IE38883B1 - Diazepine derivatives - Google Patents
Diazepine derivativesInfo
- Publication number
- IE38883B1 IE38883B1 IE00221/74A IE22174A IE38883B1 IE 38883 B1 IE38883 B1 IE 38883B1 IE 00221/74 A IE00221/74 A IE 00221/74A IE 22174 A IE22174 A IE 22174A IE 38883 B1 IE38883 B1 IE 38883B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- compound
- hydroxyalkyl
- alkylcarbonyloxyalkyl
- formula
- Prior art date
Links
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title 1
- -1 o-trifluoromethylphenyl Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 125000001209 o-nitrophenyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])[N+]([O-])=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH179973A CH584223A5 (enrdf_load_stackoverflow) | 1973-02-08 | 1973-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38883L IE38883L (en) | 1974-08-08 |
| IE38883B1 true IE38883B1 (en) | 1978-06-21 |
Family
ID=4218866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00221/74A IE38883B1 (en) | 1973-02-08 | 1974-02-06 | Diazepine derivatives |
Country Status (24)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT338799B (de) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze |
| DE2533924C3 (de) * | 1975-07-30 | 1979-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | Verfahren zur Herstellung von 6- Aryl-4H-striazolo [3,4-c] thieno [2,3-e] 1,4-diazepinen |
| DE2531678C3 (de) * | 1975-07-16 | 1979-06-28 | C.H. Boehringer Sohn, 6507 Ingelheim | Thieno [2,3e] triazole [3,4c] 5,6-dihydro-l,4diazepine und Verfahren zu ihrer Herstellung |
| DE2708121A1 (de) * | 1977-02-25 | 1978-09-07 | Boehringer Sohn Ingelheim | Triazolo-thieno-diazepin-l-one, verfahren zu ihrer herstellung und arzneimittel |
| FI63033C (fi) * | 1977-07-21 | 1983-04-11 | Boehringer Sohn Ingelheim | Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner |
| DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
| WO1995032963A1 (fr) * | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienylazole et compose de thienotriazolodiazepine |
| AU725249B2 (en) * | 1995-09-09 | 2000-10-12 | F. Hoffmann-La Roche Ag | Use of a thienotriazolodiazepine to increase apolipoprotein A-I levels |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904641A (en) * | 1971-06-18 | 1975-09-09 | Yoshitomi Pharmaceutical | Triazolothienodiazepine compounds |
-
1973
- 1973-01-29 PH PH7315453A patent/PH12303A/en unknown
- 1973-02-08 CH CH179973A patent/CH584223A5/xx not_active IP Right Cessation
-
1974
- 1974-01-22 ZA ZA740472A patent/ZA74472B/xx unknown
- 1974-01-28 IL IL44095A patent/IL44095A/xx unknown
- 1974-01-28 NL NLAANVRAGE7401117,A patent/NL174045C/xx not_active IP Right Cessation
- 1974-01-30 YU YU2287/74A patent/YU39716B/xx unknown
- 1974-02-06 IE IE00221/74A patent/IE38883B1/xx unknown
- 1974-02-06 FR FR7403922A patent/FR2217007B1/fr not_active Expired
- 1974-02-06 LU LU69338A patent/LU69338A1/xx unknown
- 1974-02-06 CA CA74191917A patent/CA1049009A/en not_active Expired
- 1974-02-06 DD DD176414A patent/DD112454A5/xx unknown
- 1974-02-06 DE DE2405682A patent/DE2405682C3/de not_active Expired
- 1974-02-07 SU SU741994653A patent/SU715028A3/ru active
- 1974-02-07 AT AT96474A patent/AT343118B/de not_active IP Right Cessation
- 1974-02-07 GB GB539676A patent/GB1456162A/en not_active Expired
- 1974-02-07 DK DK66874AA patent/DK137679B/da unknown
- 1974-02-07 PL PL1974168647A patent/PL96107B1/pl unknown
- 1974-02-07 HU HU74HO1865A patent/HU173741B/hu unknown
- 1974-02-07 PL PL1974191791A patent/PL97304B1/pl unknown
- 1974-02-07 HU HUHO1644A patent/HU170423B/hu unknown
- 1974-02-07 NO NO740405A patent/NO142260C/no unknown
- 1974-02-07 BE BE140629A patent/BE810705A/xx not_active IP Right Cessation
- 1974-02-07 GB GB568374A patent/GB1456161A/en not_active Expired
- 1974-02-07 SE SE7401664A patent/SE416399B/xx not_active IP Right Cessation
- 1974-02-07 PL PL1974191789A patent/PL97275B1/pl unknown
- 1974-02-08 AR AR252265A patent/AR203188A1/es active
- 1974-02-08 FI FI357/74A patent/FI58129C/fi active
- 1974-02-08 JP JP49015549A patent/JPS5833234B2/ja not_active Expired
- 1974-12-04 AR AR256777A patent/AR217034A1/es active
-
1978
- 1978-06-10 SU SU782633846A patent/SU1060115A3/ru active
- 1978-07-10 SU SU782633659A patent/SU747429A4/ru active
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