IL100416A - תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש - Google Patents

תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש

Info

Publication number
IL100416A
IL100416A IL10041691A IL10041691A IL100416A IL 100416 A IL100416 A IL 100416A IL 10041691 A IL10041691 A IL 10041691A IL 10041691 A IL10041691 A IL 10041691A IL 100416 A IL100416 A IL 100416A
Authority
IL
Israel
Prior art keywords
amino
nitro
carboxylic acid
compound
phenylpropyl
Prior art date
Application number
IL10041691A
Other languages
English (en)
Other versions
IL100416A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL100416A0 publication Critical patent/IL100416A0/xx
Publication of IL100416A publication Critical patent/IL100416A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL10041691A 1990-12-21 1991-12-18 תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש IL100416A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63357290A 1990-12-21 1990-12-21
US77762591A 1991-10-23 1991-10-23

Publications (2)

Publication Number Publication Date
IL100416A0 IL100416A0 (en) 1992-09-06
IL100416A true IL100416A (he) 1995-11-27

Family

ID=27091923

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10041691A IL100416A (he) 1990-12-21 1991-12-18 תולדות בנזאזפין טריציקליות המכילות קבוצת 7-])1-קרבוקסי- 3- פנילפרופיל(אמינו[ -b ,211,2,3,4,6,7,8-אוקטאהידרו- 6- אוקסו-אמינו או ניטרו ותכש

Country Status (18)

Country Link
EP (1) EP0492369B1 (he)
JP (1) JP3112327B2 (he)
KR (2) KR100220880B1 (he)
CN (1) CN1040985C (he)
AT (1) ATE158303T1 (he)
AU (1) AU642321B2 (he)
CA (1) CA2057786C (he)
DE (1) DE69127681T2 (he)
DK (1) DK0492369T3 (he)
ES (1) ES2108027T3 (he)
FI (1) FI95800C (he)
GR (1) GR3025622T3 (he)
HU (1) HU210167B (he)
IE (1) IE914507A1 (he)
IL (1) IL100416A (he)
NO (1) NO180196C (he)
NZ (1) NZ241023A (he)
PT (1) PT99849B (he)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DK0534363T3 (da) * 1991-09-27 1997-09-22 Merrell Pharma Inc 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2133963C (en) * 1992-05-15 1998-07-07 Gary A. Flynn Novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a][1,2]diazepine and pyrazolo[1,2-a][1,2]diazepine derivatives useful as inhibitors of enkephalinase and ace
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
JP3608624B2 (ja) * 1994-02-14 2005-01-12 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ阻害剤として有用な新規なインダン−２−メルカプトアセチルアミドジスルフィド誘導体類
NZ279012A (en) * 1994-02-14 1998-03-25 Merrell Pharma Inc Condensed benzazepine derivatives and medicaments
ES2145267T3 (es) * 1994-02-14 2000-07-01 Merrell Pharma Inc Nuevos derivados bisulfuro de mercaptoacetilamido de 1,3,4,5-tetrahidro-benzo(c)azepin-3-ona utiles como inhibidores de la encefalinasa y del enzima de conversion de la angiotensina.
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
EP0751774B1 (en) * 1994-03-24 2003-08-13 Merrell Pharmaceuticals Inc. Hypocholesterolemic mercaptoacetylamide disulfide derivatives
NZ282568A (en) * 1994-03-24 1997-07-27 Merrell Pharma Inc Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
SI0957109T1 (en) * 1994-12-21 2004-10-31 Aventis Pharmaceuticals Inc. Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US7078225B2 (en) 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
ZA874107B (he) * 1986-06-13 1987-12-09
AU636101B2 (en) * 1987-04-10 1993-04-22 Monash University 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Also Published As

Publication number Publication date
AU8981991A (en) 1992-06-25
EP0492369B1 (en) 1997-09-17
FI95800B (fi) 1995-12-15
DK0492369T3 (da) 1997-10-13
CN1062729A (zh) 1992-07-15
JP3112327B2 (ja) 2000-11-27
NO180196B (no) 1996-11-25
HUT60271A (en) 1992-08-28
CA2057786C (en) 2002-06-18
HU210167B (en) 1995-02-28
KR100220880B1 (ko) 1999-09-15
NZ241023A (en) 1994-10-26
CA2057786A1 (en) 1992-06-22
NO915068L (no) 1992-06-22
PT99849B (pt) 1999-06-30
ATE158303T1 (de) 1997-10-15
DE69127681T2 (de) 1998-01-15
DE69127681D1 (de) 1997-10-23
FI916017A (fi) 1992-06-22
FI916017A0 (fi) 1991-12-19
ES2108027T3 (es) 1997-12-16
GR3025622T3 (en) 1998-03-31
CN1040985C (zh) 1998-12-02
NO915068D0 (no) 1991-12-20
NO180196C (no) 1997-03-05
KR920012082A (ko) 1992-07-25
AU642321B2 (en) 1993-10-14
JPH04342588A (ja) 1992-11-30
PT99849A (pt) 1992-11-30
IE914507A1 (en) 1992-07-01
IL100416A0 (en) 1992-09-06
KR100220879B1 (ko) 2000-03-15
EP0492369A1 (en) 1992-07-01
HU914092D0 (en) 1992-03-30
FI95800C (fi) 1996-03-25

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MM9K Patent not in force due to non-payment of renewal fees