IE56652B1 - Antihypertensive n-piperazinylalkanoylanilides - Google Patents

Antihypertensive n-piperazinylalkanoylanilides

Info

Publication number
IE56652B1
IE56652B1 IE207/84A IE20784A IE56652B1 IE 56652 B1 IE56652 B1 IE 56652B1 IE 207/84 A IE207/84 A IE 207/84A IE 20784 A IE20784 A IE 20784A IE 56652 B1 IE56652 B1 IE 56652B1
Authority
IE
Ireland
Prior art keywords
group
sulphamoyl
methoxyphenyl
solvent
inyl
Prior art date
Application number
IE207/84A
Other languages
English (en)
Other versions
IE840207L (en
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of IE840207L publication Critical patent/IE840207L/xx
Publication of IE56652B1 publication Critical patent/IE56652B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IE207/84A 1983-02-12 1984-01-30 Antihypertensive n-piperazinylalkanoylanilides IE56652B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838303946A GB8303946D0 (en) 1983-02-12 1983-02-12 Antihypertensive n-piperazinylalkanoylanilides

Publications (2)

Publication Number Publication Date
IE840207L IE840207L (en) 1984-08-14
IE56652B1 true IE56652B1 (en) 1991-10-23

Family

ID=10537908

Family Applications (1)

Application Number Title Priority Date Filing Date
IE207/84A IE56652B1 (en) 1983-02-12 1984-01-30 Antihypertensive n-piperazinylalkanoylanilides

Country Status (23)

Country Link
US (1) US4940711A (xx)
EP (1) EP0120558B1 (xx)
JP (1) JPS59152379A (xx)
KR (1) KR910000451B1 (xx)
AR (1) AR241182A1 (xx)
AT (1) ATE41150T1 (xx)
AU (1) AU565208B2 (xx)
CA (1) CA1254894A (xx)
DE (1) DE3476998D1 (xx)
DK (1) DK162640C (xx)
ES (1) ES529642A0 (xx)
FI (1) FI80025C (xx)
GB (1) GB8303946D0 (xx)
GR (1) GR81460B (xx)
HU (1) HU191270B (xx)
IE (1) IE56652B1 (xx)
IL (1) IL70733A (xx)
MX (1) MX156049A (xx)
NZ (1) NZ206823A (xx)
PH (1) PH20244A (xx)
PT (1) PT78081B (xx)
SG (1) SG34889G (xx)
ZA (1) ZA84316B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
JPS61134382A (ja) * 1984-12-04 1986-06-21 Kyorin Pharmaceut Co Ltd 新規なスルファモイル安息香酸誘導体およびその製造法
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
JP2712222B2 (ja) * 1988-01-29 1998-02-10 三菱化学株式会社 抗不安薬
DK203990D0 (da) * 1990-08-24 1990-08-24 Novo Nordisk As Piperazinylderivater
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US20160214967A1 (en) * 2013-09-30 2016-07-28 The University Of Tokyo Activator of adiponectin receptor
AU2015299055C1 (en) * 2014-08-06 2021-05-06 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912788A (en) * 1959-11-16 1962-12-12 Miles Lab Phenylpiperazinylacyl anilines
DE1670200A1 (de) * 1967-03-22 1972-03-02 Byk Gulden Lomberg Chem Fab Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung
JPS5064282A (xx) * 1973-10-17 1975-05-31
JPS5849550B2 (ja) * 1974-02-07 1983-11-05 住友化学工業株式会社 シンキナアニリンユウドウタイ ノ セイホウ
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS58154573A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体及びその酸付加塩
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides

Also Published As

Publication number Publication date
ES8507529A1 (es) 1985-09-01
SG34889G (en) 1989-10-13
DK162640C (da) 1992-04-13
ES529642A0 (es) 1985-09-01
JPS59152379A (ja) 1984-08-31
FI840478A0 (fi) 1984-02-06
AU2449484A (en) 1984-08-16
PT78081A (en) 1984-03-01
IL70733A0 (en) 1984-04-30
DK162640B (da) 1991-11-25
MX156049A (es) 1988-06-21
EP0120558B1 (en) 1989-03-08
FI80025C (fi) 1990-04-10
FI80025B (fi) 1989-12-29
AR241182A1 (es) 1992-01-31
ATE41150T1 (de) 1989-03-15
FI840478A (fi) 1984-08-13
AU565208B2 (en) 1987-09-10
ZA84316B (en) 1985-02-27
IL70733A (en) 1987-10-30
DK48584A (da) 1984-08-13
DK48584D0 (da) 1984-02-03
JPH0434549B2 (xx) 1992-06-08
EP0120558A1 (en) 1984-10-03
HU191270B (en) 1987-01-28
KR910000451B1 (en) 1991-01-25
GR81460B (xx) 1984-12-11
CA1254894A (en) 1989-05-30
GB8303946D0 (en) 1983-03-16
PH20244A (en) 1986-11-10
PT78081B (en) 1986-04-17
DE3476998D1 (de) 1989-04-13
KR840007593A (ko) 1984-12-08
US4940711A (en) 1990-07-10
NZ206823A (en) 1987-07-31
IE840207L (en) 1984-08-14

Similar Documents

Publication Publication Date Title
IE56652B1 (en) Antihypertensive n-piperazinylalkanoylanilides
BRPI0611663A2 (pt) processo para sìntese de compostos orgánicos
EP0074768A2 (en) Alkanoylanilides
EP0900214B1 (en) Process for preparation of pyrimidine derivatives
JPH07103122B2 (ja) イミダゾ〔1,2−c〕キナゾリン誘導体、これらの製造方法、及びそれらを含む狭心症薬
JP2707936B2 (ja) β−オキソ−β−ベンゼンプロパンチオアミド誘導体
EP1807404A1 (en) Novel use
US6252076B1 (en) Process for preparation of pyrimidine derivatives
NO175097B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive hydrazoner
JPH0366310B2 (xx)
SU517257A3 (ru) Способ получени производных бензодиазепина
BRPI0611287A2 (pt) compostos de estirilsulfonamidas, processo para sua preparacão, composicão farmacêutica, bem como seu uso
RU2512567C2 (ru) Фенилалкилпиперазины, модулирующие активность tnf
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
JPS62145073A (ja) キナゾリン査導体
US3517010A (en) 5-acetamido-4-pyrimidinecarboxylic acids and related compounds
KR100497105B1 (ko) 3,4-디히드로퀴나졸린 유도체 및 그의 제조 방법
AU763541B2 (en) Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers
US3948915A (en) 2-Halopyrimidine derivatives and a method for their preparation
JPH033674B2 (xx)
US4202977A (en) S-Triazolo [1,5-a] pyridine derivatives
SU417945A3 (ru) Способ получения производных хиназолинона-2
NO882085L (no) Cyklobutenmellomprodukt.
JPH037266A (ja) 2―(4―フェニル―1―ピペラジニルアルキル)アミノ―5―エチニルピリミジン誘導体並びにその中間体及びその製造法
WO1998014430A1 (fr) Derives de pyrimidine

Legal Events

Date Code Title Description
MM4A Patent lapsed
HK1 Errata: patent still in force

Free format text: ADVERTISED IN JOURNAL NO.1768 OF 06/9/95,PAGE 295

MM4A Patent lapsed