IE63467B1 - Use of adamantane derivatives for the prevention and treatment of cerebral ischaemia - Google Patents
Use of adamantane derivatives for the prevention and treatment of cerebral ischaemiaInfo
- Publication number
- IE63467B1 IE63467B1 IE99690A IE99690A IE63467B1 IE 63467 B1 IE63467 B1 IE 63467B1 IE 99690 A IE99690 A IE 99690A IE 99690 A IE99690 A IE 99690A IE 63467 B1 IE63467 B1 IE 63467B1
- Authority
- IE
- Ireland
- Prior art keywords
- adamantane
- amino
- ethyl
- hydrogen
- use according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89106657A EP0392059B1 (de) | 1989-04-14 | 1989-04-14 | Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE900996L IE900996L (en) | 1990-10-14 |
| IE63467B1 true IE63467B1 (en) | 1995-04-19 |
Family
ID=8201228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE99690A IE63467B1 (en) | 1989-04-14 | 1990-03-16 | Use of adamantane derivatives for the prevention and treatment of cerebral ischaemia |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5061703A (Direct) |
| EP (1) | EP0392059B1 (Direct) |
| JP (1) | JP2821233B2 (Direct) |
| AT (1) | ATE94384T1 (Direct) |
| CA (1) | CA2014453C (Direct) |
| CH (1) | CH679208A5 (Direct) |
| DD (1) | DD293493A5 (Direct) |
| DE (2) | DE58905637D1 (Direct) |
| DK (1) | DK173356B1 (Direct) |
| ES (1) | ES2059602T3 (Direct) |
| HU (1) | HU215592B (Direct) |
| IE (1) | IE63467B1 (Direct) |
| LU (1) | LU90988I2 (Direct) |
| NL (1) | NL300107I1 (Direct) |
| PT (1) | PT93763B (Direct) |
| SE (1) | SE9001329L (Direct) |
Families Citing this family (125)
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| US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5455279A (en) * | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
| WO1992017168A1 (en) * | 1991-04-04 | 1992-10-15 | The Children's Medical Center Corporation | Method of preventing nmda receptor-mediated neuronal damage |
| US5614560A (en) * | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| DE4225730C2 (de) * | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
| IL112099A (en) * | 1993-12-23 | 1999-07-14 | Ortho Pharma Corp | N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them |
| DE19510189A1 (de) * | 1995-03-21 | 1996-09-26 | Hartmut Dr Goebel | Verwendung von Amantadin |
| DE19528388A1 (de) * | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6057373A (en) * | 1997-05-22 | 2000-05-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists |
| US6294583B1 (en) * | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
| US5952389A (en) * | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
| GB9802225D0 (en) | 1998-02-02 | 1998-04-01 | Cerebrus Ltd | Chemical compounds |
| RU2147573C1 (ru) * | 1998-08-24 | 2000-04-20 | Волгоградский государственный технический университет | Способ получения адамант-1-иламина и его производных |
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| US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
| DE10142176A1 (de) * | 2001-08-29 | 2003-03-27 | Eucro Europe Contract Res Gmbh | Verwendung einer Kombination aus ß-adrenergen Agonisten und NDMA-Antagonisten |
| US20040248984A1 (en) * | 2001-08-29 | 2004-12-09 | Josef Krieglstein | Use of $g(b)-adrenoceptor agonists for the treatment of neurodegenerative diseases |
| PL373490A1 (en) | 2001-08-29 | 2005-09-05 | Eucro European Contract Research Gmbh & Co.Kg | Use of beta-adrenoceptor agonists for the treatment of neurodegenerative diseases |
| GB0202161D0 (en) * | 2002-01-30 | 2002-03-20 | Vernalis Res Ltd | Chemical compounds V |
| AU2003251993A1 (en) * | 2002-07-19 | 2004-02-09 | Inge Grundke-Iqbal | NMDA RECEPTOR ANTAGONISTS AND THEIR USE IN INHIBITING ABNORMAL HYPERPHOSPHORYLATION OF MICROTUBULE ASSOCIATED PROTEIN tau |
| CA2502432A1 (en) | 2002-10-24 | 2004-05-06 | Merz Pharma Gmbh & Co. Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
| RU2246482C2 (ru) * | 2002-12-25 | 2005-02-20 | ООО "Циклан" | Способ получения гидрохлорида 1-амино-3,5-диметиладамантана |
| EP1631274A4 (en) * | 2003-05-27 | 2007-03-28 | Forest Laboratories | COMBINATION OF A NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONINE RECOURSE HEMMER FOR TREATING DEPRESSIONS AND OTHER MUTUAL DISORDERS |
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| ITTO20030668A1 (it) | 2003-09-02 | 2005-03-03 | Rotta Res Lab S P A O Ra Rottapharm | Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione. |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450761A (en) * | 1967-03-30 | 1969-06-17 | Sun Oil Co | 1-aminoethyldimethyladamantane |
| US4748154A (en) * | 1985-12-24 | 1988-05-31 | Takeda Chemical Industries, Ltd. | Peptide derivatives, their production and use |
| IT1205042B (it) * | 1987-05-28 | 1989-03-10 | Crinos Industria Farmaco | Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer |
-
1989
- 1989-04-14 EP EP89106657A patent/EP0392059B1/de not_active Expired - Lifetime
- 1989-04-14 ES ES89106657T patent/ES2059602T3/es not_active Expired - Lifetime
- 1989-04-14 AT AT89106657T patent/ATE94384T1/de active
- 1989-04-14 DE DE89106657T patent/DE58905637D1/de not_active Expired - Lifetime
- 1989-04-14 DE DE2002199048 patent/DE10299048I2/de active Active
-
1990
- 1990-03-16 IE IE99690A patent/IE63467B1/en not_active IP Right Cessation
- 1990-04-10 CH CH1539/90A patent/CH679208A5/de not_active IP Right Cessation
- 1990-04-11 US US07/508,109 patent/US5061703A/en not_active Expired - Lifetime
- 1990-04-11 SE SE9001329A patent/SE9001329L/xx not_active Application Discontinuation
- 1990-04-11 DK DK199000916A patent/DK173356B1/da not_active IP Right Cessation
- 1990-04-11 CA CA002014453A patent/CA2014453C/en not_active Expired - Lifetime
- 1990-04-12 PT PT93763A patent/PT93763B/pt not_active IP Right Cessation
- 1990-04-12 DD DD90339741A patent/DD293493A5/de not_active IP Right Cessation
- 1990-04-13 JP JP2099117A patent/JP2821233B2/ja not_active Expired - Lifetime
- 1990-04-13 HU HU902434A patent/HU215592B/hu unknown
-
2002
- 2002-11-13 LU LU90988C patent/LU90988I2/fr unknown
- 2002-11-14 NL NL300107C patent/NL300107I1/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2059602T3 (es) | 1994-11-16 |
| US5061703A (en) | 1991-10-29 |
| HU215592B (hu) | 1999-01-28 |
| HUT58200A (en) | 1992-02-28 |
| DE10299048I1 (de) | 2003-03-27 |
| DD293493A5 (de) | 1991-09-05 |
| EP0392059B1 (de) | 1993-09-15 |
| DE10299048I2 (de) | 2006-07-13 |
| PT93763A (pt) | 1990-11-20 |
| IE900996L (en) | 1990-10-14 |
| LU90988I2 (fr) | 2003-01-13 |
| DK91690D0 (da) | 1990-04-11 |
| CA2014453A1 (en) | 1990-10-14 |
| NL300107I2 (nl) | 2003-02-03 |
| JP2821233B2 (ja) | 1998-11-05 |
| DK173356B1 (da) | 2000-08-07 |
| ATE94384T1 (de) | 1993-10-15 |
| SE9001329L (sv) | 1990-10-15 |
| CA2014453C (en) | 2000-03-28 |
| JPH02292214A (ja) | 1990-12-03 |
| EP0392059A1 (de) | 1990-10-17 |
| NL300107I1 (nl) | 2003-02-03 |
| CH679208A5 (Direct) | 1992-01-15 |
| HU902434D0 (en) | 1990-08-28 |
| SE9001329D0 (sv) | 1990-04-11 |
| DE58905637D1 (de) | 1993-10-21 |
| DK91690A (da) | 1990-10-15 |
| PT93763B (pt) | 1996-04-30 |
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