IE59613B1 - A crystalline oral cephalosporin hydrate and its compositions - Google Patents
A crystalline oral cephalosporin hydrate and its compositionsInfo
- Publication number
- IE59613B1 IE59613B1 IE173887A IE173887A IE59613B1 IE 59613 B1 IE59613 B1 IE 59613B1 IE 173887 A IE173887 A IE 173887A IE 173887 A IE173887 A IE 173887A IE 59613 B1 IE59613 B1 IE 59613B1
- Authority
- IE
- Ireland
- Prior art keywords
- hydrate
- gelatin
- drying
- capsule
- hereinbefore described
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 229940124588 oral cephalosporin Drugs 0.000 title description 2
- 108010010803 Gelatin Proteins 0.000 claims abstract description 38
- 229920000159 gelatin Polymers 0.000 claims abstract description 38
- 239000008273 gelatin Substances 0.000 claims abstract description 38
- 235000019322 gelatine Nutrition 0.000 claims abstract description 38
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 38
- 239000013078 crystal Substances 0.000 claims abstract description 26
- 239000007902 hard capsule Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- 239000002775 capsule Substances 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 37
- 239000000243 solution Substances 0.000 claims description 35
- 238000001035 drying Methods 0.000 claims description 33
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 14
- 239000007858 starting material Substances 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 11
- -1 6-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino] 3-cephem-4-carboxylic acid Chemical compound 0.000 claims description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
- 239000011260 aqueous acid Substances 0.000 claims description 9
- 150000004683 dihydrates Chemical group 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 7
- 150000004684 trihydrates Chemical group 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
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- 238000002441 X-ray diffraction Methods 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
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- 238000010790 dilution Methods 0.000 claims 1
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
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- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
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- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61156954A JP2544113B2 (ja) | 1986-07-02 | 1986-07-02 | 安定なカプセル製剤 |
| JP21626086A JPH0717651B2 (ja) | 1986-09-12 | 1986-09-12 | 経口投与用セフアロスポリン水和物結晶 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE871738L IE871738L (en) | 1988-01-02 |
| IE59613B1 true IE59613B1 (en) | 1994-03-09 |
Family
ID=26484565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE173887A IE59613B1 (en) | 1986-07-02 | 1987-06-29 | A crystalline oral cephalosporin hydrate and its compositions |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US4812561A (enExample) |
| KR (1) | KR950005302B1 (enExample) |
| CN (1) | CN1015106B (enExample) |
| AR (1) | AR243893A1 (enExample) |
| AT (1) | AT392472B (enExample) |
| AU (1) | AU594167B2 (enExample) |
| BE (1) | BE1001691A4 (enExample) |
| CA (1) | CA1283405C (enExample) |
| CH (1) | CH672788A5 (enExample) |
| DE (1) | DE3721913A1 (enExample) |
| DK (1) | DK161080C (enExample) |
| ES (2) | ES2004952A6 (enExample) |
| FI (1) | FI89052C (enExample) |
| FR (1) | FR2601014B1 (enExample) |
| GB (1) | GB2192183B (enExample) |
| GR (1) | GR871014B (enExample) |
| HK (1) | HK47893A (enExample) |
| HU (1) | HU200777B (enExample) |
| IE (1) | IE59613B1 (enExample) |
| IL (1) | IL83059A (enExample) |
| IT (1) | IT1211469B (enExample) |
| NL (1) | NL193136C (enExample) |
| NO (1) | NO170889C (enExample) |
| NZ (1) | NZ220764A (enExample) |
| PL (1) | PL159180B1 (enExample) |
| RU (1) | RU1829932C (enExample) |
| SE (1) | SE466257B (enExample) |
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| CN1307211C (zh) * | 1998-10-27 | 2007-03-28 | 伊斯曼化学公司 | 烯烃聚合方法,新型聚乙烯以及由其制造的薄膜和制品 |
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| AT412213B (de) * | 2000-05-30 | 2004-11-25 | Sandoz Ag | Verfahren zur trocknung von amoxicillin oder amoxicillin-hältigen, oralen, festen pharmazeutischen zusammensetzungen unter verwendung eines gases mit einer definierten gasfeuchte |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| CA2533358C (en) * | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| CA2533292C (en) * | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| JP2006528189A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
| WO2005016311A1 (en) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| AU2004264356B2 (en) | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| CA2535780A1 (en) * | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| WO2005027877A1 (en) * | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| CA2550983C (en) * | 2003-12-24 | 2013-09-17 | Advancis Pharmaceutical Corporation | Enhanced absorption of modified release dosage forms |
| EP1771158A4 (en) * | 2004-07-02 | 2008-03-12 | Advancis Pharmaceutical Corp | TABLET FOR PULSE DISTRIBUTION |
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| CA2629244C (en) | 2005-11-11 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) * | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| AR062927A1 (es) * | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
| MX2009006878A (es) * | 2006-12-22 | 2009-07-07 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas. |
| US8268803B2 (en) | 2006-12-22 | 2012-09-18 | Merck Sharp & Dohme Corp. | 5, 6-ring annulated indole derivatives and use thereof |
| KR20090094154A (ko) | 2006-12-22 | 2009-09-03 | 쉐링 코포레이션 | Ｈｃｖ 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체 |
| TW200924751A (en) * | 2007-08-29 | 2009-06-16 | Schering Corp | 2,3-substituted indole derivatives and methods of use thereof |
| KR20100065167A (ko) | 2007-08-29 | 2010-06-15 | 쉐링 코포레이션 | 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체 |
| CN101821252A (zh) * | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
| MX2010005355A (es) * | 2007-11-16 | 2010-06-02 | Schering Corp | Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos. |
| US8765757B2 (en) * | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| MX2010013630A (es) * | 2008-06-13 | 2010-12-21 | Schering Corp | Derivados triciclicos de indol y metodos de uso de los mismos. |
| WO2010022126A1 (en) | 2008-08-20 | 2010-02-25 | Schering Corporation | Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| US8697694B2 (en) | 2008-08-20 | 2014-04-15 | Merck Sharp & Dohme Corp. | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
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| JP5674661B2 (ja) | 2008-08-20 | 2015-02-25 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | エチニル置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| DK2451445T3 (da) | 2009-07-06 | 2019-06-24 | Boehringer Ingelheim Int | Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens |
| US20120276047A1 (en) | 2009-11-25 | 2012-11-01 | Rosenblum Stuart B | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| EP2516430B1 (en) | 2009-12-22 | 2014-11-05 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
| WO2011103441A1 (en) | 2010-02-18 | 2011-08-25 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| BR112012022125A2 (pt) | 2010-03-09 | 2016-11-01 | Merck Sharp & Dhme Corp | composto, sal de dicloridrato, composição farmacêutica, uso do composto, e, método para tratar um paciente |
| EP2566449B1 (en) | 2010-05-04 | 2014-10-08 | Mahmut Bilgic | Pharmaceutical compositions comprising ceftibuten |
| JP2013541499A (ja) | 2010-07-26 | 2013-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法 |
| AU2011314168A1 (en) | 2010-09-29 | 2013-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
| EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| WO2013151518A1 (en) * | 2012-04-04 | 2013-10-10 | Mahmut Bilgic | Capsule formulations comprising ceftibuten |
| EP2815743A1 (en) | 2013-06-21 | 2014-12-24 | Sanovel Ilac Sanayi ve Ticaret A.S. | Ceftibuten formulations |
| US10167298B2 (en) | 2013-10-30 | 2019-01-01 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof |
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| CN103948932B (zh) * | 2014-04-17 | 2016-03-16 | 海南日中天制药有限公司 | 一种头孢克肟组合物及其制备方法 |
| EP3031450A1 (en) | 2014-12-12 | 2016-06-15 | Sanovel Ilac Sanayi ve Ticaret A.S. | Ceftibuten capsule compositions |
| US11117909B2 (en) | 2016-05-13 | 2021-09-14 | Aeromics, Inc. | Crystals |
| CN106397454B (zh) * | 2016-08-30 | 2018-08-24 | 山东罗欣药业集团股份有限公司 | 一种抗感染药物头孢布烯晶型化合物及其组合物 |
| CN106432270A (zh) * | 2016-09-21 | 2017-02-22 | 临沂草之美医药科技有限公司 | 一种制备治疗外科手术感染的药物头孢布烯晶体化合物的方法 |
| CN106397457A (zh) * | 2016-09-21 | 2017-02-15 | 临沂草之美医药科技有限公司 | 一种治疗外科手术感染的药物头孢布烯晶体化合物 |
| CN106432272A (zh) * | 2016-09-21 | 2017-02-22 | 临沂草之美医药科技有限公司 | 一种制备治疗外科手术感染的药物头孢布烯晶体化合物的方法 |
| CN106432271A (zh) * | 2016-09-21 | 2017-02-22 | 临沂草之美医药科技有限公司 | 一种治疗外科手术感染的药物头孢布烯晶体化合物 |
| JP2024524372A (ja) * | 2021-07-01 | 2024-07-05 | キューペックス バイオファーマ， インコーポレイテッド | セフチブテンの結晶形態 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819620A (en) * | 1972-06-01 | 1974-06-25 | Squibb & Sons Inc | 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacet-amido)desacetoxycephalosporanic acid dihydrate |
| JPS5726692A (en) * | 1980-07-22 | 1982-02-12 | Fujisawa Pharmaceut Co Ltd | Preparation of stable crystal of salt of ceftizoxime |
| DE3037997A1 (de) * | 1980-10-08 | 1982-05-13 | Bayer Ag | (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel |
| YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
| AU575854B2 (en) * | 1983-10-04 | 1988-08-11 | Shionogi & Co., Ltd. | 7beta-(carboxyalkenamido) cephalosporins |
| AU580855B2 (en) * | 1985-03-29 | 1989-02-02 | Shionogi & Co., Ltd. | Alkeneamidocephalosporin esters |
-
1987
- 1987-06-19 NZ NZ220764A patent/NZ220764A/xx unknown
- 1987-06-26 GB GB8715064A patent/GB2192183B/en not_active Expired - Lifetime
- 1987-06-26 NL NL8701507A patent/NL193136C/nl not_active IP Right Cessation
- 1987-06-29 GR GR871014A patent/GR871014B/el unknown
- 1987-06-29 IE IE173887A patent/IE59613B1/en not_active IP Right Cessation
- 1987-06-30 DK DK336487A patent/DK161080C/da not_active IP Right Cessation
- 1987-06-30 NO NO872729A patent/NO170889C/no not_active IP Right Cessation
- 1987-06-30 SE SE8702705A patent/SE466257B/sv not_active IP Right Cessation
- 1987-07-01 IT IT8767566A patent/IT1211469B/it active Protection Beyond IP Right Term
- 1987-07-01 HU HU872992A patent/HU200777B/hu unknown
- 1987-07-01 CH CH2482/87A patent/CH672788A5/de not_active IP Right Cessation
- 1987-07-01 PL PL1987266567A patent/PL159180B1/pl unknown
- 1987-07-01 FI FI872903A patent/FI89052C/fi not_active IP Right Cessation
- 1987-07-01 IL IL83059A patent/IL83059A/xx not_active IP Right Cessation
- 1987-07-01 US US07/068,333 patent/US4812561A/en not_active Expired - Lifetime
- 1987-07-01 AT AT1658/87A patent/AT392472B/de not_active IP Right Cessation
- 1987-07-01 FR FR878709316A patent/FR2601014B1/fr not_active Expired - Lifetime
- 1987-07-02 AU AU75040/87A patent/AU594167B2/en not_active Expired
- 1987-07-02 KR KR1019870007019A patent/KR950005302B1/ko not_active Expired - Lifetime
- 1987-07-02 ES ES8702189A patent/ES2004952A6/es not_active Expired
- 1987-07-02 DE DE19873721913 patent/DE3721913A1/de not_active Withdrawn
- 1987-07-02 AR AR87308050A patent/AR243893A1/es active
- 1987-07-02 BE BE8700740A patent/BE1001691A4/fr not_active IP Right Cessation
- 1987-07-02 CN CN87105009A patent/CN1015106B/zh not_active Expired
- 1987-07-02 CA CA000541183A patent/CA1283405C/en not_active Expired - Lifetime
- 1987-11-02 ES ES8703123A patent/ES2008759A6/es not_active Expired
- 1987-12-30 RU SU874203950A patent/RU1829932C/ru active
-
1988
- 1988-11-21 US US07/275,093 patent/US4933443A/en not_active Expired - Lifetime
-
1993
- 1993-05-20 HK HK478/93A patent/HK47893A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |