IE44569B1 - Tetrahydroisoquinolinium muscle relaxants - Google Patents

Tetrahydroisoquinolinium muscle relaxants

Info

Publication number
IE44569B1
IE44569B1 IE2688/76A IE268876A IE44569B1 IE 44569 B1 IE44569 B1 IE 44569B1 IE 2688/76 A IE2688/76 A IE 2688/76A IE 268876 A IE268876 A IE 268876A IE 44569 B1 IE44569 B1 IE 44569B1
Authority
IE
Ireland
Prior art keywords
compound
dioxa
bis
dimethyl
formula
Prior art date
Application number
IE2688/76A
Other languages
English (en)
Other versions
IE44569L (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26265501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE44569(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB4502876A external-priority patent/GB1579822A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IE44569L publication Critical patent/IE44569L/xx
Publication of IE44569B1 publication Critical patent/IE44569B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE2688/76A 1975-12-10 1976-12-09 Tetrahydroisoquinolinium muscle relaxants IE44569B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5058975 1975-12-10
GB4502876A GB1579822A (en) 1976-10-29 1976-10-29 Tetrahydroisoquinolinium muscle relaxants

Publications (2)

Publication Number Publication Date
IE44569L IE44569L (en) 1977-06-10
IE44569B1 true IE44569B1 (en) 1982-01-13

Family

ID=26265501

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2688/76A IE44569B1 (en) 1975-12-10 1976-12-09 Tetrahydroisoquinolinium muscle relaxants

Country Status (24)

Country Link
US (1) US4179507A (en:Method)
JP (1) JPS6043342B2 (en:Method)
AT (1) AT365579B (en:Method)
AU (1) AU506657B2 (en:Method)
CA (1) CA1075241A (en:Method)
CH (1) CH625223A5 (en:Method)
CY (1) CY1217A (en:Method)
DD (1) DD128320A5 (en:Method)
DE (1) DE2655883A1 (en:Method)
DK (1) DK149751C (en:Method)
FI (1) FI61485C (en:Method)
FR (1) FR2334359A1 (en:Method)
HK (1) HK35084A (en:Method)
IE (1) IE44569B1 (en:Method)
IL (1) IL51074A (en:Method)
IT (1) IT1188908B (en:Method)
KE (1) KE3361A (en:Method)
LU (1) LU76355A1 (en:Method)
MC (1) MC1119A1 (en:Method)
MY (1) MY8500287A (en:Method)
NL (1) NL178688C (en:Method)
NZ (1) NZ182847A (en:Method)
SE (1) SE434154B (en:Method)
SU (1) SU718008A3 (en:Method)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
GB9015473D0 (en) * 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
CA2284802C (en) 1997-03-25 2009-06-16 Cornell Research Foundation, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
CA2671904C (en) * 2006-12-06 2012-07-03 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
WO2008107887A2 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CA2692636A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
BRPI0816519A2 (pt) * 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CA2758353C (en) * 2009-04-14 2017-06-06 Dean David Edney Process for the preparation of a biphenyl-2-ylcarbamic acid ester
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
EP2514754B1 (en) 2011-04-08 2013-08-21 King Saud University 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation
CN102249998B (zh) * 2011-06-20 2013-09-25 浙江仙琚制药股份有限公司 一种制备顺苯磺酸阿曲库铵的方法
CN102898370A (zh) * 2012-11-11 2013-01-30 苏州二叶制药有限公司 注射用顺苯磺阿曲库铵
WO2018193463A1 (en) * 2017-04-21 2018-10-25 Neon Laboratories Limited An improved process for the preparation of tetrahydroisoquinoline compounds
CN114181147A (zh) * 2021-12-27 2022-03-15 上海药坦药物研究开发有限公司 一种苯磺阿曲库铵的处理方法
CN115850169B (zh) * 2022-10-17 2025-04-04 上海医药集团(本溪)北方药业有限公司 苯磺顺阿曲库铵杂质及其中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines

Also Published As

Publication number Publication date
FR2334359B1 (en:Method) 1981-10-16
FI61485B (fi) 1982-04-30
FI61485C (fi) 1982-08-10
ATA908476A (de) 1981-06-15
IL51074A0 (en) 1977-02-28
SE7613824L (sv) 1977-06-11
KE3361A (en) 1984-02-17
CH625223A5 (en:Method) 1981-09-15
HK35084A (en) 1984-04-27
JPS6043342B2 (ja) 1985-09-27
IT8048000A0 (it) 1980-02-25
US4179507A (en) 1979-12-18
FI763543A7 (en:Method) 1977-06-11
SU718008A3 (ru) 1980-02-25
IE44569L (en) 1977-06-10
NL178688C (nl) 1986-05-01
DD128320A5 (de) 1977-11-09
IT8048000A1 (it) 1981-08-25
AT365579B (de) 1982-01-25
DE2655883A1 (de) 1977-06-23
MC1119A1 (fr) 1977-08-12
IT1188908B (it) 1988-01-28
DK149751C (da) 1987-03-23
CA1075241A (en) 1980-04-08
FR2334359A1 (fr) 1977-07-08
SE434154B (sv) 1984-07-09
AU506657B2 (en) 1980-01-17
NL7613695A (nl) 1977-06-14
NL178688B (nl) 1985-12-02
DE2655883C2 (en:Method) 1990-02-01
DK553676A (da) 1977-06-11
IL51074A (en) 1980-05-30
JPS5277069A (en) 1977-06-29
MY8500287A (en) 1985-12-31
CY1217A (en) 1984-04-06
NZ182847A (en) 1979-06-08
DK149751B (da) 1986-09-22
LU76355A1 (en:Method) 1977-06-24
AU2037576A (en) 1978-06-15

Similar Documents

Publication Publication Date Title
IE44569B1 (en) Tetrahydroisoquinolinium muscle relaxants
JP3014457B2 (ja) 新規キヌクリジン誘導体及びその医薬組成物
US5001133A (en) Benzoic acid derivatives
DE69701298T2 (de) Hydroxypyridin-Derivate, ihre Herstellung und ihre pharmazeutische Verwendung
US2924603A (en) Aralkylbenzmorphan derivatives
JPS63502750A (ja) ２−（２−ニトロ又は２−アミノベンジル）−１，２，３，４−テトラヒドロイソキノレイン誘導体、その製造方法及びこれらの誘導体を含む薬剤組成物
CA1288102C (en) Pyridine derivatives, their preparation and their use
US4673682A (en) Isoquinoline derivatives, pharmaceutical formulations based on these compounds and the use thereof
EP0453197A1 (en) Amine derivatives
US3378561A (en) 1-beta-arylthioethyltetrahydro-isoquinolines
GB1579822A (en) Tetrahydroisoquinolinium muscle relaxants
US3910915A (en) 1-Aryl-2-{8 (substituted amino)alkanoyl{9 -1,2,3,4-tetrahydroisoquinolines
Lenz Synthesis of 7-oxygenated aporphine alkaloids from a 1-benzylideneisoquinoline enamide
US4058531A (en) Process for the preparation of 14-hydroxymorphinan derivatives
JPS61143382A (ja) １，６−ナフチリジン誘導体、その製造方法およびこれを含有する薬剤
US4166174A (en) Benzazocine derivatives and process for preparing the same
US3557122A (en) 5,6,7a,8,11,11a,12,12a-octahydroindolo (2,1-a)isoquinolin-9(10h)-ones
US4139534A (en) Process for the preparation of 14-hydroxymorphinan derivatives
EP0506903A1 (en) 4-acetoxy-piperidine derivatives, process for their preparation and use as a muscarinic m3-receptor antagonist
US4537895A (en) Isoquinoline derivatives
US4247697A (en) 3-Phenoxy morphinans and their derivatives
US4194044A (en) Process for preparing 3-phenoxy morphinans
Brooks et al. Cyclisation of N-(prop-2-ynyl) benzylamines. Part II. Synthesis of 1, 2-dihydro-3-phenylisoquinolines and an isopavine derivative
US3790581A (en) N-(1-(3-cyano-3,3-bis(optionally substituted phenyl)propyl)-4-phenylpiperidine-4-carbonyloxy)succinimides
US2946797A (en) N-aminotetrahydroisoquinolinium salts

Legal Events

Date Code Title Description
MK9A Patent expired