IL104893A0 - Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them - Google Patents

Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL104893A0
IL104893A0 IL104893A IL10489393A IL104893A0 IL 104893 A0 IL104893 A0 IL 104893A0 IL 104893 A IL104893 A IL 104893A IL 10489393 A IL10489393 A IL 10489393A IL 104893 A0 IL104893 A0 IL 104893A0
Authority
IL
Israel
Prior art keywords
sulphonamido
carboxamides
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL104893A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IL12072793A priority Critical patent/IL120727A/en
Publication of IL104893A0 publication Critical patent/IL104893A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL104893A 1992-03-06 1993-03-01 Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them IL104893A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12072793A IL120727A (en) 1992-03-06 1993-03-01 History of N amidino piperidinyl methylamine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH72892 1992-03-06
CH18093 1993-01-21

Publications (1)

Publication Number Publication Date
IL104893A0 true IL104893A0 (en) 1993-07-08

Family

ID=25683792

Family Applications (3)

Application Number Title Priority Date Filing Date
IL104893A IL104893A0 (en) 1992-03-06 1993-03-01 Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them
IL12072793A IL120727A (en) 1992-03-06 1993-03-01 History of N amidino piperidinyl methylamine
IL12072797A IL120727A0 (en) 1992-03-06 1997-04-25 Guanidine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL12072793A IL120727A (en) 1992-03-06 1993-03-01 History of N amidino piperidinyl methylamine
IL12072797A IL120727A0 (en) 1992-03-06 1997-04-25 Guanidine derivatives

Country Status (24)

Country Link
US (4) US5405854A (id)
EP (1) EP0559046B1 (id)
JP (1) JPH0780848B2 (id)
CN (1) CN1076690A (id)
AT (1) ATE203013T1 (id)
AU (1) AU665230B2 (id)
BG (1) BG61506B1 (id)
CA (1) CA2089972C (id)
CZ (1) CZ286926B6 (id)
DE (1) DE59310186D1 (id)
DK (1) DK0559046T3 (id)
ES (1) ES2161217T3 (id)
FI (1) FI103880B (id)
GR (1) GR3036870T3 (id)
HU (2) HUT70156A (id)
IL (3) IL104893A0 (id)
IS (1) IS3983A (id)
MY (1) MY131303A (id)
NO (1) NO302818B1 (id)
NZ (1) NZ247014A (id)
PT (1) PT559046E (id)
RO (1) RO112863B1 (id)
RU (1) RU2133739C1 (id)
TW (1) TW223629B (id)

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TW223629B (id) * 1992-03-06 1994-05-11 Hoffmann La Roche
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US5610308A (en) * 1995-05-18 1997-03-11 Bristol-Myers Squibb Company Process for preparing intermediates for thrombin inhibitors
CA2224437A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
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US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
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JP6415559B2 (ja) * 2013-08-16 2018-10-31 ロス アラモス ナショナル セキュリティー, エルエルシーLos Alamos National Security, Llc 植物の性能を向上させるための化合物および方法
KR102116107B1 (ko) 2013-12-30 2020-05-28 삼성디스플레이 주식회사 표시 장치
USRE49816E1 (en) 2014-01-10 2024-01-30 Cornell University Dipeptides as inhibitors of human immunoproteasomes
JP6758282B2 (ja) 2014-08-18 2020-09-23 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ ヒト免疫プロテアソーム阻害剤としてのジペプチド模倣薬
CN114306297A (zh) 2015-10-15 2022-04-12 康奈尔大学 蛋白酶体抑制剂及其用途
EP3694605A4 (en) 2017-10-11 2021-10-27 Cornell University PEPTIDOMIMETIC PROTEASOME INHIBITORS

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Also Published As

Publication number Publication date
NO302818B1 (no) 1998-04-27
HU9300572D0 (en) 1993-05-28
CA2089972A1 (en) 1993-09-07
CZ34693A3 (en) 1993-12-15
EP0559046B1 (de) 2001-07-11
US5763604A (en) 1998-06-09
AU665230B2 (en) 1995-12-21
RO112863B1 (ro) 1998-01-30
BG97493A (bg) 1994-03-24
IS3983A (is) 1993-09-07
BG61506B1 (bg) 1997-10-31
DK0559046T3 (da) 2001-11-05
JPH0780848B2 (ja) 1995-08-30
PT559046E (pt) 2002-01-30
US5405854A (en) 1995-04-11
TW223629B (id) 1994-05-11
ES2161217T3 (es) 2001-12-01
US5677448A (en) 1997-10-14
NO930819D0 (no) 1993-03-05
HU211252A9 (en) 1995-11-28
GR3036870T3 (en) 2002-01-31
AU3391693A (en) 1993-09-09
DE59310186D1 (de) 2001-08-16
ATE203013T1 (de) 2001-07-15
FI930990A (fi) 1993-09-07
IL120727A0 (en) 1997-08-14
CZ286926B6 (en) 2000-08-16
JPH0625195A (ja) 1994-02-01
FI930990A0 (fi) 1993-03-05
CA2089972C (en) 1999-06-08
NZ247014A (en) 1995-11-27
MY131303A (en) 2007-08-30
CN1076690A (zh) 1993-09-29
NO930819L (no) 1993-09-07
FI103880B1 (fi) 1999-10-15
EP0559046A1 (de) 1993-09-08
IL120727A (en) 1998-08-16
RU2133739C1 (ru) 1999-07-27
HUT70156A (en) 1995-09-28
US5578594A (en) 1996-11-26
FI103880B (fi) 1999-10-15

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