US5457189A
(en)
*
|
1989-12-04 |
1995-10-10 |
Isis Pharmaceuticals |
Antisense oligonucleotide inhibition of papillomavirus
|
US6174870B1
(en)
*
|
1989-12-04 |
2001-01-16 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide inhibition of papillomavirus
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
WO1995026204A1
(fr)
*
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Stimulation immunitaire par des analogues d'oligonucleotides de phosphorothioate
|
US6727230B1
(en)
|
1994-03-25 |
2004-04-27 |
Coley Pharmaceutical Group, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
CN1043045C
(zh)
*
|
1994-04-14 |
1999-04-21 |
同济医科大学 |
抑制内皮素生成的寡核苷酸及其应用
|
AU2584395A
(en)
*
|
1994-04-26 |
1995-11-16 |
Genta Incorporated |
Antisense oligomers for inhibiting human papillomaviruses
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US20030026782A1
(en)
*
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US5858987A
(en)
*
|
1995-05-05 |
1999-01-12 |
Mitotix, Inc. |
E6AP antisense constructs and methods of use
|
WO1996035455A1
(fr)
*
|
1995-05-11 |
1996-11-14 |
Genetic Therapy, Inc. |
Therapie genique par transduction de cellules epitheliales orales
|
US6458940B2
(en)
*
|
1995-06-06 |
2002-10-01 |
Hybridon, Inc. |
HPV-specific oligonucleotides
|
US6509149B2
(en)
*
|
1995-06-06 |
2003-01-21 |
Hybridon, Inc. |
HPV-specific oligonucleotides
|
US7566455B1
(en)
|
1995-06-07 |
2009-07-28 |
Gpc Biotech, Inc. |
E6AP-binding proteins
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
AU5333298A
(en)
|
1996-12-27 |
1998-07-31 |
Instituto De Investigaciones Bioquimicas Fundacion Campomar |
Compositions and methods for tumour therapy
|
US6127533A
(en)
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
US6576752B1
(en)
|
1997-02-14 |
2003-06-10 |
Isis Pharmaceuticals, Inc. |
Aminooxy functionalized oligomers
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
AU2002300399C1
(en)
*
|
1997-09-05 |
2006-08-31 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Human papilloma virus inhibition by anti-sense oligonucleotides
|
US6084090A
(en)
|
1997-09-05 |
2000-07-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Human papilloma virus anti-sense oligonucleotides
|
ES2374290T3
(es)
|
1998-03-20 |
2012-02-15 |
Commonwealth Scientific And Industrial Research Organisation |
Genes sintéticos y constructos genéticos que comprenden los mismos.
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
US6306105B1
(en)
*
|
1998-05-14 |
2001-10-23 |
Scimed Life Systems, Inc. |
High performance coil wire
|
EP1080226A4
(fr)
*
|
1998-05-21 |
2004-04-21 |
Isis Pharmaceuticals Inc |
Compostions et methodes pour l'administration topique d'oligonucleotides
|
SI1077722T1
(sl)
|
1998-05-22 |
2007-02-28 |
Ottawa Health Research Inst |
Metode in produkti za induciranje sluznicne imunosti
|
US20030022854A1
(en)
|
1998-06-25 |
2003-01-30 |
Dow Steven W. |
Vaccines using nucleic acid-lipid complexes
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
US6867294B1
(en)
*
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6277967B1
(en)
|
1998-07-14 |
2001-08-21 |
Isis Pharmaceuticals, Inc. |
Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
|
US6335194B1
(en)
|
1998-09-29 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of survivin expression
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
JP4854853B2
(ja)
|
1998-11-12 |
2012-01-18 |
ライフ テクノロジーズ コーポレーション |
トランスフェクション薬剤
|
US6492111B1
(en)
|
1998-11-25 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
In situ binary synthesis of biologically effective molecules
|
TR200604211T1
(tr)
*
|
1999-02-12 |
2007-02-21 |
Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited |
Yeni nükleosid ve oligonükleotid analoglarıYeni nükleosid ve oligonükleotid analogları
|
AU778737B2
(en)
*
|
1999-04-14 |
2004-12-16 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
JP4151751B2
(ja)
*
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
US6423885B1
(en)
|
1999-08-13 |
2002-07-23 |
Commonwealth Scientific And Industrial Research Organization (Csiro) |
Methods for obtaining modified phenotypes in plant cells
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US6200746B1
(en)
|
1999-08-25 |
2001-03-13 |
Pharmacia & Upjohn Company |
Methods of identifying anti-viral agents
|
US6641994B2
(en)
|
1999-08-25 |
2003-11-04 |
Pharmacia & Upjohn Company |
Methods of identifying anti-viral agents
|
ATE450621T2
(de)
|
2000-03-30 |
2009-12-15 |
Whitehead Biomedical Inst |
Mediatoren von rns-interferenz, die rns- sequenzspezifisch sind
|
JP2004501614A
(ja)
*
|
2000-04-11 |
2004-01-22 |
マイクロロジックス バイオテック,インコーポレイテッド |
Hpv特異的ショートマー
|
EP1337664A4
(fr)
*
|
2000-10-27 |
2005-01-19 |
Invitrogen Corp |
Procede d'introduction d'oligonucleotides antisens dans des cellules eucaryotes
|
BRPI0115814B8
(pt)
*
|
2000-12-01 |
2021-05-25 |
Europaeisches Laboratorium Fuer Molekularbiologie Embl |
moléculas de rna de filamento duplo, seu método de preparação e composição farmacêutica compreendendo as mesmas
|
US8834900B2
(en)
|
2001-08-17 |
2014-09-16 |
University Of Iowa Research Foundation |
Combination motif immune stimulatory oligonucleotides with improved activity
|
DE10154831A1
(de)
*
|
2001-11-08 |
2003-06-05 |
Deutsches Krebsforsch |
PNA-Konjugat oder PNA-Konjugat-Gemisch zur Therapie von mit HPV in Zusammenhang stehenden Erkrankungen
|
US7704965B2
(en)
*
|
2002-06-26 |
2010-04-27 |
The Penn State Research Foundation |
Methods and materials for treating human papillomavirus infections
|
NZ540098A
(en)
|
2002-10-29 |
2008-09-26 |
Coley Pharmaceutical Group Ltd |
Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
|
CA2502015A1
(fr)
|
2002-12-11 |
2004-06-24 |
Coley Pharmaceutical Group, Inc. |
Acides nucleiques 5'cpg et leurs methodes d'utilisation
|
US20050123902A1
(en)
*
|
2003-05-21 |
2005-06-09 |
President And Fellows Of Harvard College |
Human papillomavirus inhibitors
|
BRPI0414801A
(pt)
*
|
2003-09-25 |
2006-11-14 |
Third Wave Tech Inc |
detecção de hpv
|
US8251110B2
(en)
*
|
2004-08-17 |
2012-08-28 |
Mbhd, Llc |
Filling adapter
|
US8927208B2
(en)
*
|
2005-03-30 |
2015-01-06 |
Labo Bio-Medical Investments B.V. |
Identification of beta-papillomavirus DNA by type-specific reverse hybridization
|
US8173613B2
(en)
*
|
2005-09-22 |
2012-05-08 |
Maine Medical Center |
Modulation of mesenchymal and metastatic cell growth
|
CN101437933B
(zh)
|
2005-12-28 |
2013-11-06 |
斯克里普斯研究所 |
作为药物靶标的天然反义和非编码的rna转录物
|
US8080643B2
(en)
*
|
2006-09-05 |
2011-12-20 |
Third Wave Technologies, Inc. |
HPV primers
|
ES2727549T3
(es)
|
2008-10-03 |
2019-10-17 |
Curna Inc |
Tratamiento de las enfermedades relacionadas con la apolipoproteína a1 por inhibición del transcrito antisentido natural a la apolipoproteína a1
|
ES2600781T3
(es)
|
2008-12-04 |
2017-02-10 |
Curna, Inc. |
Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
|
EP2370582B1
(fr)
|
2008-12-04 |
2017-05-10 |
CuRNA, Inc. |
Traitement de maladies liées à un gène suppresseur de tumeur par inhibition d'un transcrit antisens naturel du gène
|
JP6091752B2
(ja)
|
2008-12-04 |
2017-03-08 |
クルナ・インコーポレーテッド |
Epoに対する天然アンチセンス転写物の抑制によるエリスロポエチン(epo)関連疾患の治療
|
JP5766126B2
(ja)
|
2009-02-12 |
2015-08-19 |
クルナ・インコーポレーテッド |
脳由来神経栄養因子(bdnf)関連疾病の、bdnfに対する天然アンチセンス転写物の抑制による治療
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
EP2408920B1
(fr)
|
2009-03-17 |
2017-03-08 |
CuRNA, Inc. |
Traitement des maladies associées à l'homologue du delta-like 1 (dlk1) par inhibition du transcrit antisens naturel de dlk1
|
KR101722541B1
(ko)
|
2009-05-06 |
2017-04-04 |
큐알엔에이, 인크. |
Ttp에 대한 천연 안티센스 전사체의 억제에 의한 트리스테트라프롤린 관련된 질환의 치료
|
CN102459596B
(zh)
|
2009-05-06 |
2016-09-07 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
CN102459597B
(zh)
|
2009-05-08 |
2020-06-30 |
库尔纳公司 |
通过针对dmd家族的天然反义转录物的抑制治疗肌营养蛋白家族相关疾病
|
CA2762369C
(fr)
|
2009-05-18 |
2021-12-28 |
Joseph Collard |
Traitement de maladies liees a un facteur de reprogrammation par l'inhibition d'un transcrit anti-sens naturel d'un facteur de reprogrammation
|
KR101703695B1
(ko)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의해 tfe3 및 인슐린 수용체 기질 2(irs2)의 치료
|
KR20120024819A
(ko)
|
2009-05-28 |
2012-03-14 |
오피케이오 큐알엔에이, 엘엘씨 |
항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 트리스테트라프롤린 관련된 질환의 치료
|
WO2010148050A2
(fr)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Traitement de maladies liées au gène du collagène par inhibition d'un produit de transcription antisens naturel à un gène du collagène
|
JP6128846B2
(ja)
|
2009-06-16 |
2017-05-17 |
クルナ・インコーポレーテッド |
パラオキソナーゼ(pon1)に対する天然アンチセンス転写物の抑制によるpon1遺伝子関連疾患の治療
|
KR101807323B1
(ko)
|
2009-06-24 |
2017-12-08 |
큐알엔에이, 인크. |
Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료
|
US8921330B2
(en)
|
2009-06-26 |
2014-12-30 |
Curna, Inc. |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
JP2013500017A
(ja)
|
2009-07-24 |
2013-01-07 |
カッパーアールエヌエー,インコーポレイテッド |
サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療
|
JP6128848B2
(ja)
|
2009-08-05 |
2017-05-17 |
クルナ・インコーポレーテッド |
インスリン遺伝子(ins)に対する天然アンチセンス転写物の抑制によるインスリン遺伝子(ins)関連疾患の治療
|
CN102625841A
(zh)
|
2009-08-11 |
2012-08-01 |
欧科库尔纳有限责任公司 |
通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
|
JP5943836B2
(ja)
|
2009-08-21 |
2016-07-05 |
カッパーアールエヌエー,インコーポレイテッド |
‘hsp70相互作用タンパク質c末端’(chip)に対する天然アンチセンス転写産物の阻害によるchip関連疾患の治療
|
US9023822B2
(en)
|
2009-08-25 |
2015-05-05 |
Curna, Inc. |
Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
|
ES2664591T3
(es)
|
2009-09-25 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
|
CN102712927B
(zh)
|
2009-12-16 |
2017-12-01 |
库尔纳公司 |
通过抑制膜结合转录因子肽酶,位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
|
EP2515947B1
(fr)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Traitement de maladies associées à la protéine ucp2 (uncoupling protein) par inhibition du produit de transcription antisens naturel en ucp2
|
DK2516648T3
(en)
|
2009-12-23 |
2018-02-12 |
Curna Inc |
TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT AGAINST HGF
|
JP5982288B2
(ja)
|
2009-12-29 |
2016-08-31 |
カッパーアールエヌエー,インコーポレイテッド |
腫瘍タンパク質63(p63)に対する天然アンチセンス転写物の阻害による腫瘍タンパク質63関連疾患の治療
|
CN102782134B
(zh)
|
2009-12-29 |
2017-11-24 |
库尔纳公司 |
通过抑制核呼吸因子1(nrf1)的天然反义转录物而治疗nrf1相关疾病
|
KR101853511B1
(ko)
|
2009-12-31 |
2018-06-20 |
큐알엔에이, 인크. |
인슐린 수용체 기질 2 및 전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의한 irs2 관련된 질환의 치료
|
ES2664605T3
(es)
|
2010-01-04 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor 8 regulador del interferón (irf8) mediante inhibición del transcrito antisentido natural al gen irf8
|
CA2786056C
(fr)
|
2010-01-06 |
2023-03-14 |
Curna, Inc. |
Traitement de maladies associees a un gene de developpement pancreatique par inhibition du produit de la transcription anti-sens naturel en un gene de developpement pancreatique
|
NO2524039T3
(fr)
|
2010-01-11 |
2018-04-28 |
|
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
US8962586B2
(en)
|
2010-02-22 |
2015-02-24 |
Curna, Inc. |
Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
|
CN102869777B
(zh)
|
2010-04-02 |
2018-11-02 |
库尔纳公司 |
通过抑制集落刺激因子3(csf3)的天然反义转录物而治疗csf3相关疾病
|
JP5978203B2
(ja)
|
2010-04-09 |
2016-08-24 |
カッパーアールエヌエー,インコーポレイテッド |
Fgf21に対する天然アンチセンス転写物の阻害による線維芽細胞増殖因子(fgf21)線維芽細胞増殖因子fgf21)関連疾患の治療
|
CN102933711B
(zh)
|
2010-05-03 |
2018-01-02 |
库尔纳公司 |
通过抑制沉默调节蛋白(sirt)的天然反义转录物而治疗沉默调节蛋白(sirt)相关疾病
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
KR20180053419A
(ko)
|
2010-05-26 |
2018-05-21 |
큐알엔에이, 인크. |
무조(無調)의 동소체 1 (atoh1)에 대한 자연 안티센스 전사체의 저해에 의한 atoh1 관련된 질환의 치료
|
CN102971423B
(zh)
|
2010-05-26 |
2018-01-26 |
库尔纳公司 |
通过抑制蛋氨酸硫氧化物还原酶a(msra)的天然反义转录物而治疗msra相关疾病
|
CN103025873B
(zh)
|
2010-06-23 |
2018-05-08 |
库尔纳公司 |
通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
|
CA2805318A1
(fr)
|
2010-07-14 |
2012-01-19 |
Curna, Inc. |
Traitement de maladies liees a « discs large homolog » (dlg) par inhibition de transcrit antisens naturel de dlg
|
JP5986998B2
(ja)
|
2010-10-06 |
2016-09-06 |
カッパーアールエヌエー,インコーポレイテッド |
シアリダーゼ4(neu4)への天然アンチセンス転写物の阻害によるneu4関連疾患の治療
|
RU2597972C2
(ru)
|
2010-10-22 |
2016-09-20 |
Курна Инк. |
Лечение заболеваний, связанных с геном альфа-l-идуронидазы (idua), путем ингибирования природного антисмыслового транскрипта гена idua
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
CA2818824A1
(fr)
|
2010-11-23 |
2012-05-31 |
Joseph Collard |
Traitement de maladies associees a nanog par l'inhibition d'un transcript antisens naturel de nanog
|
CA2838588C
(fr)
|
2011-06-09 |
2021-09-14 |
Curna, Inc. |
Traitement des maladies associees a la frataxine (fxn) par inhibition de la transcription de l'anti-sens naturel de la fxn
|
BR112014005234A2
(pt)
|
2011-09-06 |
2017-04-11 |
Curna Inc |
tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
|
WO2016011203A1
(fr)
|
2014-07-15 |
2016-01-21 |
Life Technologies Corporation |
Compositions comprenant des agrégats lipidiques et procédés d'administration efficace de molécules dans des cellules
|