ZA874107B - - Google Patents
Info
- Publication number
- ZA874107B ZA874107B ZA874107A ZA874107A ZA874107B ZA 874107 B ZA874107 B ZA 874107B ZA 874107 A ZA874107 A ZA 874107A ZA 874107 A ZA874107 A ZA 874107A ZA 874107 B ZA874107 B ZA 874107B
- Authority
- ZA
- South Africa
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87375486A | 1986-06-13 | 1986-06-13 | |
| AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA874107B true ZA874107B (he) | 1987-12-09 |
Family
ID=25598925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA874107A ZA874107B (he) | 1986-06-13 | 1987-06-08 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0249223B1 (he) |
| JP (1) | JP2542213B2 (he) |
| KR (1) | KR950014572B1 (he) |
| AR (1) | AR247213A1 (he) |
| AT (1) | AT398425B (he) |
| AU (1) | AU601433B2 (he) |
| CA (1) | CA1337654C (he) |
| DK (1) | DK170840B1 (he) |
| ES (1) | ES2044870T3 (he) |
| GR (1) | GR3006802T3 (he) |
| IE (1) | IE61476B1 (he) |
| ZA (1) | ZA874107B (he) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| AU642321B2 (en) * | 1990-12-21 | 1993-10-14 | Merrell Pharmaceuticals Inc. | Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace |
| US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| ES2106112T3 (es) * | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
| JP3460838B2 (ja) * | 1992-02-14 | 2003-10-27 | メレルファーマスーティカルズインコーポレイテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な，アミノアセチルメルカプトアセチルアミド誘導体類 |
| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| US5646276A (en) * | 1992-05-13 | 1997-07-08 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| DK0640086T3 (da) * | 1992-05-15 | 1999-12-06 | Merrell Pharma Inc | Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| DK0669936T3 (da) * | 1992-10-30 | 2001-02-05 | Merrell Pharma Inc | Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| DK0729456T3 (da) * | 1993-11-19 | 1998-03-30 | Merrell Pharma Inc | Ny fremgangsmåde til fremstilling af (S)-1-(2(S)-(1,3-dihydro-1,3-dioxo-isoindol-2-yl)-1-oxo-3-phenylpropyl)-1,2,3,4-tetrahydro-2-pyridincarboxylsyremethylester og mellemprodukter derfor |
| KR100364947B1 (ko) * | 1994-02-14 | 2003-03-06 | 메렐 파마슈티칼스 인크. | 엔케팔리나제및ace의억제제로서유용한신규의머캅토아세틸아미도1,3,4,5-테트라히드로-벤조[c]아제핀-3-온디술파이드유도체 |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| JP3561753B2 (ja) * | 1994-02-14 | 2004-09-02 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類 |
| KR100348949B1 (ko) * | 1994-02-14 | 2003-01-24 | 메렐 파마슈티칼스 인크. | 엔케팔리나제의억제제로서유용한신규의인단-2-머캅토아세틸아미드디술파이드유도체 |
| CA2183320C (en) * | 1994-02-14 | 1999-10-26 | Gary A. Flynn | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| EP0751783B1 (en) * | 1994-03-24 | 2000-02-02 | Merrell Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives |
| JPH10503468A (ja) * | 1994-03-24 | 1998-03-31 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体 |
| US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| CA2208569C (en) * | 1994-12-21 | 2000-07-11 | Hoechst Marion Roussel, Inc. | Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
| EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
-
1987
- 1987-06-08 CA CA000539111A patent/CA1337654C/en not_active Expired - Lifetime
- 1987-06-08 ZA ZA874107A patent/ZA874107B/xx unknown
- 1987-06-09 AU AU74022/87A patent/AU601433B2/en not_active Expired
- 1987-06-09 AR AR87307816A patent/AR247213A1/es active
- 1987-06-11 KR KR1019870005908A patent/KR950014572B1/ko not_active IP Right Cessation
- 1987-06-11 EP EP87108410A patent/EP0249223B1/en not_active Expired - Lifetime
- 1987-06-11 IE IE154787A patent/IE61476B1/en not_active IP Right Cessation
- 1987-06-11 ES ES87108410T patent/ES2044870T3/es not_active Expired - Lifetime
- 1987-06-12 DK DK300487A patent/DK170840B1/da not_active IP Right Cessation
- 1987-06-12 JP JP62145419A patent/JP2542213B2/ja not_active Expired - Lifetime
- 1987-10-12 AT AT0269187A patent/AT398425B/de not_active IP Right Cessation
-
1993
- 1993-01-14 GR GR930400057T patent/GR3006802T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK170840B1 (da) | 1996-02-05 |
| GR3006802T3 (he) | 1993-06-30 |
| AU601433B2 (en) | 1990-09-13 |
| JP2542213B2 (ja) | 1996-10-09 |
| AU7402287A (en) | 1987-12-17 |
| CA1337654C (en) | 1995-11-28 |
| ES2044870T3 (es) | 1994-01-16 |
| AT398425B (de) | 1994-12-27 |
| KR880000399A (ko) | 1988-03-25 |
| KR950014572B1 (ko) | 1995-12-08 |
| JPS62298591A (ja) | 1987-12-25 |
| DK300487A (da) | 1987-12-14 |
| DK300487D0 (da) | 1987-06-12 |
| AR247213A1 (es) | 1994-11-30 |
| EP0249223A2 (en) | 1987-12-16 |
| IE61476B1 (en) | 1994-11-02 |
| EP0249223B1 (en) | 1992-10-14 |
| EP0249223A3 (en) | 1989-01-25 |
| ATA269187A (de) | 1994-04-15 |
| IE871547L (en) | 1987-12-13 |