IE44569B1 - Tetrahydroisoquinolinium muscle relaxants - Google Patents

Tetrahydroisoquinolinium muscle relaxants

Info

Publication number
IE44569B1
IE44569B1 IE2688/76A IE268876A IE44569B1 IE 44569 B1 IE44569 B1 IE 44569B1 IE 2688/76 A IE2688/76 A IE 2688/76A IE 268876 A IE268876 A IE 268876A IE 44569 B1 IE44569 B1 IE 44569B1
Authority
IE
Ireland
Prior art keywords
compound
dioxa
bis
dimethyl
formula
Prior art date
Application number
IE2688/76A
Other languages
English (en)
Other versions
IE44569L (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26265501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE44569(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB4502876A external-priority patent/GB1579822A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IE44569L publication Critical patent/IE44569L/xx
Publication of IE44569B1 publication Critical patent/IE44569B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE2688/76A 1975-12-10 1976-12-09 Tetrahydroisoquinolinium muscle relaxants IE44569B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5058975 1975-12-10
GB4502876A GB1579822A (en) 1976-10-29 1976-10-29 Tetrahydroisoquinolinium muscle relaxants

Publications (2)

Publication Number Publication Date
IE44569L IE44569L (en) 1977-06-10
IE44569B1 true IE44569B1 (en) 1982-01-13

Family

ID=26265501

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2688/76A IE44569B1 (en) 1975-12-10 1976-12-09 Tetrahydroisoquinolinium muscle relaxants

Country Status (24)

Country Link
US (1) US4179507A (enExample)
JP (1) JPS6043342B2 (enExample)
AT (1) AT365579B (enExample)
AU (1) AU506657B2 (enExample)
CA (1) CA1075241A (enExample)
CH (1) CH625223A5 (enExample)
CY (1) CY1217A (enExample)
DD (1) DD128320A5 (enExample)
DE (1) DE2655883A1 (enExample)
DK (1) DK149751C (enExample)
FI (1) FI61485C (enExample)
FR (1) FR2334359A1 (enExample)
HK (1) HK35084A (enExample)
IE (1) IE44569B1 (enExample)
IL (1) IL51074A (enExample)
IT (1) IT1188908B (enExample)
KE (1) KE3361A (enExample)
LU (1) LU76355A1 (enExample)
MC (1) MC1119A1 (enExample)
MY (1) MY8500287A (enExample)
NL (1) NL178688C (enExample)
NZ (1) NZ182847A (enExample)
SE (1) SE434154B (enExample)
SU (1) SU718008A3 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
GB9015473D0 (en) * 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
PE68399A1 (es) * 1997-03-25 1999-07-23 Cornell Res Foundation Inc Derivado de isoquinolina como bloqueador neuromuscular de accion ultra corta
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008273724B2 (en) * 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
AU2008264802A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
ES2535326T3 (es) * 2009-04-14 2015-05-08 Glaxo Group Limited Procedimiento de preparación de un éster de ácido bifenil-2-ilcarbámico
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
EP2514754B1 (en) 2011-04-08 2013-08-21 King Saud University 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation
CN102249998B (zh) * 2011-06-20 2013-09-25 浙江仙琚制药股份有限公司 一种制备顺苯磺酸阿曲库铵的方法
CN102898370A (zh) * 2012-11-11 2013-01-30 苏州二叶制药有限公司 注射用顺苯磺阿曲库铵
WO2018193463A1 (en) * 2017-04-21 2018-10-25 Neon Laboratories Limited An improved process for the preparation of tetrahydroisoquinoline compounds
CN114181147A (zh) * 2021-12-27 2022-03-15 上海药坦药物研究开发有限公司 一种苯磺阿曲库铵的处理方法
CN115850169B (zh) * 2022-10-17 2025-04-04 上海医药集团(本溪)北方药业有限公司 苯磺顺阿曲库铵杂质及其中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines

Also Published As

Publication number Publication date
FI61485C (fi) 1982-08-10
HK35084A (en) 1984-04-27
FI763543A7 (enExample) 1977-06-11
FR2334359A1 (fr) 1977-07-08
ATA908476A (de) 1981-06-15
KE3361A (en) 1984-02-17
MC1119A1 (fr) 1977-08-12
AU506657B2 (en) 1980-01-17
SE434154B (sv) 1984-07-09
SU718008A3 (ru) 1980-02-25
IL51074A (en) 1980-05-30
NZ182847A (en) 1979-06-08
DE2655883C2 (enExample) 1990-02-01
SE7613824L (sv) 1977-06-11
AU2037576A (en) 1978-06-15
CA1075241A (en) 1980-04-08
AT365579B (de) 1982-01-25
IT8048000A0 (it) 1980-02-25
DE2655883A1 (de) 1977-06-23
NL178688C (nl) 1986-05-01
NL178688B (nl) 1985-12-02
NL7613695A (nl) 1977-06-14
FR2334359B1 (enExample) 1981-10-16
IE44569L (en) 1977-06-10
LU76355A1 (enExample) 1977-06-24
JPS5277069A (en) 1977-06-29
DD128320A5 (de) 1977-11-09
IT8048000A1 (it) 1981-08-25
DK149751B (da) 1986-09-22
DK149751C (da) 1987-03-23
CH625223A5 (enExample) 1981-09-15
IT1188908B (it) 1988-01-28
MY8500287A (en) 1985-12-31
FI61485B (fi) 1982-04-30
CY1217A (en) 1984-04-06
IL51074A0 (en) 1977-02-28
JPS6043342B2 (ja) 1985-09-27
DK553676A (da) 1977-06-11
US4179507A (en) 1979-12-18

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MK9A Patent expired