IL105806A - Aminoquinoline derivatives and pharmaceutical compositions containing the same - Google Patents

Aminoquinoline derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL105806A
IL105806A IL105806A IL10580693A IL105806A IL 105806 A IL105806 A IL 105806A IL 105806 A IL105806 A IL 105806A IL 10580693 A IL10580693 A IL 10580693A IL 105806 A IL105806 A IL 105806A
Authority
IL
Israel
Prior art keywords
group
substituted
formula
pyrimidinyl
ethyl
Prior art date
Application number
IL105806A
Other languages
English (en)
Other versions
IL105806A0 (en
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of IL105806A0 publication Critical patent/IL105806A0/xx
Publication of IL105806A publication Critical patent/IL105806A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL105806A 1992-05-27 1993-05-25 Aminoquinoline derivatives and pharmaceutical compositions containing the same IL105806A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15891292 1992-05-27

Publications (2)

Publication Number Publication Date
IL105806A0 IL105806A0 (en) 1993-09-22
IL105806A true IL105806A (en) 1998-02-22

Family

ID=15682065

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105806A IL105806A (en) 1992-05-27 1993-05-25 Aminoquinoline derivatives and pharmaceutical compositions containing the same

Country Status (18)

Country Link
US (2) US5519016A (enExample)
EP (1) EP0572259A1 (enExample)
KR (1) KR100266305B1 (enExample)
CN (1) CN1042936C (enExample)
AU (1) AU656859B2 (enExample)
CA (1) CA2096998A1 (enExample)
CZ (1) CZ99693A3 (enExample)
FI (1) FI932412A7 (enExample)
HU (1) HUT64051A (enExample)
ID (1) ID20476A (enExample)
IL (1) IL105806A (enExample)
MX (1) MX9303158A (enExample)
NO (1) NO304832B1 (enExample)
NZ (1) NZ247720A (enExample)
PH (1) PH31078A (enExample)
RU (1) RU2124510C1 (enExample)
TW (1) TW234121B (enExample)
ZA (1) ZA933732B (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
RU2140919C1 (ru) * 1994-07-18 1999-11-10 Убе Индастриз Лтд. Производные 8-трифторметилхинолинкарбоновой кислоты, фармацевтическая композиция и способ ингибирования вируса иммунодефицита
DE4425649A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue 1-[4-(Aminomethyl)phenyl] substituierte Chinoloncarbonsäuren
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DE4425660A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren
NZ296532A (en) * 1994-11-24 2000-02-28 F Substituted 5-benzyl-2,4,-diaminopyrimidines
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
ES2200439T3 (es) * 1995-09-22 2004-03-01 Wakunaga Pharmaceutical Co., Ltd. Intermedios para utilizar en la preparacion de nuevos derivados del acido piridonocarboxilico o sus sales.
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
CN1264837C (zh) * 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
ATE293096T1 (de) * 1998-08-12 2005-04-15 Ihara Chemical Ind Co Difluormethoxybenzolderivate und ihre verwendung als zwischenprodukte
DK1140932T3 (da) * 1998-12-21 2004-07-05 Aventis Pharma Sa Derivater af benzo-1,8-naphtyridin
AU3223801A (en) * 2000-02-09 2001-08-20 Daiichi Seiyaku Co Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
AU2002230893B2 (en) 2000-12-14 2005-06-09 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
ATE304539T1 (de) 2000-12-14 2005-09-15 Procter & Gamble Antimikrobielle chinolone
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP2005521690A (ja) * 2002-02-22 2005-07-21 ファルマシア・コーポレーション ゴム系を含む眼科用製剤
EP1478404A1 (en) * 2002-02-22 2004-11-24 Pharmacia Corporation Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US7176220B2 (en) * 2002-11-20 2007-02-13 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as pharmaceutical agent
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
JP5255183B2 (ja) 2003-09-04 2013-08-07 ウォックハート リミテッド ベンゾキノリジン−２−カルボン酸アルギニン塩四水和物
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
ATE482208T1 (de) * 2004-03-10 2010-10-15 Us Of America Represented By T Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids- related complex (arc)
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
US7531554B2 (en) * 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
KR100589429B1 (ko) 2004-08-31 2006-06-14 한국화학연구원 Ｎ-1 위치에 아미노피리딜기가 치환된 퀴놀론 유도체의 제조방법
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
RU2349586C2 (ru) * 2004-09-17 2009-03-20 Сайлин Фармасьютикалз, Инк. Аналоги хинолона
EP1809639B1 (en) * 2004-11-11 2009-10-14 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) * 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
ES2352799T3 (es) 2005-07-27 2011-02-23 Achillion Pharmaceuticals, Inc. 8-metoxi-9h-isotiazolo[5,4-b]quinolina-3,4-dionas y compuestos relacionados.
JP4669040B2 (ja) * 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
CN101045724B (zh) * 2006-03-28 2011-08-17 宝洁公司 用于制备喹诺酮中间体的偶联方法
BRPI0709209A2 (pt) * 2006-03-28 2011-06-28 Procter & Gamble processo de redução de hidreto para preparo de intermediários de quinolona
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
ES2366150T3 (es) 2006-03-28 2011-10-17 Warner Chilcott Company, Llc Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico.
US20080318939A1 (en) * 2007-06-22 2008-12-25 Whitten Jeffrey P Methods for treating ophthalmic disorders
WO2009002870A1 (en) * 2007-06-22 2008-12-31 Cylene Pharmaceuticals, Inc. Methods for treating aberrant cell proliferation disorders
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CA2699151A1 (en) * 2007-09-11 2009-03-19 Activx Biosciences, Inc. Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors
KR101597841B1 (ko) * 2007-09-12 2016-02-26 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ-３ 억제제로서의 스피로시클릭 아미노퀴놀론
EP2209380A4 (en) * 2007-10-09 2011-09-14 Mark T Hamann METHOD OF USE OF COMPOSITIONS WITH ANTIDEPRESSIVE EFFICACY, MOOD EFFICACY AND OTHER NEUROLOGICAL EFFECTIVENESS AND COMPOSITIONS THEREOF
US20100273787A1 (en) * 2007-11-15 2010-10-28 Robert Schwarcz Kynurenine-aminotransferase inhibitors
EP2231665A4 (en) * 2008-01-07 2012-04-25 Ardea Biosciences Inc NEW COMPOSITIONS AND METHODS OF USE
US8173636B2 (en) * 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents
BRPI1010981A2 (pt) 2009-05-15 2018-12-04 Redx Pharma Ltd "derivados de fármaco redox"
CN116444491A (zh) * 2023-03-30 2023-07-18 浙江工业大学 一种喹诺酮类衍生物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
IT1197841B (it) * 1986-10-14 1988-12-06 Mediolanum Farmaceutici Srl Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
JPH0751579B2 (ja) * 1987-11-07 1995-06-05 日本新薬株式会社 キノリンカルボン酸誘導体
CA2053926A1 (en) * 1989-04-28 1990-10-29 Genkichi Ohta Anti-hiv agent
DE3934082A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel
JPH0754830Y2 (ja) * 1990-01-24 1995-12-18 株式会社ユニシアジェックス 荷重センサ取付構造
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제
EP0593766B1 (en) * 1991-05-28 2000-09-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

Also Published As

Publication number Publication date
NZ247720A (en) 1994-09-27
ZA933732B (en) 1993-12-15
PH31078A (en) 1998-02-05
CN1086515A (zh) 1994-05-11
ID20476A (id) 1998-12-24
KR100266305B1 (ko) 2000-09-15
NO931867D0 (no) 1993-05-24
EP0572259A1 (en) 1993-12-01
TW234121B (enExample) 1994-11-11
MX9303158A (es) 1994-04-29
AU656859B2 (en) 1995-02-16
HUT64051A (en) 1993-11-29
US5688791A (en) 1997-11-18
AU3981593A (en) 1993-12-02
CN1042936C (zh) 1999-04-14
CZ99693A3 (en) 1993-12-15
KR930023360A (ko) 1993-12-18
HU9301536D0 (en) 1993-09-28
US5519016A (en) 1996-05-21
NO304832B1 (no) 1999-02-22
FI932412L (fi) 1993-11-28
FI932412A7 (fi) 1993-11-28
FI932412A0 (fi) 1993-05-26
CA2096998A1 (en) 1993-11-28
NO931867L (no) 1993-11-29
IL105806A0 (en) 1993-09-22
RU2124510C1 (ru) 1999-01-10

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