IE912126A1 - Polycyclic guanine derivatives - Google Patents

Polycyclic guanine derivatives

Info

Publication number
IE912126A1
IE912126A1 IE212691A IE212691A IE912126A1 IE 912126 A1 IE912126 A1 IE 912126A1 IE 212691 A IE212691 A IE 212691A IE 212691 A IE212691 A IE 212691A IE 912126 A1 IE912126 A1 IE 912126A1
Authority
IE
Ireland
Prior art keywords
purin
imidazo
phenylmethyl
hexahydro
dimethyl
Prior art date
Application number
IE212691A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IE912126A1 publication Critical patent/IE912126A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Filtering Materials (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IE212691A 1990-06-21 1991-06-20 Polycyclic guanine derivatives IE912126A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54156890A 1990-06-21 1990-06-21

Publications (1)

Publication Number Publication Date
IE912126A1 true IE912126A1 (en) 1992-01-01

Family

ID=24160139

Family Applications (1)

Application Number Title Priority Date Filing Date
IE212691A IE912126A1 (en) 1990-06-21 1991-06-20 Polycyclic guanine derivatives

Country Status (21)

Country Link
US (1) US5393755A (forum.php)
EP (1) EP0538332B1 (forum.php)
JP (1) JPH0747589B2 (forum.php)
KR (1) KR960004532B1 (forum.php)
AT (1) ATE155786T1 (forum.php)
AU (1) AU651607B2 (forum.php)
CA (1) CA2085733C (forum.php)
CZ (1) CZ281920B6 (forum.php)
DE (1) DE69126980T2 (forum.php)
FI (1) FI925731A0 (forum.php)
HU (1) HUT65623A (forum.php)
IE (1) IE912126A1 (forum.php)
IL (1) IL98559A0 (forum.php)
NO (1) NO924940D0 (forum.php)
NZ (1) NZ238609A (forum.php)
OA (1) OA09723A (forum.php)
PL (1) PL169481B1 (forum.php)
RU (1) RU2080322C1 (forum.php)
TW (1) TW197441B (forum.php)
WO (1) WO1991019717A1 (forum.php)
ZA (1) ZA914727B (forum.php)

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US5824683A (en) * 1995-11-28 1998-10-20 Schering Corporation 2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
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US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
US6130053A (en) * 1999-08-03 2000-10-10 Cell Pathways, Inc. Method for selecting compounds for inhibition of neoplastic lesions
US6200771B1 (en) 1998-10-15 2001-03-13 Cell Pathways, Inc. Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
US6133271A (en) * 1998-11-19 2000-10-17 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
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US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
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US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6486155B1 (en) 1998-11-24 2002-11-26 Cell Pathways Inc Method of inhibiting neoplastic cells with isoquinoline derivatives
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
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ES2166270B1 (es) * 1999-07-27 2003-04-01 Almirall Prodesfarma Sa Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
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EP1648895B1 (en) * 2003-07-31 2007-05-30 Schering Corporation Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
EP1650206A4 (en) * 2003-08-01 2006-12-20 Nippon Soda Co PHENYLAZOLE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND ANTIOXIDANTS
EP1691788A2 (en) * 2003-11-21 2006-08-23 Schering Corporation Phosphodiesterase v inhibitor formulations
US20070004745A1 (en) * 2005-03-25 2007-01-04 Schering-Plough Corporation Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
CN103467471A (zh) * 2005-06-06 2013-12-25 武田药品工业株式会社 有机化合物
EP1919287A4 (en) * 2005-08-23 2010-04-28 Intra Cellular Therapies Inc ORGANIC COMPOUNDS FOR TREATING A REDUCED DOPAMINE RECEPTOR SIGNALING ACTIVITY
BRPI0618482A2 (pt) * 2005-11-09 2011-08-30 Tosoh Corp nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma
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CA2845454C (en) 2007-12-06 2017-02-07 Takeda Pharmaceutical Company Limited Organic compounds useful as inhibitors of phosphodiesterase 1
CN101969774A (zh) 2007-12-06 2011-02-09 细胞内治疗公司 有机化合物
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CA2755117C (en) 2009-03-13 2018-09-11 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
US9468637B2 (en) 2009-05-13 2016-10-18 Intra-Cellular Therapies, Inc. Organic compounds
JP6166534B2 (ja) 2009-08-05 2017-07-19 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規調節タンパク質および阻害剤
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
EP2576551A4 (en) 2010-05-31 2014-04-16 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
US9371327B2 (en) 2010-05-31 2016-06-21 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
EP2717877B1 (en) 2011-06-10 2017-11-08 Intra-Cellular Therapies, Inc. Organic compounds
EP2956141A4 (en) 2013-02-17 2016-10-26 Intra Cellular Therapies Inc NEW USES
ES2717688T3 (es) 2013-03-15 2019-06-24 Intra Cellular Therapies Inc Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
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Also Published As

Publication number Publication date
PL169481B1 (pl) 1996-07-31
OA09723A (en) 1993-08-30
HU9204032D0 (en) 1993-03-29
WO1991019717A1 (en) 1991-12-26
RU2080322C1 (ru) 1997-05-27
PL297299A1 (forum.php) 1992-07-13
FI925731A7 (fi) 1992-12-17
IL98559A0 (en) 1992-07-15
AU651607B2 (en) 1994-07-28
CZ374992A3 (en) 1993-10-13
DE69126980D1 (de) 1997-09-04
KR960004532B1 (ko) 1996-04-06
US5393755A (en) 1995-02-28
NO924940L (no) 1992-12-18
NO924940D0 (no) 1992-12-18
CA2085733C (en) 1996-03-05
FI925731A0 (fi) 1992-12-17
TW197441B (forum.php) 1993-01-01
NZ238609A (en) 1993-12-23
CZ281920B6 (cs) 1997-04-16
CA2085733A1 (en) 1991-12-22
HUT65623A (en) 1994-07-28
JPH05508647A (ja) 1993-12-02
EP0538332A1 (en) 1993-04-28
ZA914727B (en) 1992-03-25
EP0538332B1 (en) 1997-07-23
DE69126980T2 (de) 1998-01-08
AU8199291A (en) 1992-01-07
JPH0747589B2 (ja) 1995-05-24
ATE155786T1 (de) 1997-08-15

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