GR3029975T3 - Crystalline carbapenem derivative. - Google Patents

Crystalline carbapenem derivative.

Info

Publication number
GR3029975T3
GR3029975T3 GR990401054T GR990401054T GR3029975T3 GR 3029975 T3 GR3029975 T3 GR 3029975T3 GR 990401054 T GR990401054 T GR 990401054T GR 990401054 T GR990401054 T GR 990401054T GR 3029975 T3 GR3029975 T3 GR 3029975T3
Authority
GR
Greece
Prior art keywords
carbapenem derivative
crystalline carbapenem
crystalline
derivative
pyrrolidinylthio
Prior art date
Application number
GR990401054T
Other languages
English (en)
Inventor
Isao Kawamoto
Masao Miyauchi
Rokuro Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of GR3029975T3 publication Critical patent/GR3029975T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
GR990401054T 1992-11-17 1999-04-16 Crystalline carbapenem derivative. GR3029975T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30688492 1992-11-17
JP17026793 1993-07-09

Publications (1)

Publication Number Publication Date
GR3029975T3 true GR3029975T3 (en) 1999-07-30

Family

ID=26493307

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401054T GR3029975T3 (en) 1992-11-17 1999-04-16 Crystalline carbapenem derivative.

Country Status (21)

Country Link
US (1) US5424306A (el)
EP (1) EP0599512B1 (el)
JP (1) JP2848552B2 (el)
KR (1) KR100236845B1 (el)
CN (1) CN1036714C (el)
AT (1) ATE178066T1 (el)
AU (1) AU677235B2 (el)
CA (1) CA2103223C (el)
CZ (1) CZ280507B6 (el)
DE (1) DE69324106T2 (el)
DK (1) DK0599512T3 (el)
ES (1) ES2131560T3 (el)
FI (1) FI103576B1 (el)
GR (1) GR3029975T3 (el)
HK (1) HK1011977A1 (el)
HU (1) HU219582B (el)
IL (1) IL107596A (el)
NO (1) NO304431B1 (el)
NZ (1) NZ250201A (el)
PH (1) PH30464A (el)
TW (1) TW360657B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU711128C (en) * 1996-05-09 2002-11-07 Sankyo Company Limited Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
JP2009143808A (ja) * 2006-03-28 2009-07-02 Kaneka Corp メロペネム中間体の単離方法
SG185318A1 (en) 2007-01-12 2012-11-29 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
NO168304C (no) * 1988-04-01 1992-02-05 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater
JPH0745499B2 (ja) * 1988-05-10 1995-05-17 三共株式会社 １―メチルカルバペネム誘導体
EP0462521A1 (en) * 1990-06-19 1991-12-27 Takeda Chemical Industries, Ltd. Crystalline penem, its production and use

Also Published As

Publication number Publication date
AU677235B2 (en) 1997-04-17
FI935063A0 (fi) 1993-11-16
JP2848552B2 (ja) 1999-01-20
US5424306A (en) 1995-06-13
FI935063A (fi) 1994-05-18
HUT66001A (en) 1994-08-29
TW360657B (en) 1999-06-11
EP0599512B1 (en) 1999-03-24
KR100236845B1 (ko) 2000-02-01
IL107596A (en) 1998-02-08
CN1093366A (zh) 1994-10-12
HU219582B (hu) 2001-05-28
CZ280507B6 (cs) 1996-02-14
EP0599512A1 (en) 1994-06-01
DE69324106D1 (de) 1999-04-29
JPH07165759A (ja) 1995-06-27
KR940011463A (ko) 1994-06-21
NO304431B1 (no) 1998-12-14
CA2103223A1 (en) 1994-05-18
ATE178066T1 (de) 1999-04-15
ES2131560T3 (es) 1999-08-01
NZ250201A (en) 1995-04-27
CN1036714C (zh) 1997-12-17
NO934140D0 (no) 1993-11-16
FI103576B (fi) 1999-07-30
CA2103223C (en) 2002-09-24
DE69324106T2 (de) 1999-12-09
CZ245493A3 (en) 1995-08-16
FI103576B1 (fi) 1999-07-30
AU5063193A (en) 1994-06-02
PH30464A (en) 1997-05-28
DK0599512T3 (da) 1999-10-11
HK1011977A1 (en) 1999-07-23
NO934140L (no) 1994-05-18
IL107596A0 (en) 1994-02-27

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