CN1015106B - 一种口服头孢菌素的结晶性水合物的制备方法 - Google Patents

一种口服头孢菌素的结晶性水合物的制备方法

Info

Publication number
CN1015106B
CN1015106B CN87105009A CN87105009A CN1015106B CN 1015106 B CN1015106 B CN 1015106B CN 87105009 A CN87105009 A CN 87105009A CN 87105009 A CN87105009 A CN 87105009A CN 1015106 B CN1015106 B CN 1015106B
Authority
CN
China
Prior art keywords
method described
water
hydrate
capsule
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87105009A
Other languages
English (en)
Chinese (zh)
Other versions
CN87105009A (zh
Inventor
滨岛好男
南恭二
河田享三
坂元照男
武田豊彦
铃木裕介
辻川正则
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61156954A external-priority patent/JP2544113B2/ja
Priority claimed from JP21626086A external-priority patent/JPH0717651B2/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to CN91105982A priority Critical patent/CN1036632C/zh
Publication of CN87105009A publication Critical patent/CN87105009A/zh
Publication of CN1015106B publication Critical patent/CN1015106B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
CN87105009A 1986-07-02 1987-07-02 一种口服头孢菌素的结晶性水合物的制备方法 Expired CN1015106B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN91105982A CN1036632C (zh) 1986-07-02 1987-07-02 含口服头孢菌素结晶性水合物的组合物制法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP61156954A JP2544113B2 (ja) 1986-07-02 1986-07-02 安定なカプセル製剤
JP156954/86 1986-07-02
JP216260/86 1986-09-12
JP21626086A JPH0717651B2 (ja) 1986-09-12 1986-09-12 経口投与用セフアロスポリン水和物結晶

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN91105982A Division CN1036632C (zh) 1986-07-02 1987-07-02 含口服头孢菌素结晶性水合物的组合物制法

Publications (2)

Publication Number Publication Date
CN87105009A CN87105009A (zh) 1988-03-23
CN1015106B true CN1015106B (zh) 1991-12-18

Family

ID=26484565

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105009A Expired CN1015106B (zh) 1986-07-02 1987-07-02 一种口服头孢菌素的结晶性水合物的制备方法

Country Status (27)

Country Link
US (2) US4812561A (enExample)
KR (1) KR950005302B1 (enExample)
CN (1) CN1015106B (enExample)
AR (1) AR243893A1 (enExample)
AT (1) AT392472B (enExample)
AU (1) AU594167B2 (enExample)
BE (1) BE1001691A4 (enExample)
CA (1) CA1283405C (enExample)
CH (1) CH672788A5 (enExample)
DE (1) DE3721913A1 (enExample)
DK (1) DK161080C (enExample)
ES (2) ES2004952A6 (enExample)
FI (1) FI89052C (enExample)
FR (1) FR2601014B1 (enExample)
GB (1) GB2192183B (enExample)
GR (1) GR871014B (enExample)
HK (1) HK47893A (enExample)
HU (1) HU200777B (enExample)
IE (1) IE59613B1 (enExample)
IL (1) IL83059A (enExample)
IT (1) IT1211469B (enExample)
NL (1) NL193136C (enExample)
NO (1) NO170889C (enExample)
NZ (1) NZ220764A (enExample)
PL (1) PL159180B1 (enExample)
RU (1) RU1829932C (enExample)
SE (1) SE466257B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN1307211C (zh) * 1998-10-27 2007-03-28 伊斯曼化学公司 烯烃聚合方法,新型聚乙烯以及由其制造的薄膜和制品

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US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
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MX2009006878A (es) * 2006-12-22 2009-07-07 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
US8268803B2 (en) 2006-12-22 2012-09-18 Merck Sharp & Dohme Corp. 5, 6-ring annulated indole derivatives and use thereof
KR20090094154A (ko) 2006-12-22 2009-09-03 쉐링 코포레이션 Ｈｃｖ 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
TW200924751A (en) * 2007-08-29 2009-06-16 Schering Corp 2,3-substituted indole derivatives and methods of use thereof
KR20100065167A (ko) 2007-08-29 2010-06-15 쉐링 코포레이션 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체
CN101821252A (zh) * 2007-08-29 2010-09-01 先灵公司 取代的吲哚衍生物及其使用方法
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AU2009282574B2 (en) 2008-08-20 2014-08-21 Merck Sharp & Dohme Corp. Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
JP5674661B2 (ja) 2008-08-20 2015-02-25 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． エチニル置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用
EP2435424B1 (en) 2009-05-29 2015-01-21 Merck Sharp & Dohme Corp. Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
DK2451445T3 (da) 2009-07-06 2019-06-24 Boehringer Ingelheim Int Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens
US20120276047A1 (en) 2009-11-25 2012-11-01 Rosenblum Stuart B Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
EP2516430B1 (en) 2009-12-22 2014-11-05 Merck Sharp & Dohme Corp. Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
WO2011103441A1 (en) 2010-02-18 2011-08-25 Schering Corporation Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
BR112012022125A2 (pt) 2010-03-09 2016-11-01 Merck Sharp & Dhme Corp composto, sal de dicloridrato, composição farmacêutica, uso do composto, e, método para tratar um paciente
EP2566449B1 (en) 2010-05-04 2014-10-08 Mahmut Bilgic Pharmaceutical compositions comprising ceftibuten
JP2013541499A (ja) 2010-07-26 2013-11-14 メルク・シャープ・エンド・ドーム・コーポレイション 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法
AU2011314168A1 (en) 2010-09-29 2013-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
EA201391519A1 (ru) 2011-04-13 2014-03-31 Мерк Шарп И Доум Корп. 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний
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WO2013151518A1 (en) * 2012-04-04 2013-10-10 Mahmut Bilgic Capsule formulations comprising ceftibuten
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CN103948932B (zh) * 2014-04-17 2016-03-16 海南日中天制药有限公司 一种头孢克肟组合物及其制备方法
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CN106432271A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢布烯晶体化合物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1307211C (zh) * 1998-10-27 2007-03-28 伊斯曼化学公司 烯烃聚合方法,新型聚乙烯以及由其制造的薄膜和制品

Also Published As

Publication number Publication date
KR950005302B1 (ko) 1995-05-23
GB2192183A (en) 1988-01-06
DK336487D0 (da) 1987-06-30
AT392472B (de) 1991-04-10
ATA165887A (de) 1990-09-15
FI89052B (fi) 1993-04-30
AU7504087A (en) 1988-01-07
NL193136B (nl) 1998-08-03
IE59613B1 (en) 1994-03-09
AU594167B2 (en) 1990-03-01
PL159180B1 (pl) 1992-11-30
FI89052C (fi) 1993-08-10
HU200777B (en) 1990-08-28
US4812561A (en) 1989-03-14
BE1001691A4 (fr) 1990-02-13
GB2192183B (en) 1990-05-16
CN87105009A (zh) 1988-03-23
FI872903L (fi) 1988-01-03
US4933443A (en) 1990-06-12
KR880001670A (ko) 1988-04-26
ES2008759A6 (es) 1989-08-01
IE871738L (en) 1988-01-02
IL83059A0 (en) 1987-12-31
FR2601014B1 (fr) 1990-09-14
RU1829932C (ru) 1993-07-23
HUT44257A (en) 1988-02-29
DE3721913A1 (de) 1988-01-07
SE8702705D0 (sv) 1987-06-30
ES2004952A6 (es) 1989-02-16
CH672788A5 (enExample) 1989-12-29
FR2601014A1 (fr) 1988-01-08
NL193136C (nl) 1998-12-04
NO170889C (no) 1992-12-23
GR871014B (en) 1987-11-02
PL266567A1 (en) 1988-07-21
NZ220764A (en) 1989-09-27
DK336487A (da) 1988-01-03
FI872903A0 (fi) 1987-07-01
DK161080B (da) 1991-05-27
AR243893A1 (es) 1993-09-30
IL83059A (en) 1992-03-29
SE466257B (sv) 1992-01-20
IT8767566A0 (it) 1987-07-01
NL8701507A (nl) 1988-02-01
IT1211469B (it) 1989-11-03
HK47893A (en) 1993-05-27
NO872729L (no) 1988-01-04
CA1283405C (en) 1991-04-23
GB8715064D0 (en) 1987-08-05
NO170889B (no) 1992-09-14
NO872729D0 (no) 1987-06-30
DK161080C (da) 1991-11-11
SE8702705L (sv) 1988-01-03

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