IL101925A - Inhibitors of cathepsin g and elastase for preventing connective tissue degradation - Google Patents

Inhibitors of cathepsin g and elastase for preventing connective tissue degradation

Info

Publication number
IL101925A
IL101925A IL10192592A IL10192592A IL101925A IL 101925 A IL101925 A IL 101925A IL 10192592 A IL10192592 A IL 10192592A IL 10192592 A IL10192592 A IL 10192592A IL 101925 A IL101925 A IL 101925A
Authority
IL
Israel
Prior art keywords
val
ala
pro
seq
group
Prior art date
Application number
IL10192592A
Other languages
English (en)
Other versions
IL101925A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL101925A0 publication Critical patent/IL101925A0/xx
Publication of IL101925A publication Critical patent/IL101925A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Vehicle Body Suspensions (AREA)
  • Transceivers (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Dental Preparations (AREA)
IL10192592A 1991-05-23 1992-05-19 Inhibitors of cathepsin g and elastase for preventing connective tissue degradation IL101925A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70449991A 1991-05-23 1991-05-23

Publications (2)

Publication Number Publication Date
IL101925A0 IL101925A0 (en) 1992-12-30
IL101925A true IL101925A (en) 1996-03-31

Family

ID=24829789

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10192592A IL101925A (en) 1991-05-23 1992-05-19 Inhibitors of cathepsin g and elastase for preventing connective tissue degradation

Country Status (17)

Country Link
US (1) US5510333A (de)
EP (1) EP0587799B1 (de)
JP (1) JP3442075B2 (de)
AT (1) ATE181925T1 (de)
AU (1) AU655301B2 (de)
DE (1) DE69229552T2 (de)
DK (1) DK0587799T3 (de)
ES (1) ES2136091T3 (de)
FI (1) FI935172A7 (de)
GR (1) GR3031005T3 (de)
HU (1) HU217612B (de)
IL (1) IL101925A (de)
NO (1) NO934218D0 (de)
NZ (1) NZ242807A (de)
PT (1) PT100517B (de)
WO (1) WO1992020357A1 (de)
ZA (1) ZA923602B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
WO1993021221A1 (en) * 1992-04-10 1993-10-28 Abbott Laboratories Pulmonary surfactant protein fragments
JP2668003B2 (ja) * 1992-06-12 1997-10-27 ファイザー インク． ヒトの心臓キマーゼを含むアンギオテンシンｉキマーゼに関する阻害剤
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
PT912601E (pt) * 1996-04-22 2004-04-30 Massachusetts Inst Technology Supressao da resposta imune via inibicao da catepsina s
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2008054144A1 (en) * 2006-11-03 2008-05-08 Amorepacific Corporation Skin external composition containing cathepsin g inhibitors for preventing skin aging and the screening method for development of antiaging materials
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
AU2021289665A1 (en) 2020-06-10 2022-12-15 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CN118265527A (zh) 2021-10-20 2024-06-28 美莱奥生物制药第四有限公司 用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂
WO2024254398A2 (en) * 2023-06-07 2024-12-12 Redd Pharmaceuticals, Inc. Modulation of neutrophil activation and neutrophil extracellular trap (net) formation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230275A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
IL77748A (en) * 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
ATE71934T1 (de) * 1985-06-07 1992-02-15 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
EP0307662A3 (de) * 1987-08-24 1990-07-25 Kabushiki Kaisha Vitamin Kenkyusyo Enkephalin-Analoge
EP0356595A1 (de) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Peptidase-Hemmer
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
DE3938971A1 (de) * 1989-11-24 1991-05-29 Biotechnolog Forschung Gmbh Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat

Also Published As

Publication number Publication date
DK0587799T3 (da) 1999-11-22
FI935172L (fi) 1993-11-22
ZA923602B (en) 1993-02-24
EP0587799B1 (de) 1999-07-07
HU9303314D0 (en) 1994-03-28
PT100517A (pt) 1993-09-30
ES2136091T3 (es) 1999-11-16
US5510333A (en) 1996-04-23
EP0587799A4 (de) 1995-06-14
AU2184192A (en) 1992-12-30
EP0587799A1 (de) 1994-03-23
ATE181925T1 (de) 1999-07-15
HU217612B (hu) 2000-03-28
IL101925A0 (en) 1992-12-30
JPH06508355A (ja) 1994-09-22
FI935172A0 (fi) 1993-11-22
PT100517B (pt) 1999-06-30
WO1992020357A1 (en) 1992-11-26
AU655301B2 (en) 1994-12-15
NO934218L (no) 1993-11-22
GR3031005T3 (en) 1999-12-31
NZ242807A (en) 1994-07-26
HUT65140A (en) 1994-04-28
JP3442075B2 (ja) 2003-09-02
NO934218D0 (no) 1993-11-22
DE69229552T2 (de) 1999-12-23
FI935172A7 (fi) 1993-11-22
DE69229552D1 (de) 1999-08-12

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