IL100416A - תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש - Google Patents
תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכשInfo
- Publication number
- IL100416A IL100416A IL10041691A IL10041691A IL100416A IL 100416 A IL100416 A IL 100416A IL 10041691 A IL10041691 A IL 10041691A IL 10041691 A IL10041691 A IL 10041691A IL 100416 A IL100416 A IL 100416A
- Authority
- IL
- Israel
- Prior art keywords
- amino
- nitro
- carboxylic acid
- compound
- phenylpropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63357290A | 1990-12-21 | 1990-12-21 | |
| US77762591A | 1991-10-23 | 1991-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL100416A0 IL100416A0 (en) | 1992-09-06 |
| IL100416A true IL100416A (he) | 1995-11-27 |
Family
ID=27091923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10041691A IL100416A (he) | 1990-12-21 | 1991-12-18 | תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0492369B1 (he) |
| JP (1) | JP3112327B2 (he) |
| KR (2) | KR100220880B1 (he) |
| CN (1) | CN1040985C (he) |
| AT (1) | ATE158303T1 (he) |
| AU (1) | AU642321B2 (he) |
| CA (1) | CA2057786C (he) |
| DE (1) | DE69127681T2 (he) |
| DK (1) | DK0492369T3 (he) |
| ES (1) | ES2108027T3 (he) |
| FI (1) | FI95800C (he) |
| GR (1) | GR3025622T3 (he) |
| HU (1) | HU210167B (he) |
| IE (1) | IE914507A1 (he) |
| IL (1) | IL100416A (he) |
| NO (1) | NO180196C (he) |
| NZ (1) | NZ241023A (he) |
| PT (1) | PT99849B (he) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| ATE155143T1 (de) * | 1991-09-27 | 1997-07-15 | Merrell Pharma Inc | 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
| DK0640086T3 (da) * | 1992-05-15 | 1999-12-06 | Merrell Pharma Inc | Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer |
| CA2146238C (en) * | 1992-10-30 | 2001-03-13 | Gary A. Flynn | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| EP0750631B1 (en) * | 1994-02-14 | 2000-04-05 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| ES2168355T3 (es) * | 1994-02-14 | 2002-06-16 | Merrell Pharma Inc | Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa. |
| US5750521A (en) * | 1994-02-14 | 1998-05-12 | Hoechst Marion Roussel Inc. | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE |
| EP0746566A1 (en) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| PT751783E (pt) * | 1994-03-24 | 2000-05-31 | Merrell Pharma Inc | Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos |
| CN1144482A (zh) * | 1994-03-24 | 1997-03-05 | 默里尔药物公司 | 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物 |
| MX9704677A (es) * | 1994-12-21 | 1997-09-30 | Hoechst Marion Roussel Inc | Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios. |
| US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| US7078225B2 (en) | 2000-06-02 | 2006-07-18 | Nippon Shokubai Co., Ltd. | Method for enzymatically producing an optically active cyanohydrin |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
| CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
| AU636101B2 (en) * | 1987-04-10 | 1993-04-22 | Monash University | 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues |
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
-
1991
- 1991-12-17 CA CA002057786A patent/CA2057786C/en not_active Expired - Fee Related
- 1991-12-17 AT AT91121638T patent/ATE158303T1/de not_active IP Right Cessation
- 1991-12-17 NZ NZ241023A patent/NZ241023A/en unknown
- 1991-12-17 ES ES91121638T patent/ES2108027T3/es not_active Expired - Lifetime
- 1991-12-17 AU AU89819/91A patent/AU642321B2/en not_active Ceased
- 1991-12-17 DE DE69127681T patent/DE69127681T2/de not_active Expired - Fee Related
- 1991-12-17 DK DK91121638.0T patent/DK0492369T3/da active
- 1991-12-17 EP EP91121638A patent/EP0492369B1/en not_active Expired - Lifetime
- 1991-12-18 PT PT99849A patent/PT99849B/pt not_active IP Right Cessation
- 1991-12-18 IL IL10041691A patent/IL100416A/he not_active IP Right Cessation
- 1991-12-19 FI FI916017A patent/FI95800C/fi active IP Right Grant
- 1991-12-20 CN CN91111735A patent/CN1040985C/zh not_active Expired - Fee Related
- 1991-12-20 JP JP03354999A patent/JP3112327B2/ja not_active Expired - Fee Related
- 1991-12-20 IE IE450791A patent/IE914507A1/en not_active IP Right Cessation
- 1991-12-20 KR KR1019910023702A patent/KR100220880B1/ko not_active IP Right Cessation
- 1991-12-20 HU HU914092A patent/HU210167B/hu not_active IP Right Cessation
- 1991-12-20 NO NO915068A patent/NO180196C/no unknown
-
1997
- 1997-12-10 GR GR970403274T patent/GR3025622T3/el unknown
-
1999
- 1999-03-27 KR KR1019990010649A patent/KR100220879B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU914092D0 (en) | 1992-03-30 |
| NO915068L (no) | 1992-06-22 |
| IL100416A0 (en) | 1992-09-06 |
| CN1040985C (zh) | 1998-12-02 |
| CA2057786A1 (en) | 1992-06-22 |
| EP0492369B1 (en) | 1997-09-17 |
| KR920012082A (ko) | 1992-07-25 |
| DE69127681T2 (de) | 1998-01-15 |
| IE914507A1 (en) | 1992-07-01 |
| JPH04342588A (ja) | 1992-11-30 |
| AU642321B2 (en) | 1993-10-14 |
| DK0492369T3 (da) | 1997-10-13 |
| FI916017A0 (fi) | 1991-12-19 |
| KR100220879B1 (ko) | 2000-03-15 |
| DE69127681D1 (de) | 1997-10-23 |
| HUT60271A (en) | 1992-08-28 |
| EP0492369A1 (en) | 1992-07-01 |
| FI95800C (fi) | 1996-03-25 |
| JP3112327B2 (ja) | 2000-11-27 |
| GR3025622T3 (en) | 1998-03-31 |
| FI95800B (fi) | 1995-12-15 |
| NO915068D0 (no) | 1991-12-20 |
| NO180196B (no) | 1996-11-25 |
| PT99849A (pt) | 1992-11-30 |
| ATE158303T1 (de) | 1997-10-15 |
| NZ241023A (en) | 1994-10-26 |
| AU8981991A (en) | 1992-06-25 |
| FI916017A (fi) | 1992-06-22 |
| CN1062729A (zh) | 1992-07-15 |
| NO180196C (no) | 1997-03-05 |
| KR100220880B1 (ko) | 1999-09-15 |
| HU210167B (en) | 1995-02-28 |
| CA2057786C (en) | 2002-06-18 |
| PT99849B (pt) | 1999-06-30 |
| ES2108027T3 (es) | 1997-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |