IE60358B1 - 1,4-dihydropyridines, process for preparation thereof and their application as medicinal products - Google Patents

1,4-dihydropyridines, process for preparation thereof and their application as medicinal products

Info

Publication number
IE60358B1
IE60358B1 IE236488A IE236488A IE60358B1 IE 60358 B1 IE60358 B1 IE 60358B1 IE 236488 A IE236488 A IE 236488A IE 236488 A IE236488 A IE 236488A IE 60358 B1 IE60358 B1 IE 60358B1
Authority
IE
Ireland
Prior art keywords
methyl
ethyl
formula
amino
dihydro
Prior art date
Application number
IE236488A
Other languages
English (en)
Other versions
IE882364L (en
Original Assignee
Delagrange Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delagrange Lab filed Critical Delagrange Lab
Publication of IE882364L publication Critical patent/IE882364L/en
Publication of IE60358B1 publication Critical patent/IE60358B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IE236488A 1987-08-03 1988-08-02 1,4-dihydropyridines, process for preparation thereof and their application as medicinal products IE60358B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (2)

Publication Number Publication Date
IE882364L IE882364L (en) 1989-02-03
IE60358B1 true IE60358B1 (en) 1994-06-29

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
IE236488A IE60358B1 (en) 1987-08-03 1988-08-02 1,4-dihydropyridines, process for preparation thereof and their application as medicinal products

Country Status (34)

Country Link
US (1) US4952592A (enExample)
EP (1) EP0302980B1 (enExample)
JP (1) JPH0733383B2 (enExample)
KR (1) KR960001724B1 (enExample)
CN (1) CN1038587C (enExample)
AT (1) ATE61588T1 (enExample)
BE (1) BE1001055A4 (enExample)
CA (2) CA1306261C (enExample)
CH (1) CH675999A5 (enExample)
CZ (1) CZ282077B6 (enExample)
DD (1) DD282008A5 (enExample)
DE (2) DE3768658D1 (enExample)
DK (1) DK430288A (enExample)
ES (1) ES2007543A6 (enExample)
FI (1) FI91406C (enExample)
GB (1) GB2208861B (enExample)
GR (2) GR880100507A (enExample)
HU (1) HU204523B (enExample)
IE (1) IE60358B1 (enExample)
IL (1) IL87321A (enExample)
IN (1) IN167550B (enExample)
IS (1) IS1549B (enExample)
IT (1) IT1235013B (enExample)
LU (1) LU87297A1 (enExample)
MA (1) MA21344A1 (enExample)
NO (1) NO170934C (enExample)
NZ (1) NZ225661A (enExample)
PH (1) PH25645A (enExample)
PT (1) PT88173B (enExample)
RU (1) RU2036922C1 (enExample)
SK (1) SK278775B6 (enExample)
TN (1) TNSN88081A1 (enExample)
YU (1) YU46547B (enExample)
ZA (1) ZA885684B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
ES2166462T3 (es) * 1995-08-02 2002-04-16 Smithkline Beecham Corp Antagonistas del receptor de la endotelina.
RU2168987C2 (ru) * 1997-04-15 2001-06-20 Санкт-Петербургская Государственная Химико-Фармацевтическая Академия Гипотензивное средство
RU2155036C2 (ru) * 1998-11-11 2000-08-27 Азад Зияд Оглы Абышев Средство для лечения ишемической болезни сердца
IT1304513B1 (it) * 1998-12-30 2001-03-19 Endura Spa Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
KR100756565B1 (ko) * 2000-04-11 2007-09-07 상꾜 가부시키가이샤 칼슘 채널 블록커를 함유하는 안정화된 약제 조성물
RU2187303C2 (ru) * 2000-10-12 2002-08-20 Азад Зияд Оглы Абышев Способ получения таблеток диуманкала - forte по 0,01 г
GEP20074134B (en) 2002-08-19 2007-06-25 Pfizer Prod Inc Combination therapy for hyperproliferative diseases
JP2008507585A (ja) * 2004-07-26 2008-03-13 コセリックス インク 微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
WO2007050783A2 (en) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
DK3911648T3 (da) 2019-01-18 2025-01-13 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
ES8507495A1 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
KR890003743A (ko) 1989-04-17
FI883603A7 (fi) 1989-02-04
CZ282077B6 (cs) 1997-05-14
RU2036922C1 (ru) 1995-06-09
TNSN88081A1 (fr) 1990-07-10
NO883406D0 (no) 1988-08-01
NO170934C (no) 1992-12-30
IS1549B (is) 1994-06-08
FI91406B (fi) 1994-03-15
EP0302980B1 (fr) 1991-03-13
CN1038587C (zh) 1998-06-03
IL87321A0 (en) 1989-01-31
NO883406L (no) 1989-02-06
CA1306262C (fr) 1992-08-11
YU46547B (sh) 1993-11-16
DK430288D0 (da) 1988-08-02
CH675999A5 (en) 1990-11-30
FI883603A0 (fi) 1988-08-01
FI91406C (fi) 1994-06-27
AU606441B2 (en) 1991-02-07
HU204523B (en) 1992-01-28
YU147088A (en) 1990-04-30
NZ225661A (en) 1990-08-28
GB2208861A (en) 1989-04-19
EP0302980A1 (fr) 1989-02-15
BE1001055A4 (fr) 1989-06-20
DE3768658D1 (de) 1991-04-18
CN1031531A (zh) 1989-03-08
MA21344A1 (fr) 1989-04-01
ZA885684B (en) 1989-04-26
PT88173B (pt) 1995-03-01
LU87297A1 (fr) 1989-02-02
CA1306261C (fr) 1992-08-11
IL87321A (en) 1993-04-04
AU2033088A (en) 1989-02-09
DE3825962A1 (de) 1989-02-16
ATE61588T1 (de) 1991-03-15
US4952592A (en) 1990-08-28
PH25645A (en) 1991-08-21
IT1235013B (it) 1992-06-16
PT88173A (pt) 1989-06-30
GR880100507A (el) 1989-05-25
NO170934B (no) 1992-09-21
JPH0733383B2 (ja) 1995-04-12
GB8818356D0 (en) 1988-09-07
DK430288A (da) 1989-02-03
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
IS3378A7 (is) 1989-02-04
GB2208861B (en) 1991-07-17
IT8848259A0 (it) 1988-08-02
KR960001724B1 (ko) 1996-02-03
JPH01294675A (ja) 1989-11-28
CZ541388A3 (en) 1997-01-15
HUT54142A (en) 1991-01-28
SK541388A3 (en) 1998-02-04
SK278775B6 (sk) 1998-02-04
IN167550B (enExample) 1990-11-10
ES2007543A6 (es) 1989-06-16
IE882364L (en) 1989-02-03

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Legal Events

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MM4A Patent lapsed