IL101613A - Water-in-oil microemulsions that convert to oil-in- water emulsions upon the addition of water - Google Patents
Water-in-oil microemulsions that convert to oil-in- water emulsions upon the addition of waterInfo
- Publication number
- IL101613A IL101613A IL101613A IL10161392A IL101613A IL 101613 A IL101613 A IL 101613A IL 101613 A IL101613 A IL 101613A IL 10161392 A IL10161392 A IL 10161392A IL 101613 A IL101613 A IL 101613A
- Authority
- IL
- Israel
- Prior art keywords
- oil
- microemulsion
- water
- active material
- surfactant
- Prior art date
Links
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68769191A | 1991-04-19 | 1991-04-19 | |
US83734792A | 1992-02-14 | 1992-02-14 | |
US84193192A | 1992-02-25 | 1992-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL101613A true IL101613A (en) | 1998-02-22 |
Family
ID=27418494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL101613A IL101613A (en) | 1991-04-19 | 1992-04-16 | Water-in-oil microemulsions that convert to oil-in- water emulsions upon the addition of water |
Country Status (16)
Country | Link |
---|---|
US (3) | US5444041A (pt) |
EP (1) | EP0580778B1 (pt) |
JP (1) | JPH06507172A (pt) |
CN (1) | CN1066183A (pt) |
AT (1) | ATE183099T1 (pt) |
AU (1) | AU668509B2 (pt) |
CA (1) | CA2108266C (pt) |
DE (1) | DE69229779T2 (pt) |
DK (1) | DK0580778T3 (pt) |
ES (1) | ES2136620T3 (pt) |
GR (1) | GR3031718T3 (pt) |
IE (1) | IE921212A1 (pt) |
IL (1) | IL101613A (pt) |
MX (1) | MX9201816A (pt) |
PT (1) | PT100400B (pt) |
WO (1) | WO1992018147A1 (pt) |
Families Citing this family (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992018147A1 (en) * | 1991-04-19 | 1992-10-29 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
EP0671937A4 (en) * | 1992-10-16 | 1996-09-18 | Smithkline Beecham Corp | COMPOSITIONS FOR PHARMACEUTICAL EMULSIONS. |
WO1994008603A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Compositions |
WO1994008605A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Therapeutic microemulsions |
AU679013B2 (en) * | 1992-10-16 | 1997-06-19 | Ibah, Inc. | Convertible microemulsion formulations |
DK17093D0 (da) * | 1993-02-15 | 1993-02-15 | Lyfjathroun H F | Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder |
JPH06279228A (ja) * | 1993-03-30 | 1994-10-04 | Kao Corp | 発泡性組成物 |
US5948825A (en) * | 1993-04-19 | 1999-09-07 | Institute For Advanced Skin Research Inc. | Microemulsion preparation containing a slightly absorbable substance |
US6191105B1 (en) * | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
EP0721380B1 (en) * | 1993-09-29 | 1999-05-26 | Technobiochip | Protein thin films and compositions for use in their preparation |
DE4335045A1 (de) * | 1993-10-14 | 1995-04-20 | Henkel Kgaa | Fließfähiges Emulsionskonzentrat |
JPH09510182A (ja) * | 1993-11-17 | 1997-10-14 | エルディーエス・テクノロジーズ・インコーポレーテッド | カプセル封入されたドラッグデリバリー用透明液 |
JP4157969B2 (ja) * | 1994-03-18 | 2008-10-01 | スパーナス ファーマシューティカルズ インコーポレイテッド | 乳化薬物送達システム |
GB9412394D0 (en) * | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
US5672358A (en) * | 1994-06-21 | 1997-09-30 | Ascent Pharmaceuticals, Inc. | Controlled release aqueous emulsion |
JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
US5707641A (en) * | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
JPH11500914A (ja) | 1995-02-25 | 1999-01-26 | インペリアル キャンサー リサーチ テクノロジィ リミテッド | 乾癬モデルとしての形質転換動物 |
DE19509079A1 (de) * | 1995-03-15 | 1996-09-19 | Beiersdorf Ag | Kosmetische oder dermatologische Mikroemulsionen |
FR2733151B1 (fr) | 1995-04-20 | 1997-05-23 | Seppic Sa | Composition therapeutique comprenant un antigene ou un generateur in vivo d'un compose comprenant une sequence d'acides amines |
US6689370B1 (en) | 1995-04-20 | 2004-02-10 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
US6117432A (en) * | 1995-04-20 | 2000-09-12 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
US6008228A (en) * | 1995-06-06 | 1999-12-28 | Hoffman-La Roche Inc. | Pharmaceutical compositions containing proteinase inhibitors |
US5766636A (en) * | 1995-09-06 | 1998-06-16 | Natura, Inc. | Edible, low calorie compositions of a carrier and an active ingredient and methods for preparation thereof |
SE9503143D0 (sv) | 1995-09-12 | 1995-09-12 | Astra Ab | New preparation |
TW410158B (en) * | 1995-11-30 | 2000-11-01 | Chemo Sero Therapeut Res Inst | Oil adjuvant vaccine and method for preparing same |
US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
AU1671197A (en) * | 1996-02-13 | 1997-09-02 | Nisshin Oil Mills, Ltd., The | Vaccine-containing emulsion and vaccine-containing powder for oral administration and process for producing the same |
US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US6197333B1 (en) | 1996-03-28 | 2001-03-06 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved liposome compositions |
US5726154A (en) * | 1996-06-28 | 1998-03-10 | University Of Utah Research Foundation | Stabilization and oral delivery of calcitonin |
EP0826766B2 (en) * | 1996-08-30 | 2011-07-20 | Ajinomoto Co., Inc. | Wash composition |
AU4491697A (en) * | 1996-09-27 | 1998-04-17 | Trega Biosciences, Inc. | Compositions of therapeutic agents suitable for oral administration |
SE511313C2 (sv) | 1997-01-13 | 1999-09-06 | Gs Dev Ab | Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US7585645B2 (en) * | 1997-05-27 | 2009-09-08 | Sembiosys Genetics Inc. | Thioredoxin and thioredoxin reductase containing oil body based products |
IS4518A (is) * | 1997-07-09 | 1999-01-10 | Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group | Nýtt lyfjaform fyrir bóluefni |
US6217886B1 (en) | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
FR2767064B1 (fr) * | 1997-08-07 | 1999-11-12 | Centre Nat Rech Scient | Procede de liberation d'un principe actif contenu dans une emulsion multiple |
US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US6024786A (en) * | 1997-10-30 | 2000-02-15 | Hewlett-Packard Company | Stable compositions of nano-particulate unmodified pigments and insoluble colorants in aqueous microemulsions, and principle of stability and methods of formation thereof |
US20020031513A1 (en) * | 1997-11-24 | 2002-03-14 | Shamir Leibovitz | Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals |
US6017545A (en) * | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
US6221378B1 (en) | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
DE19806889A1 (de) * | 1998-02-19 | 1999-08-26 | Beiersdorf Ag | Verwendung von Acyl-Carnitin |
US20030180368A1 (en) * | 1998-03-14 | 2003-09-25 | Cenes Drug Delivery Limited | Production of microparticles |
TWI241915B (en) | 1998-05-11 | 2005-10-21 | Ciba Sc Holding Ag | A method of preparing a pharmaceutical end formulation using a nanodispersion |
US8466134B1 (en) | 1998-06-26 | 2013-06-18 | Athena Neurosciences, Inc. | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
US6241969B1 (en) | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
FR2780644B1 (fr) * | 1998-07-03 | 2001-07-20 | Oreal | Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse et d'une phase aqueuse, stabilisee a l'aide de particules de gel cubique |
EP0976394A1 (en) * | 1998-07-30 | 2000-02-02 | Biosearch Italia S.p.A. | New injectable formulations |
CA2339991C (en) | 1998-08-13 | 2007-01-02 | Cima Labs Inc. | Microemulsions as solid dosage forms for oral administration |
US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
DE19859427A1 (de) * | 1998-12-22 | 2000-06-29 | Beiersdorf Ag | Kosmetische oder pharmazeutische lecithinhaltige Gele oder niedrigviskose, lecithinhaltige O/W-Mikroemulsionen |
GB9903547D0 (en) * | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
EP1064934A1 (en) * | 1999-06-30 | 2001-01-03 | Applied Research Systems ARS Holding N.V. | GRF-containing lyophilized pharmaceutical composition |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
GB0005736D0 (en) * | 2000-03-09 | 2000-05-03 | G C Hahn Co Ltd | Low fat edible emulsions |
DE10015463B4 (de) * | 2000-03-29 | 2008-01-10 | Heide, Peter Edgar, Dr. | Creme in Form einer überwässerten Wasser-in-Öl-Emulsion |
JP2003535905A (ja) * | 2000-06-21 | 2003-12-02 | フェリング ベスローテン フェンノートシャップ | 可溶化されたタンパク質ワクチン |
US20100129332A1 (en) * | 2000-07-31 | 2010-05-27 | Tamar Tennenbaum | Methods and pharmaceutical compositions for healing wounds |
DK1383540T3 (da) | 2000-07-31 | 2009-08-24 | Univ Bar Ilan | Fremgangsmdåer og farmaceutiske sammensætninger til sårheling |
US20030148924A1 (en) * | 2002-07-09 | 2003-08-07 | Tamar Tennenbaum | Methods and pharmaceutical compositions of healing wounds |
US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
US6582682B2 (en) * | 2000-10-30 | 2003-06-24 | Noville, Inc. | Oral care compositions comprising stabilized chlorine dioxide |
CN1406131A (zh) * | 2000-12-25 | 2003-03-26 | 株式会社资生堂 | 活化交感神经的香料组合物 |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
AU2002367976B2 (en) * | 2001-06-05 | 2007-06-21 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
WO2003047494A2 (en) * | 2001-12-03 | 2003-06-12 | Dor Biopharma Inc. | Reverse micelle compositions and uses thereof |
AU2002362039B2 (en) * | 2001-12-03 | 2007-07-26 | Soligenix, Inc | Stabilized reverse micelle compositions and uses thereof |
AU2003215885B2 (en) * | 2002-02-25 | 2008-07-03 | Lyfjathroun Hf | Absorption enhancing agent |
US20050124705A1 (en) * | 2002-03-28 | 2005-06-09 | Beiersdorf Ag | Cosmetic or pharmaceutical, low-viscosity oil-in-water emulsions containing phospholipids |
AU2003223005A1 (en) * | 2002-05-06 | 2003-11-17 | Vectura Limited | Application device for topical administration of pharmaceutical agents |
WO2003105768A2 (en) * | 2002-06-13 | 2003-12-24 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
DE10226990A1 (de) * | 2002-06-18 | 2004-03-18 | Sanguibiotech Ag | Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff |
CA2430889A1 (en) * | 2002-06-19 | 2003-12-19 | Bayer Corporation | Stabilization of brain natriuretic peptide (bnp) in blood samples, methods and compositions related thereto |
US6855332B2 (en) | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
US20040115226A1 (en) * | 2002-12-12 | 2004-06-17 | Wenji Li | Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same |
US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
KR100515752B1 (ko) * | 2003-05-16 | 2005-09-20 | 주식회사 엘지화학 | 초임계 유체를 이용한 스티렌과 말레이미드 공중합체의제조 방법 |
US7291501B2 (en) | 2003-07-16 | 2007-11-06 | Abbott Laboratories | Stable compositions for measuring human natriuretic peptides |
US7445933B2 (en) * | 2003-07-16 | 2008-11-04 | Abbott Laboratories, Inc. | Stable calibrators or controls for measuring human natriuretic peptides |
US7004340B2 (en) * | 2003-07-25 | 2006-02-28 | Alpha Security Products, Inc. | Bottle security device |
ZA200601089B (en) | 2003-08-07 | 2007-05-30 | Hearlor Ltd | Pharmaceutical compositions and methods for accelerating wound healing |
US9259390B2 (en) * | 2003-08-13 | 2016-02-16 | The University Of Houston System | Parenteral and oral formulations of benzimidazoles |
EP1677762A1 (en) | 2003-10-27 | 2006-07-12 | Dow Corning Corporation | A controlled-release composition for topical application and a method of delivering an active agent to a substrate |
CA2537029C (en) * | 2003-11-26 | 2013-03-12 | Likan Liang | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
PE20050596A1 (es) * | 2003-12-19 | 2005-10-18 | Novartis Ag | Microemulsion que comprende un inhibidor renina |
US20050232974A1 (en) * | 2004-04-19 | 2005-10-20 | Gore Makarand P | System and a method for pharmaceutical dosage preparation using jettable microemulsions |
WO2005105040A2 (en) * | 2004-04-26 | 2005-11-10 | Micelle Products, Inc. | Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications |
US7357957B2 (en) * | 2004-05-07 | 2008-04-15 | Fractec Research & Development Inc. | Spreadable food product |
US20070093610A1 (en) * | 2004-05-12 | 2007-04-26 | Kim Dong R | Method for preparing styrene and maleimide copolymer using super critical fluid |
AU2005269753B2 (en) | 2004-07-19 | 2011-08-18 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
US20060078623A1 (en) * | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
EA200700440A1 (ru) * | 2004-09-13 | 2008-02-28 | Бхарат Сирумс Энд Вэксинс Лтд. | Композиции стабильных эмульсий для внутривенного введения, имеющие защитную эффективность |
DE102004049574A1 (de) | 2004-10-12 | 2006-04-20 | Doris Dr. Barnikol-Keuten | Arzneimittel und System zur perkutanen Arzneistoffverabreichung |
EP1844789B8 (en) * | 2005-01-19 | 2014-10-08 | Sumitomo Dainippon Pharma Co., Ltd. | Emulsified composition for dilution and cancer vaccine composition |
US20060205904A1 (en) * | 2005-03-11 | 2006-09-14 | St Clair David J | Oil gels of controlled distribution block copolymers and ester oils |
KR20080009201A (ko) | 2005-04-15 | 2008-01-25 | 클라루스 쎄러퓨틱스, 아이엔씨. | 소수성 약물의 약물전달시스템 및 이를 포함하는 조성물 |
US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
AU2006272780A1 (en) * | 2005-07-22 | 2007-02-01 | The Regents Of The University Of California | Heparin compostions and selectin inhibition |
US20070042007A1 (en) * | 2005-08-19 | 2007-02-22 | Joseph Schwarz | Topical composition for delivery of salicylate esters |
ZA200802546B (en) * | 2005-08-29 | 2009-10-28 | Healor Ltd | Methods and compositions for prvention and treatment of diabetic and aged skin |
DOP2006000267A (es) | 2005-11-30 | 2009-06-30 | Colgate Palmalive Company | Composiciones y métodos de limpieza |
EP1978997A1 (en) * | 2005-12-22 | 2008-10-15 | Apollo Life Sciences Limited | Transdermal delivery of pharmaceutical agents |
EP2526950A1 (en) * | 2006-04-07 | 2012-11-28 | Merrion Research III Limited | Solid oral dosage form containing an enhancer |
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
US9918934B2 (en) * | 2006-12-12 | 2018-03-20 | Edgar Joel Acosta-Zara | Linker-based lecithin microemulsion delivery vehicles |
US7968635B2 (en) * | 2006-12-28 | 2011-06-28 | Continental Ag | Tire compositions and components containing free-flowing filler compositions |
FR2915101B1 (fr) * | 2007-04-23 | 2011-07-29 | Fabre Pierre Dermo Cosmetique | Composition dermatologique pour la prevention et/ou le traitement de la rosacee, de la couperose ou des peaux qui presentent des rougeurs diffuses ou des petits vaisseaux dilates |
AU2008281374B2 (en) * | 2007-07-30 | 2012-05-31 | Healor Ltd. | Pharmaceutical composition for treating wounds and related methods |
KR101503474B1 (ko) * | 2007-09-27 | 2015-03-18 | 리켄 비타민 가부시키가이샤 | 연질 캅셀 충전용 액상 조성물 |
JP5156458B2 (ja) * | 2008-03-31 | 2013-03-06 | 理研ビタミン株式会社 | ソフトカプセル充填用液状組成物 |
PT2203181T (pt) | 2007-10-16 | 2018-05-10 | Biocon Ltd | Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico |
US20100279934A1 (en) * | 2008-01-02 | 2010-11-04 | Kringle Pharma, Inc. | Topical compositions for delivery of proteins and peptides |
KR20110007614A (ko) * | 2008-05-07 | 2011-01-24 | 메리온 리서치 Ⅲ 리미티드 | GnRH 관련 화합물의 조성물 및 제조 방법 |
US20100004196A1 (en) * | 2008-06-17 | 2010-01-07 | Hopitaux Universitaires De Geneve | Heparan sulfate proteoglycan composition and use thereof |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
ES2601827T3 (es) * | 2009-02-24 | 2017-02-16 | Arava Bio-Tech Ltd. | Agentes antagonistas de visfatina para el tratamiento del acné y de otras afecciones |
TWI480286B (zh) * | 2009-02-25 | 2015-04-11 | Merrion Res Iii Ltd | 雙膦酸鹽類組合物及藥物遞送 |
SI2475384T1 (sl) * | 2009-09-10 | 2016-12-30 | Merial, Inc. | Nove formulacije cepiva, ki obsegajo adjuvante, vsebujoče saponin |
NZ601109A (en) * | 2009-12-10 | 2014-06-27 | Merck Patent Gmbh | Pharmaceutical composition comprising oligopeptides, preferably cilengitide |
JP2013516500A (ja) | 2010-01-11 | 2013-05-13 | ヒールオア・リミテッド | 炎症性疾患および障害を治療するための方法 |
KR20120117013A (ko) | 2010-01-12 | 2012-10-23 | 노보 노르디스크 에이/에스 | 인슐린 펩티드의 경구 투여를 위한 약학적 조성물 |
US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
WO2011120033A1 (en) * | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
FR2964332A1 (fr) * | 2010-09-06 | 2012-03-09 | Capsum | Nanodispersions inverses stables |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
CA2813088C (en) | 2010-12-01 | 2019-05-14 | Omnis Biotechnology Inc. | Thixotropic compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
CN103476419A (zh) | 2011-01-07 | 2013-12-25 | 梅里翁第三研究有限公司 | 口服投药的含铁药物组合物 |
GB201107630D0 (en) * | 2011-05-06 | 2011-06-22 | Proxima Concepts Ltd | Microemulsions |
KR102196009B1 (ko) | 2011-10-25 | 2021-01-04 | 프로테나 바이오사이언시즈 리미티드 | 항체 제형 및 방법 |
US11458096B2 (en) | 2014-04-09 | 2022-10-04 | Pulse Pharmaceuticals Pvt. Ltd. | Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base |
EP2946788A1 (en) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
WO2016033556A1 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
EP3250191B1 (en) | 2015-01-29 | 2024-01-17 | Novo Nordisk A/S | Tablets comprising glp-1 agonist and enteric coating |
US9872832B2 (en) * | 2015-10-23 | 2018-01-23 | LG Bionano, LLC | Nanoemulsions having reversible continuous and dispersed phases |
RU2731643C1 (ru) * | 2016-09-16 | 2020-09-07 | Кемин Индастриз, Инк. | Кормовая добавка для животных |
US20180147215A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
KR101786914B1 (ko) * | 2017-01-31 | 2017-11-15 | 주식회사 삼양사 | 피부 리프팅 또는 탄력 개선을 위한 점착성 탄력 밴드 |
CN112915916B (zh) * | 2021-01-29 | 2022-05-24 | 江南大学 | 一种pH刺激响应型胆汁盐Pickering复合乳化剂 |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US962957A (en) * | 1909-03-26 | 1910-06-28 | Albert G Hermanson | Mole-plow. |
US962956A (en) * | 1909-10-02 | 1910-06-28 | Almon E Hall | Coin-mailing device. |
US3083142A (en) * | 1958-02-27 | 1963-03-26 | Glaxo Group Ltd | Improved swine erysipelas vaccine |
US3100178A (en) * | 1961-08-31 | 1963-08-06 | Parke Davis & Co | Vaccine products and method of preparing same |
US3149036A (en) * | 1961-10-16 | 1964-09-15 | Merck & Co Inc | Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent |
US3438782A (en) * | 1965-01-18 | 1969-04-15 | Vitamins Inc | Edible oil supplement for feed ration |
US3492399A (en) * | 1965-09-27 | 1970-01-27 | Samuel J Prigal | Emulsion compositions and methods |
GB1171125A (en) * | 1966-06-08 | 1969-11-19 | Glaxo Lab Ltd | Improvements in or relating to Injectable Preparations |
US3776857A (en) * | 1971-09-24 | 1973-12-04 | Witco Chemical Corp | Water-in-oil emulsions |
US3983228A (en) * | 1973-08-28 | 1976-09-28 | Merck & Co., Inc. | Water-in-oil adjuvant composition |
DE2514873C2 (de) * | 1975-04-05 | 1983-12-29 | Merck Patent Gmbh, 6100 Darmstadt | Salbengrundlage |
FR2321896A1 (fr) * | 1975-08-29 | 1977-03-25 | Anvar | Agents adjuvants immunologiques actifs en solution aqueuse |
US4122158A (en) * | 1976-09-23 | 1978-10-24 | Alza Corporation | Topical therapeutic preparations |
JPS5940137B2 (ja) * | 1976-10-14 | 1984-09-28 | 武田薬品工業株式会社 | 経口投与用医薬組成物 |
US4104403A (en) * | 1976-12-21 | 1978-08-01 | Witco Chemical Corporation | Water-oil emulsions and method of preparing same |
US4183918A (en) * | 1977-03-08 | 1980-01-15 | Exxon Research & Engineering Co. | Detoxifying-medicinal emulsions |
US4241051A (en) * | 1977-11-04 | 1980-12-23 | Christie Robert B | Calcitonin |
US4395394A (en) * | 1979-10-26 | 1983-07-26 | Pfizer Inc. | Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants |
CH653362A5 (fr) * | 1980-09-19 | 1985-12-31 | Elf Aquitaine | Procede de culture de microorganismes avec l'emploi de substances nutritives. |
FR2502951B1 (fr) * | 1981-04-06 | 1985-12-06 | Sandoz Sa | Compositions pharmaceutiques topiques sous forme d'une micro-emulsion |
EP0073856A1 (en) * | 1981-08-28 | 1983-03-16 | Gist-Brocades N.V. | Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines, process for preventing infectious bronchitis and infectious-bronchitis virus strain |
NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
US4731384A (en) * | 1983-07-01 | 1988-03-15 | Troponwerke Gmbh & Co, Kg | Etofenamate formulation |
JPS6061535A (ja) * | 1983-08-24 | 1985-04-09 | エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト | 製薬学的組成物 |
US4692433A (en) * | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
DE3339236A1 (de) * | 1983-10-28 | 1985-05-09 | Bayer Ag | Arzneimittelzubereitung |
DE3406497A1 (de) * | 1984-02-23 | 1985-09-05 | Mueller Bernhard Willi Werner | Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung |
JPS60199833A (ja) * | 1984-03-26 | 1985-10-09 | Meiji Milk Prod Co Ltd | 医薬品、化粧品等用w/o/w型複合エマルジヨンの製造法 |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
CH662944A5 (it) * | 1984-10-18 | 1987-11-13 | Pier Luigi Prof Dr Luisi | Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione. |
GB8426467D0 (en) * | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
JPS61185332A (ja) * | 1985-02-12 | 1986-08-19 | Morinaga Milk Ind Co Ltd | 安定な油中水型乳化物およびその製造法 |
US4690774A (en) * | 1985-09-11 | 1987-09-01 | Chesebrough Pond's Inc. | Novel translucent water in oil emulsions |
US4980084A (en) * | 1985-09-11 | 1990-12-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Water rinsable petroleum jelly compositions |
US5036045A (en) * | 1985-09-12 | 1991-07-30 | The University Of Virginia Alumni Patents Foundation | Method for increasing growth hormone secretion |
US4797272A (en) * | 1985-11-15 | 1989-01-10 | Eli Lilly And Company | Water-in-oil microemulsions for cosmetic uses |
US4781914A (en) * | 1985-12-04 | 1988-11-01 | Charles Of The Ritz Group Ltd. | Sunscreen and moisturizer |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
JPS62270521A (ja) * | 1986-05-16 | 1987-11-24 | Green Cross Corp:The | フルルビプロフエン眼投与製剤 |
US5371109A (en) * | 1986-07-01 | 1994-12-06 | Drilletten Ab | Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase |
SE457693B (sv) * | 1986-07-01 | 1989-01-23 | Drilletten Ab | Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas |
ES2039219T3 (es) * | 1986-08-11 | 1993-09-16 | American Cyanamid Company | Composiciones para administracion parenteral y su uso. |
GB8630273D0 (en) * | 1986-12-18 | 1987-01-28 | Til Medical Ltd | Pharmaceutical delivery systems |
IE60024B1 (en) * | 1987-02-03 | 1994-05-18 | Stiefel Laboratories Ltd | Microemulsions |
CA1301642C (en) * | 1987-03-30 | 1992-05-26 | Howard Bernard Dawson | Chemical formulations |
US4720353A (en) * | 1987-04-14 | 1988-01-19 | Richardson-Vicks Inc. | Stable pharmaceutical w/o emulsion composition |
US5064653A (en) * | 1988-03-29 | 1991-11-12 | Ferris Mfg. Co. | Hydrophilic foam compositions |
US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
US5036108A (en) * | 1988-12-14 | 1991-07-30 | Kao Corporation | Water-in-oil emulsion cosmetic |
KR910004884B1 (ko) * | 1989-02-01 | 1991-07-15 | 한국식품개발연구원 | 유지류의 산화억제방법 |
US5002771A (en) * | 1989-02-06 | 1991-03-26 | Rorer Pharmaceutical Corp. | Calcitonin suppository formulations |
DE3919982A1 (de) * | 1989-06-19 | 1990-12-20 | Liedtke Pharmed Gmbh | Orale lipidarzneiform |
JP2785981B2 (ja) * | 1989-11-20 | 1998-08-13 | 株式会社資生堂 | 乳化組成物 |
US5045337A (en) * | 1990-04-19 | 1991-09-03 | The Procter & Gamble Company | Food microemulsion |
US5162378A (en) * | 1990-04-20 | 1992-11-10 | Revlon Consumer Products Corporation | Silicone containing water-in-oil microemulsions having increased salt content |
US5110606A (en) * | 1990-11-13 | 1992-05-05 | Affinity Biotech, Inc. | Non-aqueous microemulsions for drug delivery |
WO1992018147A1 (en) * | 1991-04-19 | 1992-10-29 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
IL102633A0 (en) * | 1991-07-26 | 1993-01-14 | Smithkline Beecham Corp | Compositions |
DE69216836T2 (de) * | 1991-07-26 | 1997-06-12 | Smithkline Beecham Corp | W/o mikroemulsionen |
WO1993006921A1 (en) * | 1991-10-04 | 1993-04-15 | Gs Biochem Ab | Particles, method of preparing said particles and uses thereof |
US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
EP0671937A4 (en) * | 1992-10-16 | 1996-09-18 | Smithkline Beecham Corp | COMPOSITIONS FOR PHARMACEUTICAL EMULSIONS. |
WO1994008603A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Compositions |
WO1994008605A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Therapeutic microemulsions |
-
1992
- 1992-04-15 WO PCT/US1992/003086 patent/WO1992018147A1/en active IP Right Grant
- 1992-04-15 DK DK92911731T patent/DK0580778T3/da active
- 1992-04-15 IE IE121292A patent/IE921212A1/en not_active IP Right Cessation
- 1992-04-15 EP EP92911731A patent/EP0580778B1/en not_active Expired - Lifetime
- 1992-04-15 AT AT92911731T patent/ATE183099T1/de active
- 1992-04-15 JP JP4511743A patent/JPH06507172A/ja not_active Ceased
- 1992-04-15 DE DE69229779T patent/DE69229779T2/de not_active Expired - Lifetime
- 1992-04-15 CA CA002108266A patent/CA2108266C/en not_active Expired - Lifetime
- 1992-04-15 AU AU18966/92A patent/AU668509B2/en not_active Expired
- 1992-04-15 ES ES92911731T patent/ES2136620T3/es not_active Expired - Lifetime
- 1992-04-16 PT PT100400A patent/PT100400B/pt not_active IP Right Cessation
- 1992-04-16 IL IL101613A patent/IL101613A/en not_active IP Right Cessation
- 1992-04-18 CN CN92102762A patent/CN1066183A/zh active Pending
- 1992-04-20 MX MX9201816A patent/MX9201816A/es unknown
- 1992-05-20 US US07/885,202 patent/US5444041A/en not_active Expired - Lifetime
-
1995
- 1995-04-20 US US08/425,475 patent/US5646109A/en not_active Expired - Lifetime
- 1995-04-20 US US08/425,787 patent/US5633226A/en not_active Expired - Lifetime
-
1999
- 1999-11-03 GR GR990402810T patent/GR3031718T3/el unknown
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AU668509B2 (en) | 1996-05-09 |
ATE183099T1 (de) | 1999-08-15 |
DE69229779D1 (de) | 1999-09-16 |
US5646109A (en) | 1997-07-08 |
JPH06507172A (ja) | 1994-08-11 |
IE921212A1 (en) | 1992-10-21 |
WO1992018147A1 (en) | 1992-10-29 |
CA2108266A1 (en) | 1992-10-20 |
ES2136620T3 (es) | 1999-12-01 |
US5633226A (en) | 1997-05-27 |
DE69229779T2 (de) | 1999-12-23 |
DK0580778T3 (da) | 2000-01-31 |
US5444041A (en) | 1995-08-22 |
PT100400B (pt) | 1999-08-31 |
GR3031718T3 (en) | 2000-02-29 |
CN1066183A (zh) | 1992-11-18 |
CA2108266C (en) | 2003-06-03 |
EP0580778A4 (en) | 1996-01-31 |
EP0580778A1 (en) | 1994-02-02 |
PT100400A (pt) | 1993-08-31 |
EP0580778B1 (en) | 1999-08-11 |
AU1896692A (en) | 1992-11-17 |
MX9201816A (es) | 1992-10-30 |
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