IE65168B1 - Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent - Google Patents

Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent

Info

Publication number
IE65168B1
IE65168B1 IE268589A IE268589A IE65168B1 IE 65168 B1 IE65168 B1 IE 65168B1 IE 268589 A IE268589 A IE 268589A IE 268589 A IE268589 A IE 268589A IE 65168 B1 IE65168 B1 IE 65168B1
Authority
IE
Ireland
Prior art keywords
derivatives
solution
crystals
autoclave
dissolved
Prior art date
Application number
IE268589A
Other languages
English (en)
Other versions
IE892685L (en
Inventor
Celal Dr Albayrak
Georg Dr Rossling
Johannes Dr Tack
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IE892685L publication Critical patent/IE892685L/xx
Publication of IE65168B1 publication Critical patent/IE65168B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
IE268589A 1988-08-23 1989-08-18 Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent IE65168B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3828905A DE3828905A1 (de) 1988-08-23 1988-08-23 Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel

Publications (2)

Publication Number Publication Date
IE892685L IE892685L (en) 1990-02-23
IE65168B1 true IE65168B1 (en) 1995-10-04

Family

ID=6361599

Family Applications (1)

Application Number Title Priority Date Filing Date
IE268589A IE65168B1 (en) 1988-08-23 1989-08-18 Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent

Country Status (12)

Country Link
EP (1) EP0357163B1 (enrdf_load_html_response)
JP (1) JP3142539B2 (enrdf_load_html_response)
AT (1) ATE76758T1 (enrdf_load_html_response)
AU (1) AU641363B2 (enrdf_load_html_response)
DE (2) DE3828905A1 (enrdf_load_html_response)
DK (1) DK30391A (enrdf_load_html_response)
ES (1) ES2042986T3 (enrdf_load_html_response)
GR (1) GR3005457T3 (enrdf_load_html_response)
IE (1) IE65168B1 (enrdf_load_html_response)
NO (1) NO302101B1 (enrdf_load_html_response)
PT (1) PT91501B (enrdf_load_html_response)
WO (1) WO1990001952A1 (enrdf_load_html_response)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (enrdf_load_html_response) 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
IE80926B1 (en) * 1991-07-05 1999-06-30 Nycomed Imaging As Improvements in or relating to contrast agents
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
SG54121A1 (en) * 1991-09-17 1998-11-16 Sonus Pharma Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
JP3621413B2 (ja) * 1993-01-25 2005-02-16 アマシャム・ヘルス・エーエス 超音波造影剤としての相転移コロイド
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
CN1061893C (zh) * 1993-03-08 2001-02-14 柯铭清 声学造影剂
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
JP3559849B2 (ja) * 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
NZ276167A (en) * 1993-12-15 1996-11-26 Bracco Research Sa Ultrasound contrast medium comprising two gases in aqueous suspension
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
EP0766968B1 (en) * 1995-10-06 2001-01-17 Nihon Medi-Physics Co., Ltd. Diagnostic imaging agent
DE19543077C2 (de) * 1995-11-13 1997-10-16 Schering Ag Verwendung von gashaltigen Metallkomplexen als Ultraschallkontrastmittel
PT904113E (pt) * 1996-03-05 2004-09-30 Acusphere Inc Gases fluorados microencapsulados para utilizacao como agentes de aquisicao de imagem
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE19709704C2 (de) * 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6284222B1 (en) 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
DE19851605A1 (de) * 1998-11-09 2000-05-11 Messer Griesheim Gmbh Mikropartikel enthaltendes Injektionsanästhesiemittel
JP4544551B2 (ja) * 1999-07-28 2010-09-15 日本曹達株式会社 トリ−ｏ−チモチド類を成分化合物とする分子化合物
WO2002045721A1 (en) * 2000-12-04 2002-06-13 Uws Ventures Limited Noble gas complexes
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen

Also Published As

Publication number Publication date
DE58901585D1 (de) 1992-07-09
ES2042986T3 (es) 1993-12-16
JP3142539B2 (ja) 2001-03-07
EP0357163A1 (de) 1990-03-07
NO302101B1 (no) 1998-01-26
ATE76758T1 (de) 1992-06-15
PT91501A (pt) 1990-03-08
DE3828905A1 (de) 1990-03-15
AU641363B2 (en) 1993-09-23
JPH04501559A (ja) 1992-03-19
NO910711L (no) 1991-02-22
WO1990001952A1 (de) 1990-03-08
DK30391D0 (da) 1991-02-21
EP0357163B1 (de) 1992-06-03
AU4065189A (en) 1990-03-23
IE892685L (en) 1990-02-23
GR3005457T3 (enrdf_load_html_response) 1993-05-24
DK30391A (da) 1991-02-21
NO910711D0 (no) 1991-02-22
PT91501B (pt) 1995-05-31

Similar Documents

Publication Publication Date Title
IE65168B1 (en) Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
US5730954A (en) Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
JP4202139B2 (ja) 温度依存性造影剤による強化型超音波検出
US5141739A (en) Delivery of x-ray contrast agents using receptor mediated endocytosis
EP1742669B1 (en) Compositions and methods for enhancing contrast in imaging
US5508021A (en) Non-fluorinated polymeric shells for medical imaging
DE69231950T3 (de) Gasgefüllte liposome als ultraschall-kontrastmittel
US4927623A (en) Dissolution of gas in a fluorocarbon liquid
JP2009508924A (ja) シリコンを含む造影剤
KR102161271B1 (ko) 감열성 나노입자 제제 및 그의 제조 방법
CN115400229B (zh) 一种金属有机骨架纳米造影剂在超灵敏磁共振成像中的应用
US20210321985A1 (en) Compositions and methods for targeted contrast agents for molecular imaging
JP2009096749A (ja) コレステロール誘導体、リポソーム及びｘ線用造影剤
JP2715240B2 (ja) 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤
KR20010006195A (ko) 친지성 상형성제용 혈액-풀 캐리어
CN106831480B (zh) 基于碘帕醇脂质衍生物的造影剂及其制备方法与用途
EP1608340A2 (en) A method of preparing gas-filled polymer matrix microparticles useful for delivering drug
DK1940354T3 (en) Viscous injectable medicinal preparation which comprises ethanol and a fat-soluble compound røntgenopak
CN120361256A (zh) 一种靶向psma受体的纳米复合体、制备方法及其应用
JP2021123552A (ja) Ｇｄ内包カーボンナノチューブ含有造影剤
Ahmed Effect of drug physicochemical properties on the release from liposomal systems in vitro and in vivo
JP2009051782A (ja) リポソーム及び造影剤
HK1097449A1 (en) Methods for in vivo delivery of biologics and compositions useful therefor
HK1097449B (en) Methods for in vivo delivery of biologics and compositions useful therefor
JP2005170928A (ja) リポソーム含有ｘ線造影剤およびその製造方法

Legal Events

Date Code Title Description
MM4A Patent lapsed