IL105883A - Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them - Google Patents

Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them

Info

Publication number
IL105883A
IL105883A IL10588393A IL10588393A IL105883A IL 105883 A IL105883 A IL 105883A IL 10588393 A IL10588393 A IL 10588393A IL 10588393 A IL10588393 A IL 10588393A IL 105883 A IL105883 A IL 105883A
Authority
IL
Israel
Prior art keywords
glycosylation
glycosylated
devoid
positions
plasminogen activator
Prior art date
Application number
IL10588393A
Other languages
English (en)
Other versions
IL105883A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL105883A0 publication Critical patent/IL105883A0/xx
Publication of IL105883A publication Critical patent/IL105883A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL10588393A 1992-06-03 1993-06-02 Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them IL105883A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03

Publications (2)

Publication Number Publication Date
IL105883A0 IL105883A0 (en) 1993-10-20
IL105883A true IL105883A (en) 2003-04-10

Family

ID=25402765

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10588393A IL105883A (en) 1992-06-03 1993-06-02 Tissue plasminogen activator glycosylation variants, glycosylated at any one of positions 103 to 105 and devoid of glycosylation at position 117, with improved therapeutic properties, method of preparing and compositions comprising them

Country Status (20)

Country Link
US (1) US5612029A (pt)
EP (2) EP0786257B1 (pt)
JP (1) JP3559559B2 (pt)
AT (2) ATE246000T1 (pt)
AU (1) AU664469B2 (pt)
CA (1) CA2129660C (pt)
DE (3) DE69333127T2 (pt)
DK (2) DK0786257T3 (pt)
EE (1) EE03128B1 (pt)
ES (2) ES2107041T3 (pt)
FI (1) FI117940B (pt)
GE (1) GEP20012448B (pt)
GR (1) GR3024806T3 (pt)
HK (2) HK1000449A1 (pt)
IL (1) IL105883A (pt)
LU (1) LU90800I2 (pt)
NL (1) NL300050I2 (pt)
NZ (1) NZ253556A (pt)
PT (1) PT786257E (pt)
WO (1) WO1993024635A1 (pt)

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US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
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US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
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US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
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US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
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US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
AP2007004251A0 (en) * 2005-06-02 2007-12-31 Avestha Gengraine Tech Pvt Ltd A method for production of a bioengineered form oftissue plasminogen activator
US7932084B2 (en) * 2005-09-08 2011-04-26 University Of Virginia Patent Foundation Methods and compositions for growing adipose stem cells
US20080069857A1 (en) * 2006-04-12 2008-03-20 Yoon Yeo Compositions And Methods For Inhibiting Adhesions
US8969295B2 (en) * 2006-04-14 2015-03-03 Massachusetts Institute Of Technology Identifying and modulating molecular pathways that mediate nervous system plasticity
BRPI0716143A2 (pt) 2006-08-29 2013-11-26 Genentech Inc Uso de tenecteplase para tratar derrame isquêmico agudo
WO2008060374A2 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
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KR100834561B1 (ko) 2006-12-08 2008-06-02 가톨릭대학교 산학협력단 크링글 도메인 1 및 2로 이루어진 비-글리코실화 재조합단백질, 그 제조 방법 및 이를 포함하는 조성물
EP2289541A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
EP2289542A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
EP2869834B1 (en) * 2012-07-05 2019-12-11 Hadasit Medical Research Services & Development Limited Plasminogen activator mutants as anti-fibrinolytic agents
US10415027B2 (en) 2012-12-05 2019-09-17 National Jewish Health Treatment for airway cast obstruction
CN103623396B (zh) * 2013-04-07 2016-03-02 安源生物科技(上海)有限公司 包含重组组织型纤溶酶原激活剂的药物组合物
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
CN107073292B (zh) * 2014-11-03 2021-07-02 溶栓科学有限责任公司 用于安全和有效的溶栓的方法和组合物
EP3577136A1 (en) 2017-02-03 2019-12-11 Acticor Biotech Inhibition of platelet aggregation using anti-human gpvi antibodies
JP2020520386A (ja) 2017-05-16 2020-07-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 急性虚血性脳卒中の処置のための方法及び医薬組成物
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US12123000B2 (en) 2018-06-15 2024-10-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Use of PI3KC2B inhibitors for the preservation of vascular endothelial cell barrier integrity
WO2021148439A1 (en) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
EP4161579A1 (en) 2020-06-09 2023-04-12 Institut National de la Santé et de la Recherche Médicale (INSERM) Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
WO2023156683A1 (en) 2022-02-21 2023-08-24 Acticor Biotech Treatment of cardiovascular diseases using anti-human gpvi antibodies

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Also Published As

Publication number Publication date
JP3559559B2 (ja) 2004-09-02
DK0786257T3 (da) 2003-10-06
FI943632A (fi) 1994-10-04
EP0643772A1 (en) 1995-03-22
ATE246000T1 (de) 2003-08-15
JPH07507448A (ja) 1995-08-24
LU90800I2 (fr) 2001-10-08
DE69312493T2 (de) 1998-01-15
PT786257E (pt) 2003-12-31
EP0643772B1 (en) 1997-07-23
DK0643772T3 (da) 1998-02-02
ES2107041T3 (es) 1997-11-16
AU4397393A (en) 1993-12-30
NZ253556A (en) 1995-11-27
ES2203668T3 (es) 2004-04-16
FI117940B (fi) 2007-04-30
CA2129660A1 (en) 1993-12-09
ATE155816T1 (de) 1997-08-15
EE03128B1 (et) 1998-10-15
AU664469B2 (en) 1995-11-16
WO1993024635A1 (en) 1993-12-09
US5612029A (en) 1997-03-18
NL300050I1 (nl) 2001-10-01
IL105883A0 (en) 1993-10-20
DE69333127D1 (de) 2003-09-04
DE10199044I2 (de) 2006-02-09
DE69312493D1 (de) 1997-09-04
GR3024806T3 (en) 1998-01-30
CA2129660C (en) 2005-06-28
HK1001190A1 (en) 1998-05-29
NL300050I2 (nl) 2001-11-01
DE69333127T2 (de) 2004-05-06
GEP20012448B (en) 2001-05-25
DE10199044I1 (de) 2002-02-21
EP0786257A1 (en) 1997-07-30
FI943632A0 (fi) 1994-08-04
HK1000449A1 (en) 2004-03-05
EP0786257B1 (en) 2003-07-30

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