ245493A3 (en) 1995-08-16
EP0599512B1 (en) 1999-03-24
CN1093366A (zh) 1994-10-12
HUT66001A (en) 1994-08-29
NO934140D0 (no) 1993-11-16
EP0599512A1 (en) 1994-06-01
FI103576B1 (fi) 1999-07-30
IL107596A0 (en) 1994-02-27
NO304431B1 (no) 1998-12-14
HU219582B (hu) 2001-05-28
US5424306A (en) 1995-06-13
KR100236845B1 (ko) 2000-02-01
JPH07165759A (ja) 1995-06-27
DE69324106D1 (de) 1999-04-29
ES2131560T3 (es) 1999-08-01
AU677235B2 (en) 1997-04-17
FI103576B (fi) 1999-07-30
CN1036714C (zh) 1997-12-17
CZ280507B6 (cs) 1996-02-14
AU5063193A (en) 1994-06-02

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